Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard
Conclusion More preterm infants are surviving with worse respiratory outcomes, particularly severe BPD requiring postdischarge respiratory support. Ultimately, these survivors will develop chronic respiratory diseases requiring greater healthcare resources. (Source: Thorax)
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Kwok, T. C., Poulter, C., Algarni, S., Szatkowski, L., Sharkey, D. Tags: Open access, Thorax Paediatric lung disease Source Type: research

Increasing respiratory burden of prematurity: can we turn the tide?
Despite many improvements in neonatal care, prematurity remains a significant cause of childhood mortality and morbidity, and the second largest cause of death in children worldwide.1 2 Chronic lung disease of prematurity, also known as bronchopulmonary dysplasia (BPD) is the most common respiratory complication, associated with poor long-term health and neurodisability.3 Early lung protective ventilation strategies can affect lung function and respiratory outcomes long into school age.4 In this issue of Thorax, Kwok et al describe changes in the outcomes of preterm babies in England and Wales over the last decade (2010&nd...
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Zivanovic, S., Chaban, B. Tags: Thorax Editorial Source Type: research

Can Red Blood Cell and Platelet Transfusions Have a Pathogenic Role in Bronchopulmonary Dysplasia?
To evaluate whether transfusions in infants born preterm contribute to the pathogenesis of bronchopulmonary dysplasia (BPD). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 19, 2023 Category: Pediatrics Authors: Timothy M. Bahr, Gregory L. Snow, Thomas R. Christensen, Patricia Davenport, Erick Henry, Sarah M. Tweddell, Sarah J. Ilstrup, Bradley A. Yoder, Robin K. Ohls, Martha C. Sola-Visner, Robert D. Christensen Tags: Original Articles Source Type: research

Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper
CONCLUSION: Bioinformatic analyses can help identify BPD endotypes that associate with clinical definitions of BPD.PMID:37968635 | DOI:10.1186/s12931-023-02596-y (Source: Respiratory Care)
Source: Respiratory Care - November 16, 2023 Category: Respiratory Medicine Authors: Alvaro G Moreira Tanima Arora Shreyas Arya Caitlyn Winter Charles T Valadie Przemko Kwinta Source Type: research

Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper
CONCLUSION: Bioinformatic analyses can help identify BPD endotypes that associate with clinical definitions of BPD.PMID:37968635 | DOI:10.1186/s12931-023-02596-y (Source: Respiratory Care)
Source: Respiratory Care - November 16, 2023 Category: Respiratory Medicine Authors: Alvaro G Moreira Tanima Arora Shreyas Arya Caitlyn Winter Charles T Valadie Przemko Kwinta Source Type: research

How is preterm birth working out: cardiopulmonary response to exercise in extreme prematurity
Extract Preterm birth affects more than 15 million children born across the world each year, and complications related to prematurity are the leading cause of death in young children [1]. Those infants born extremely premature, <30 weeks gestational age (GA), are at particularly high risk of increased morbidity and mortality [2]. Bronchopulmonary dysplasia (BPD), or chronic lung disease of prematurity, impacts ~30% of infants who were born extremely premature. BPD was first described almost 60 years ago in moderately preterm infants (~34 weeks GA) and primarily as the result of ventilator-induced lun...
Source: European Respiratory Journal - November 16, 2023 Category: Respiratory Medicine Authors: Hysinger, E. B., Critser, P. Tags: Editorials Source Type: research

Cardiopulmonary response to exercise in adults born very preterm
Conclusions Results suggest limitations with peripheral oxygen uptake in the muscles with reduced V'O2/WR and peak circulatory power, but normal cardiac output. Investigations into skeletal muscle perfusion and oxygen use during exercise are warranted to better understand mechanisms of exercise limitation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 16, 2023 Category: Respiratory Medicine Authors: Delfrate, J., Girard-Bock, C., Curnier, D., Perie-Curnier, D., Cloutier, A., Gascon, G., Landry, J. S., Masse, B., Stickland, M. K., Nuyt, A. M., Luu, T. M., the HAPI Collaborating Group, AdomiMotohikoAlosNathalieAl SimaaniAmyBertagnolliMarianeBigrasJean- Tags: Lung biology and experimental studies Original Articles: Preterm birth and lung health Source Type: research

Association between bronchopulmonary dysplasia and death or neurodevelopmental impairment at 3  years in preterm infants without severe brain injury
ConclusionOur findings indicate that BPD is strongly associated with death or NDI in preterm infants without severe neonatal brain injury at 3 years of age. Further research is needed to understand the mechanisms linking the development of BPD with death or NDI and whether appropriate treatment of BPD may ameliorate or prevent the development of neurological complications. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 15, 2023 Category: Neurology Source Type: research

Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper
Bronchopulmonary dysplasia has multiple definitions that are currently based on phenotypic characteristics. Using an unsupervised machine learning approach, we created BPD subclasses (e.g., endotypes) by clust... (Source: Respiratory Research)
Source: Respiratory Research - November 15, 2023 Category: Respiratory Medicine Authors: Alvaro G. Moreira, Tanima Arora, Shreyas Arya, Caitlyn Winter, Charles T. Valadie and Przemko Kwinta Tags: Research Source Type: research

Corrigendum to "Heparin improves alveolarization and vascular development in hyperoxia-induced bronchopulmonary dysplasia by inhibiting neutrophil extracellular traps" [Biochem. Biophys. Res. Commun. (2020)]
Biochem Biophys Res Commun. 2023 Nov 6:149129. doi: 10.1016/j.bbrc.2023.149129. Online ahead of print.NO ABSTRACTPMID:37940468 | DOI:10.1016/j.bbrc.2023.149129 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - November 8, 2023 Category: Biochemistry Authors: Yuanyuan Sun Cuie Chen Xixi Zhang Shi Wang Ronghe Zhu Aihua Zhou Shujun Chen Jianhua Feng Source Type: research

Corrigendum to "Heparin improves alveolarization and vascular development in hyperoxia-induced bronchopulmonary dysplasia by inhibiting neutrophil extracellular traps" [Biochem. Biophys. Res. Commun. (2020)]
Biochem Biophys Res Commun. 2023 Nov 6:149129. doi: 10.1016/j.bbrc.2023.149129. Online ahead of print.NO ABSTRACTPMID:37940468 | DOI:10.1016/j.bbrc.2023.149129 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - November 8, 2023 Category: Biochemistry Authors: Yuanyuan Sun Cuie Chen Xixi Zhang Shi Wang Ronghe Zhu Aihua Zhou Shujun Chen Jianhua Feng Source Type: research

Association of early and current life factors with telomere length in preterm-born children
ConclusionsTelomere length was associated with sex, IUGR and deprivation, especially in females with IUGR, but not with prematurity, BPD, lung function or cardiovascular measurements. (Source: PLoS One)
Source: PLoS One - November 8, 2023 Category: Biomedical Science Authors: Ella A. Kotecha Source Type: research

Zinc Supplementation in Very Low Birth Weight Infants: A Randomized Controlled Trial
Conclusion Zn supplementation for VLBW infants is found to be effective to decrease feeding intolerance, NEC, and LOS episodes in this vulnerable population. Current data support the supplementation of VLBW infants with higher than regular dose of Zn. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 8, 2023 Category: Perinatology & Neonatology Authors: Sahin, Suzan Sari, Fatma N. Bidev, Duygu Bozkurt, Ozlem Dizdar, Evrim A. Oguz, Serife S. Tags: Original Article Source Type: research

Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: statistical analysis plan for the international, multicenter, randomized PLUSS trial
Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks ’ gestation and is associated with an increased risk of adverse neuro... (Source: Trials)
Source: Trials - November 6, 2023 Category: General Medicine Authors: Kate L Francis, Christopher J D McKinlay, C Omar F Kamlin, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Peter G Davis, Susan M Donath and Brett J Manley Tags: Update Source Type: research

Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension
Long-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN is associated with increased mortality in hypoxic-ischemic encephalopathy, though the effects on neurodevelopment are less clear. Preterm infants can develop pulmonary hypertension (PH) early in the postnatal course or later in the setting of bronchopulmonary dysplasia (BPD). BPD-PH is associated with higher mortality, particularly within the first year....
Source: Clinics in Perinatology - November 6, 2023 Category: Perinatology & Neonatology Authors: Emily S. Stieren, Deepika Sankaran, Satyan Lakshminrusimha, Catherine A. Rottkamp Source Type: research