A Systematic Review of Clinical Practice Guidelines for Managing Pulmonary Toxicities Caused by Immune Checkpoint Inhibitors: Quality of Treatment Recommendations and Differences in Management Strategies Between Guidelines
CONCLUSION: Prospectively designed research projects focusing on all types of ca-PT and their histopathologic subtypes are urgently needed. Due to the lack of high-quality recommendations in available CPGs, the disparities in treatment recommendations between high-quality CPGs, and the similarities in recommendations that exists between high-quality and low-quality CPGs, clinicians should thoroughly assess and responsibly appraise all available CPG recommendations in formulating treatment strategies for ca-PT.PMID:38033741 | PMC:PMC10683390 | DOI:10.1177/11795549231203153 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 30, 2023 Category: Cancer & Oncology Authors: Kofi N Donkor Hyeree Jang Reena Sail Source Type: research
Role of the cAMP-PKA-NF- κB pathway in Mucin1 over-expression in A549 cells during Respiratory syncytial virus infection
Respiratory syncytial virus (RSV) is the most common pathogen associated with acute lower respiratory tract infections in infants and young children worldwide. RSV commonly presents as bronchiolitis in young c... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - November 30, 2023 Category: Infectious Diseases Authors: Yingkang Jin, Dongwei Zhang, Kuimiao Deng, Peiqiong Wu, Diyuan Yang, Zhiwei Xie, Wenjun Qiu and Guangyuan Yu Tags: Research Source Type: research
2064 Going green and on screen: digitalising patient information resources in a paediatric emergency department
Conclusion
Since go–live (August 2022) electronic resources have become the standard first offer for families
44 core electronic ED resources cover safety net advice for common conditions, health promotion and signposting links to support health inequalities
Sharing options: scanned via QR code (see figure 1), sent via text/SMS or printed to avoid impacts related to digital poverty
All resources can be translated via a Google translate function (132 languages)
The entire trust library of 1358 resources are accessible to any clinician and any patient user
On average, ED resources are accessed 4675 times/month.
To...
Source: Emergency Medicine Journal - November 28, 2023 Category: Emergency Medicine Authors: Gibbs, S., Sabir, L. Tags: APEM Lightning Papers Source Type: research
Prevalence and risk factors of urinary tract infection among children with bronchiolitis
The co-occurrence of bronchiolitis and urinary tract infections (UTI) in hospitalized children is associated with high morbidity and economic strain. However, due to a low prevalence ( (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 28, 2023 Category: Perinatology & Neonatology Authors: Wallaa Garout Source Type: research
Clinical risk factors and prognostic model for patients with bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation
Bone Marrow Transplantation, Published online: 27 November 2023; doi:10.1038/s41409-023-02151-9Clinical risk factors and prognostic model for patients with bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - November 27, 2023 Category: Hematology Authors: Qiu-Sha Huang Tian-Xiao Han Qi Chen Jin Wu Peng Zhao Ye-Jun Wu Yun He Xiao-Lu Zhu Hai-Xia Fu Feng-Rong Wang Yuan-Yuan Zhang Xiao-Dong Mo Wei Han Chen-Hua Yan Jing-Zhi Wang Huan Chen Yu-Hong Chen Ting-Ting Han Meng Lv Yao Chen Yu Wang Lan-Ping Xu Kai-Yan L Source Type: research
Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial
Introduction
Bronchiolitis is an acute viral infection of the lower respiratory tract. It is most commonly caused by respiratory syncytial virus. Being a common reason for hospitalisation, it affects 13–17% of all hospitalised children younger than 2 years. Only supportive therapy, including suctioning nasal secretions, water–electrolyte balance maintenance and oxygen supplementation when needed, is recommended. However, non-evidence-based diagnostic and therapeutic approaches, including the use of inhaled bronchodilators, nebulised epinephrine, and nebulised and systemic steroids, are common. The inhalation of...
Source: BMJ Open - November 27, 2023 Category: General Medicine Authors: Szupienko, S., Buczek, A., Szymanski, H. Tags: Open access, Paediatrics Source Type: research
Low peripheral blood CCL5 and TNF α gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants
Respiratory syncytial virus (RSV) infection in infants ranges from asymptomatic or mild upper respiratory infections to severe lower respiratory tract infections, primarily bronchiolitis, requiring hospitalization and intensive care [1]. Ribonucleic acids (RNAs) and double-stranded RNA (dsRNA) generated during RSV replication are recognized by retinoic-acid-inducible gene I (RIG-I) and Toll-like Receptors, triggering intracellular signaling pathways that induce the expression of proinflammatory cytokines, chemokines, and interferons (IFN) [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - November 24, 2023 Category: Infectious Diseases Authors: Carlos Pita-Mart ínez, Carmen Goez-Sanz, Ana Virseda-Berdices, Alejandro Gonzalez-Praetorius, Esther Mazario-Martín, María Rodriguez-Mesa, Rafael Amigot-Sánchez, Vanesa Matías, Salvador Resino, Isidoro Martínez Tags: Short Communication Source Type: research
Low peripheral blood chemokine (C-C motif) ligand 5 and tumor necrosis factor α gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants
Respiratory syncytial virus (RSV) infection in infants ranges from asymptomatic or mild upper respiratory infections to severe lower respiratory tract infections, primarily bronchiolitis, requiring hospitalization and intensive care [1]. RNAs and double-stranded RNA generated during RSV replication are recognized by retinoic-acid-inducible gene I and toll-like receptors, triggering intracellular signaling pathways that induce the expression of proinflammatory cytokines, chemokines, and interferons (IFN) [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - November 24, 2023 Category: Infectious Diseases Authors: Carlos Pita-Mart ínez, Carmen Goez-Sanz, Ana Virseda-Berdices, Alejandro Gonzalez-Praetorius, Esther Mazario-Martín, María Rodriguez-Mesa, Rafael Amigot-Sánchez, Vanesa Matías, Salvador Resino, Isidoro Martínez Tags: Short Communication Source Type: research
Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review
ConclusionAlthough these 31 proteins regulate different factors and molecular pathways in all five diseases, they ultimately lead to the regulation of inflammatory pathways. In other words, the expression of some proteins in COPD and mustard-exposed patients increases inflammatory reactions, while in IPF, they cause lung fibrosis. Asthma, causes allergic reactions due to T-cell differentiation toward Th2. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 20, 2023 Category: Allergy & Immunology Authors: Hadi Rezaeeyan,
Masoud Arabfard,
Hamid R. Rasouli,
Alireza Shahriary,
B. Fatemeh Nobakht M. Gh Tags: REVIEW ARTICLE Source Type: research
Long-term ozone exposure and lung function in middle childhood
CONCLUSIONS: In this sample with low O3 concentrations, we did not observe adverse associations between O3 exposures averaged from birth to age 8 and lung function in middle childhood.PMID:37967704 | DOI:10.1016/j.envres.2023.117632 (Source: Environmental Research)
Source: Environmental Research - November 15, 2023 Category: Environmental Health Authors: Marnie F Hazlehurst Logan C Dearborn Allison R Sherris Christine T Loftus Margaret A Adgent Adam A Szpiro Yu Ni Drew B Day Joel D Kaufman Neeta Thakur Rosalind J Wright Sheela Sathyanarayana Kecia N Carroll Paul E Moore Catherine J Karr Source Type: research
Long-term ozone exposure and lung function in middle childhood
CONCLUSIONS: In this sample with low O3 concentrations, we did not observe adverse associations between O3 exposures averaged from birth to age 8 and lung function in middle childhood.PMID:37967704 | DOI:10.1016/j.envres.2023.117632 (Source: Environmental Research)
Source: Environmental Research - November 15, 2023 Category: Environmental Health Authors: Marnie F Hazlehurst Logan C Dearborn Allison R Sherris Christine T Loftus Margaret A Adgent Adam A Szpiro Yu Ni Drew B Day Joel D Kaufman Neeta Thakur Rosalind J Wright Sheela Sathyanarayana Kecia N Carroll Paul E Moore Catherine J Karr Source Type: research
High-flow nasal cannula use in pediatric patients for other indications than acute bronchiolitis —a scoping review of randomized controlled trials
Conclusion: This systematic scoping review provides an overview of current evidence for HFNC use in pediatric patients. Future studies should aim for better quality and include economic evaluation with cost-effectiveness analysis.Protocol registration: Protocol has been publishedhttps://osf.io/a3y46/.What is Known:• High flow nasal cannula has been effective in acute bronchiolitis and neonatal respiratory care.• The use of HFNC on other conditions is also common and increasing, but the evidence supporting this has not been previously summarized.What is New:• We found that HFNC has been studies in relatively few studi...
Source: European Journal of Pediatrics - November 14, 2023 Category: Pediatrics Source Type: research
Effects of respiratory flora regulation on microbial environment and IL-10/STAT3 signaling pathway in the bronchiolitis obliterans after lung transplantation
Cell Mol Biol (Noisy-le-grand). 2023 Oct 31;69(10):201-206. doi: 10.14715/cmb/2023.69.10.29.ABSTRACTOur purpose of this study was to explore the application effect of respiratory flora regulation in bronchiolitis obliterans after lung transplantation, and its regulatory effect on the microbial environment of the lesion and the IL-10/STAT3 signaling pathway. 25 clean-grade C57BL/6 male mice and 5 BALB/c male mice were selected for orthotopic tracheal transplantation and postoperative respiratory flora regulation in a hospital animal room from Jan 2019 to Dec 2021. Next, the changes in the microbial environment and the IL-10...
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Xin Wang Tianhua Liu Yizhuo Chen Ziqing Xu Jianghua Zhan Ming Dong Source Type: research
Effects of respiratory flora regulation on microbial environment and IL-10/STAT3 signaling pathway in the bronchiolitis obliterans after lung transplantation
Cell Mol Biol (Noisy-le-grand). 2023 Oct 31;69(10):201-206. doi: 10.14715/cmb/2023.69.10.29.ABSTRACTOur purpose of this study was to explore the application effect of respiratory flora regulation in bronchiolitis obliterans after lung transplantation, and its regulatory effect on the microbial environment of the lesion and the IL-10/STAT3 signaling pathway. 25 clean-grade C57BL/6 male mice and 5 BALB/c male mice were selected for orthotopic tracheal transplantation and postoperative respiratory flora regulation in a hospital animal room from Jan 2019 to Dec 2021. Next, the changes in the microbial environment and the IL-10...
Source: Mol Biol Cell - November 13, 2023 Category: Molecular Biology Authors: Xin Wang Tianhua Liu Yizhuo Chen Ziqing Xu Jianghua Zhan Ming Dong Source Type: research
Effects of respiratory flora regulation on microbial environment and IL-10/STAT3 signaling pathway in the bronchiolitis obliterans after lung transplantation
Cell Mol Biol (Noisy-le-grand). 2023 Oct 31;69(10):201-206. doi: 10.14715/cmb/2023.69.10.29.ABSTRACTOur purpose of this study was to explore the application effect of respiratory flora regulation in bronchiolitis obliterans after lung transplantation, and its regulatory effect on the microbial environment of the lesion and the IL-10/STAT3 signaling pathway. 25 clean-grade C57BL/6 male mice and 5 BALB/c male mice were selected for orthotopic tracheal transplantation and postoperative respiratory flora regulation in a hospital animal room from Jan 2019 to Dec 2021. Next, the changes in the microbial environment and the IL-10...
Source: Cellular and Molecular Biology - November 13, 2023 Category: Molecular Biology Authors: Xin Wang Tianhua Liu Yizhuo Chen Ziqing Xu Jianghua Zhan Ming Dong Source Type: research
