Naturally Occurring Anti-D in a Male Blood Donor, Unresolved Mystery
AbstractIn accordance with numerous national and international criteria, screening donated blood for abnormal antibodies against red cell antigens is crucial for patient safety. Antibodies can be formed by three mechanisms: by immune responses, naturally occurring, or passively acquired. In accordance with departmental policy, ICT was performed on a 30-yearold male blood donor's sample in addition to ABO Rh grouping. He tested A Rh Dnegative and had a positive ICT (+ 2). Anti-D was identified by using the antibody screening and identification panel. Retesting revealed similar results, so we called the donor. We were una...
Source: Indian Journal of Hematology and Blood Transfusion - April 25, 2024 Category: Hematology Source Type: research
Modelling COVID-19 Vaccination in the UK: Impact of the Autumn 2022 and Spring 2023 Booster Campaigns
ConclusionOur modelling demonstrates that the autumn 2022/spring 2023 booster campaign reduced COVID-19-associated morbidity and mortality. Booster campaigns with alternative eligibility criteria warrant consideration in the UK, given their potential to further reduce morbidity and mortality as future variants emerge. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 25, 2024 Category: Infectious Diseases Source Type: research
Patterns of peripartum depression and anxiety during the pre-vaccine COVID-19 pandemic
This study aims to describe prevalence and course of depression and anxiety symptoms in pregnancy during the pre-vaccine COVID-19 pa... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 25, 2024 Category: OBGYN Authors: Marie R. Altendahl, Liwen Xu, Ifeyinwa Asiodu, W. John Boscardin, Stephanie L. Gaw, Valerie J. Flaherman, Vanessa L. Jacoby, Misty C. Richards, Deborah Krakow and Yalda Afshar Tags: Research Source Type: research
Construction and efficacy testing of DNA vaccines containing HLA-A*02:01-restricted SARS-CoV-2 T-cell epitopes predicted by immunoinformatics
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 24. doi: 10.3724/abbs.2024039. Online ahead of print.ABSTRACTVaccines play essential roles in the fight against the COVID-19 pandemic. The development and assessment of COVID-19 vaccines have generally focused on the induction and boosting of neutralizing antibodies targeting the SARS-CoV-2 spike (S) protein. Due to rapid and continuous variation in the S protein, such vaccines need to be regularly updated to match newly emerged dominant variants. T-cell vaccines that target MHC I- or II-restricted epitopes in both structural and non-structural viral proteins have the potential...
Source: Acta Biochimica et Biophysica Sinica - April 24, 2024 Category: Biochemistry Authors: Dan Tan Ning Kang Yuanfei Zhu Jia Hou Hanqing Wang Huijun Xu Cheng Zu Zixiang Gao Mu Liu Nannan Liu Qiang Deng Hongzhou Lu Jing Liu Youhua Xie Source Type: research
Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
Rev Inst Med Trop Sao Paulo. 2024 Apr 19;66:e24. doi: 10.1590/S1678-9946202466024. eCollection 2024.ABSTRACTInactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses with...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: Karim Yaqub Ibrahim Raquel Megale Moreira Carolina Ferreira Dos Santos T ânia Mara Varejão Strabelli Juliana de C ássia Belizário Maria Isabel de Moraes Pinto Ana Karolina Barreto Berselli Marinho Juliana Marquezi Pereira Liliane Saraiva de Mello Maur Source Type: research
Non-specific effects of the inactivated influenza vaccine. A test-negative study: The inactivated influenza vaccine and SARS-CoV-2 infections
CONCLUSIONS: While earlier observational studies suggested a protective non-specific effect of IIV and SARS-CoV-2 infections, this smaller, but well controlled test-negative design study does not suggest an effect, either positive or negative. Larger test-negative design studies, or alternative designs such as the self-controlled case series design are needed to confirm these findings and provide more definite answers on the topic.PMID:38658205 | DOI:10.1016/j.vaccine.2024.04.044 (Source: Vaccine)
Source: Vaccine - April 24, 2024 Category: Allergy & Immunology Authors: Anne Jasmijn Sellies Mirjam J Knol Hester E de Melker Patricia C J L Bruijning-Verhagen Annemarijn R de Boer Source Type: research
COVID-19 Vaccination-Related Myocarditis: What We Learned From Our Experience and What We Need to Do in The Future
Korean Circ J. 2024 Apr 1. doi: 10.4070/kcj.2024.0065. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vacci...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Jae-Hyeong Park Kye Hun Kim Source Type: research
Evolution of illness severity in hospital admissions due to COVID-19, Qu ébec, Canada, January to April 2022
CONCLUSION: Severity of admissions due to COVID-19 decreased in the first months of 2022, when predominant circulating variants were considered to be of similar severity. Monitoring hospital admissions due to COVID-19 can contribute to disease severity surveillance.PMID:38655241 | PMC:PMC11037885 | DOI:10.14745/ccdr.v50i12a08 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - April 24, 2024 Category: Infectious Diseases Authors: Ernest Lo Élise Fortin Rodica Gilca Pierre-Luc Tr épanier Hany Geagea Zhou Zhou Source Type: research
COVID-19 outcome trends by vaccination status in Canada, December 2020-January 2022
CONCLUSION: Vaccination remains one of the most important public health interventions, particularly among older adults, to protect against COVID-19 severe outcomes as the pandemic evolves. Routine monitoring of COVID-19 outcomes by vaccination status can identify changes in COVID-19 epidemiology and inform public health action and policy.PMID:38655240 | PMC:PMC11037879 | DOI:10.14745/ccdr.v50i12a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - April 24, 2024 Category: Infectious Diseases Authors: Demy Dam Sharifa Merali Michelle Chen Cameron Coulby Brigitte Ho Mi Fane Felix Bang Jordan Robson Samara David Source Type: research
Adherence to Covid-19 vaccination during the pandemic: the influence of fake news
Rev Bras Enferm. 2024 Apr 22;77(1):e20230284. doi: 10.1590/0034-7167-2023-0284. eCollection 2024.ABSTRACTOBJECTIVES: to understand how fake news has influenced adherence to Covid-19 immunization, from the perspective of health professionals.METHODS: a qualitative, descriptive-exploratory study was conducted in Campo Grande - MS. Twenty nursing professionals working in vaccine rooms or managing immunobiologicals participated through semi-structured interviews. The interviews were audio-recorded, fully transcribed, and subjected to thematic content analysis.RESULTS: two categories emerged in which the professionals highlight...
Source: Revista Brasileira de Enfermagem - April 24, 2024 Category: Nursing Authors: Luana Cristina Roberto Borges Sonia Silva Marcon Gabrielly Segatto Brito Miriam Terabe Nathalia Ivulic Pleutim Ana Heloisa Mendes Elen Ferraz Teston Source Type: research
Impact of COVID-19 on essential healthcare services at the primary healthcare level in Armenia: a qualitative study
CONCLUSIONS: The COVID-19 pandemic has had a profound impact on the delivery and utilization of essential healthcare services at PHC facilities, especially for those with chronic conditions who needed continuous care. Unified national-level guidance and technical capacity are needed to direct the provision of essential services at the PHC level, promote effective health communication, and implement digital platforms for the uninterrupted provision of essential care during public health emergencies.PMID:38658818 | DOI:10.1186/s12875-024-02377-6 (Source: Primary Care)
Source: Primary Care - April 24, 2024 Category: Primary Care Authors: Varduhi Hayrumyan Arpine Abrahamyan Arusyak Harutyunyan Lorky Libaridian Serine Sahakyan Source Type: research
Magnetic Resonance Imaging of Cardiac Involvement in COVID-19
Br J Radiol. 2024 Apr 24:tqae086. doi: 10.1093/bjr/tqae086. Online ahead of print.ABSTRACTThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a diverse pattern of myocardial injuries, including myocarditis, which is linked to adverse outcomes in patients. Research indicates that myocardial injury is associated with higher mortality in hospitalized severe COVID-19 patients (75.8% versus 9.7%). Cardiovascular Magnetic Resonance (CMR) has emerged as a crucial tool in diagnosing both ischemic and non-ischemic myocardial injuries, providing detailed insights into the impact of COVID-19 on myocardial tissue and fun...
Source: The British Journal of Radiology - April 24, 2024 Category: Radiology Authors: Moezedin Javad Rafiee Matthias G Friedrich Source Type: research
Construction and efficacy testing of DNA vaccines containing HLA-A*02:01-restricted SARS-CoV-2 T-cell epitopes predicted by immunoinformatics
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 24. doi: 10.3724/abbs.2024039. Online ahead of print.ABSTRACTVaccines play essential roles in the fight against the COVID-19 pandemic. The development and assessment of COVID-19 vaccines have generally focused on the induction and boosting of neutralizing antibodies targeting the SARS-CoV-2 spike (S) protein. Due to rapid and continuous variation in the S protein, such vaccines need to be regularly updated to match newly emerged dominant variants. T-cell vaccines that target MHC I- or II-restricted epitopes in both structural and non-structural viral proteins have the potential...
Source: Acta Biochimica et Biophysica Sinica - April 24, 2024 Category: Biochemistry Authors: Dan Tan Ning Kang Yuanfei Zhu Jia Hou Hanqing Wang Huijun Xu Cheng Zu Zixiang Gao Mu Liu Nannan Liu Qiang Deng Hongzhou Lu Jing Liu Youhua Xie Source Type: research
Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons
Rev Inst Med Trop Sao Paulo. 2024 Apr 19;66:e24. doi: 10.1590/S1678-9946202466024. eCollection 2024.ABSTRACTInactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses with...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: Karim Yaqub Ibrahim Raquel Megale Moreira Carolina Ferreira Dos Santos T ânia Mara Varejão Strabelli Juliana de C ássia Belizário Maria Isabel de Moraes Pinto Ana Karolina Barreto Berselli Marinho Juliana Marquezi Pereira Liliane Saraiva de Mello Maur Source Type: research
Non-specific effects of the inactivated influenza vaccine. A test-negative study: The inactivated influenza vaccine and SARS-CoV-2 infections
CONCLUSIONS: While earlier observational studies suggested a protective non-specific effect of IIV and SARS-CoV-2 infections, this smaller, but well controlled test-negative design study does not suggest an effect, either positive or negative. Larger test-negative design studies, or alternative designs such as the self-controlled case series design are needed to confirm these findings and provide more definite answers on the topic.PMID:38658205 | DOI:10.1016/j.vaccine.2024.04.044 (Source: Vaccine)
Source: Vaccine - April 24, 2024 Category: Allergy & Immunology Authors: Anne Jasmijn Sellies Mirjam J Knol Hester E de Melker Patricia C J L Bruijning-Verhagen Annemarijn R de Boer Source Type: research
