Less invasive surfactant administration versus endotracheal surfactant instillation followed by limited peak pressure ventilation in preterm infants with respiratory distress syndrome in China: study protocol for a randomized controlled trial
DiscussionData from recent systematic review and meta-analysis have suggested a possible improvement in outcomes of preterm infants with RDS by the LISA technique. However, robust evidence is lacking. Why LISA plays a potential role in reducing respiratory morbidity, mainly BPD in preterm infants, remains unclear. The possible explanations are the active and uninterrupted delivery of continuous positive airway pressure during the LISA procedure and the avoidance of complications caused by intubation and relatively high pressure/volume ventilation following surfactant administration. We hypothesized that LISA ’s effective...
Source: Trials - June 10, 2020 Category: Research Source Type: clinical trials

Forced Oscillometry in Infants With Bronchopulmonary Dysplasia
Conditions:   Infant, Premature, Diseases;   Bronchopulmonary Dysplasia;   Respiratory Distress Syndrome Intervention:   Device: Non-invasive forced airway oscillometry Sponsor:   Winston Manimtim Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 17, 2020 Category: Research Source Type: clinical trials

A randomized controlled trial protocol comparing the feeds of fresh versus frozen mother ’s own milk for preterm infants in the NICU
DiscussionOur double-blinded, randomized, controlled trial aims to examine whether fresh human milk can improve infant outcomes. The results of this study will impact both Chinese and international medical practice and feeding policy for preterm infants. In addition, data from our study will inform changes in health policy in NICUs across China, such that mothers are encouraged to enter the NICU and express fresh milk for their infants.Trial registrationChinese Clinical Trial Registry; #ChiCTR1900020577; registered January 1, 2019;http://www.chictr.org.cn/showprojen.aspx?proj=34276 (Source: Trials)
Source: Trials - February 10, 2020 Category: Research Source Type: clinical trials

Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia
Condition:   Bronchopulmonary Dysplasia Intervention:   Biological: Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Sponsors:   Ottawa Hospital Research Institute;   Canadian Institutes of Health Research (CIHR);   Ontario Institute of Regenerative Medicine (OIRM);   Stem Cell Network Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 5, 2020 Category: Research Source Type: clinical trials