Bronchopulmonary Dysplasia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Synergistic effects of achieving perinatal interventions on bronchopulmonary dysplasia in preterm infants
Conclusion: Six perinatal interventions can effectively reduce the risk of sBPD and death in a synergistic form.What is Known:• Bronchopulmonary dysplasia (BPD) is a multifactorial chronic lung disease associated with prematurity. The effective management of BPD requires a comprehensive set of interventions. However, the extent to which these interventions can mitigate the risk of severe outcomes, such as severe BPD or mortality, or if they possess synergistic effects remains unknown.What is New:• The implementation of various perinatal interventions, such as prenatal steroids, birth in centers with tertiary NICU, ea...
Source: European Journal of Pediatrics - January 17, 2024 Category: Pediatrics Source Type: research

Transpyloric feeding is associated with adverse in-hospital outcomes in infants with severe bronchopulmonary dysplasia
Journal of Perinatology, Published online: 13 January 2024; doi:10.1038/s41372-024-01867-wTranspyloric feeding is associated with adverse in-hospital outcomes in infants with severe bronchopulmonary dysplasia (Source: Journal of Perinatology)
Source: Journal of Perinatology - January 13, 2024 Category: Perinatology & Neonatology Authors: Jonathan C. Levin Matthew J. Kielt Lystra P. Hayden Sara Conroy William E. Truog Milenka Cuevas Guaman Steven H. Abman Leif D. Nelin Rachel L. Rosen Kristen T. Leeman Source Type: research

Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0157OC. Online ahead of print.ABSTRACTBronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is characterized by impaired lung development with sustained functional abnormalities due to alterations of airways and the distal lung. Although clinical studies have shown striking associations between antenatal stress and BPD, little is known about underlying pathogenetic mechanisms. Whether dysanapsis, the concept of discordant growth of airways and parenchyma, contributes to late respiratory disease due to antenatal stress is unknown. We hypothe...
Source: Am J Respir Cell Mol... - January 11, 2024 Category: Respiratory Medicine Authors: Elizabeth A McGinn Elisa Bye Tania Gonzalez Alexander Sosa Jill Bilodeaux Gregory Seedorf Bradford J Smith Steven H Abman Erica W Mandell Source Type: research

Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0157OC. Online ahead of print.ABSTRACTBronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is characterized by impaired lung development with sustained functional abnormalities due to alterations of airways and the distal lung. Although clinical studies have shown striking associations between antenatal stress and BPD, little is known about underlying pathogenetic mechanisms. Whether dysanapsis, the concept of discordant growth of airways and parenchyma, contributes to late respiratory disease due to antenatal stress is unknown. We hypothe...
Source: American Journal of Respiratory Cell and Molecular Biology - January 11, 2024 Category: Molecular Biology Authors: Elizabeth A McGinn Elisa Bye Tania Gonzalez Alexander Sosa Jill Bilodeaux Gregory Seedorf Bradford J Smith Steven H Abman Erica W Mandell Source Type: research

Efficacy of inhaled nitric oxide in preterm infants ≤ 34 weeks: a systematic review and meta—analysis of randomized controlled trials
Conclusion: Inhaled NO reduced the incidence of BPD in neonates at 36 weeks of gestation, and the effect of the treatment depended on neonatal age, birth weight, duration and dose of iNO. Therefore, iNO can be considered a promising treatment for the potential prevention of BPD in premature infants. More data, however, would be needed to support nitric oxide registration in this specific patient population, to minimize its off-label use. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 11, 2024 Category: Drugs & Pharmacology Source Type: research

Retinopathy of Prematurity in Very Low Birthweight Neonates of Gestation Less Than 32 weeks in Malaysia
ConclusionsThe incidence and severity of ROP increased with decreasing gestation and birthweight. Prolonged duration of oxygen therapy, infection, invasive respiratory support, and conditions commonly causing fluctuations of oxygenation were significant factors associated with increased risk of ROP. Receiving oxygen at birth did not increase risk. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - January 11, 2024 Category: Pediatrics Source Type: research

IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3
CONCLUSION: IRF4 may affect the protective role of Tregs in the proliferation of pulmonary vascular endothelial cells and pulmonary vascular development in BPD model mice by inhibiting the FOXP3 level.PMID:38195465 | DOI:10.1186/s10020-023-00770-y (Source: Molecular Medicine)
Source: Molecular Medicine - January 9, 2024 Category: Molecular Biology Authors: Ying Zhu Langyue He Yue Zhu Huici Yao Jianfeng Jiang Hongyan Lu Source Type: research

Pulmonary Hypertension in Established Bronchopulmonary Dysplasia
Preterm infants with bronchopulmonary dysplasia (BPD) are prone to develop pulmonary hypertension (PH). Strong laboratory and clinical data suggest that antenatal factors, such as preeclampsia, chorioamnionitis, oligohydramnios, and placental dysfunction leading to fetal growth restriction, increase susceptibility for BPD-PH after premature birth. Echocardiogram metrics and serial assessments of NT-proBNP provide useful tools to diagnose and monitor clinical course during the management of BPD-PH, as well as monitoring for such complicating conditions as left ventricular diastolic dysfunction, shunt lesions, and pulmonary ...
Source: Clinics in Perinatology - January 9, 2024 Category: Perinatology & Neonatology Authors: Steven H. Abman, Satyan Lakshminrusimha Source Type: research

Breastfeeding as protective factor against bronchopulmonary dysplasia in preterm infants
Br J Nutr. 2024 Jan 2:1-24. doi: 10.1017/S0007114523002982. Online ahead of print.ABSTRACTBreastfeeding is associated with fewer comorbidities in very low birth weight (VLBW) preterm infants. Bronchopulmonary dysplasia (BPD) of VLBW infants is a multifactorial pathology in which nutritional aspects may be of special importance. The aim of this study is to determine, in a cohort of VLBW infants, whether breast milk nutrition is associated with a reduced prevalence and severity of BPD.A retrospective study was conducted to record the intake of mother's own milk (MOM), pasteurised donor human milk (DHM) or preterm formula mil...
Source: The British Journal of Nutrition - January 2, 2024 Category: Nutrition Authors: Jose Uberos Isabel Sanchez-Ruiz Elizabeth Fern ández-Marin Aida Ruiz-L ópez Isabel Cubero Millan Ana Campos-Mart ínez Source Type: research

Hyperoxia ‐induced airflow restriction and Renin‐Angiotensin System expression in a bronchopulmonary dysplasia mouse model
Longitudinal changes in Renin-Angiotensin System expression and markers of airflow restriction following neonatal hyperoxia. AbstractMechanisms underlying hyperoxia-induced airflow restriction in the pediatric lung disease Bronchopulmonary dysplasia (BPD) are unclear. We hypothesized a role for Renin-Angiotensin System (RAS) activity in BPD. RAS is comprised of a pro-developmental pathway consisting of angiotensin converting enzyme-2 (ACE2) and angiotensin II receptor type 2 (AT2), and a pro-fibrotic pathway mediated by angiotensin II receptor type 1 (AT1). We investigated associations between neonatal hyperoxia, airflow r...
Source: Physiological Reports - January 2, 2024 Category: Physiology Authors: Jasmine Dowell, Zachary Bice, Ke Yan, Girija G. Konduri Tags: ORIGINAL ARTICLE Source Type: research

Gse223745 cellular senescence contributes to the progression of hyperoxic bronchopulmonary dysplasia
Contributors : Xigang Jing ; Shuna Jia ; Maggie Teng ; Billy W Day ; Adeleye J Afolayan ; Jason A Jarzembowski ; Martin J Hessner ; Kirkwood A Pritchard ; Stephen Naylor ; G G Konduri ; Ru-Jeng TengSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusOxidative stress (OS), inflammation, and endoplasmic reticulum (ER) stress sequentially occur in the rat model of hyperoxia (HOX) induced bronchopulmonary dysplasia (BPD), and they all increase DNA damage. Tumor suppressors increase after DNA damage, followed by apoptosis or cellular senescence when the damage becomes irreparable. Although cellular senes...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research

Pneumoprotein CC16 in the Umbilical Cord Blood of Preterm Neonates
Conclusion Prolonged rupture of membranes was significantly negatively associated with cord serum CC16, after adjusting for GA, conception, and delivery mode, and CC16 was significantly inversely associated with BPD, after adjusting for GA and birth weight. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 31, 2023 Category: Perinatology & Neonatology Authors: Rallis, Dimitrios Papathanasiou, Aimilia Eirini Christou, Helen Tags: Original Article Source Type: research

Research hotspots and emerging trends in mesenchymal stem/stromal cells in bronchopulmonary dysplasia
In this study, relevant publications from the Web of Science Core Collection were downloaded in January 2023. The acquired data were analyzed and predicted for trends and hotspots in this field using CiteSpace software. Results revealed that in recent years, the focus of co-cited references has been primarily on the clinical studies of MSCs and the application of MSCs derivatives for treating BPD models. The keywords that have gained attention are extracellular vesicles and exosomes. The United States has emerged as the most influential co-authoring country in this field. Among the co-cited journals, the American Journal o...
Source: Human Cell - December 30, 2023 Category: Cytology Source Type: research