Modulatory effect of interleukin-2 loaded chitosan nano sphere on regulatory T cell activity in streptozotocin-induced diabetic mice

CONCLUSIONS: Low-dose IL-2 selectively modulates FoxP3 + Tregs, and TGFβ 1 increases their levels. These results demonstrated that IL-2-free and chitosan-loaded nanoparticles can be therapeutic agents in T1D.PMID:38599099 | DOI:10.1016/j.intimp.2024.112019

Source: International Immunopharmacology - April 10, 2024 Category: Allergy & Immunology Authors: Salma Aboelnazar Hossam Ghoneim Thanaa Shalaby Sally Sorour Eman M Osman Source Type: research