Desloratadine and depression, a drug safety signal based on worldwide spontaneous reporting of side effects.
CONCLUSION: We hypothesize that desloratadine may enter the CNS and that it hence in rare cases may cause a clinically relevant state of depression, a relation that patients and their treating physicians should be made aware of.
PMID: 30084285 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 7, 2018 Category: General Medicine Authors: Boer J, Ederveen E, Grundmark B Tags: Ups J Med Sci Source Type: research
Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
Conclusions: Brazilian commercial antihistamines presented different profiles of inhibition of wheal and flares in the histamine test, as well as adverse effects. Generic loratadine, fexofenadine and cetirizine presented larger flares than brand drugs. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 3, 2018 Category: Dermatology Source Type: research
Effect of mometasone furoate nasal spray on the DNA of nasal mucosal cells
Conclusion:
Treatment with MF spray for 4 weeks does not cause DNA breaks within cells in the nasal mucosa. These results could form
the basis of clinical trials involving treatment with different ICs over longer treatment periods.
PMID: 29714449 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - May 2, 2018 Category: General Medicine Tags: Turk J Med Sci Source Type: research
A fully validated method for the simultaneous determination of 11 antihistamines in breast milk by gas chromatography-mass spectrometry.
Abstract
Antihistamines are excreted into breast milk in small amounts; however, there are no adequate published studies or data concerning their effects on newborns and safety during breastfeeding. Thus, the development of sensitive and specific methodologies for the determination of antihistamines in breast milk is critical. A simple and sensitive GC-MS method for the simultaneous determination of eleven antihistamines (diphenhydramine, orphenadrine, chlorpheniramine, dimethindene, meclozine, hydroxyzine, loratadine, desloratadine, cetirizine, rupatadine and ebastine) in breast milk was developed and val...
Source: Biomedical Chromatography : BMC - April 12, 2018 Category: Biomedical Science Authors: Katselou M, Athanaselis S, Nikolaou P, Qammaz S, Dona A, Spiliopoulou C, Papoutsis I Tags: Biomed Chromatogr Source Type: research
Chronic spontaneous urticaria in children ‐ a systematic review on interventions and comorbidities
ConclusionsH1‐antihistamines are effective for CSU in children < 12 years old, with reassuring safety data at licensed doses. Cyclosporine seems effective, but the level of evidence is low.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - February 2, 2018 Category: Allergy & Immunology Authors: H élène Cornillier, Bruno Giraudeau, Stéphane Munck, Florence Hacard, Annie‐Pierre Jonville‐bera, Gwenaëlle d'Acremont, Bach‐Nga Pham, Annabel Maruani Tags: Original Article Source Type: research
The treatment outcomes and dose de ‐escalation of desloratadine up‐dosing in chronic spontaneous urticaria
International Journal of Dermatology,Volume 57, Issue 4, Page 423-427, April 2018. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - January 30, 2018 Category: Dermatology Source Type: research
The treatment outcomes and dose de ‐escalation of desloratadine up‐dosing in chronic spontaneous urticaria
ConclusionMost patients need higher than the standard doses to obtain remission. Once the disease is completely controlled, however, maintenance of the same dosage for at least 8 weeks before dose reduction is suggested in order to avoid recurrence of the symptoms. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - January 30, 2018 Category: Dermatology Authors: Charoen Choonhakarn, Suteeraporn Chaowattanapanit, Narachai Julanon Tags: Report Source Type: research
Effectiveness and Safety of the Combination of the Traditional Chinese Medicine Prescription Jade Screen and Desloratadine in the Treatment of Chronic Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Conclusion: Using Jade Screen and desloratadine together to treat chronic urticaria gains a better clinical effect than using desloratadine alone.
PMID: 29259640 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 21, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models
Abstract
Drugs carry a proarrhythmic risk, which gets even greater when they are used in combination. In vitro assessment of the proarrhythmic potential of drugs is limited to one compound and thus neglects the potential of drug–drug interactions, including those involving active metabolites. Here we present the results of an in vitro study of potential drug–drug interactions at the level of the hERG channel for the combination of up to three compounds: loratadine, desloratadine and ketoconazole. Experiments were performed at room temperature on an automated patch‐clamp device CytoPatch 2, with the use of heterogeneo...
Source: Journal of Applied Toxicology - November 16, 2017 Category: Toxicology Authors: Barbara Wi śniowska, Bartosz Lisowski, Magdalena Kulig, Sebastian Polak Tags: RESEARCH ARTICLE Source Type: research
Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).
CONCLUSIONS: This study shows that rupatadine and, to a lesser extent, levocetirizine, but not desloratadine, inhibit PAF-induced degranulation in both LAD2 and hLMCs. These findings support the dual antihistamine and anti-PAF effect of rupatadine in allergic disorders.
PMID: 27758758 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - November 5, 2017 Category: Allergy & Immunology Authors: Munoz-Cano R, Ainsua-Enrich E, Torres-Atencio I, Martin M, Sánchez-Lopez J, Bartra J, Picado C, Mullol J, Valero A Tags: J Investig Allergol Clin Immunol Source Type: research
Improving mechanical properties of desloratadine via multicomponent crystal formation.
We report the first multicomponent crystal of desloratadine, an important anti-histamine drug, with a pharmaceutically acceptable coformer of benzoic acid. The single crystal structure analysis revealed that this novel multicomponent crystal is categorized as salt due to the proton transfer from benzoic acid to the desloratadine molecule. By forming the salt multicomponent crystal, we demonstrated that the tabletability and plasticity of the multicomponent crystal was improved from the parent drug. In addition, neither capping nor lamination tendency was observed in the desloratadine-benzoic acid multicomponent crystal. Th...
Source: European Journal of Pharmaceutical Sciences - September 25, 2017 Category: Drugs & Pharmacology Authors: Ainurofiq A, Mauludin R, Mudhakir D, Umeda D, Soewandhi SN, Putra OD, Yonemochi E Tags: Eur J Pharm Sci Source Type: research
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
Authors: Tomida T, Ishimura M, Iwaki M
Abstract
The utility of HepaRG cells as an in vitro cell-based assay system for predicting drug-induced phospholipidosis (PLD) was investigated. In experiment 1, 10 PLD-positive compounds and 11 PLD-negative compounds were selected. HepaRG cells were treated with each compound for 48 hr. In experiment 2, loratadine and desloratadine, a major metabolite of loratadine, were used to assess metabolic activation for PLD. HepaRG cells were treated with loratadine and desloratadine in the presence or absence of 500 μM 1-aminobenzotriazole (ABT), a broad CYP inhibitor, for 4...
Source: Journal of Toxicological Sciences - September 16, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research
Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project
ConclusionsThe risk of VA associated with a few specific antihistamines could be ascribable to heterogeneity in pattern of use or in receptor binding profile. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 22, 2017 Category: Drugs & Pharmacology Source Type: research
