Hydroxypropyl Methylcellulose Orodispersible Film Containing Desloratadine for Geriatric Use: Formulation and Evaluation
(Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry)
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - December 6, 2023 Category: Allergy & Immunology Authors: Al-Oran, Aya Yahya F. Yenilmez, Evrim Tags: Research article Source Type: research
Effects of temperature, humidity, light, and soil on drug stability in hair: a preliminary study for estimating personal profiles using micro-segmental analysis of corpse hair
ConclusionsAlthough the exposure to sunlight and storage in soil for long times made drug-distribution analysis difficult, MSA could be applied even to hair strands collected from corpses left in severe environments. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 6, 2023 Category: Forensic Medicine Source Type: research
Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug –Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil
ConclusionThese findings substantially enhance our comprehension of CYP2C8-mediated oxidation and DDIs, holding crucial implications for drug development and the planning of clinical trials involving these inhibitors. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - November 3, 2023 Category: Drugs & Pharmacology Source Type: research
Chronic recurrent urticaria in a patient with recurrent herpes labialis: complete remission after administration of aciclovir and antihistamines
We present a 41-year-old female patient with chronic recurrent urticaria associated with angioedema and bronchospasm, in whom her herpes genitalis was found to be concurrent within the history and clinical examination. According to the history, the herpes was also recurrent and dated back about a year. Chlamydia trachomatis infection was also found, with serological findings corresponding to vaginal discomfort. Treatment with acyclovir 400mg thrice daily for an initial period of 7 days in combination with desloratadine 5mg daily was started as we observed complete remission of the urticarial rash. Due to worsening vaginal ...
Source: Herpes - October 4, 2023 Category: Infectious Diseases Authors: Georgi Tchernev Simona Kordeva Source Type: research
Chronic recurrent urticaria in a patient with recurrent herpes labialis: complete remission after administration of aciclovir and antihistamines
We present a 41-year-old female patient with chronic recurrent urticaria associated with angioedema and bronchospasm, in whom her herpes genitalis was found to be concurrent within the history and clinical examination. According to the history, the herpes was also recurrent and dated back about a year. Chlamydia trachomatis infection was also found, with serological findings corresponding to vaginal discomfort. Treatment with acyclovir 400mg thrice daily for an initial period of 7 days in combination with desloratadine 5mg daily was started as we observed complete remission of the urticarial rash. Due to worsening vaginal ...
Source: Herpes - October 4, 2023 Category: Infectious Diseases Authors: Georgi Tchernev Simona Kordeva Source Type: research
First evidence of environmental bioaccumulation of pharmaceuticals on adult native anurans (Rhinella arenarum) from Argentina
Environ Pollut. 2023 Jul 20:122231. doi: 10.1016/j.envpol.2023.122231. Online ahead of print.ABSTRACTThe presence of pharmaceutically active compounds (PhACs) in surface water is well known, whereas their natural occurrence in biota is much less explored. The aim of this work was to evaluate the bioaccumulation of PhACs in adult toads of the neotropical species Rhinella arenarum. Three sites were selected in Buenos Aires (Argentina): a reference site (Site 1), a site with direct discharge from a secondary wastewater treatment plant (WWTP) (Site 2) and a site 300 m downstream of the WWTP discharge (Site 3). Surface water sa...
Source: Environmental Pollution - July 22, 2023 Category: Environmental Health Authors: C Salgado Costa F Bahl G S Natale T M Mac Loughlin D J G Marino A Venturino S Rodriguez-Mozaz L H M L M Santos Source Type: research
Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids
CONCLUSIONS: Pentoxifylline synergizes with 5-Fluorouracil (5-FU) in attenuating organoid formation. It does so by interfering with an IL-6-STAT3 axis leading to the emergence of chemoresistant ALDHhigh cell subpopulations in 5-FU treated PDOs. A larger cohort of CRC-PDOs will be required to validate and expand on the findings of this proof-of-concept study.PMID:37460938 | DOI:10.1186/s13046-023-02754-6 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - July 17, 2023 Category: Cancer & Oncology Authors: Mario Cioce Maria Rita Fumagalli Sara Donzelli Frauke Goeman Valeria Canu Daniela Rutigliano Giulia Orlandi Andrea Sacconi Claudio Pulito Alina Catalina Palcau Maurizio Fanciulli Aldo Morrone Maria Grazia Diodoro Marco Caricato Anna Crescenzi Martina Verr Source Type: research
Proapoptotic and proautophagy effect of H1-receptor antagonist desloratadine in human glioblastoma cell lines
In this study, we aimed to investigate the potential of desloratadine to induce apoptosis/autophagy as genetically regulated processes that can seal cancer cell fates. All experiments were performed on U251 human glioblastoma cell line and primary human glioblastoma cell culture. Cytotoxic effect of desloratadine was investigated using MTT and CV assays, while oxidative stress, apoptosis, and autophagy were detected by flow cytometry and immunoblot. Desloratadine treatment decreased cell viability of U251 human glioblastoma cell line and primary human glioblastoma cell culture (IC50 value 50 µM) by an increase of intrac...
Source: Medical Oncology - July 15, 2023 Category: Cancer & Oncology Source Type: research
Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment
Talanta. 2023 May 30;264:124762. doi: 10.1016/j.talanta.2023.124762. Online ahead of print.ABSTRACTIn this work, a wide-scope liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of environmental levels of multiclass drugs and their metabolites in water and fish samples was developed. The method allowed the reliable determination of 44 drugs, covering a rather wide range of chemistries and physicochemical characteristics. In order to obtain a reliable and robust analytical protocol, different combinations of extraction and cleanup techniques were systematically examined. Aqueo...
Source: Talanta - June 5, 2023 Category: Chemistry Authors: Klaudija Ivankovic Karlo Jambrosic Iva Mikac Damir Kapetanovic Marijan Ahel Senka Terzic Source Type: research
Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment
Talanta. 2023 May 30;264:124762. doi: 10.1016/j.talanta.2023.124762. Online ahead of print.ABSTRACTIn this work, a wide-scope liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of environmental levels of multiclass drugs and their metabolites in water and fish samples was developed. The method allowed the reliable determination of 44 drugs, covering a rather wide range of chemistries and physicochemical characteristics. In order to obtain a reliable and robust analytical protocol, different combinations of extraction and cleanup techniques were systematically examined. Aqueo...
Source: Talanta - June 5, 2023 Category: Chemistry Authors: Klaudija Ivankovic Karlo Jambrosic Iva Mikac Damir Kapetanovic Marijan Ahel Senka Terzic Source Type: research
P19-derived neuronal cells express H < sub > 1 < /sub > , H < sub > 2 < /sub > , and H < sub > 3 < /sub > histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents
This report aimed to characterize the response of neurons differentiated from mouse P19 embryonal carcinoma cells to histamine treatment, and to investigate the modulation of this response by antihistamine drugs, vegetal diamine oxidase, and catalase. The exposure of P19 neurons to histamine reduced cell viability to 65% maximally. This effect involves specific histamine receptors, since it was prevented by treatment with desloratadine and cimetidine, respectively, H1 and H2 antagonists, but not by the H3 antagonist ciproxifan. RT-PCR analysis showed that P19 neurons express H1 and H2 receptors, and the H3 receptor, althou...
Source: Amino Acids - May 12, 2023 Category: Biochemistry Authors: Mariela Gomez Perez Georgiana Tanasie Armelle Tchoumi Neree Narjara Gonzalez Suarez Clara Lafortune Joanne Paquin Lucia Marcocci Paola Pietrangeli Borhane Annabi Mircea Alexandru Mateescu Source Type: research
P19-derived neuronal cells express H < sub > 1 < /sub > , H < sub > 2 < /sub > , and H < sub > 3 < /sub > histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents
This report aimed to characterize the response of neurons differentiated from mouse P19 embryonal carcinoma cells to histamine treatment, and to investigate the modulation of this response by antihistamine drugs, vegetal diamine oxidase, and catalase. The exposure of P19 neurons to histamine reduced cell viability to 65% maximally. This effect involves specific histamine receptors, since it was prevented by treatment with desloratadine and cimetidine, respectively, H1 and H2 antagonists, but not by the H3 antagonist ciproxifan. RT-PCR analysis showed that P19 neurons express H1 and H2 receptors, and the H3 receptor, althou...
Source: Amino Acids - May 12, 2023 Category: Biochemistry Authors: Mariela Gomez Perez Georgiana Tanasie Armelle Tchoumi Neree Narjara Gonzalez Suarez Clara Lafortune Joanne Paquin Lucia Marcocci Paola Pietrangeli Borhane Annabi Mircea Alexandru Mateescu Source Type: research
P19-derived neuronal cells express H < sub > 1 < /sub > , H < sub > 2 < /sub > , and H < sub > 3 < /sub > histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents
This report aimed to characterize the response of neurons differentiated from mouse P19 embryonal carcinoma cells to histamine treatment, and to investigate the modulation of this response by antihistamine drugs, vegetal diamine oxidase, and catalase. The exposure of P19 neurons to histamine reduced cell viability to 65% maximally. This effect involves specific histamine receptors, since it was prevented by treatment with desloratadine and cimetidine, respectively, H1 and H2 antagonists, but not by the H3 antagonist ciproxifan. RT-PCR analysis showed that P19 neurons express H1 and H2 receptors, and the H3 receptor, althou...
Source: Amino Acids - May 12, 2023 Category: Biochemistry Authors: Mariela Gomez Perez Georgiana Tanasie Armelle Tchoumi Neree Narjara Gonzalez Suarez Clara Lafortune Joanne Paquin Lucia Marcocci Paola Pietrangeli Borhane Annabi Mircea Alexandru Mateescu Source Type: research
P19-derived neuronal cells express H < sub > 1 < /sub > , H < sub > 2 < /sub > , and H < sub > 3 < /sub > histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents
This report aimed to characterize the response of neurons differentiated from mouse P19 embryonal carcinoma cells to histamine treatment, and to investigate the modulation of this response by antihistamine drugs, vegetal diamine oxidase, and catalase. The exposure of P19 neurons to histamine reduced cell viability to 65% maximally. This effect involves specific histamine receptors, since it was prevented by treatment with desloratadine and cimetidine, respectively, H1 and H2 antagonists, but not by the H3 antagonist ciproxifan. RT-PCR analysis showed that P19 neurons express H1 and H2 receptors, and the H3 receptor, althou...
Source: Amino Acids - May 12, 2023 Category: Biochemistry Authors: Mariela Gomez Perez Georgiana Tanasie Armelle Tchoumi Neree Narjara Gonzalez Suarez Clara Lafortune Joanne Paquin Lucia Marcocci Paola Pietrangeli Borhane Annabi Mircea Alexandru Mateescu Source Type: research
