A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats
by Eva Wex, Eva Thaler, Sylvia Blum, David Lamb
Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction, plasma exudation and tissue oedema formation. To validate the efficacy of novel pharmacological interventions, appropriate and practicable in vivo models reflecting mast cell-dependent mechanisms in the lung, are missing. Thus, we developed a novel model of passive pulmonary anaphylaxis in rats. Rats were passively sensitized...
Source: PLoS One - December 26, 2014 Category: Biomedical Science Authors: Eva Wex et al. Source Type: research
Late-breaking abstract: A novel model of IgE-mediated passive pulmonary anaphylaxis in rats
Conclusions: This model of passive pulmonary anaphylaxis provides a tissue relevant readout of early mast cell activity and pharmacological benchmarking reflects responses observed in asthmatic patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Wex, E., Thaler, E., Blum, S., Lamb, D. Tags: 5.3 Allergy and Immunology Source Type: research
Systematic review of treatments for chronic spontaneous urticaria with inadequate response to licensed first‐line treatments
ConclusionsThis review confirms that available evidence to guide treatment choice for patients with CSU with inadequate response to H1 antihistamines varies in quality. Further research is warranted due to low‐quality trials with methodological and reporting limitations. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - December 16, 2014 Category: Dermatology Authors: Sarah Mitchell, Maria‐Magdalena Balp, Miny Samuel, Doreen McBride, Marcus Maurer Tags: Pharmacology and Therapeutics Source Type: research
Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients
Abstract
Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The present study is to investigate whether FCER1A polymorphisms are associated with the risk of CSU, and to determine whether these polymorphisms influence the therapeutic efficacy of nonsedating H1-antihistamines. 191 CSU patients treated by nonsedating H1-antihistamines monotherapy (inc...
Source: Archives of Dermatological Research - November 21, 2014 Category: Dermatology Source Type: research
Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.
Authors: Nagaya Y, Nozaki Y, Kobayashi K, Takenaka O, Nakatani Y, Kusano K, Yoshimura T, Kusuhara H
Abstract
In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (CCSF) has been widely used as a surrogate for unbound brain concentrations (Cu,brain). However, previous rodent studies demonstrated that when drugs undergo active efflux by transporters, such as P-glycoprotein (P-gp), at the blood-brain barrier, the CCSF overestimates the corresponding Cu,brain. To investigate the utility of CCSF as a surrogate for interstitial fluid (ISF) concentration (CISF) in nonhuman primat...
Source: Drug Metabolism and Pharmacokinetics - November 18, 2014 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
H1-antihistamines for chronic spontaneous urticaria.
CONCLUSIONS: Although the results of our review indicate that at standard doses of treatment, several antihistamines are effective when compared with placebo, all results were gathered from a few studies or, in some cases, from single-study estimates. The quality of the evidence was affected by the small number of studies in each comparison and the small sample size for many of the outcomes, prompting us to downgrade the quality of evidence for imprecision (unless stated for each comparison, the quality of the evidence was low).No single H1-antihistamine stands out as most effective. Cetirizine at 10 mg once daily in the s...
Source: Cochrane Database of Systematic Reviews - November 14, 2014 Category: Journals (General) Authors: Sharma M, Bennett C, Cohen SN, Carter B Tags: Cochrane Database Syst Rev Source Type: research
Effect of ingested H antihistamines on methacholine challenge
Current guidelines recommend withholding H1 antihistamines before methacholine challenge.1 There does not appear to be much evidence to support this recommendation. We performed a double-blind random-order study comparing single-dose diphenhydramine, desloratadine, and cetirizine to placebo on the airway response to methacholine. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 24, 2014 Category: Allergy & Immunology Authors: Donald W. Cockcroft, Beth E. Davis, Yeonju Roh, Joe-Ann Lourens Tags: Letter to the Editor Source Type: research
[Ecchymosis During Montelukast Therapy: About One Case.]
Abstract
A young girl aged 13-years-old treated with montelukast, fluticasone/salmeterol, desloratadine, fluticasone furoate and salbutamol has presented numerous spontaneous bruises after that treatment with montelukast was substituted by the generic form. Stopping montelukast allow a significant improvement in bruises.
PMID: 25270304 [PubMed - as supplied by publisher] (Source: Therapie)
Source: Therapie - October 2, 2014 Category: Psychiatry & Psychology Authors: Béné J, Gantois E, Landouzy M, Auffret M, Coupé P, Courouble M, Gautier S Tags: Therapie Source Type: research
Update on Antihistamine Treatment for Chronic Urticaria in Children
Opinion statement
Urticaria is a heterogeneous group of diseases, which may have different causes and mechanisms but share similar clinical features. It is clinically defined by the presence of wheals and/or angioedema. The diagnosis of urticaria is based on the evaluation of clinical manifestations. Urticaria is conventionally classified as acute or chronic. Chronic urticaria (CU) has been defined as daily or nearly daily occurrence of wheals and/or angioedema lasting longer than 6 weeks. Very little is known of the epidemiology of urticaria in infants and children, and still less is known of the prev...
Source: Current Treatment Options in Allergy - September 1, 2014 Category: Allergy & Immunology Source Type: research
Phytodermatitis to Euphorbia trigona.
Abstract
A 56-year-old Caucasian woman presented with acute onset of dermatitis on her face accompanied by intense itching. The patient reported that the condition began after cleaning a decorative plant, Euphorbia trigona, and contact with some drops of the plant's latex sap released upon cutting its leaves. The clinical examination revealed erythema and edema of the infraorbital and perioral regions (Figure 1). The patient was in otherwise good general health, had no personal or family history of systemic or skin disease, and was not receiving any concomitant medications. Therapy with topical methylpredn...
Source: Skinmed - July 1, 2014 Category: Dermatology Authors: Darlenski R, Kazandjieva J, Tsankov N Tags: Skinmed Source Type: research
Bilastine as a potential treatment in allergic rhinitis.
CONCLUSION: Bilastine is a novel H1 antihistamine with anti-allergic properties which is highly effective in the treatment of symptoms of allergic rhinitis. It has a favorable pharmacokinetic and pharmacodynamic profile and is generally well tolerated.
PMID: 25197918 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 1, 2014 Category: ENT & OMF Authors: Kowal K, DuBuske L Tags: Am J Rhinol Allergy Source Type: research
Acute urticaria as a side effect of the Mirena(R) (levonorgestrel-releasing intrauterine system): a case report
Conclusion:
The patient's acute urticaria seems to have been associated with the Mirena(R) levonorgestrel intrauterine system implantation, since she had no history of allergic reactions to materials used during the operation such as plastic, metal, alcohol, medications, and povidone-iodine. (Source: BMC Research Notes)
Source: BMC Research Notes - April 3, 2014 Category: Research Authors: Xiangjuan ChenXueqing WuHaiyan Zhu Source Type: research
Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study
ConclusionsThis results provide early evidence that antihistamine has a synergic effect with minimizing the side‐effect of isotretinoin, and may be used as an adjuvant treatment of moderate acne. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - February 21, 2014 Category: Dermatology Authors: H.E. Lee, I.K. Chang, Y. Lee, C.D. Kim, Y.J. Seo, J.H. Lee, M. Im Tags: Original Article Source Type: research
Processes involved in sweeping as sample enrichment method in cyclodextrin‐modified micellar electrokinetic chromatography of hydrophobic basic analytes
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - December 14, 2013 Category: Biochemistry Authors: Mohamed El‐Awady, Ute Pyell Tags: Research Article Source Type: research
Treatment of recalcitrant chronic urticaria with nonsedating antihistamines: is there evidence for updosing?
Abstract
Nonsedating antihistamines are the first-choice treatment for all forms of urticaria. In patients with recalcitrant urticaria who do not respond to conventional doses of antihistamines, current guidelines recommend increasing doses by up to 4 times in order to obtain better control of the disease. Although few studies have been conducted, there are convincing data from controlled trials for cetirizine, levocetirizine, and desloratadine that support the use of increased doses of such drugs in unresponsive patients. The use of higher doses of antihistamines has not been associated with increased adv...
Source: Journal of Investigational Allergology and Clinical Immunology - August 28, 2013 Category: Allergy & Immunology Authors: Sánchez-Borges M, Caballero-Fonseca F, Capriles-Hulett A Tags: J Investig Allergol Clin Immunol Source Type: research
