Hydrocortisone to treat early bronchopulmonary dysplasia in very preterm infants: study protocol for a randomized controlled trial
This study protocol is for a multicenter double-blind randomized controlled trial of low-dose HC in the treatment of early BPD. Early BPD infants will be randomly assigned to the HC treatment group or control group. Infants in the HC group will receive 0.5  mg/kg HC twice a day for 7 days and then 0.5 mg/kg HC once a day for 3 days. The control group will be given the same volume of placebo and no intervention on the basis of routine treatment. The primary outcome is survival without moderate or severe BPD at 36 weeks postmenstrual age. Seco ndary outcomes are the short- and long-term effects on growth, metabolis...
Source: Trials - September 2, 2020 Category: Research Source Type: clinical trials

Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia
Condition:   Bronchopulmonary Dysplasia of Newborn Interventions:   Drug: Sildenafil;   Drug: Placebo Sponsors:   Christoph P Hornik, MD MPH;   National Heart, Lung, and Blood Institute (NHLBI);   University of North Carolina, Chapel Hill Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 25, 2020 Category: Research Source Type: clinical trials