Current Status and Trends in Lung Transplant Research Funded by the National Natural Science Foundation of China
CONCLUSIONS: In the past 37 years, National Natural Science Foundation of China-funded projects have significantly advanced the clinical application and basic research of lung transplantation. However, compared with developed countries and other solidorgan transplantations, several problems still require attention and improvements in lung transplant research in China.PMID:38140933 | DOI:10.6002/ect.2023.0220 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 23, 2023 Category: Transplant Surgery Authors: Xianyu Xie Zijun Zhao Qinde Wu Source Type: research
Current Status and Trends in Lung Transplant Research Funded by the National Natural Science Foundation of China
CONCLUSIONS: In the past 37 years, National Natural Science Foundation of China-funded projects have significantly advanced the clinical application and basic research of lung transplantation. However, compared with developed countries and other solidorgan transplantations, several problems still require attention and improvements in lung transplant research in China.PMID:38140933 | DOI:10.6002/ect.2023.0220 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 23, 2023 Category: Transplant Surgery Authors: Xianyu Xie Zijun Zhao Qinde Wu Source Type: research
Current Status and Trends in Lung Transplant Research Funded by the National Natural Science Foundation of China
CONCLUSIONS: In the past 37 years, National Natural Science Foundation of China-funded projects have significantly advanced the clinical application and basic research of lung transplantation. However, compared with developed countries and other solidorgan transplantations, several problems still require attention and improvements in lung transplant research in China.PMID:38140933 | DOI:10.6002/ect.2023.0220 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 23, 2023 Category: Transplant Surgery Authors: Xianyu Xie Zijun Zhao Qinde Wu Source Type: research
Use of POCUS for the assessment of dehydration in pediatric patients —a narrative review
Conclusion: POCUS can provide important information in the assessment of intravascular fluid status in emergency scenarios, but measurements may be confounded by a number of other clinical variables. The inclusion of lung and cardiac views may assist in better understanding the patient ’s physiology and etiology regarding volume status.What is Known:• In pediatric practice, POCUS (point-of-care ultrasound) has been mostly implemented to recognize lung conditions (like pneumonia and bronchiolitis) and pleural and pericardial effusions, but less to evaluate fluid depletion.• The size of the IVC (inferior vena cava) and...
Source: European Journal of Pediatrics - December 22, 2023 Category: Pediatrics Source Type: research
Lung ultrasound for the sick child: less harm and more information than a radiograph
Conclusion: the aim of this review is to discuss the following key points:How to perform a lung ultrasound scanMain ultrasonographic features of the healthy lungThe functional approach: Lung Ultrasound Score in the child and the neonateWhat is Known:• Lung Ultrasound (LUS) is applied in pediatric and neonatal age for the diagnosis of pneumothorax, consolidation, and pleural effusion.• Recently, LUS has been introduced into clinical practice as a bedside diagnostic method for monitoring surfactant use in NARDS and lung recruitment in PARDS.What is New:• Lung Ultrasound (LUS) has proven to be useful in confirming dia...
Source: European Journal of Pediatrics - December 21, 2023 Category: Pediatrics Source Type: research
Risk factors and prediction models for bronchiolitis obliterans after severe adenoviral pneumonia
Conclusion: Age < 1 year, PICU admission, long fever duration, and bilateral lung infection are independent risk factors for PIBO in children with SAP. The nomogram model may aid clinicians in the early diagnosis and intervention of PIBO.What is Known:• Adenoviruses are the most common pathogens associated with PIBO.• Wheezing, tachypnoea, hypoxemia, and mechanical ventilation are the risk factors for PIBO.What is New:• Age < 1 year, admission to PICU, long duration of fever days, and bilateral lung infection are independent risk factors for PIBO in children with SAP.• A prediction model presente...
Source: European Journal of Pediatrics - December 20, 2023 Category: Pediatrics Source Type: research
Pathology of COVID-19 Lung Disease
The pathology of severe COVID-19 lung injury is predominantly diffuse alveolar damage, with other reported patterns including acute fibrinous organizing pneumonia, organizing pneumonia, and bronchiolitis. Lung injury was caused by primary viral injury, exaggerated immune responses, and superinfection with bacteria and fungi. Although fatality rates have decreased from the early phases of the pandemic, persistent pulmonary dysfunction occurs and its pathogenesis remains to be fully elucidated. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - December 20, 2023 Category: Pathology Authors: Alain C. Borczuk Source Type: research
Luteolin-7-O-glucoside promotes macrophage release of IFN- β by maintaining mitochondrial function and corrects the disorder of glucose metabolism during RSV infection
Eur J Pharmacol. 2023 Dec 17:176271. doi: 10.1016/j.ejphar.2023.176271. Online ahead of print.ABSTRACTRespiratory syncytial virus (RSV) pneumonia is the main cause of acute bronchiolitis in infants. Luteolin-7-O-glucoside (LUT-7G) is a natural flavonoid, which exists in a variety of plants and has the potential to treat viral pneumonia. We established RSV pneumonia mouse models and RSV-infected cell models. Clodronate liposomes were used to deplete macrophages. We used HE staining and immunohistochemistry to determine inflammatory damage and virus replication. We detected the expression levels of inflammatory factors and I...
Source: European Journal of Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Weifeng Li Xuan Wang Yanzhen Chen Yali Ding Xiaoyin Ling Bin Yuan Jialei Tao Source Type: research
Luteolin-7-O-glucoside promotes macrophage release of IFN- β by maintaining mitochondrial function and corrects the disorder of glucose metabolism during RSV infection
Eur J Pharmacol. 2023 Dec 17:176271. doi: 10.1016/j.ejphar.2023.176271. Online ahead of print.ABSTRACTRespiratory syncytial virus (RSV) pneumonia is the main cause of acute bronchiolitis in infants. Luteolin-7-O-glucoside (LUT-7G) is a natural flavonoid, which exists in a variety of plants and has the potential to treat viral pneumonia. We established RSV pneumonia mouse models and RSV-infected cell models. Clodronate liposomes were used to deplete macrophages. We used HE staining and immunohistochemistry to determine inflammatory damage and virus replication. We detected the expression levels of inflammatory factors and I...
Source: European Journal of Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Weifeng Li Xuan Wang Yanzhen Chen Yali Ding Xiaoyin Ling Bin Yuan Jialei Tao Source Type: research
GSE250419 Gut microbiota-derived TMAO aggravated BOS by increasing TREM-1+ macrophages through NLRP3 inflammasome after orthotopic tracheal transplantation in mice
Conclusions: The results indicated that gut microbiota dysbiosis and gut microbiota derived TMAO induced TREM-1+ macrophages via NLRP3 inflammasome activation, thereby exacerbating OB progression. The clear implications of this study suggest novel therapeutic targets for allograft rejection. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 18, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
CT evaluation of systemic artery to pulmonary artery fistula: an underdiagnosed disease in patients with hemoptysis
CONCLUSIONS: SA-PAF is a benign vascular anomaly which is frequently overlooked when evaluating hemoptysis by either clinician or radiologists but is an important factor in the differential diagnosis of patients with hemoptysis.PMID:38090324 | PMC:PMC10713311 | DOI:10.21037/jtd-23-861 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - December 13, 2023 Category: Respiratory Medicine Authors: Jung Han Woo Yoon Ki Cha Sang Yub Lee Jong Hee Kim Jun Gon Kim Yiseul Son Myung Jin Chung Source Type: research
Management of bronchiolitis in infants in primary care settings: What to do and what not to do
Can Fam Physician. 2023 Dec;69(12):845-847. doi: 10.46747/cfp.6912845.NO ABSTRACTPMID:38092455 | DOI:10.46747/cfp.6912845 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - December 13, 2023 Category: Primary Care Authors: Marie-Pier Lirette Mar ía José Conejero Müller Jennifer Young Source Type: research
CT evaluation of systemic artery to pulmonary artery fistula: an underdiagnosed disease in patients with hemoptysis
CONCLUSIONS: SA-PAF is a benign vascular anomaly which is frequently overlooked when evaluating hemoptysis by either clinician or radiologists but is an important factor in the differential diagnosis of patients with hemoptysis.PMID:38090324 | PMC:PMC10713311 | DOI:10.21037/jtd-23-861 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - December 13, 2023 Category: Respiratory Medicine Authors: Jung Han Woo Yoon Ki Cha Sang Yub Lee Jong Hee Kim Jun Gon Kim Yiseul Son Myung Jin Chung Source Type: research
Management of bronchiolitis in infants in primary care settings: What to do and what not to do
Can Fam Physician. 2023 Dec;69(12):845-847. doi: 10.46747/cfp.6912845.NO ABSTRACTPMID:38092455 | DOI:10.46747/cfp.6912845 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - December 13, 2023 Category: Primary Care Authors: Marie-Pier Lirette Mar ía José Conejero Müller Jennifer Young Source Type: research
CT evaluation of systemic artery to pulmonary artery fistula: an underdiagnosed disease in patients with hemoptysis
CONCLUSIONS: SA-PAF is a benign vascular anomaly which is frequently overlooked when evaluating hemoptysis by either clinician or radiologists but is an important factor in the differential diagnosis of patients with hemoptysis.PMID:38090324 | PMC:PMC10713311 | DOI:10.21037/jtd-23-861 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - December 13, 2023 Category: Respiratory Medicine Authors: Jung Han Woo Yoon Ki Cha Sang Yub Lee Jong Hee Kim Jun Gon Kim Yiseul Son Myung Jin Chung Source Type: research
