The effect of antiallergic treatment with desloratadine-montelukast on salivary glands function in allergic rhinitis.
In conclusion, our study showed that hypofunction of SG was present in all patients with AR. This hypofunction, as tested by semi-quantitative SG scintigraphy, and also the quality of life did not improve after treatment with montelukast and desloratadine.
PMID: 25397624 [PubMed - indexed for MEDLINE] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 18, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2–11 years
ConclusionRupatadine is effective and well tolerated in the relief of urticaria symptoms, improving quality of life over 6 weeks in children with CSU. This is the first study using a modified UAS to assess severity and efficacy outcome in CSU in children. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - November 12, 2015 Category: Allergy & Immunology Authors: Paul Potter, Essack Mitha, László Barkai, Györgyi Mezei, Eva Santamaría, Iñaki Izquierdo, Marcus Maurer Tags: Original Article Source Type: research
360 degree perspective on allergic rhinitis management in Italy: a survey of GPs, pharmacists and patients
Conclusions:
Allergic rhinitis is largely managed by GPs in Italy, with pharmacists also playing a role, yet awareness of the ARIA guidelines among these groups is low. Patient satisfaction with treatment is moderate or low. New more effective treatments are needed to improve AR management in Italy. Allergy education programs need to be better targeted to GPs and pharmacists, and communication with patients regarding symptom control must be improved. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - November 2, 2015 Category: Allergy & Immunology Authors: G. CanonicaMassimo TriggianiGianEnrico Senna Source Type: research
Torsade De Pointes And Qt Prolongation Could Result From Desloratadine Anti-Allergy Treatment
This signal detection pharmacovigilance activity aims to determine if treatment with desloratadine is associated with more than expected reporting of torsade de pointes and electrocardiogram QT prolongation (TQP) events in real-world settings. (Source: Value in Health)
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: AK Ali Tags: RESPIRATORY-RELATED DISORDERS – Clinical Outcomes Studies Source Type: research
Desloratadine citrate disodium injection, a potent histamine H1 receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis Guinea pig model and histamine-induced Human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades.
Abstract
Chemokines have chemotactic properties on leukocyte subsets whose modulation plays a pivotal role in allergic inflammatory processes. Our present study was designed to investigate the anti-allergic and anti-inflammatory properties of desloratadine citrate disodium injection (DLC) and elucidate the molecular mechanisms of its anti-inflammatory properties. The anti-allergic effects of DLC were evaluated based on allergic symptoms, serological marker production and histological changes of the nasal mucosa in guinea pigs model of allergic rhinitis. The anti-inflammatory properties and molecular mechan...
Source: European Journal of Pharmacology - October 8, 2015 Category: Drugs & Pharmacology Authors: Chen M, Xu S, Zhou P, He G, Jie Q, Wu Y Tags: Eur J Pharmacol Source Type: research
Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers
Conclusions
Taken together, these results indicated that the incidence of the DSM phenotype in the Chinese population was low and that food intake could significantly decrease the absorption rate and extent of desloratadine. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 8, 2015 Category: Drugs & Pharmacology Source Type: research
Rupatadine effective in the treatment of chronic spontaneous urticaria in children aged 2‐11 years: a randomized, double blind, placebo and desloratadine controlled study
ConclusionThis is the first study to use a modified UAS to assess severity and outcome in CSU in children. Rupatadine is effective in the relief of urticaria symptoms and quality of life over 6 weeks in children with chronic spontaneous urticaria.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - August 12, 2015 Category: Allergy & Immunology Authors: Paul Potter, Essack Mitha, Laszlo Barkai, Mezei Gyorgyl, Eva Santamaria, Iñaki Izquierdo, Marcus Maurer Tags: Original Article Source Type: research
Effects of desloratadine citrate disodium injection on rat models of ovalbumin‐induced allergic rhinitis: involvement of T‐cell responses modulation
ConclusionDLC (IV), given after an allergen challenge, improved Th1 cytokines level and restrained Th2 responses alleviating the symptoms of AR. Our results indicate that DLC injection may exhibit such effects through the modulation of T‐cell responses. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 8, 2015 Category: Allergy & Immunology Authors: Xin Yuan, Arijit Ghosh, Qiong Jie, Guangwei He, Yulin Wu Tags: ORIGINAL ARTICLE Source Type: research
Effects of allergic rhinitis and desloratadine on the submandibular gland in a rat allergy model
ConclusionThe AR‐induced pathological changes were diminished by desloratadine treatment. Thus, the new‐generation antihistamine desloratadine may be used to treatment of AR patients who have xerostomia. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 1, 2015 Category: Allergy & Immunology Authors: Arzu Tatar, Secil Nazife Parlak, Muhammet Yayla, Rustem Anil Ugan, Elif Polat, Zekai Halici Tags: ORIGINAL ARTICLE Source Type: research
Identification and mechanistic investigation of drug-drug interactions associated with myopathy - A translational approach.
This article is protected by copyright. All rights reserved.
PMID: 25975815 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - May 14, 2015 Category: Drugs & Pharmacology Authors: Han X, Quinney SK, Wang Z, Zhang P, Duke J, Desta Z, Elmendorf JS, Flockhart DA, Li L Tags: Clin Pharmacol Ther Source Type: research
Development of a highly sensitive LC–MS/MS method for simultaneous determination of rupatadine and its two active metabolites in human plasma: Application to a clinical pharmacokinetic study
Publication date: 10 July 2015 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 111 Author(s): Chenglong Sun , Qian Li , Liping Pan , Bing Liu , Pan Gu , Junying Zhang , Li Ding , Chungyong Wu An easy LC–ESI–MS/MS method was developed and validated for simultaneous determination of rupatadine (RT) and its two active metabolites, namely desloratadine (DT) and 3-hydroxydesloratadine (3-OH-DT), in human plasma. The chromatographic separation was carried out on a C18 column with gradient elution by using methanol and 10mM ammonium acetate containing 0.1% (v/v) formic acid. The lower limit of qua...
Source: Journal of Pharmaceutical and Biomedical Analysis - May 3, 2015 Category: Drugs & Pharmacology Source Type: research
Anti-allergic and anti-inflammatory properties of a potent histamine H1 receptor antagonist, Desloratadine citrate disodium injection, and its anti-inflammatory mechanism on EA.hy926 endothelial cells.
Abstract
The present study, demonstrates that, Desloratadine Citrate Disodium Injection (DLC) possesses antihistaminic, anti-allergic and anti-inflammatory properties and elucidates its molecular mechanisms of anti-inflammatory properties. In vitro antihistamine activity of DLC was determined in guinea pig isolated tissues. In vivo antihistamine effects were evaluated after following intravenous administration of DLC in mice with histamine- induced paw edema and in rats with increased capillary permeability. Anti-allergic effects were assessed through passive cutaneous anaphylactic (PCA) reactions in sensi...
Source: European Journal of Pharmacology - February 19, 2015 Category: Drugs & Pharmacology Authors: Jie Q, Kodithuwakku ND, Yuan X, He G, Chen M, Xu S, Wu Y Tags: Eur J Pharmacol Source Type: research
A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats
by Eva Wex, Eva Thaler, Sylvia Blum, David Lamb
Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction, plasma exudation and tissue oedema formation. To validate the efficacy of novel pharmacological interventions, appropriate and practicable in vivo models reflecting mast cell-dependent mechanisms in the lung, are missing. Thus, we developed a novel model of passive pulmonary anaphylaxis in rats. Rats were passively sensitized...
Source: PLoS One - December 26, 2014 Category: Biomedical Science Authors: Eva Wex et al. Source Type: research
Late-breaking abstract: A novel model of IgE-mediated passive pulmonary anaphylaxis in rats
Conclusions: This model of passive pulmonary anaphylaxis provides a tissue relevant readout of early mast cell activity and pharmacological benchmarking reflects responses observed in asthmatic patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Wex, E., Thaler, E., Blum, S., Lamb, D. Tags: 5.3 Allergy and Immunology Source Type: research
Systematic review of treatments for chronic spontaneous urticaria with inadequate response to licensed first‐line treatments
ConclusionsThis review confirms that available evidence to guide treatment choice for patients with CSU with inadequate response to H1 antihistamines varies in quality. Further research is warranted due to low‐quality trials with methodological and reporting limitations. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - December 16, 2014 Category: Dermatology Authors: Sarah Mitchell, Maria‐Magdalena Balp, Miny Samuel, Doreen McBride, Marcus Maurer Tags: Pharmacology and Therapeutics Source Type: research
