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Bronchopulmonary Dysplasia and Cell Senescence: A Case of Old Lungs in Young Infants?
Am J Respir Cell Mol Biol. 2023 Dec 18. doi: 10.1165/rcmb.2023-0442ED. Online ahead of print.NO ABSTRACTPMID:38109692 | DOI:10.1165/rcmb.2023-0442ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - December 18, 2023 Category: Respiratory Medicine Authors: Paul T Schumacker Source Type: research

Bronchopulmonary Dysplasia and Cell Senescence: A Case of Old Lungs in Young Infants?
Am J Respir Cell Mol Biol. 2023 Dec 18. doi: 10.1165/rcmb.2023-0442ED. Online ahead of print.NO ABSTRACTPMID:38109692 | DOI:10.1165/rcmb.2023-0442ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 18, 2023 Category: Molecular Biology Authors: Paul T Schumacker Source Type: research

One-year survival and outcomes of infants born at 22 and 23 weeks of gestation in Sweden 2004-2007, 2014-2016 and 2017-2019
Conclusion Increased perinatal activity was associated with reduced mortality and increased chances of survival without MNM in infants born at 22 and 23 weeks of GA. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Farooqi, A., Hakansson, S., Serenius, F., Kallen, K., Björklund, L., Normann, E., Domellöf, M., Aden, U., Abrahamsson, T., Elfvin, A., Sävman, K., Bergström, P. U., Stephansson, O., Ley, D., Hellstrom-Westas, L., Norman, M. Tags: Editor's choice Original research Source Type: research

Neurodevelopment and healthcare utilisation at age 5-6 years in bronchopulmonary dysplasia: an EPIPAGE-2 cohort study
Conclusions BPD was strongly and independently associated with many neurodevelopmental disabilities. Improving medical and neurodevelopmental management of BPD in very preterm children should be a priority to reduce its long-term consequences. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Treluyer, L., Nuytten, A., Guellec, I., Jarreau, P.-H., Benhammou, V., Cambonie, G., Truffert, P., Marchand-Martin, L., Ancel, P. Y., Torchin, H. Tags: Original research Source Type: research

Retracted: Functional Analysis of Bronchopulmonary Dysplasia-Related Neuropeptides in Preterm Infants and miRNA-Based Diagnostic Model Construction
Comput Math Methods Med. 2023 Dec 6;2023:9850462. doi: 10.1155/2023/9850462. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/5682599.].PMID:38094431 | PMC:PMC10718829 | DOI:10.1155/2023/9850462 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - December 14, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research

Lung ultrasound score as a tool to predict severity of bronchopulmonary dysplasia in neonates born ≤25 weeks of gestational age
Journal of Perinatology, Published online: 12 December 2023; doi:10.1038/s41372-023-01811-4Lung ultrasound score as a tool to predict severity of bronchopulmonary dysplasia in neonates born ≤25 weeks of gestational age (Source: Journal of Perinatology)
Source: Journal of Perinatology - December 12, 2023 Category: Perinatology & Neonatology Authors: Haifeng Zong Zhifeng Huang Yongping Fu Xueyu Chen Yanliang Yu Yingsui Huang Yichu Huang Hongyan Sun Chuanzhong Yang Source Type: research

Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1
Free Radic Biol Med. 2023 Dec 9:S0891-5849(23)01146-2. doi: 10.1016/j.freeradbiomed.2023.12.001. Online ahead of print.ABSTRACTPregnant women exposed to polycyclic aromatic hydrocarbons (PAHs) are at increased risk for premature delivery. Premature infants often require supplemental oxygen, a known risk factor for bronchopulmonary dysplasia (BPD). Cytochrome P450 (CYP) enzymes have been implicated in hyperoxic lung injury. We hypothesize that prenatal PAH exposure exacerbates oxygen-mediated lung injury in neonatal mice, and that this effect is differentially altered in mice lacking the gene for (Cyp)1a1, 1a2, or 1b1. Time...
Source: Free Radical Biology and Medicine - December 11, 2023 Category: Biology Authors: Rachel Stading Lauren Swanson Guobin Xia Weiwu Jiang Lihua Wang Xanthi Couroucli Krithika Lingappan Bhagavatula Moorthy Source Type: research

Lack of Effect for Oropharyngeal Surfactant —Method or Timing?
The study by Murphy et al presented Prophylactic Oropharyngeal Surfactant for Preterm Infants (POPART), a multicenter randomized clinical trial examining the effects of prophylactic surfactant administered into the oropharynx prior to routine resuscitation of preterm neonates. Among 251 neonates (mean [SD] gestational age, 26 [1.5] weeks; 126 in the intervention group and 125 in the control group) from 9 different sites across Europe, the study found no statistically significant difference in the proportion of neonates requiring intubation within 120 hours of birth (63.5% vs 64.8%; relative risk [RR], 0.98 [95% CI, 0.81-1....
Source: JAMA Pediatrics - December 11, 2023 Category: Pediatrics Source Type: research

Pathogenesis and Physiologic Mechanisms of Neonatal Pulmonary Hypertension
Neonatal pulmonary hypertension (PH) is a devastating disorder of the pulmonary vasculature characterized by elevated pulmonary vascular resistance and mean pulmonary arterial pressure. Occurring predominantly because of maldevelopment or maladaptation of the pulmonary vasculature, PH in neonates is associated with suboptimal short-term and long-term outcomes because its pathobiology is unclear in most circumstances, and it responds poorly to conventional pulmonary vasodilators. Understanding the pathogenesis and pathophysiology of neonatal PH can lead to novel strategies and precise therapies. The review is designed to ac...
Source: Clinics in Perinatology - December 11, 2023 Category: Perinatology & Neonatology Authors: Karen C. Young, Augusto F. Schmidt, April W. Tan, Lourenco Sbragia, Ahmed Elsaie, Binoy Shivanna Source Type: research

The Association Between Two Different Lipid Injectable Emulsions and Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Retrospective Cohort Study
CONCLUSIONS: SMOFlipid may represent a better alternative for VLBW infants who require prolonged parenteral nutrition. This article is protected by copyright. All rights reserved.PMID:38062851 | DOI:10.1002/jpen.2588 (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - December 8, 2023 Category: Nutrition Authors: Xing Li Ling Chen Hai-Feng Lv Rui Zhao Miao-Fa Ying Li Wei Ye Zhang Zhou Jiang Source Type: research