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Maternal and neonatal outcomes following magnesium sulfate in the setting of chorioamnionitis: a meta-analysis
ConclusionCurrent evidence indicates that magnesium sulfate is not associated with an increased risk of maternal chorioamnionitis. However, it should be noted that its effect on neonatal outcomes of offspring born in the setting of chorioamnionitis might be subtle if any, although the available evidence is very limited. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - February 14, 2024 Category: OBGYN Source Type: research

Enteral supplementation with arachidonic and docosahexaenoic acid and pulmonary outcome in extremely preterm infants.
Childhood morbidity derived from preterm birth is one of the most common causes of long-term sequelae in middle and high-income countries [1]. In infants born before 29 weeks of gestation, the lung disease bronchopulmonary dysplasia (BPD) affects nearly every second individual and the incidence has been unchanged or even increased, despite other improvements in preterm care [2 –4]. Lung damage coupled to BPD may have life-long consequences on respiratory health in this population [5,6]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 13, 2024 Category: Biomedical Science Authors: Dirk Wackernagel, Anders K. Nilsson, Ulrika Sj öbom, Ann Hellström, Susanna Klevebro, Ingrid Hansen-Pupp Tags: Original research article Source Type: research

Psychomotor and Cognitive Outcome in Very Preterm Infants in Vorarlberg, Austria, 2007 –2019
Conclusion This study showed a remarkably good neurodevelopmental outcome in preterm infants with low rates of adverse outcome, similar to (inter)national reports, especially in the group of extremely preterm infants. Research is needed to explore the role of social factors and infants' environment, especially cognitive outcome and language skills. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Neuropediatrics)
Source: Neuropediatrics - February 12, 2024 Category: Neurology Authors: Jenni, Fabio Konzett, Karin Gang, Stefanie Sparr, Verena Simma, Burkhard Tags: Original Article Source Type: research

Combined gestational age and serum fucose for early prediction of risk for bronchopulmonary dysplasia in premature infants
As the predominant complication in preterm infants, Bronchopulmonary Dysplasia (BPD) necessitates accurate identification of infants at risk and expedited therapeutic interventions for an improved prognosis. T... (Source: BMC Pediatrics)
Source: BMC Pediatrics - February 12, 2024 Category: Pediatrics Authors: Liangliang Li, Shimin Xu, Miaomiao Li, Xiangyun Yin, Hongmin Xi, Ping Yang, Lili Ma, Lijuan Zhang and Xianghong Li Tags: Research Source Type: research

The role of placental insufficiency in spontaneous preterm birth: A literature review
Preterm birth (PTB) describes delivery before 37  weeks of gestation [1]. Globally, it accounts for 11 % of births, and is the leading cause of childhood mortality [2]. It is spontaneous in approximately two thirds of cases [3]. PTB is associated with serious morbidities including intraventricular haemorrhage, cystic periventricular leukomalac ia, necrotising enterocolitis, cerebral palsy, retinopathy of prematurity and bronchopulmonary dysplasia [4–7]. The projected cost of PTB on public health services in the UK is £2.946 billion per year [8], thus having a significant economic impact on individuals, their familie...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 10, 2024 Category: OBGYN Authors: Megan Preston, Megan Hall, Andrew Shennan, Lisa Story Tags: Review article Source Type: research

Large airway T cells in adults with former bronchopulmonary dysplasia
Bronchopulmonary Dysplasia (BPD) in infants born prematurely is a risk factor for chronic airway obstruction later in life. The distribution of T cell subtypes in the large airways is largely unknown. (Source: Respiratory Research)
Source: Respiratory Research - February 9, 2024 Category: Respiratory Medicine Authors: Jing Gao, Petra Um-Bergstr öm, Melvin Pourbazargan, Eva Berggren-Broström, ChuanXing Li, Heta Merikallio, Riitta Kaarteenaho, Nichole Stacey Reinke, Craig E Wheelock, Erik Melén, Lindén Anders, Åsa M Wheelock, Georgios Rassidakis, Cristian Ortiz-Vill Tags: Research Source Type: research

Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants
CONCLUSION: KL-6 could be a useful screening biomarker for early detection of infants at increased risk for developing BPD.PMID:38328675 | PMC:PMC10846922 | DOI:10.1155/2024/3623948 (Source: Critical Care Research and Practice)
Source: Critical Care Research and Practice - February 8, 2024 Category: Intensive Care Authors: Petya Radulova Margaritka Boncheva Gencho Nachev Boriana Slancheva Violeta Dimitrova Source Type: research

Reengagement with Physiology in Neonatal Heart and Lung Care: A Priority for Training and Practice.
Despite advances in respiratory, nutritional, and neuroprotective strategies, improving short and long-term outcomes for neonates with complex cardiorespiratory disease remains a challenge. [1] [2-4] Neonates, especially those born prematurely, are highly vulnerable to end-organ injury due to developmental immaturity of the myocardium and vascular bed, altered hemodynamic or respiratory states, and unanticipated adverse effects of medications or other interventions. The consequences of abnormal lung-heart interactions may play a role in the long-term health of individuals born premature; specifically, early cardiovascular ...
Source: The Journal of Pediatrics - February 6, 2024 Category: Pediatrics Authors: Patrick J. McNamara, Steven Abman, Philip T. Levy Tags: Commentary Source Type: research

Assessing the role of tracheostomy placement in bronchopulmonary dysplasia with pulmonary hypertension
Journal of Perinatology, Published online: 05 February 2024; doi:10.1038/s41372-024-01881-yAssessing the role of tracheostomy placement in bronchopulmonary dysplasia with pulmonary hypertension (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 5, 2024 Category: Perinatology & Neonatology Authors: Timothy D. Hicks Julian Cameron Shuo Wang Amir Ashrafi Jacqueline Szmuszkovicz Narayan Iyer Manvi Bansal Source Type: research

Association between Antenatal Antibiotic Exposure and Bronchopulmonary Dysplasia: A Systematic Review and Bayesian Model-Averaged Meta-Analysis
CONCLUSIONS: The currently available evidence suggests a lack of association between antenatal antibiotics and BPD. However, our results should not be interpreted as an argument for widespread use of antibiotics in the setting of preterm delivery.PMID:38310865 | DOI:10.1159/000536220 (Source: Neonatology)
Source: Neonatology - February 4, 2024 Category: Perinatology & Neonatology Authors: Karen Van Mechelen Tamara M Hundscheid Elke van Westering-Kroon Franti šek Bartoš Eduardo Villamor Source Type: research

Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression
This study aims to investigate the effect and mechanism of lysine demethylase 3A (KDM3A) on hyperoxia-induced BPD. Hyperoxia-induced BPD mouse and alveolar epithelial cell models were constructed. The effects of hyperoxia on lung development were evaluated by histological and morphological analysis. The levels of KDM3A, E26 transformation specific-1 (ETS1), H3 lysine 9 dimethylation (H3K9me2), and endoplasmic reticulum (ER) stress-related indexes were quantified by RT-qPCR, Western blot, and IF staining. Cell apoptosis was assessed by flow cytometry and TUNEL staining. Transfection of oe-ETS1, oe-KDM3A, and sh-ETS1 was app...
Source: Experimental Cell Research - January 29, 2024 Category: Cytology Authors: Min Yang Yanping Chen Xueshan Huang Fang Shen Yanni Meng Source Type: research