Cutaneous adverse reactions associated with COVID-19 vaccines: Current evidence and potential immune mechanisms
Clin Immunol. 2024 Apr 18:110220. doi: 10.1016/j.clim.2024.110220. Online ahead of print.ABSTRACTAs the number of vaccinated individuals has increased, there have been increasing reports of cutaneous hypersensitivity reactions. The main COVID-19 vaccines administered include messenger ribonucleic acid vaccines, non-replicating viral vector vaccines, inactivated whole-virus vaccines, and protein-based vaccines. These vaccines contain active components such as polyethylene glycol, polysorbate 80, aluminum, tromethamine, and disodium edetate dihydrate. Recent advances in understanding the coordination of inflammatory response...
Source: Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Po-Chien Wu Wan-Chen Lin Chuang-Wei Wang Wen-Hung Chung Chun-Bing Chen Source Type: research
How do we change our approach to COVID with the changing face of disease?
Expert Rev Anti Infect Ther. 2024 Apr 20. doi: 10.1080/14787210.2024.2345881. Online ahead of print.ABSTRACTINTRODUCTION: The emergence of SARS-CoV-2 triggered a global health emergency, causing > 7 million deaths thus far. Limited early knowledge spurred swift research, treatment, and vaccine developments. Implementation of public health measures such as, lockdowns and social distancing, disrupted economies and strained healthcare. Viral mutations highlighted the need for flexible strategies and strong public health infrastructure, with global collaboration crucial for pandemic control.AREAS COVERED: (i) Revisiting dia...
Source: Expert Review of Anti-Infective Therapy - April 20, 2024 Category: Infectious Diseases Authors: Vasso Apostolopoulos Jack Feehan Vivek P Chavda Source Type: research
How do we change our approach to COVID with the changing face of disease?
Expert Rev Anti Infect Ther. 2024 Apr 26:1-9. doi: 10.1080/14787210.2024.2345881. Online ahead of print.ABSTRACTINTRODUCTION: The emergence of SARS-CoV-2 triggered a global health emergency, causing > 7 million deaths thus far. Limited early knowledge spurred swift research, treatment, and vaccine developments. Implementation of public health measures such as, lockdowns and social distancing, disrupted economies and strained healthcare. Viral mutations highlighted the need for flexible strategies and strong public health infrastructure, with global collaboration crucial for pandemic control.AREAS COVERED: (i) Revisiting...
Source: Expert Review of Anti-Infective Therapy - April 20, 2024 Category: Infectious Diseases Authors: Vasso Apostolopoulos Jack Feehan Vivek P Chavda Source Type: research
Influence of vaccination on critical COVID-19 patients with acute respiratory failure: a retrospective cohort study
ConclusionsVaccination status did not significantly influence mortality rates, the occurrence of ARDS, or the viral shedding duration in COVID-19 patients with acute respiratory failure. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research
Incidence of SARS-CoV-2 Seropositivity in Pediatric Healthcare Workers Prior to Widespread Vaccination: A Five-month Longitudinal Cohort Study
CONCLUSION: Incidence of seropositivity was 8.2%. Although seropositivity was higher among ED staff during early stages of the pandemic, this difference declined over time, likely due to universal adoption of personal protective equipment (PPE).PMID:38641316 | DOI:10.1016/j.ijid.2024.107064 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Mark Griffiths Dunia Hatabah Patrick Sullivan Grace Mantus Travis Sanchez Maria Zlotorzynska Stacy Heilman Andres Camacho-Gonzalez Deborah Leake Rawan Korman Mimi Le Mehul Suthara Jens Wrammert Miriam B Vos Claudia R Morris Source Type: research
Predictors of willingness to receive updated 2023-2024 COVID-19 booster vaccines among a convenience sample in Minnesota
CONCLUSIONS: Our study emphasizes the importance of perceived vaccine safety as a predictor of intention to accept COVID-19 vaccines and highlights the continued need to effectively communicate with the public about the safety of vaccines.PMID:38641495 | DOI:10.1016/j.vaccine.2024.04.053 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: I J Ricke A B Spaulding N N Rajtar E M Benton I G Anderson L Lundberg A Mussiel R H N Nguyen Source Type: research
COVID-19 vaccine uptake among children and adolescents in Norway: A comprehensive registry-based cohort study of over 800,000 individuals
This study aimed to comprehensively examine individual and familial factors associated with vaccine uptake in children and adolescents in Norway. We utilized nationwide registry-data from various health registries and Statistics Norway, encompassing all children and adolescents living in Norway during the pandemic, until 31-Dec-2022. Vaccine uptake is defined as receiving at least one dose of COVID-19 vaccine. We employed a forward stepwise logistic regression model and a random forest machine-learning algorithm to explore the relationship between vaccine uptake and socio-cultural, demographic, and health-related factors. ...
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Saima Orangzeb Anteneh Desalegn Nhung T H Trinh Jing Zhao Hedvig Nordeng Angela Lupattelli Source Type: research
Recombinant ACE2 - Opportunities and Challenges in COVID-19 Treatment
Infect Disord Drug Targets. 2024 Apr 18. doi: 10.2174/0118715265298816240321045741. Online ahead of print.ABSTRACTIt was in 2019 that the world experienced the devastation caused by SARS-COV-2, contributing to a large number of deaths. This contagious virus not only challenged the health care system but has also hit the economy very badly. There has been a lot of research on effective vaccine development, and there has been some success in the same, but no effective antiviral drugs are available in the market. No doubt vaccination can prevent the disease, but it doesn't have the potential to cure an infected person, for wh...
Source: Infectious Disorders Drug Targets - April 19, 2024 Category: Infectious Diseases Authors: Rahul Sandhu Mandeep Kaur Akriti Aggarwal Source Type: research
Impact of shift work and other work-related factors on anti-SARS-CoV-2 spike-protein serum concentrations in healthcare workers after primary mRNA vaccination - a retrospective cohort study
CONCLUSION: Working late or night shifts shortly before or after mRNA vaccination against COVID-19 does not appear to significantly impact serum anti-S antibody levels. This result merits consideration since it supports flexible vaccination appointments for healthcare workers, including those working late or night shifts.PMID:38639178 | DOI:10.57187/s.3708 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 19, 2024 Category: General Medicine Authors: Gianluca Mauro Menghini Robert Thurnheer Christian R Kahlert Philipp Kohler Fabian Gr ässli Reto Stocker Manuel Battegay Danielle Vuichard-Gysin Source Type: research
Proteomic and cellular characterization of Omicron breakthrough infections and a third homologous or heterologous boosting vaccination in a longitudinal cohort
CONCLUSION: Breakthrough infections can trigger more intensive inflammatory chemokine responses than vaccination. T-cell and innate immune activation have been shown to be closely related to enhanced antibody levels after vaccination and therefore might be potential targets for vaccine adjuvant design.PMID:38641227 | DOI:10.1016/j.mcpro.2024.100769 (Source: Molecular and Cellular Proteomics : MCP)
Source: Molecular and Cellular Proteomics : MCP - April 19, 2024 Category: Molecular Biology Authors: Yi Zhang Zhangfan Fu Haocheng Zhang Ke Lin Jieyu Song Jingxin Guo Qiran Zhang Guanmin Yuan Hongyu Wang Mingxiang Fan Yuanhan Zhao Rui Sun Tiannan Guo Ning Jiang Chao Qiu Wenhong Zhang Jingwen Ai Source Type: research
Beyond prevention: Unveiling the benefits of triple vaccination on COVID-19 severity and resource utilization in solid organ transplant recipients
CONCLUSION: In solid organ transplant recipients with COVID-19, triple vaccination, but not double vaccination, against SARS-CoV-2 was associated with significantly less hospital resource utilization, decreased disease severity, and fewer short-term complications. These real-world data from extensively matched controls support the protective effects of COVID-19 vaccination with boosters in this vulnerable population.PMID:38641149 | DOI:10.1016/j.trim.2024.102048 (Source: Transplant Immunology)
Source: Transplant Immunology - April 19, 2024 Category: Transplant Surgery Authors: Jared R Zhang John C Johnson Richard G Preble Muhammad Mujtaba A Scott Lea Heather L Stevenson Michael Kueht Source Type: research
Beyond prevention: Unveiling the benefits of triple vaccination on COVID-19 severity and resource utilization in solid organ transplant recipients
CONCLUSION: In solid organ transplant recipients with COVID-19, triple vaccination, but not double vaccination, against SARS-CoV-2 was associated with significantly less hospital resource utilization, decreased disease severity, and fewer short-term complications. These real-world data from extensively matched controls support the protective effects of COVID-19 vaccination with boosters in this vulnerable population.PMID:38641149 | DOI:10.1016/j.trim.2024.102048 (Source: Transplant Immunology)
Source: Transplant Immunology - April 19, 2024 Category: Transplant Surgery Authors: Jared R Zhang John C Johnson Richard G Preble Muhammad Mujtaba A Scott Lea Heather L Stevenson Michael Kueht Source Type: research
Can essential fatty acids (EFAs) prevent and ameliorate post-COVID-19 long haul manifestations?
It is hypothesized that COVID-19, post-COVID and post-mRNA COVID-19 (and other related) vaccine manifestations including “long haul syndrome” are due to deficiency of essential fatty acids (EFAs) and dysregula... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 19, 2024 Category: Lipidology Authors: Undurti N. Das Tags: Review Source Type: research
Immunogenicity and safety of a recombinant COVID-19 vaccine (ZF2001) as heterologous booster after priming with inactivated vaccine in healthy children and adolescents aged 3-17 years: an open-labeled, single-arm clinical trial
Considering that neutralizing antibody levels induced by two doses of the inactivated vaccine decreased over time and had fallen to low levels by 6 months, and homologous and heterologous booster immunization ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 19, 2024 Category: Infectious Diseases Authors: Tao Huang, Qianqian Hu, Xiang Zhou, Huaiyu Yang, Wei Xia, Feng Cao, Minglu Deng, Xiaoxue Teng, Fan Ding, Zaixin Zhong, Lidong Gao, Jiufeng Sun and Lihui Gong Tags: Research Source Type: research
