Phthiriasis capitis ab initio. Use of entodermoscopy for quick differentiation between Phthirus pubis and Pediculus capitis nits,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Squamous cell carcinoma superimposed on necrobiosis lipoidica: a rare complication,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Dermoscopy of late-onset nevus comedonicus,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Multiple seborrheic keratoses in a previously irradiated site,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

UVB, UVA, and visible light (blue-violet range) transmittance of clothing used in Brazil,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Photoepicutaneous tests: a series of 37 Brazilian patients,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Assessing beauticians’ knowledge of cutaneous melanoma and willingness to contribute to melanoma surveillance practices on the general population,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Depressive symptoms before and during treatment of acne with isotretinoin and its correlations: a prospective study,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Case for diagnosis. Hyperpigmented and excoriated papules and nodules in a diabetic patient,
Abstract Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected. (Source: Anai...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Case for diagnosis. Eyelid edema and erythematous papules disseminated on the face,
Abstract Lupus miliaris disseminatus faciei or acne agminata is a chronic inflammatory disorder of the skin, considered an intriguing entity due to its pathogenesis, which is still largely speculative. It has been linked to tuberculosis, sarcoidosis, rosacea, and other granulomatous diseases, but it is considered an independent entity. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Case for diagnosis. Phagedenic ulcer on the thorax,
Abstract Paget's disease is a rare disorder of the nipple and/or the areola that is characterized by an erythematosquamous lesion and is often associated with in situ or invasive breast carcinoma. The authors present an atypical, exuberant case that had evolved over eight years, emphasizing the importance of early diagnosis. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Cauliflower-like exophytic mass on the skin: polypoid melanoma. Clinical, dermoscopic, and histologic features,
Abstract Polypoid melanoma is a variant of nodular melanoma, whose poor prognosis depends on its thickness and the presence of ulceration at the time of diagnosis. The authors report two cases of polypoid melanoma, presenting as broad, cauliflower-like, polypoid masses. Dermoscopy was characterized by a multicolored pattern, atypical polymorphic vessels, and the fiber sign. Clinical and dermoscopic features can help to diagnose polypoid melanoma and exclude other possible differential diagnoses. However, histology remains mandatory to confirm the diagnostic suspicion. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Leprosy in Brazil in the 21st century: analysis of epidemiological and operational indicators using inflection point regression,
The objective of this study was to analyze the trend of epidemiological and operational indicators of leprosy in Brazil, from 2001 to 2017. This was a time series study involving nine indicators. The inflection point regression model was used. Decreasing trends were observed for the following: general detection ( − 4.8%), children under 15 ( − 3.7%), prevalence ( − 7.0%), and grade 2/million inhabitants ( − 3.5%). The proportion of individuals with grade 2 disability showed an upward trend (2.0%) from 2001 as well as contacts examined from 2003 (5.0%). The proportions of cure and of individuals with...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Paracoccidioidomycosis: an uncommon clinical presentation,
Abstract Paracoccidoiomycosis is a systemic mycosis with a higher incidence in males with history of exposure to the rural environment; its classic clinical manifestation is an oro-pulmonary lesion. The authors report a case of a female, urban, 76-year-old patient with atypical clinical-dermatological presentation and diagnostic conclusion after histopathological examination. The clinical response was quick and complete after treatment with itraconazole 400 mg/day in the first month, decreased to 200 mg/day until the sixth month of treatment. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Immunoreactive cutaneous sporotrichosis,
Abstract Sporothrix spp. infection can occur through the inoculation of the organism in the skin through direct contact with the soil (sapronotic infection), through contact with animals, such as infected cats and dogs (zoonotic infection), or less frequently via inhalation. With a subacute or chronic evolution, approximately 80% of patients affected by the disease present with the lymphocutaneous form; episodes associated with a hypersensitivity reaction are rare. The authors report the case of a 12-year-old child with immunoreactive sporotrichosis manifested clinically as erythema nodosum lesions in the lower limbs, asso...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Azathioprine: its uses in dermatology,
Abstract This is a narrative review of azathioprine. This medication is immunomodulatory and immunosuppressive, and it has been used widely through different medical specialties to modify disease. It has been proven useful for several dermatoses and it has encountered success when used as an off-label indication for other dermatologic diseases. Its mechanism of action is described thoroughly, as well as precautions for monitoring adequate levels in patients using it. Dermatologists should also be aware of the possible adverse events it may present. In dermatology it can be used in bullous and autoimmune diseases, and in ot...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Tumor in the plantar region: dermatofibrosarcoma protuberans in an infrequent topography,
Abstract Dermatofibrosarcoma protuberans is a rare mesenchymal tumor; it is locally aggressive and presents high rates of local recurrence. It may present as a nodular or plaque vegetating lesion. It mainly affects the trunk and proximal limbs, being rare in the distal extremities. Biopsy and immunohistochemistry help confirm the diagnosis. The authors report a case of dermatofibrosarcoma protuberans with plantar region involvement, a rare presentation. To the best of the authors ’ knowledge, only 11 cases of involvement of the feet were described in the international literature. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Acute bullous hemorrhagic prurigo: a diagnostic challenge,
Abstract Insect bites and bite wounds are quite common and most often have mild repercussions in humans. Statistics on the incidence of accidents caused by insects are not available, and the skin reactions after the bites are not always known. The authors present two cases of patients with hemorrhagic blisters on their hands after tabanidae bites and discuss the factors that cause the problem and the importance of the differential diagnosis of blisters with hemorrhagic content on human skin. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Primary hypothyroidism with exuberant dermatological manifestations,
This report highlights the importance of cutaneous manifestations as markers of thyroid disease. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Keep it simple. A ten-year experience in reconstructions after Mohs micrographic surgery,
Abstract Background: Mohs micrographic surgery is worldwide used for treating skin cancers. After obtaining tumor-free margins, choosing the most appropriate type of closure can be challenging. Objectives: Our aim was to associate type of surgical reconstructions after Mohs micrographic surgery with the characteristics of the tumors as histological subtype, anatomical localization and especially number of surgical stages to achieve complete excision of the tumour. Methods: Transversal, retrospective analyses of medical records. Compilation of data such as gender, age, tumor location, histological subtype, number of stages ...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Serum irisin level, insulin resistance, and lipid profiles in patients with hidradenitis suppurativa: a case-control study,
This study aimed to evaluate serum irisin, plasma glucose, insulin, and lipid levels in hidradenitis suppurativa, and elucidate possible associations with disease activity, inflammatory, or metabolic parameters. Methods: This case-control study included 37 patients (M/F: 9/28) and 37 sex-, age- and body mass index -matched healthy controls (M/F: 11/26). Demographic data, Hurley stage of disease, fasting glucose, insulin, total cholesterol, high density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, C-reactive protein levels, erythrocyte sedimentation rate, hematologic parameters, and serum iri...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity,
Abstract Background: In recent studies, microRNAs (mi-RNAs) have been shown to play an important role in psoriasis pathogenesis. However, studies evaluating mi-RNAs in the blood of psoriasis patients including a large number of mi-RNA panels are scarce. Objective: The authors aimed to assess mi-RNA expressions in blood samples of psoriasis patients, as well as to evaluate the association between mi-RNA expression and psoriasis severity. Methods: This was a case-control study on 52 patients with psoriasis vulgaris and 54 controls. Patients' medical history, psoriasis area and severity index (PASI) scores, and dermatology li...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between 2004 and 2017,
Conclusions: The data of the analyzed population (predominance of young women), as well as the location of the lesions (face and cervical area) and the main allergens involved were consistent wi th those from the world literature. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

How does the mitotic index impact patients with T1 melanoma? Comparison between the 7th and 8th edition of the American Joint Committee on Cancer melanoma staging system,
Abstract Background: The mitotic index is no longer used to classify T1 melanoma patients into T1a and T1b, so it should not be used to indicate sentinel node biopsy in these patients. Objectives: To evaluate patients with T1 melanoma who underwent sentinel lymph node biopsy and to compare those who were classified as T1a with those classified T1b, according to the 7th and 8th Edition of the melanoma staging system, regarding a positive biopsy result. The authors also aimed to assess whether there is any difference in the results in both staging systems. Material and methods: This was a retrospective analysis of 1213 patie...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Evaluation of ex vivo melanogenic response to UVB, UVA, and visible light in facial melasma and unaffected adjacent skin,
Abstract Background: The independent role of solar radiation in the differential melanogenesis between melasma and adjacent skin is unknown. Objectives: To assess the melanogenic responses of skin with facial melasma and of the adjacent skin to UVB, UVA, and visible light, in an ex vivo model. Methods: This was a quasi-experimental study involving 22 patients with melasma. Facial melasma and adjacent skin samples were collected and stored in DMEM medium, at room temperature. One fragment was placed under the protection from light, while another was exposed to UVB, UVA, and visible light (blue-violet component): 166 mJ/cm2,...
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Donovanosis,
Abstract Donovanosis is a chronic, progressive, and indolent bacterial disease that affects the skin and mucous membranes of the genital and perigenital regions, often associated with sexual transmission, and with low infectivity. The malignant transformation of donovanosis lesions occurs exceptionally, as is usually seen in long-term ulcerations. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

A case of calciphylaxis with an unfavorable outcome,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Eroded plaques involving the breasts: a unique location of pemphigus vulgaris,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Ecthyma gangrenosum and severe transitory neutropenia in an immunocompetent girl,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Necrolytic migratory erythema associated with painful plantar keratoderma. A new diagnostic clue for this paraneoplastic syndrome?,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Purpura annularis telangiectodes of Majocchi,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Malignant melanoma after treatment for Merkel cell carcinoma,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Onset of vitiligo in a patient with acquired secondary hypogonadism under treatment with testosterone gel 2%: inside the pathogenesis,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Allergic contact dermatitis by shampoo components: a descriptive analysis of 20 cases,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Case for diagnosis. Penile lesion in HIV-negative patient,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Case for diagnosis. Infiltrated areas on the trunk,
Abstract Leprosy is an infectious disease with chronic evolution, caused by Mycobacterium leprae, an acid-fast bacillus that mainly affects the skin and peripheral nervous tissue. Many of the clinical manifestations of leprosy can mimic connective tissue diseases. The authors present the case of a 49-year-old woman who had been treated for four years for systemic lupus erythematosus in a rheumatological service. Skin biopsy of a plaque on the inguinal region was compatible with borderline lepromatous leprosy associated with a type 1 lepra reaction. The patient is undergoing treatment with multibacillary multidrug therapy, ...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Case for diagnosis. Subcutaneous nodules in the plantar region,
Abstract The authors report a case of mobile and painful nodules on the bilateral plantar surface of a female patient referred by the rheumatology service, where she was being followed-up for rheumatoid arthritis. A nodule excision was performed for differential diagnosis and symptom relief; the histopathological analysis was compatible with a rheumatoid nodule. Although rheumatoid nodules are a common manifestation of rheumatoid arthritis, exclusive plantar involvement is seldom described in the literature. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Multisystemic fusariosis with fulminant evolution,
This report presents the case of a 13-year-old female patient with history of acute myeloid leukemia, who, after a bone marrow transplant, began to vomit and experienced rapidly progressive deterioration of consciousness, in addition to disseminated erythematous-violaceous macules, and some blisters with hemorrhagic content inside. Skin biopsy evidenced intravascular filamentous structures. A blood culture confirmed the presence of Fusarium oxysporum. Intravenous treatment with voriconazole was initiated. The patient evolved unfavorably with multiple necrotic skin lesions, ischemic brain lesions, and death. (Source: Anais ...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Clinical and epidemiological aspects of American cutaneous leishmaniasis with genital involvement,
Abstract Genital lesions are an unusual presentation of American cutaneous leishmaniasis. Conditions such as disseminated cutaneous leishmaniasis and HIV infection may be associated with genital involvement. The authors present five cases of American cutaneous leishmaniasis with genital lesions and discuss the clinical and epidemiological aspects observed in this case series. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Digital dermoscopy: a complementary method in the diagnosis of scabies,
Abstract Scabies is an ectoparasitosis caused by Sarcoptes scabiei var. hominis, characterized clinically by pruritic lesions in typical locations; the crusted form is a rare manifestation. The diagnosis is usually established based on the clinical picture, but dermoscopy can be an important complementary method, as it allows the observation of a brownish triangular structure with a hang-glider appearance. A case of crusted scabies is reported; the magnification of the images obtained by digital dermoscopy allowed the demonstration of a structure usually observed only with videodermoscopy. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Scalp cooling to prevent chemotherapy-induced alopecia,
Abstract Chemotherapy-induced alopecia causes an important impact on cancer patients and its risk of persistence is currently a considerable issue in cancer survivors. Of the various interventions proposed for the prevention of chemotherapy-induced alopecia, scalp cooling has emerged as an effective and safe strategy. This paper aims to provide an overview on scalp cooling and chemotherapy-induced alopecia prevention. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma,
The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. thos...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Successful treatment of a patient with cutaneous co-infection caused by Mucor irregularis and Klebsiella pneumoniae,
Abstract The authors report a rare case of primary cutaneous mucormycosis caused by Mucor irregularis and cutaneous Klebsiella pneumoniae infections in a 67-year-old Chinese woman. After the administration of liposomal amphotericin B combined with cefoperazone/sulbactam sodium, the patient recovered. Invasive fungal infection combined with cutaneous bacterial infection should receive attention. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Multiple pilomatricomas in twins with Rubinstein-Taybi syndrome,
Abstract Pilomatricomas are benign tumors originating from the capillary matrix, which may present as solitary lesions or, less commonly, multiple. Myotonic dystrophy and familial adenomatous polyposis are the most frequently associated disorders with multiple pilomatricomas. There are few reports relating these tumors to other genetic syndromes. Rubinstein-Taybi syndrome is a rare autosomal dominant disorder characterized by intellectual disability and typical dysmorphic characteristics. There are five case reports relating to multiple pilomatricoma to Rubinstein-Taybi syndrome, an association that needs to be clarified. ...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Spitz nevus and infliximab: association or coincidence?,
Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Disseminated fusariosis in a patient with bone marrow aplasia,
Abstract Fusariosis is a superficial or systemic infection, which occurs mainly in immunocompromised hosts, especially in patients with hematological neoplasia; 70% – 75% of the cases present cutaneous manifestations. The disseminated form is rare and difficult to diagnose; even with specific treatment, the evolution is usually fatal. Currently, it is considered an emerging disease; in some centers, it is the second most common cause of invasive mycosis, after aspergillosis. The authors describe a case of a female patient with idiopathic bone marrow aplasia and disseminated fusariosis, who initially appeared to benef...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Profile of the use of dermoscopy among dermatologists in Brazil (2018),
Abstract Background: Dermoscopy increases the diagnostic accuracy in dermatology. The aspects related to training, usage profile, or perceptions of usefulness of dermoscopy among dermatologists in Brazil have not been described. Objectives: To evaluate the profile of the use of dermoscopy and the perception of the impact of the technique on clinical practice. Methods: The Brazilian Society of Dermatology invited all members to complete an online form with 20 items regarding demographic data, dermatological assistance, use of dermoscopy, and perceptions of the impact of the technique on clinical practice. The proportions be...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Comparison of basal cell carcinoma subtypes observed in preoperative biopsy and Mohs micrographic surgery,
Conclusions: The agreement between the histopathological subtypes of basal cell carcinoma as seen in preoperative biopsy and Mohs surgery was low. However, preoperative biopsy presented good accuracy (83%) in detecting aggressive histopathological subtypes. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Atypical manifestations of recent syphilis: study of 19 cases,
Conclusions: In view of the findings of the present investigation, it is important to emphasize that all patients who present with cord-like lesions on the penis must undergo a rapid test for syphilis, VDRL, serologies for HIV viral hepatitis B and C and, whenever possible, histopathological and Doppler exams. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research

Outcome of staged excision with pathologic margin control in high-risk basal cell carcinoma of the head region,
Conclusions: High-risk basal cell carcinoma had a high cure rate by staged excision. Patients with more risk factors and those with nasal and recurrent basal cell carcinoma required more staged excisions. Failure of tr eatment is more probable in patients with more risk factors, long-standing lesions, and high-risk pathologic and recurrent basal cell carcinomas. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research