Desloratadine use during pregnancy and risk of adverse fetal outcomes: a nationwide cohort study
Publication date: Available online 3 March 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Niklas Worm Andersson, Henrik Enghusen Poulsen, Jon Trærup Andersen (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 5, 2020 Category: Allergy & Immunology Source Type: research
Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat
AbstractAllergic rhinitis (AR) is an IgE-mediated inflammation which causes olfactory dysfunction. Antihistamines have been widely used to treat AR while few studies have investigated the effect of antihistamines on improving the sense of smell. In addition, the underlying mechanisms are not well elucidated. We established the ovalbumin (OVA)-induced allergic rhinitis rat model and administrated desloratadine to AR rats. The AR symptoms, serum level of OVA-specific IgE and IL-17, and expression of IL-4, IL-5 and IL-13 in nasal mucosa were measured. The olfactory dysfunction was monitored by buried food test and the express...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 19, 2020 Category: Allergy & Immunology Source Type: research
Efficacy of desloratadine and levocetirizine in patients with cedar pollen induced allergic rhinitis: A randomized, double-blind study
No comparative study of antihistamines that differ in structural system has been conducted in allergic rhinitis. This was a randomized, double-blind, crossover comparative study to verify the efficacy of antihistamines that differ in structural system. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Syuji Yonekura, Yoshitaka Okamoto Source Type: research
Carboxymethyl-botryosphaeran stabilized carbon nanotubes aqueous dispersion: A new platform design for electrochemical sensing of desloratadine.
Abstract The polysaccharide carboxymethyl-botryosphaeran (CMB) was used to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in water. This feature was applied in modifying a glassy carbon electrode (GCE) to construct a sensitive voltammetric sensor for the determination of desloratadine (DESL), a tricyclic antihistamine. The morphology and spectroscopic behavior of the sensor were evaluated. The modified sensor was characterized as homogeneous, and presented a higher electroactive area and a lower charge transfer resistance compared to the unmodified GCE. Using linear sweep voltammetry at 25 m...
Source: Talanta - January 30, 2020 Category: Chemistry Authors: Salamanca-Neto CAR, Olean-Oliveira A, Scremin J, Ceravolo GS, Dekker RFH, Barbosa-Dekker AM, Teixeira MFS, Sartori ER Tags: Talanta Source Type: research
[ASAP] Reversible, Two-Step Single-Crystal to Single-Crystal Phase Transitions between Desloratadine Forms I, II, and III
Crystal Growth& DesignDOI: 10.1021/acs.cgd.9b01522 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - January 28, 2020 Category: Chemistry Authors: Vijay K. Srirambhatla †?, Rui Guo‡, Daniel M. Dawson§, Sarah L. Price‡, and Alastair J. Florence*†? Source Type: research
Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way.
Abstract The biopharmaceutical classification of drugs was designed as a basis for bio-waivers - a mechanism with the double ethical benefit of delivering new drug formulations to the market with less human testing and lower cost. However, many drugs defy simple classification because in vitro permeability and stability assessment can be challenging as shown in this study for desloratadine. Literature shows that desloratadine is highly soluble, while data on luminal stability and permeability are circumstantial. Combined with borderline bioavailability and not really known fraction of absorbed dose, desloratadine ...
Source: Acta Pharmaceutica - January 21, 2020 Category: Drugs & Pharmacology Authors: Berginc K, Sibinovska N, Žakelj S, Trontelj J, Legen I Tags: Acta Pharm Source Type: research
Developing A High-performance Liquid Chromatography Method for Simultaneous Determination of Loratadine and its Metabolite Desloratadine in Human Plasma.
CONCLUSION: The results obtained indicate that the proposed method is rapid, sensitive in the nanogram range, accurate, selective, robust and reproducible compared to other reported methods. PMID: 31774044 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 24, 2019 Category: Drugs & Pharmacology Authors: Sebaiy MM, Ziedan NI Tags: Curr Drug Metab Source Type: research
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.
Abstract 1. Desloratadine is an antiallergic drug with species-dependent metabolic profiles in mice, rats, monkeys, and humans. We investigated whether humanized-liver mice could reproduce the reported human-specific in vivo metabolic profile for desloratadine in terms of the formation of 3-hydroxydesloratadine and its O-glucuronide.2. Hepatocytes prepared from humans and humanized-liver mice both preferentially catalyzed the formation of 3-hydroxydesloratadine and its O-glucuronide in vitro.3. After a single oral administration of desloratadine, plasma levels of desloratadine and its metabolites (3-hydroxydeslora...
Source: Xenobiotica - November 5, 2019 Category: Research Authors: Uehara S, Yoneda N, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H Tags: Xenobiotica Source Type: research
Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria
The Pharmacogenomics Journal, Published online: 13 August 2019; doi:10.1038/s41397-019-0094-0Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria (Source: The Pharmacogenomics Journal)
Source: The Pharmacogenomics Journal - August 13, 2019 Category: Drugs & Pharmacology Authors: Juan Li Wangqing Chen Cong Peng Wu Zhu Zhaoqian Liu Wei Zhang Juan Su Jie Li Xiang Chen Source Type: research
Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine
We examined brain H1R binding potential ratio (BPR), H1R occupancy (H1RO), and subjective sleepiness after oral desloratadine administration in comparison to loratadine. Eight healthy male volunteers underwent PET imaging with [11C] ‐doxepin, a PET tracer for H1Rs, after a single oral administration of desloratadine (5 mg), loratadine (10 mg), or placebo in a double‐blind crossover study. BPR and H1RO in the cerebral cortex were calculated, and plasma concentrations of loratadine and desloratadine were measured. Subjective sleepiness was quantified by the Line Analogue Rating Scale (LARS) and the Stanford Sl...
Source: Pharmacology Research and Perspectives - July 12, 2019 Category: Drugs & Pharmacology Authors: Tadaho Nakamura, Kotaro Hiraoka, Ryuichi Harada, Takuro Matsuzawa, Yoichi Ishikawa, Yoshihito Funaki, Takeo Yoshikawa, Manabu Tashiro, Kazuhiko Yanai, Nobuyuki Okamura Tags: ORIGINAL ARTICLE Source Type: research
[ASAP] Route to Prolonged Residence Time at the Histamine H < sub > 1 < /sub > Receptor: Growing from Desloratadine to Rupatadine
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b00447 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 5, 2019 Category: Chemistry Authors: Reggie Bosma †?, Zhiyong Wang†?, Albert J. Kooistra†#, Nick Bushby§, Sebastiaan Kuhne†, Jelle van den Bor†, Michael J. Waring??, Chris de Graaf†?, Iwan J. de Esch†, Henry F. Vischer†, Robert J. Sheppard‡, Maikel Wijtmans†, and Rob Leu Source Type: research
To switch or not to switch —first Germany-wide study from the perspective of pharmacists in the European environment
ConclusionPharmacists strongly welcome further switches. This leads to high acceptance rates, especially for a switch of desloratadine, as this was the most named active ingredient possible for a switch within the survey.Impact of findings on practice statementsThe outcome of this survey can support pharmaceutical companies in decision-making about which active substances they should submit a switch application for. Additionally, this helps fulfil patient needs, because pharmacists know best what is beneficial for patient self-care. In addition, all other actors involved in this process can see what is required and can ret...
Source: Journal of Public Health - June 29, 2019 Category: Health Management Source Type: research
Histamine and Delirium: Current Opinion
This study indicated that switch from H2 blockers to PPIs reduced delirium and, thus, providing an appropriate strategy to combat drug-induced delirium using antiulcer drugs (Fujii et al., 2012). The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep and augment the firing rate of neurons in ventrolateral GABAergic preoptic nucleus, but the underlining mechanism is yet to be clearly determined. Interestingly, the propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibite...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research
OTC Drugs for Seasonal Allergies
Date: April 22, 2019 Issue #: 1570Summary: Patients with seasonal allergies often experience nasal itching and congestion, sneezing, rhinorrhea, and itchy, watery eyes. Oral, intranasal, and ophthalmic preparations are widely available over the counter (OTC) for relief of symptoms. Prescription products for management of allergic rhinitis and allergic conjunctivitis are reviewed separately. (Source: The Medical Letter)
Source: The Medical Letter - March 20, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Aerius Afrin Alavert Alaway Allegra Allergic rhinitis Antihistamines Avamys azelastine Benadryl Budesonide cetirizine Clarinex Claritin conjunctivities Cromolyn Desloratadine diphenhydramine Dristan Drixoral Fexofen Source Type: research
Ecotoxic effects of loratadine and its metabolic and light-induced derivatives.
Abstract Loratadine and desloratadine are second-generation antihistaminic drugs. Because of human administration, they are continuously released via excreta into wastewater treatment plants and occur in surface waters as residues and transformation products (TPs). Loratadine and desloratadine residues have been found at very low concentrations (ng/L) in the aquatic environment but their toxic effects are still not well known. Both drugs are light-sensitive even under environmentally simulated conditions and some of the photoproducts have been isolated and characterized. The aim of the present study was to investi...
Source: Ecotoxicology and Environmental Safety - December 19, 2018 Category: Environmental Health Authors: Iesce MR, Lavorgna M, Russo C, Piscitelli C, Passananti M, Temussi F, DellaGreca M, Cermola F, Isidori M Tags: Ecotoxicol Environ Saf Source Type: research
Screening and evaluation of fungal resources for loratadine metabolites.
Abstract Loratadine is a selective inverse agonist of peripheral histamine H1-receptors. Microbial biotransformation gained a lot of attention for its ability to convert molecules to valuable medicinally active substances. The main objective of the present research was to investigate the ability of different fungi to biotransform the drug loratadine to its active metabolite desloratadine, because desloratadine is four times more potent, possess longer duration of action than loratadine and is effective at low doses. The screening studies were performed with selected fungi using their respective broth media and ste...
Source: Journal of Biosciences - December 1, 2018 Category: Biomedical Science Authors: Keerthana M, Vidyavathi M Tags: J Biosci Source Type: research
Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.
This study aimed to establish mechanistic links between the prolonged intake of desloratadine, a common H1 receptor blocker (i.e. antihistamine), and development of obesity and metabolic syndrome. Male Sprague-Dawley rats were treated orally for 16 weeks with desloratadine. We analyzed the dynamics of body weight gain; tissue fat accumulation/density; contractility of isolated mesenteric lymphatic vessels; levels of blood lipids, glucose and insulin; together with parameters of liver function. Prolonged intake of desloratadine induced development of an obesity-like phenotype and signs of metabolic syndrome. These alteratio...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - November 26, 2018 Category: Physiology Authors: Gasheva OY, Tsoy Nizamutdinova I, Hargrove L, Gobbell C, Troyanova-Wood M, Alpini SF, Pal S, Du C, Hitt AR, Yakovlev VV, Newell-Rogers MK, Zawieja DC, Meininger CJ, Alpini GD, Francis H, Gashev AA Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model
ConclusionWe think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - October 1, 2018 Category: ENT & OMF Source Type: research
Desloratadine and depression, a drug safety signal based on worldwide spontaneous reporting of side effects.
CONCLUSION: We hypothesize that desloratadine may enter the CNS and that it hence in rare cases may cause a clinically relevant state of depression, a relation that patients and their treating physicians should be made aware of. PMID: 30084285 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 7, 2018 Category: General Medicine Authors: Boer J, Ederveen E, Grundmark B Tags: Ups J Med Sci Source Type: research
Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
Abstract: Background: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines. Objectives: To evaluate the tolerability and efficacy of the main commercial brand and generic H1 antihistamines, regarding the suppression of the wheal and flare to the histamine test. Methods: A quasi-experimental, open study with 10 healthy adults submitted to the histamine test on the ventral aspect of the forearms. After 20 minutes, wheal and flares were measured. The tests were performed after two hours of intake of dexchlorph...
Source: Anais Brasileiros de Dermatologia - May 3, 2018 Category: Dermatology Source Type: research
Effect of mometasone furoate nasal spray on the DNA of nasal mucosal cells
Conclusion: Treatment with MF spray for 4 weeks does not cause DNA breaks within cells in the nasal mucosa. These results could form the basis of clinical trials involving treatment with different ICs over longer treatment periods. PMID: 29714449 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - May 2, 2018 Category: General Medicine Tags: Turk J Med Sci Source Type: research
A fully validated method for the simultaneous determination of 11 antihistamines in breast milk by gas chromatography-mass spectrometry.
Abstract Antihistamines are excreted into breast milk in small amounts; however, there are no adequate published studies or data concerning their effects on newborns and safety during breastfeeding. Thus, the development of sensitive and specific methodologies for the determination of antihistamines in breast milk is critical. A simple and sensitive GC-MS method for the simultaneous determination of eleven antihistamines (diphenhydramine, orphenadrine, chlorpheniramine, dimethindene, meclozine, hydroxyzine, loratadine, desloratadine, cetirizine, rupatadine and ebastine) in breast milk was developed and validated. ...
Source: Biomedical Chromatography : BMC - April 12, 2018 Category: Biomedical Science Authors: Katselou M, Athanaselis S, Nikolaou P, Qammaz S, Dona A, Spiliopoulou C, Papoutsis I Tags: Biomed Chromatogr Source Type: research
Chronic spontaneous urticaria in children ‐ a systematic review on interventions and comorbidities
Abstract BackgroundChronic spontaneous urticaria (CSU) is not frequent in children. Management guidelines have been developed for adults and randomized controlled trials (RCTs) included teenagers aged 12 to 18, but data for children under age 12 are limited. We performed a systematic review to assess comorbidities in children
Source: Pediatric Allergy and Immunology - February 2, 2018 Category: Allergy & Immunology Authors: H élène Cornillier, Bruno Giraudeau, Stéphane Munck, Florence Hacard, Annie‐Pierre Jonville‐bera, Gwenaëlle d'Acremont, Bach‐Nga Pham, Annabel Maruani Tags: Original Article Source Type: research
The treatment outcomes and dose de ‐escalation of desloratadine up‐dosing in chronic spontaneous urticaria
International Journal of Dermatology,Volume 57, Issue 4, Page 423-427, April 2018. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - January 30, 2018 Category: Dermatology Source Type: research
The treatment outcomes and dose de ‐escalation of desloratadine up‐dosing in chronic spontaneous urticaria
ConclusionMost patients need higher than the standard doses to obtain remission. Once the disease is completely controlled, however, maintenance of the same dosage for at least 8 weeks before dose reduction is suggested in order to avoid recurrence of the symptoms. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - January 30, 2018 Category: Dermatology Authors: Charoen Choonhakarn, Suteeraporn Chaowattanapanit, Narachai Julanon Tags: Report Source Type: research
Effectiveness and Safety of the Combination of the Traditional Chinese Medicine Prescription Jade Screen and Desloratadine in the Treatment of Chronic Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Authors: Yuan SF, Guan JZ, Hao Y, Chai JY, Gao FL, Shi SQ, Wang JX, He J, Shi JH Abstract Objective: The aim of this study is to systematically evaluate the clinical efficacy and safety of the traditional Chinese medicine prescription Jade Screen combined with desloratadine in the treatment of chronic urticaria. Methods: Two researchers independently conducted literature searches. The extracted data were analyzed using Rev Man 5.2.3 software. The established retrieval time range of the various databases was up to 15 March, 2017. Results: Sixteen randomized controlled trials were included in this study. The ...
Source: Evidence-based Complementary and Alternative Medicine - December 21, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models
Abstract Drugs carry a proarrhythmic risk, which gets even greater when they are used in combination. In vitro assessment of the proarrhythmic potential of drugs is limited to one compound and thus neglects the potential of drug–drug interactions, including those involving active metabolites. Here we present the results of an in vitro study of potential drug–drug interactions at the level of the hERG channel for the combination of up to three compounds: loratadine, desloratadine and ketoconazole. Experiments were performed at room temperature on an automated patch‐clamp device CytoPatch 2, with the use of het...
Source: Journal of Applied Toxicology - November 16, 2017 Category: Toxicology Authors: Barbara Wi śniowska, Bartosz Lisowski, Magdalena Kulig, Sebastian Polak Tags: RESEARCH ARTICLE Source Type: research
Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).
CONCLUSIONS: This study shows that rupatadine and, to a lesser extent, levocetirizine, but not desloratadine, inhibit PAF-induced degranulation in both LAD2 and hLMCs. These findings support the dual antihistamine and anti-PAF effect of rupatadine in allergic disorders. PMID: 27758758 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - November 5, 2017 Category: Allergy & Immunology Authors: Munoz-Cano R, Ainsua-Enrich E, Torres-Atencio I, Martin M, Sánchez-Lopez J, Bartra J, Picado C, Mullol J, Valero A Tags: J Investig Allergol Clin Immunol Source Type: research
Improving mechanical properties of desloratadine via multicomponent crystal formation.
We report the first multicomponent crystal of desloratadine, an important anti-histamine drug, with a pharmaceutically acceptable coformer of benzoic acid. The single crystal structure analysis revealed that this novel multicomponent crystal is categorized as salt due to the proton transfer from benzoic acid to the desloratadine molecule. By forming the salt multicomponent crystal, we demonstrated that the tabletability and plasticity of the multicomponent crystal was improved from the parent drug. In addition, neither capping nor lamination tendency was observed in the desloratadine-benzoic acid multicomponent crystal. Th...
Source: European Journal of Pharmaceutical Sciences - September 25, 2017 Category: Drugs & Pharmacology Authors: Ainurofiq A, Mauludin R, Mudhakir D, Umeda D, Soewandhi SN, Putra OD, Yonemochi E Tags: Eur J Pharm Sci Source Type: research
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
Authors: Tomida T, Ishimura M, Iwaki M Abstract The utility of HepaRG cells as an in vitro cell-based assay system for predicting drug-induced phospholipidosis (PLD) was investigated. In experiment 1, 10 PLD-positive compounds and 11 PLD-negative compounds were selected. HepaRG cells were treated with each compound for 48 hr. In experiment 2, loratadine and desloratadine, a major metabolite of loratadine, were used to assess metabolic activation for PLD. HepaRG cells were treated with loratadine and desloratadine in the presence or absence of 500 μM 1-aminobenzotriazole (ABT), a broad CYP inhibitor, for 48 hr. A...
Source: Journal of Toxicological Sciences - September 16, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research
Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project
ConclusionsThe risk of VA associated with a few specific antihistamines could be ascribable to heterogeneity in pattern of use or in receptor binding profile. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 22, 2017 Category: Drugs & Pharmacology Source Type: research
Second generation H1 - antihistamines interaction with food and alcohol —A systematic review
Publication date: September 2017 Source:Biomedicine & Pharmacotherapy, Volume 93 Author(s): Paweł Paśko, Tomasz Rodacki, Renata Domagała-Rodacka, Krzysztof Palimonka, Monika Marcinkowska, Danuta Owczarek Histamine is a mediator of many physiological processes. It plays an important role in modulating allergy reactions and immune system responses. H1 receptor is a therapeutic target for drugs applied in allergic diseases such as allergic rhinoconjunctivitis, urticarial, or atopic dermatitis. H1‐antihistamines display different chemical structures, pharmacokinetics and a potential for drug–drug and drug-f...
Source: Biomedicine and Pharmacotherapy - June 15, 2017 Category: Drugs & Pharmacology Source Type: research
Second generation H1 - antihistamines interaction with food and alcohol-A systematic review.
Abstract Histamine is a mediator of many physiological processes. It plays an important role in modulating allergy reactions and immune system responses. H1 receptor is a therapeutic target for drugs applied in allergic diseases such as allergic rhinoconjunctivitis, urticarial, or atopic dermatitis. H1-antihistamines display different chemical structures, pharmacokinetics and a potential for drug-drug and drug-food interactions. Drug-food interactions are known to reduce therapeutic effects of the medicine, as well as to induce a potent adverse drug reactions. Considering it all, a systematic review was conducted ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 13, 2017 Category: Drugs & Pharmacology Authors: Paśko P, Rodacki T, Domagała-Rodacka R, Palimonka K, Marcinkowska M, Owczarek D Tags: Biomed Pharmacother Source Type: research
Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).
CONCLUSIONS: This study shows that rupatadine and, to a lesser extent, levocetirizine, but not desloratadine, inhibit PAF-induced degranulation in both LAD2 and hLMCs. These findings support the dual antihistamine and anti-PAF effect of rupatadine in allergic disorders. PMID: 28570220 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - June 1, 2017 Category: Allergy & Immunology Authors: Munoz-Cano R, Ainsua-Enrich E, Torres-Atencio I, Martin M, Sánchez-Lopez J, Bartra J, Picado C, Mullol J, Valero A Tags: J Investig Allergol Clin Immunol Source Type: research
CRP relevance in clinical assessment of chronic spontaneous urticaria Tunisian patients.
This study enrolled 30 CSU patients and same number of controls. We assessed the Urticaria Activity Score (UAS), Total antioxidant status (TAS), glutathione S-Transferase (GST), Superoxide dismutase (SOD), glutathione peroxidase (GPx), Catalase (CAT), Albumin, Alpha 1, alpha2, beta1 beta2, gamma globulins, CRP and hematologic numeration. RESULTS: At baseline Alpha1, alpha2, beta1, beta2, gamma globulins, CRP, SOD activity, leukocytes and basophils were significantly higher in patients versus controls (p
Source: Cutaneous and Ocular Toxicology - March 28, 2017 Category: Toxicology Authors: Maouia A, Youssef M, Leban N, Helal AN, Kassab A Tags: Cutan Ocul Toxicol Source Type: research
Ciprofloxacin induced acute generallised exanthematous pustulosis
We describe a case of AGEP in a 61-year-old woman that was hospitalized for the acute onset of fever, erythroderma, and pustulosis. Clinical history revealed that she had been treating a bacterial inguinal intertrigo for 4 days with ciprofloxacin 500 mg tablets twice daily and desloratadine 5 mg tablet once daily. To the best of our knowledge, this is the third reported case of AGEP caused by ciprofloxacin, supporting two other previous reports. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 27, 2017 Category: Drugs & Pharmacology Authors: Caterina Foti Paolo Romita Giovanni Zanframundo Mario Mastrolonardo Gianni Angelini Gianfranco Calogiuri Eustacchio Nettis Domenico Bonamonte Source Type: research
Use of anti-allergic drugs in children.
ntilde;o G, Solís-Sánchez G Abstract Allergic rhinitis is one of the most frequent chronic diseases in children. We have analysed the prescriptions habits of anti-allergic medications in children (
Source: Allergologia et Immunopathologia - February 1, 2017 Category: Allergy & Immunology Authors: Suárez-Castañón C, Modroño-Riaño G, Solís-Sánchez G Tags: Allergol Immunopathol (Madr) Source Type: research
Sedative Effects of Levocetirizine: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
ConclusionLevocetirizine has modest sedative effects with a risk ratio of 1.67 when compared with placebo. The sedative effects observed for levocetirizine are not different from other second-generation antihistamines. (Source: Drugs)
Source: Drugs - January 9, 2017 Category: Drugs & Pharmacology Source Type: research
D-optimal mixture design optimization of a HPLC method for simultaneous determination of commonly used antihistaminic parent molecules and their active metabolites in human serum and urine.
Abstract This present study describes a specific, precise, sensitive and accurate method for simultaneous determination of hydroxyzine, loratadine, terfenadine, rupatadine and their main active metabolites cetirizine, desloratadine and fexofenadine in serum and urine by using meclizine as an internal standard. Solid phase extraction method for sample clean-up and preconcentration of analytes was carried out by using Phenomenex Strata-X-C and Strata X polymeric cartridges. Chromatographic analysis was performed on a Phenomenex cyano (150 mm x 4.6 mm i.d., 5 µm) analytical column. A D-opti...
Source: Biomedical Chromatography : BMC - January 6, 2017 Category: Biomedical Science Authors: Kanthiah S, Valliappan K Tags: Biomed Chromatogr Source Type: research
Evidence for the hERG Liability of Antihistamines, Antipsychotics, and Anti-Infective Agents: A Systematic Literature Review From the ARITMO Project.
Abstract A systematic review was performed to categorize the hERG (human ether-a-go-go-related gene) liability of antihistamines, antipsychotics, and anti-infectives and to compare it with current clinical risk of torsade de pointes (TdP). Eligible studies were hERG assays reporting half-minimal inhibitory concentrations (IC50). A "hERG safety margin" was calculated from the IC50 divided by the peak human plasma concentration (free Cmax ). A margin below 30 defined hERG liability. Each drug was assigned an "uncertainty score" based on volume, consistency, precision, and internal and external va...
Source: The Journal of Clinical Pharmacology - December 26, 2016 Category: Drugs & Pharmacology Authors: Hazell L, Raschi E, De Ponti F, Thomas SH, Salvo F, Ahlberg Helgee E, Boyer S, Sturkenboom M, Shakir S Tags: J Clin Pharmacol Source Type: research
Rapid micellar HPLC analysis of loratadine and its major metabolite desloratadine in nano-concentration range using monolithic column and fluorometric detection: application to pharmaceuticals and biological fluids
Loratadine is a commonly used selective non-sedating antihistaminic drug. Desloratadine is the active metabolite of loratadine and, in addition, a potential impurity in loratadine bulk powder stated by the Uni... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - December 1, 2016 Category: Chemistry Authors: Fathalla Belal, Sawsan Abd El-Razeq, Mohamed El-Awady, Sahar Zayed and Sona Barghash Source Type: research
Association of ORAI1 gene polymorphisms with chronic spontaneous urticaria and the efficacy of the nonsedating H1 antihistamine desloratadine
Chronic spontaneous urticaria (CSU) is a common skin disease associated with mast cell activation and degranulation.1,2 The degranulation process of mast cells is mediated mainly by calcium-release –activated calcium channels–mediated Ca2+ influx. ORAI1, encoded by ORAI1 gene, is the pore-forming subunit of calcium-release–activated calcium channels.3-5 A study on ORAI1 knockout mouse demonstrated that ORAI1 is essential for mast cell degranulation, leukotriene (LTC4) secretion, histami ne release as well as TNF-α secretion. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 15, 2016 Category: Allergy & Immunology Authors: Jie Li, Aiyuan Guo, Wangqing Chen, Lianghua Bin, Yijing He, Wu Zhu, Cong Peng, Siyu Yan, Mingliang Chen, Jianglin Zhang, Juan Su, Mei Yi, Zhaoqian Liu, Wei Zhang, Weiqi Zeng, Donald Y.M. Leung, Xiang Chen Tags: Letter to the Editor Source Type: research
Association of ORAI1 Gene Polymorphisms with Chronic Spontaneous Urticaria and the Efficacy of the Nonsedating H1-antihistamine Desloratadine
Human ORAI1 polymorphisms were associated with susceptibility to CSU, and the South Han Chinese CSU who carry rs3741595C allele have reduced responsiveness to nonsedating H1-antihistamines. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 15, 2016 Category: Allergy & Immunology Authors: Jie Li, Aiyuan Guo, Wangqing Chen, Lianghua Bin, Yijing He, Wu Zhu, Siyu Yan, Cong Peng, Mingliang Chen, Jianglin Zhang, Juan Su, Mei Yi, Zhaoqian Liu, Wei Zhang, Weiqi Zeng, Donald Y.M. Leung, Xiang Chen Source Type: research
Development and Validation of Stabilityindicating RPHPLC Method for The Estimation of Pseudoephedrine Ambroxol and Desloratadine in Bulk and Their Tablet Dosage Forms
N. Mallikarjuna Rao* and D. Gowri Sankar (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - November 2, 2016 Category: Drugs & Pharmacology Source Type: research
A Network Meta-analysis of Randomized Controlled Trials Focusing on Different Allergic Rhinitis Medications
This study is aimed to investigate the effectiveness of 4 allergic rhinitis (AR) drugs (loratadine, cetirizine, montelukast, and desloratadine) in reducing functional problems in patients, as indicated by rhinoconjunctivitis quality of life questionnaire scores. After an exhaustive search of electronic databases containing published scientific literature, high-quality randomized controlled trials relevant to our study were selected based on a stringent predefined inclusion and exclusion criteria. Statistical analyses were conducted using STATA 12.0 and comprehensive meta-analysis (CMA 2.0) software. The literature search b...
Source: American Journal of Therapeutics - November 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research
Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers.
Authors: Antonijoan R, Coimbra J, García-Gea C, Puntes M, Gich I, Campo C, Valiente R, Labeaga L Abstract OBJECTIVE: To compare the peripheral antihistaminic activity of bilastine, rupatadine and desloratadine in inhibiting the histamine-induced wheal and flare (W&F) response. RESEARCH DESIGN AND METHODS: Twenty-four healthy volunteers aged 18-40 years participated in this crossover, randomized, double-blind, placebo-controlled clinical study. Subjects received single doses of bilastine 20 mg, desloratadine 5 mg, rupatadine 10 mg and placebo. W&F responses induced by intrader...
Source: Current Medical Research and Opinion - September 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research
Chronic Urticaria in Special Populations: Children, Pregnancy, Lactation and Elderly People
Opinion statementChronic urticaria can occur at any age and in both sexes. Regardless of the different populations affected, a stepwise treatment approach is recommended, beginning with non-sedating antihistamines, from licensed doses to a “controlled overdose” up to fourfold, followed by a change to a different antihistamine and/or addition of a leukotriene antagonist if symptoms persist; systemic corticosteroids in short courses (3 to 7 days) can be used for exacerbations. As a third-line therapy in adults, omalizumab is now co nsidered of choice and only in nonresponsive cases to omalizumab cyclosporin ...
Source: Current Treatment Options in Allergy - September 23, 2016 Category: Allergy & Immunology Source Type: research