A Network Meta-analysis of Randomized Controlled Trials Focusing on Different Allergic Rhinitis Medications
This study is aimed to investigate the effectiveness of 4 allergic rhinitis (AR) drugs (loratadine, cetirizine, montelukast, and desloratadine) in reducing functional problems in patients, as indicated by rhinoconjunctivitis quality of life questionnaire scores. After an exhaustive search of electronic databases containing published scientific literature, high-quality randomized controlled trials relevant to our study were selected based on a stringent predefined inclusion and exclusion criteria. Statistical analyses were conducted using STATA 12.0 and comprehensive meta-analysis (CMA 2.0) software. The literature search b...
Source: American Journal of Therapeutics - November 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research
Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers.
CONCLUSIONS: Bilastine 20 mg induced significantly greater inhibition of the W&F response compared with desloratadine 5 mg and rupatadine 10 mg throughout the 24-hour study period, and had the fastest onset of action. Only bilastine significantly reduced itching sensation versus placebo.
PMID: 27659218 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research
Chronic Urticaria in Special Populations: Children, Pregnancy, Lactation and Elderly People
Opinion statementChronic urticaria can occur at any age and in both sexes. Regardless of the different populations affected, a stepwise treatment approach is recommended, beginning with non-sedating antihistamines, from licensed doses to a “controlled overdose” up to fourfold, followed by a change to a different antihistamine and/or addition of a leukotriene antagonist if symptoms persist; systemic corticosteroids in short courses (3 to 7 days) can be used for exacerbations. As a third-line therapy in adults, omalizumab is now co nsidered of choice and only in nonresponsive cases to omalizumab cyclosporin or other opt...
Source: Current Treatment Options in Allergy - September 22, 2016 Category: Allergy & Immunology Source Type: research
Association between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double-blind, randomized and controlled clinical trial
Conclusion The DP combination was able to effectively control acute symptoms of rhinitis in children, improving symptoms and nasal function. Compared to the DB combination, it showed similar clinical action, but with a lower incidence of adverse events and higher dosing convenience. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - September 12, 2016 Category: ENT & OMF Source Type: research
The efficacy and safety of H1-antihistamine versus Montelukast for allergic rhinitis: A systematic review and meta-analysis.
CONCLUSION: Montelukast has a significant influence in improving patients' nasal symptoms quality of live but is not as effective as SAHs, and may have a slight advantage over SAHs in relieving nighttime symptoms significantly. Combined therapy is more effective in improving patients' day time symptom than Montelukast. Probably, patients might have a lower asthenia incidence rate when using Montelukas.
PMID: 27522261 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 10, 2016 Category: Drugs & Pharmacology Authors: Wei C Tags: Biomed Pharmacother Source Type: research
BRET-based β-arrestin2 recruitment to the histamine H1 receptor for investigating antihistamine binding kinetics
In this study, a real-time proximity assay between H1R and β-arrestin2 in living cells was established to investigate the dynamics of antihistamine binding to the H1R. No receptor reserve was found for the histamine-induced recruitment of β-arrestin2 to the H1R and the transiently recruited β-arrestin2 therefore reflected occupancy of the receptor by histamine. Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced β-arrestin2 recruitment as compared to displacing radioligand binding from the H1R. This homogeneous functional method unambiguously determined the fifty-fold difference in the...
Source: Pharmacological Research - July 26, 2016 Category: Drugs & Pharmacology Source Type: research
H1-Antihistamine Premedication in NSAID-Associated Urticaria
Conclusions and Clinical Relevance In the majority of patients with NSAID-induced or NSAID-exacerbated urticaria concurrently suffering from intermittent pain, a premedication regimen with 5 mg desloratadine 30 minutes before intake of a strong COX-I inhibitor seems to be effective, safe, and practicable. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 5, 2016 Category: Allergy & Immunology Source Type: research
Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal.
CONCLUSIONS: Measurement of the histamine-induced wheal can predict which patients will have a strong clinical response to antihistamines but has limited utility for identifying nonresponders. The clinical significance of these data could be relevant in the search for new urticaria treatment regimens.
PMID: 27326985 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 31, 2016 Category: Allergy & Immunology Authors: Sánchez J, Zakzuk J, Cardona R Tags: J Investig Allergol Clin Immunol Source Type: research
The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.
CONCLUSIONS: ET-1 is one of the mediators that impact AR development and ET-1 antagonists can be useful for symptom control and for decreasing allergic inflammation in AR patients.
PMID: 27016898 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - March 29, 2016 Category: ENT & OMF Tags: Rhinology Source Type: research
Carbopol®-crospovidone interpolymer complex for pH-dependent desloratadine release
Publication date: 10 May 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 123 Author(s): G. Szakonyi, R. Zelkó Hydrogen-bonded interpolymer complexes are prepared using special polymers interactions between relatively weak hydrogen bonds and other components when they are numerous with consecutive configurations. Drug molecules possessing hydrogen donor or acceptor groups or both intercalate into the complex and show different release patterns. While numerous studies have investigated polymer component behaviours in different media and the resulting drug release profiles, few have focused on t...
Source: Journal of Pharmaceutical and Biomedical Analysis - February 20, 2016 Category: Drugs & Pharmacology Source Type: research
Effectiveness of allergic rhinitis treatments in real-life with a focus on MP-AzeFlu.
Authors: Klimek L, Demoly P, Price D
Abstract
For any allergic rhinitis (AR) treatment, it is crucial to provide evidence not only of efficacy (assessed in randomized controlled trials (RCTs)) but also of effectiveness in real-life. Observational studies provide valuable data on the use and results associated with interventions prescribed in real-life. However, real-life evidence supporting available AR treatment options is sparse with effectiveness only established for oral antihistamines (desloratadine, ebastine), intranasal corticosteroids (mometasone furoate, fluticasone propionate (FP)), allergen immu...
Source: Expert Review of Clinical Pharmacology - February 14, 2016 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids.
Authors: Takagi M, Sanoh S, Santoh M, Ejiri Y, Kotake Y, Ohta S
Abstract
Drug-induced phospholipidosis (PLD) is one of the adverse reactions to treatment with cationic amphiphilic drugs. Recently, simple and reliable evaluation methods for PLD have been reported. However, the predictive power of these methods for in vivo PLD induction is insufficient in some cases. To accurately predict PLD, we focused on drug metabolism and used three-dimensional cultures of hepatocytes known as spheroids. Here we used the fluorescent phospholipid dye N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dihexadecanoyl-sn-glycero-3-p...
Source: Journal of Toxicological Sciences - January 16, 2016 Category: Toxicology Tags: J Toxicol Sci Source Type: research
Assessment of the effects of antihistamine drugs on mood, sleep quality, sleepiness, and dream anxiety.
CONCLUSION: Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.
PMID: 24673474 [PubMed - indexed for MEDLINE] (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - December 25, 2015 Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
The effect of antiallergic treatment with desloratadine-montelukast on salivary glands function in allergic rhinitis.
In conclusion, our study showed that hypofunction of SG was present in all patients with AR. This hypofunction, as tested by semi-quantitative SG scintigraphy, and also the quality of life did not improve after treatment with montelukast and desloratadine.
PMID: 25397624 [PubMed - indexed for MEDLINE] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 18, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2–11 years
ConclusionRupatadine is effective and well tolerated in the relief of urticaria symptoms, improving quality of life over 6 weeks in children with CSU. This is the first study using a modified UAS to assess severity and efficacy outcome in CSU in children. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - November 12, 2015 Category: Allergy & Immunology Authors: Paul Potter, Essack Mitha, László Barkai, Györgyi Mezei, Eva Santamaría, Iñaki Izquierdo, Marcus Maurer Tags: Original Article Source Type: research
