Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: study protocol for the international, multicenter, randomized PLUSS trial
DiscussionCombining budesonide with surfactant for intratracheal administration is a simple intervention that may reduce BPD in extremely preterm infants and translate into health benefits in later childhood. The PLUSS trial is powered for the primary outcome and will address gaps in the evidence due to its pragmatic and inclusive design, targeting all extremely preterm infants regardless of their initial mode of respiratory support. Should intratracheal budesonide mixed with surfactant increase survival free of BPD, without severe adverse effects, this readily available intervention could be introduced immediately into cl...
Source: Trials - May 9, 2023 Category: Research Source Type: clinical trials

Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study
Condition:   Bronchopulmonary Dysplasia; Retinopathy of Prematurity Intervention:   Diagnostic Test: Integrated proteomic HPLC-ESI-MS analysis of salivary peptides Sponsor:   Fondazione Policlinico Universitario Agostino Gemelli IRCCS Active, not recruiting (Source:
Source: - March 23, 2023 Category: Research Source Type: clinical trials

Effect of Caffeine Versus Probiotic on Preterm Neonates With Bronchopulmonary Dysplasia
Condition:   Bronchopulmonary Dysplasia Interventions:   Drug: Caffeine;   Drug: Probiotic Formula Sponsor:   Tanta University Recruiting (Source:
Source: - January 12, 2023 Category: Research Source Type: clinical trials