Bronchopulmonary Dysplasia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00073-0. doi: 10.1016/S2213-2600(24)00073-0. Online ahead of print.ABSTRACTBACKGROUND: Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation.METHODS: This prospective, multicen...
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Sascha Meyer Johannes Bay Axel R Franz Harald Erhardt Lars Klein Jutta Petzinger Christoph Binder Susanne Kirschenhofer Anja Stein Britta H üning Axel Heep Eva Cloppenburg Julia Muyimbwa Torsten Ott Julia Sandk ötter Norbert Teig Susanne Wiegand Michael Source Type: research

Brain network characterization of preterm infants with bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) affects the microstructure of white matter in preterm infants, but its influence on the changes of the brain structural network has not been elaborated. To investigate the connectivity characteristics of the brain structural network of BPD by using diffusion tensor imaging. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 20, 2024 Category: Neurology Authors: Ying Liu, Binbin Nie, Bing Wu, Shuai Wang, Qiaozhi Ma, Tao Han, Feng Wang, Han Meng, Hao Xie, Xuetao Mu Tags: Research Paper Source Type: research

The impact of combined administration of surfactant and intratracheal budesonide compared to surfactant alone on bronchopulmonary dysplasia (BPD) and mortality rate in preterm infants with respiratory distress syndrome: a single-blind randomized clinical trial
Respiratory distress syndrome (RDS) is one of the most important and common disorders among premature infants. (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 20, 2024 Category: Pediatrics Authors: Asghar Marzban, Samira Mokhtari, Pouria Tavakkolian, Reza Mansouri, Nahid Jafari and Azam Maleki Tags: Research Source Type: research

Caregiver Decision-Making Regarding Tracheostomies in Preterm Infants with Severe Bronchopulmonary Dysplasia
1. Describe caregiver decision-making experiences regarding tracheostomy placement in infants with severe bronchopulmonary dysplasia, including from families that have chosen not to proceed with tracheostomy and families that speak Spanish.2. Practically integrate caregiver perspectives and advice to improve clinical care for other families facing this decision. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Rachel M. Macak, Teresa Glade, Ivy Hansen, Tsivya Devereaux, Kristen Ameel, Katie Gradick, Dominic Moore, Jody L. Lin Source Type: research

Paediatric intensive care admissions of preterm children born
Conclusions Most babies born <32 weeks and discharged home from neonatal care do not require PICU admission in the first 2 years. The odds of unplanned admissions to PICU were greater in the most preterm and those with significant neonatal morbidity. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: van Hasselt, T. J., Gale, C., Battersby, C., Davis, P. J., Draper, E., Seaton, S. E., On behalf of the United Kingdom Neonatal Collaborative and the Paediatric Critical Care Society Study Group (PCCS-SG) Tags: Open access Original research Source Type: research

Late surfactant administration after 48 hours of age in preterm neonates with respiratory insufficiency: a systematic review and meta-analysis
Conclusions Administration of late surfactant does not improve the rates of death or BPD at 36 weeks when administered to preterm infants with prolonged respiratory insufficiency. Additional adequately powered trials are needed to establish the efficacy of late surfactant therapy in preterm infants. PROSPERO registration number CRD42023432463. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Solis-Garcia, G., Elias, S., Dunn, M., Jasani, B. Tags: Original research Source Type: research

Effects of prophylactic hydrocortisone in a tertiary Canadian NICU
Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Recent evidence suggests that the use of physiological doses of hydrocortisone for the prevention of death or BPD may outweigh the potential risks.1–3 Starting in 2019, all infants born <28 weeks gestational age (GA) in our tertiary care NICU received physiologic doses of hydrocortisone, starting within 24 hours post-birth. Our objective was to determine the effect of prophylactic hydrocortisone on the incidence of survival without moderate or severe BPD; secondary objectives assessed duration of respiratory support and safety outcomes. We...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: de Souza, M., Melika, R., Thebaud, B., Barrowman, N. J., Tsampalieros, A., Lemyre, B. Tags: PostScript Source Type: research

Bronchopulmonary dysplasia: temporal trend from 2010 to 2019 in the Brazilian Network on Neonatal Research
Conclusion The frequency of BPD in survivors was constant and BPD or death decreased by 1.05% at each study year. These results show some improvement in perinatal care in Brazilian units which resulted in a reduction of BPD or death, but further improvements are still needed to reduce BPD in survivors. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Stolz, C., Costa-Nobre, D. T., Sanudo, A., Ferreira, D. M. d. L. M., Sales Alves, J. M., dos Santos, J. P., Miyoshi, M. H., Silva, N. M. d. M., Melo, F. P. d. G., da Silva, R. V. C., Barcala, D., Vale, M. S., de Souza Rugolo, L. M. S., Diniz, E. M. A., Ri Tags: Original research Source Type: research

Association between viral infection and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis
Conclusion: Viral infections, especially CMV, are associated with an increased risk of BPD in preterm infants. Methodologically reliable prospective studies with large samples are needed to validate our conclusions, and high-quality randomized controlled studies are needed to explore the effect of prevention or treatment of viral infections on the incidence of BPD.What is Known:• Studies have attempted to identify viral infections and bronchopulmonary dysplasia in preterm infants; however, results have been inconsistent.What is New:• Systematic demonstration that viral infections, particularly cytomegalovirus, are posi...
Source: European Journal of Pediatrics - April 18, 2024 Category: Pediatrics Source Type: research

Glucocorticosteroids and bronchopulmonary dysplasia : is epigenetics the missing link?
Pediatr Res. 2024 Apr 16. doi: 10.1038/s41390-024-03203-6. Online ahead of print.NO ABSTRACTPMID:38627592 | DOI:10.1038/s41390-024-03203-6 (Source: Pediatric Research)
Source: Pediatric Research - April 16, 2024 Category: Pediatrics Authors: Olivier Baud Elodie Zana-Taieb Daniel Vaiman Source Type: research

Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews
CONCLUSIONS: This overview summarises the evidence of nine SRs investigating the effect of postnatal corticosteroids in preterm infants at risk for BPD. Late initiated (≥ seven days after birth) systemic administration of dexamethasone is considered an effective intervention to reduce the risk of BPD in infants with a high risk profile for BPD, based on a favourable balance between benefits and harms. Endotracheal instillation of corticosteroids (budesonide) with surfactant as a carrier is a promising intervention, based on the beneficial effect on desirable outcomes without (so far) negative side effects. Pending result...
Source: Cochrane Database of Systematic Reviews - April 10, 2024 Category: General Medicine Authors: Moniek van de Loo Anton van Kaam Martin Offringa Lex W Doyle Chris Cooper Wes Onland Source Type: research