Histamine skin prick tests: from established diagnostic technique to advanced experimental biomarker
Introduction Skin prick tests have a long history as diagnostic and pharmacodynamic biomarker. Besides visual assessments of the wheal and flare, objective blood flow measurements using laser Doppler imaging (LDI) and laser speckle contrast imaging (LSCI) have been reported. In light of these advancements, an up-to-date characterization of the histamine-evoked response is worthwhile. Methods A single-center study was completed in healthy males. Two parameters were addressed: (1) dermal blood flow (DBF) within a 7.65 mm ring encircling the skin prick site (DBFring), and (2) surface area of the flare (AREAflare). First, ...
Source: Skin Pharmacology and Physiology - January 9, 2023 Category: Dermatology Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research

Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model
CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - December 5, 2022 Category: Toxicology Authors: Nilay Duman Re şat Duman Ayhan Vurmaz Source Type: research