Anti-allergic and anti-inflammatory properties of a potent histamine H1 receptor antagonist, Desloratadine citrate disodium injection, and its anti-inflammatory mechanism on EA.hy926 endothelial cells.

Anti-allergic and anti-inflammatory properties of a potent histamine H1 receptor antagonist, Desloratadine citrate disodium injection, and its anti-inflammatory mechanism on EA.hy926 endothelial cells.
Eur J Pharmacol. 2015 Feb 19;
Authors: Jie Q, Kodithuwakku ND, Yuan X, He G, Chen M, Xu S, Wu Y
Abstract
The present study, demonstrates that, Desloratadine Citrate Disodium Injection (DLC) possesses antihistaminic, anti-allergic and anti-inflammatory properties and elucidates its molecular mechanisms of anti-inflammatory properties. In vitro antihistamine activity of DLC was determined in guinea pig isolated tissues. In vivo antihistamine effects were evaluated after following intravenous administration of DLC in mice with histamine- induced paw edema and in rats with increased capillary permeability. Anti-allergic effects were assessed through passive cutaneous anaphylactic (PCA) reactions in sensitized rodents and ovalbumin-induced allergic rhinitis in rats. Anti-inflammatory properties and molecular mechanisms of DLC were determined on histamine- and lipopolysaccharide (LPS) - induced EA.hy926 endothelial cells. DLC exhibited significant and reversible inhibition of histamine-induced contractions of isolated guinea pig ileum with pA2 value of 8.88. Histamine-induced paw edema and increased capillary permeability were notably inhibited by DLC intravenous administration. In the model of PCA reactions, DLC showed significant activity ...

Source: European Journal of Pharmacology - February 19, 2015 Category: Drugs & Pharmacology Authors: Jie Q, Kodithuwakku ND, Yuan X, He G, Chen M, Xu S, Wu Y Tags: Eur J Pharmacol Source Type: research