Hommage au Professeur Jean-Louis Imbs
Therapie. 2021 Nov 10:S0040-5957(21)00237-7. doi: 10.1016/j.therap.2021.11.001. Online ahead of print.NO ABSTRACTPMID:34844762 | DOI:10.1016/j.therap.2021.11.001 (Source: Therapie)
Source: Therapie - November 30, 2021 Category: Psychiatry & Psychology Authors: Pascal Bousquet Source Type: research

Tyrosine kinase inhibitors as next generation oncological therapeutics: Current strategies, limitations and future perspectives
Therapie. 2021 Nov 2:S0040-5957(21)00215-8. doi: 10.1016/j.therap.2021.10.010. Online ahead of print.ABSTRACTProtein kinases, a class of enzymes that govern various biological phenomena at a cellular level, are responsible for signal transduction in cells that regulate cellular proliferation, differentiation, and growth. Protein kinase enzyme mutation results in abnormal cell division leading to a pathological condition like cancer. Tyrosine kinase (TK) inhibitors, which helps as a potential drug candidate for the treatment of cancer, are continuously being developed. Majority of these drug candidates are being administere...
Source: Therapie - November 26, 2021 Category: Psychiatry & Psychology Authors: Aishwarya Shinde Kanan Panchal Sumeet Katke Rishi Paliwal Akash Chaurasiya Source Type: research

Tyrosine kinase inhibitors as next generation oncological therapeutics: Current strategies, limitations and future perspectives
Therapie. 2021 Nov 2:S0040-5957(21)00215-8. doi: 10.1016/j.therap.2021.10.010. Online ahead of print.ABSTRACTProtein kinases, a class of enzymes that govern various biological phenomena at a cellular level, are responsible for signal transduction in cells that regulate cellular proliferation, differentiation, and growth. Protein kinase enzyme mutation results in abnormal cell division leading to a pathological condition like cancer. Tyrosine kinase (TK) inhibitors, which helps as a potential drug candidate for the treatment of cancer, are continuously being developed. Majority of these drug candidates are being administere...
Source: Therapie - November 26, 2021 Category: Psychiatry & Psychology Authors: Aishwarya Shinde Kanan Panchal Sumeet Katke Rishi Paliwal Akash Chaurasiya Source Type: research

Tyrosine kinase inhibitors as next generation oncological therapeutics: Current strategies, limitations and future perspectives
Therapie. 2021 Nov 2:S0040-5957(21)00215-8. doi: 10.1016/j.therap.2021.10.010. Online ahead of print.ABSTRACTProtein kinases, a class of enzymes that govern various biological phenomena at a cellular level, are responsible for signal transduction in cells that regulate cellular proliferation, differentiation, and growth. Protein kinase enzyme mutation results in abnormal cell division leading to a pathological condition like cancer. Tyrosine kinase (TK) inhibitors, which helps as a potential drug candidate for the treatment of cancer, are continuously being developed. Majority of these drug candidates are being administere...
Source: Therapie - November 26, 2021 Category: Psychiatry & Psychology Authors: Aishwarya Shinde Kanan Panchal Sumeet Katke Rishi Paliwal Akash Chaurasiya Source Type: research

Tyrosine kinase inhibitors as next generation oncological therapeutics: Current strategies, limitations and future perspectives
Therapie. 2021 Nov 2:S0040-5957(21)00215-8. doi: 10.1016/j.therap.2021.10.010. Online ahead of print.ABSTRACTProtein kinases, a class of enzymes that govern various biological phenomena at a cellular level, are responsible for signal transduction in cells that regulate cellular proliferation, differentiation, and growth. Protein kinase enzyme mutation results in abnormal cell division leading to a pathological condition like cancer. Tyrosine kinase (TK) inhibitors, which helps as a potential drug candidate for the treatment of cancer, are continuously being developed. Majority of these drug candidates are being administere...
Source: Therapie - November 26, 2021 Category: Psychiatry & Psychology Authors: Aishwarya Shinde Kanan Panchal Sumeet Katke Rishi Paliwal Akash Chaurasiya Source Type: research

Raising public awareness about the misuse of predatory journals: One year after the "hydroxychloroquine and push-scooters accidents" hoax
Therapie. 2021 Oct 29:S0040-5957(21)00214-6. doi: 10.1016/j.therap.2021.10.009. Online ahead of print.NO ABSTRACTPMID:34819237 | DOI:10.1016/j.therap.2021.10.009 (Source: Therapie)
Source: Therapie - November 25, 2021 Category: Psychiatry & Psychology Authors: Mathieu E Rebeaud Florian Cova Valentin Ruggeri Micha ël Rochoy Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
CONCLUSION: This meta-analysis has shown that a tight control of blood glucose levels is associated with a decrease of specific microvascular complication of diabetes: photocoagulation, progression of diabetic retinopathy, incidence or progression of macular oedema, risk of microalbuminuria and risk of macroalbuminuria or proteinuria. Regarding all the other outcomes (vision loss, surgery of cataract, proliferative or non-proliferative retinopathy, death related to kidney disease, development of kidney disease, doubling of serum creatinine, neuropathy), no significant result was found.PMID:34782145 | DOI:10.1016/j.therap.2...
Source: Therapie - November 16, 2021 Category: Psychiatry & Psychology Authors: Sophie Sun Lucie Hisland Guillaume Grenet Fran çois Gueyffier Catherine Cornu Nemat Jaafari R émy Boussageon Source Type: research

Pharmacokinetics of ceftolozane/tazobactam continuous infusion on renal replacement therapy: A pediatric case report
Therapie. 2021 Oct 20:S0040-5957(21)00208-0. doi: 10.1016/j.therap.2021.10.003. Online ahead of print.NO ABSTRACTPMID:34776252 | DOI:10.1016/j.therap.2021.10.003 (Source: Therapie)
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Charlotte Collignon Ines Gana Sihem Benaboud Julie Toubiana Martin Castelle Mehdi Oualha Charles de Marcellus Source Type: research

Green tea and hepatoxicity: Two case reports
Therapie. 2021 Oct 23:S0040-5957(21)00209-2. doi: 10.1016/j.therap.2021.10.004. Online ahead of print.NO ABSTRACTPMID:34776253 | DOI:10.1016/j.therap.2021.10.004 (Source: Therapie)
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Soizic Percevault Bruno Charpiat Fanny Leboss é Jean-Yves Mabrut Thierry Vial Matthieu Colom Source Type: research

A historical cohort study to investigation of statins safety in COVID-19 hospitalized patients
Therapie. 2021 Oct 24:S0040-5957(21)00211-0. doi: 10.1016/j.therap.2021.10.006. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: A notable proportion of COVID-19 patients need statins for their co-existing conditions. Statins possess several anti-inflammatory properties. We have attempted to describe potential association of exposure to statins and severity of COVID symtpoms in a historical study in hospitalized COVID-19 patients.METHODS: This single-center, historical cohort study was performed in Baharloo hospital as a referral hospital for COVID-19 patients in Tehran. Patients were divided into two groups; 163 s...
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Saeed Nateghi Mohammad Mahmoudi Gomari Hadiseh Hosamirudsari Behnam Behnoush Asma Razmjoofard Goli Azimi Shokooh Ordookhani Ali Jafarpour Neda Faraji Source Type: research

Parental self-medication with antibiotics in a Tunisian pediatric center
CONCLUSION: Our study confirmed that parental knowledge about antibiotic use is low. In fact, the government should from one hand, organize antibiotic delivery and prohibit off the counter sells and in the other hand promote the education of the public through different procedures to stop this major health problem.PMID:34776255 | DOI:10.1016/j.therap.2021.10.007 (Source: Therapie)
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Asma Ben Mabrouk Fatma Larbi Ammari Amina Werdani Nesrine Jemmali Jihene Chelli Houcem Elomma Mrabet Ahmed Rassas Mohamed Habib Sfar Sana El Mhamdi Bahri Mahjoub Source Type: research

Pharmacokinetics of ceftolozane/tazobactam continuous infusion on renal replacement therapy: A pediatric case report
Therapie. 2021 Oct 20:S0040-5957(21)00208-0. doi: 10.1016/j.therap.2021.10.003. Online ahead of print.NO ABSTRACTPMID:34776252 | DOI:10.1016/j.therap.2021.10.003 (Source: Therapie)
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Charlotte Collignon Ines Gana Sihem Benaboud Julie Toubiana Martin Castelle Mehdi Oualha Charles de Marcellus Source Type: research

Green tea and hepatoxicity: Two case reports
Therapie. 2021 Oct 23:S0040-5957(21)00209-2. doi: 10.1016/j.therap.2021.10.004. Online ahead of print.NO ABSTRACTPMID:34776253 | DOI:10.1016/j.therap.2021.10.004 (Source: Therapie)
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Soizic Percevault Bruno Charpiat Fanny Leboss é Jean-Yves Mabrut Thierry Vial Matthieu Colom Source Type: research

A historical cohort study to investigation of statins safety in COVID-19 hospitalized patients
Therapie. 2021 Oct 24:S0040-5957(21)00211-0. doi: 10.1016/j.therap.2021.10.006. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: A notable proportion of COVID-19 patients need statins for their co-existing conditions. Statins possess several anti-inflammatory properties. We have attempted to describe potential association of exposure to statins and severity of COVID symtpoms in a historical study in hospitalized COVID-19 patients.METHODS: This single-center, historical cohort study was performed in Baharloo hospital as a referral hospital for COVID-19 patients in Tehran. Patients were divided into two groups; 163 s...
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Saeed Nateghi Mohammad Mahmoudi Gomari Hadiseh Hosamirudsari Behnam Behnoush Asma Razmjoofard Goli Azimi Shokooh Ordookhani Ali Jafarpour Neda Faraji Source Type: research

Parental self-medication with antibiotics in a Tunisian pediatric center
CONCLUSION: Our study confirmed that parental knowledge about antibiotic use is low. In fact, the government should from one hand, organize antibiotic delivery and prohibit off the counter sells and in the other hand promote the education of the public through different procedures to stop this major health problem.PMID:34776255 | DOI:10.1016/j.therap.2021.10.007 (Source: Therapie)
Source: Therapie - November 15, 2021 Category: Psychiatry & Psychology Authors: Asma Ben Mabrouk Fatma Larbi Ammari Amina Werdani Nesrine Jemmali Jihene Chelli Houcem Elomma Mrabet Ahmed Rassas Mohamed Habib Sfar Sana El Mhamdi Bahri Mahjoub Source Type: research

Initial data on the safety of metopimazine during pregnancy and the risk of major birth defects and pregnancy loss  - An observational study using the EFEMERIS database
CONCLUSION: This study illustrates the wide use of metopimazine during pregnancy in France although no studies on efficacy or safety in pregnant women are available. The results of this study do not indicate any teratogenic effect or an increased risk of pregnancy loss of metopimazine.PMID:34756562 | DOI:10.1016/j.therap.2021.09.006 (Source: Therapie)
Source: Therapie - November 10, 2021 Category: Psychiatry & Psychology Authors: Cl émentine Vabre M élanie Araujo Christine Damase-Michel Caroline Hurault-Delarue Isabelle Lacroix Source Type: research

Initial data on the safety of metopimazine during pregnancy and the risk of major birth defects and pregnancy loss  - An observational study using the EFEMERIS database
CONCLUSION: This study illustrates the wide use of metopimazine during pregnancy in France although no studies on efficacy or safety in pregnant women are available. The results of this study do not indicate any teratogenic effect or an increased risk of pregnancy loss of metopimazine.PMID:34756562 | DOI:10.1016/j.therap.2021.09.006 (Source: Therapie)
Source: Therapie - November 10, 2021 Category: Psychiatry & Psychology Authors: Cl émentine Vabre M élanie Araujo Christine Damase-Michel Caroline Hurault-Delarue Isabelle Lacroix Source Type: research

Initial data on the safety of metopimazine during pregnancy and the risk of major birth defects and pregnancy loss  - An observational study using the EFEMERIS database
CONCLUSION: This study illustrates the wide use of metopimazine during pregnancy in France although no studies on efficacy or safety in pregnant women are available. The results of this study do not indicate any teratogenic effect or an increased risk of pregnancy loss of metopimazine.PMID:34756562 | DOI:10.1016/j.therap.2021.09.006 (Source: Therapie)
Source: Therapie - November 10, 2021 Category: Psychiatry & Psychology Authors: Cl émentine Vabre M élanie Araujo Christine Damase-Michel Caroline Hurault-Delarue Isabelle Lacroix Source Type: research

Initial data on the safety of metopimazine during pregnancy and the risk of major birth defects and pregnancy loss  - An observational study using the EFEMERIS database
CONCLUSION: This study illustrates the wide use of metopimazine during pregnancy in France although no studies on efficacy or safety in pregnant women are available. The results of this study do not indicate any teratogenic effect or an increased risk of pregnancy loss of metopimazine.PMID:34756562 | DOI:10.1016/j.therap.2021.09.006 (Source: Therapie)
Source: Therapie - November 10, 2021 Category: Psychiatry & Psychology Authors: Cl émentine Vabre M élanie Araujo Christine Damase-Michel Caroline Hurault-Delarue Isabelle Lacroix Source Type: research

Case report: Nicolau livedoid dermatitis following an intramuscular injection of sustained release octreotide
Therapie. 2021 Apr 24:S0040-5957(21)00105-0. doi: 10.1016/j.therap.2021.04.009. Online ahead of print.NO ABSTRACTPMID:34740446 | DOI:10.1016/j.therap.2021.04.009 (Source: Therapie)
Source: Therapie - November 6, 2021 Category: Psychiatry & Psychology Authors: Mathilde B érard Marina Babin Delphine Bourneau-Martin Christian Le Clec'h Source Type: research

Case report: Nicolau livedoid dermatitis following an intramuscular injection of sustained release octreotide
Therapie. 2021 Apr 24:S0040-5957(21)00105-0. doi: 10.1016/j.therap.2021.04.009. Online ahead of print.NO ABSTRACTPMID:34740446 | DOI:10.1016/j.therap.2021.04.009 (Source: Therapie)
Source: Therapie - November 6, 2021 Category: Psychiatry & Psychology Authors: Mathilde B érard Marina Babin Delphine Bourneau-Martin Christian Le Clec'h Source Type: research

Case report: Nicolau livedoid dermatitis following an intramuscular injection of sustained release octreotide
Therapie. 2021 Apr 24:S0040-5957(21)00105-0. doi: 10.1016/j.therap.2021.04.009. Online ahead of print.NO ABSTRACTPMID:34740446 | DOI:10.1016/j.therap.2021.04.009 (Source: Therapie)
Source: Therapie - November 6, 2021 Category: Psychiatry & Psychology Authors: Mathilde B érard Marina Babin Delphine Bourneau-Martin Christian Le Clec'h Source Type: research

Case report: Nicolau livedoid dermatitis following an intramuscular injection of sustained release octreotide
Therapie. 2021 Apr 24:S0040-5957(21)00105-0. doi: 10.1016/j.therap.2021.04.009. Online ahead of print.NO ABSTRACTPMID:34740446 | DOI:10.1016/j.therap.2021.04.009 (Source: Therapie)
Source: Therapie - November 6, 2021 Category: Psychiatry & Psychology Authors: Mathilde B érard Marina Babin Delphine Bourneau-Martin Christian Le Clec'h Source Type: research

Mazzotti reaction: Ivermectin-associated polyarthritis after delayed scabies treatment. Case report and review of the literature
Therapie. 2021 Oct 14:S0040-5957(21)00205-5. doi: 10.1016/j.therap.2021.10.001. Online ahead of print.NO ABSTRACTPMID:34732299 | DOI:10.1016/j.therap.2021.10.001 (Source: Therapie)
Source: Therapie - November 4, 2021 Category: Psychiatry & Psychology Authors: Jessica Amado Antonio Victoria Rollason Stefano Musumeci Axel Finckh Ilias Lazarou Emmanuel Laffitte Mathieu Nendaz Jacques Serratrice Matteo Coen Source Type: research

Mazzotti reaction: Ivermectin-associated polyarthritis after delayed scabies treatment. Case report and review of the literature
Therapie. 2021 Oct 14:S0040-5957(21)00205-5. doi: 10.1016/j.therap.2021.10.001. Online ahead of print.NO ABSTRACTPMID:34732299 | DOI:10.1016/j.therap.2021.10.001 (Source: Therapie)
Source: Therapie - November 4, 2021 Category: Psychiatry & Psychology Authors: Jessica Amado Antonio Victoria Rollason Stefano Musumeci Axel Finckh Ilias Lazarou Emmanuel Laffitte Mathieu Nendaz Jacques Serratrice Matteo Coen Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Application of benvitimod on psoriasis: A systematic review and meta-analysis of randomized controlled trials. A systematic review of benvitimod on psoriasis
CONCLUSIONS: Benvitimod was effective and safe for psoriasis. More RCTs with high qualities are needed to further verify the current conclusion.PMID:34689959 | DOI:10.1016/j.therap.2021.09.005 (Source: Therapie)
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Lianghong Chen Yan Wu Bihuan Xiao Xinghua Gao Yan Sun Source Type: research

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19
Therapie. 2021 Oct 8:S0040-5957(21)00204-3. doi: 10.1016/j.therap.2021.09.007. Online ahead of print.ABSTRACTSARS-CoV-2 is a positive-sense RNA virus and it is the causative agent of the global COVID-19 outbreak. COVID-19 is similar to the previous outbreaks for instance SARS in 2002-2003 and MERS in 2012. As the peptides have many advantages, peptide-based therapeutics might be one of the possible ways in the development of COVID-19 specific drugs. SARS-CoV-2 enters into a human via its S protein by attaching with human hACE2 present on the cell membrane in the lungs and intestines of humans. hACE2 cleaves S protein into ...
Source: Therapie - October 25, 2021 Category: Psychiatry & Psychology Authors: Jagat Narayan Shah Guang-Qin Guo Anand Krishnan Muthusamy Ramesh Naresh Kumar Katari Mohd Shahbaaz Magda H Abdellattif Sachin Kumar Singh Kamal Dua Source Type: research

Observational study of links of interest disclosure at the Congress of General Medicine France and links of interest of French physicians attending
CONCLUSION: The legal obligation to declare one's conflict of interest at congresses is little respected in France. Involvement of the organizers and using pre-established disclosure formats would improve transparency. It is necessary to develop the independence of speakers to improve research and medical expertise.PMID:34688470 | DOI:10.1016/j.therap.2021.09.004 (Source: Therapie)
Source: Therapie - October 24, 2021 Category: Psychiatry & Psychology Authors: Adriaan Barbaroux Guillaume Lardy Source Type: research

The discovery of hypoglycaemic sulphonamides  - Montpellier, 1942
Therapie. 2021 Sep 22:S0040-5957(21)00181-5. doi: 10.1016/j.therap.2021.09.003. Online ahead of print.ABSTRACTThe pathophysiological study of diabetes mellitus took an important place in the school of Montpellier since the end of the XIXth century with Emmanuel Hedon's (1863-1933) contribution to the demonstration of the endocrine function of the pancreas. In 1942, a new sulfonamide compound (2254RP) was tested in the infectious diseases department of Pr M. Janbon (1898-1996) on cases of typhoid fever, leading to several deaths rapidly related to hypoglycaemia. The physiologist Auguste Loubatières (1912-1977) rapidl...
Source: Therapie - October 17, 2021 Category: Psychiatry & Psychology Authors: Thierry Lavabre-Bertrand Jean-Luc Faillie Source Type: research