Bronchopulmonary Dysplasia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: statistical analysis plan for the international, multicenter, randomized PLUSS trial
Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks ’ gestation and is associated with an increased risk of adverse neuro... (Source: Trials)
Source: Trials - November 6, 2023 Category: General Medicine Authors: Kate L Francis, Christopher J D McKinlay, C Omar F Kamlin, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Peter G Davis, Susan M Donath and Brett J Manley Tags: Update Source Type: research

Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension
Long-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN is associated with increased mortality in hypoxic-ischemic encephalopathy, though the effects on neurodevelopment are less clear. Preterm infants can develop pulmonary hypertension (PH) early in the postnatal course or later in the setting of bronchopulmonary dysplasia (BPD). BPD-PH is associated with higher mortality, particularly within the first year....
Source: Clinics in Perinatology - November 6, 2023 Category: Perinatology & Neonatology Authors: Emily S. Stieren, Deepika Sankaran, Satyan Lakshminrusimha, Catherine A. Rottkamp Source Type: research

We Still Don ’t Know When to Close a Patent Ductus Arteriosus in Very Premature Infants
Very premature and extremely premature infants with patent ductus arteriosus (PDA) are at increased risk for bronchopulmonary dysplasia and mortality. 1,2 Surgical ligation is used less frequently, but is more likely to occur in smaller and more medically complex infants, and is associated with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and severe intraventricular hemorrhage.3 The majority of recent PDA studies have focused on refining diagnostic parameters to identify populations that are most at-risk, optimizing pharmacologic management strategies, and improving the timing of medical treatment. (S...
Source: The Journal of Pediatrics - November 3, 2023 Category: Pediatrics Authors: Maria Gillam-Krakauer, Jeff Reese Tags: Editorials Source Type: research

We Still Don ’t Know When to Close a Patent Ductus Arteriosus in Infants Born Very Premature
Infants born very prematurely with patent ductus arteriosus (PDA) are at increased risk for bronchopulmonary dysplasia (BPD) and mortality.1,2 Surgical ligation is used less frequently but is more likely to occur in infants who are smaller and more medically complex and is associated with necrotizing enterocolitis, BPD, and severe intraventricular hemorrhage.3 The majority of recent studies on PDA have focused on refining diagnostic parameters to identify populations that are most at-risk, optimizing pharmacologic management strategies, and improving the timing of medical treatment. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 3, 2023 Category: Pediatrics Authors: Maria Gillam-Krakauer, Jeff Reese Tags: Editorials Source Type: research

Recruitment of PVT1 Enhances YTHDC1-Mediated m6A Modification of IL-33 in Hyperoxia-Induced Lung Injury During Bronchopulmonary Dysplasia
In conclusion, silencing PVT1 demonstrated beneficial effects in alleviating BPD by facilitating YTHDC1-mediated m6A modification of IL-33. Inhibition of the PVT1/IL-33 axis to suppress apoptosis in lung alveolar epithelial cells may hold promise as a therapeutic approach for managing hyperoxia-induced lung injury in BPD. (Source: Inflammation)
Source: Inflammation - November 2, 2023 Category: Allergy & Immunology Source Type: research

Intratracheal Instillation of Budesonide –Surfactant for Prevention of Bronchopulmonary Dysplasia in Extremely Premature Infants
Conclusion In extremely preterm infants, the budesonide–surfactant combination therapy reduced the rates of BPD or death in infants weighing ≥750 grams; however, this beneficial effect was not seen in infants weighing <750 grams. Further investigation of this treatment may be indicated before it is considered a standard approach to management. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - November 1, 2023 Category: Perinatology & Neonatology Authors: Dolma, Kalsang Zayek, Michael Gurung, Aayushka Eyal, Fabien Tags: Original Article Source Type: research

Practice variation in timing of antenatal corticosteroid administration in early ‐onset fetal growth restriction: A secondary analysis of the Dutch STRIDER study
ConclusionsNo significant differences in neonatal outcomes were observed when comparing early and late strategy of antenatal corticosteroid administration on neonatal outcomes in pregnancies complicated by early-onset fetal growth restriction. We found no apparent risk contribution of interval between corticosteroid administration and delivery in multivariate analysis. Gestational age at delivery was found to be an important predictor of neonatal outcome. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - October 31, 2023 Category: OBGYN Authors: Leah I. Prins, Mette van de Meent, Judith Kooiman, Anouk Pels, Sanne J. Gordijn, Titia Lely, Wessel Ganzevoort Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia
Journal of Perinatology, Published online: 31 October 2023; doi:10.1038/s41372-023-01809-yMulti-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia (Source: Journal of Perinatology)
Source: Journal of Perinatology - October 31, 2023 Category: Perinatology & Neonatology Authors: Candice D. Fike Judy L. Aschner Charul Avachat Angela K. Birnbaum Catherine M. T. Sherwin Source Type: research

Diuretic Tolerance to Repeated-dose Furosemide in Infants Born Very Preterm with Bronchopulmonary Dysplasia
To assess the presence and timing of furosemide diuretic tolerance in infants with bronchopulmonary dysplasia (BPD), and to determine if tolerance is modified by thiazide co-administration. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 31, 2023 Category: Pediatrics Authors: Nicolas A. Bamat, Matthew Huber, Justine Shults, Yun Li, Zili Zong, Athena Zuppa, Eric C. Eichenwald, Matthew M. Laughon, Sara B. DeMauro, Kristin J. McKenna, Benjamin Laskin, Scott A. Lorch Tags: Original Articles Source Type: research

Death of children with Down syndrome by gestational age and cause
CONCLUSIONS: These data on the high mortality and morbidity of preterm infants with DS may be useful for patient treatment and parent counseling in NICUs treating critically ill infants.IMPACT: Most infants with Down syndrome born at <34 weeks' gestation are born by cesarean section because of the non-reassuring fetal status. The mortality rate before discharge for infants with Down syndrome born at <34 weeks' gestation was 40%, and 30% of survivors developed moderate or severe cerebral palsy. The risk of death due to bronchopulmonary dysplasia and pulmonary hypertension was high in very preterm infants with Down syn...
Source: Pediatric Research - October 29, 2023 Category: Pediatrics Authors: Tomoyuki Shimokaze Katsuaki Toyoshima Tomoko Saito Kaoru Katsumata Takahiro Kemmotsu Hiroshi Ishikawa Kenji Kurosawa Source Type: research

Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?
Journal of Perinatology, Published online: 28 October 2023; doi:10.1038/s41372-023-01808-zDoes faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia? (Source: Journal of Perinatology)
Source: Journal of Perinatology - October 28, 2023 Category: Perinatology & Neonatology Authors: Fernando A. Munoz Emily Hawkins Carter Erika M. Edwards Maggie Jerome Jonathan S. Litt Source Type: research

Association of infant tidal breathing with later lung function in preterm individuals
Conclusion: In our preterm cohort, an increase in infant minute ventilation was associated with increased hyperinflation (RV/TLC) and ventilation inhomogeneity (LCI) in adolescence, suggesting that early changes in breathing pattern might indicate later changes, but not for airway obstruction. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Salem, Y., Willers, C. C., Kentgens, A.-C., Jakob, J., Wyler, F., Frey, U., Latzin, P., Yammine, S. Tags: Paediatric respiratory epidemiology Source Type: research