Determinants of radiological patterns and severity in immunocompromised adults with Metapneumovirus infection
Respir Med. 2024 Mar 14:107604. doi: 10.1016/j.rmed.2024.107604. Online ahead of print.ABSTRACTBACKGROUND: Human Metapneumovirus (HMPV) belongs to the Pneumoviridae family and is responsible for respiratory infections. Mild infections are well-recognized in children, while its precise impact in various categories of immunocompromised adults has not been well addressed.RESEARCH QUESTION: We retrospectively studied HMPV infections in immunocompromised adults followed in two large French university medical centers.STUDY DESIGN AND METHODS: We identified immunocompromised adults with positive HMPV Polymerase Chain Reaction (PC...
Source: Respiratory Care - March 16, 2024 Category: Respiratory Medicine Authors: A Al-Hamoud N Pansu A-L Brun N Etienne E Farfour V Avettand-Fenoel C Rouzaud A Roux F Suarez H Salvator A Serris E Catherinot O Lortholary Source Type: research
Determinants of radiological patterns and severity in immunocompromised adults with Metapneumovirus infection
Respir Med. 2024 Mar 14:107604. doi: 10.1016/j.rmed.2024.107604. Online ahead of print.ABSTRACTBACKGROUND: Human Metapneumovirus (HMPV) belongs to the Pneumoviridae family and is responsible for respiratory infections. Mild infections are well-recognized in children, while its precise impact in various categories of immunocompromised adults has not been well addressed.RESEARCH QUESTION: We retrospectively studied HMPV infections in immunocompromised adults followed in two large French university medical centers.STUDY DESIGN AND METHODS: We identified immunocompromised adults with positive HMPV Polymerase Chain Reaction (PC...
Source: Respiratory Care - March 16, 2024 Category: Respiratory Medicine Authors: A Al-Hamoud N Pansu A-L Brun N Etienne E Farfour V Avettand-Fenoel C Rouzaud A Roux F Suarez H Salvator A Serris E Catherinot O Lortholary Source Type: research
Twenty-year-old patient with polyarthritis since childhood showing cysts and ground glass attenuation on HRCT
We present a case of a 20-year-old woman reporting polyarthritis, muscle weakness, dyspnoea and multiple intensive care unit admissions due to respiratory failure, without haemoptysis, since 4 months of age. The mother had systemic erythematous lupus. On physical examination, digital clubbing and mild desaturation were found. Laboratory tests demonstrated 1:640 nuclear homogeneous pattern antinuclear antibodies (ANA) and erythrocyte sedimentation rate (ESR) of 61 mm. Spirometry exhibited forced vital capacity of 53%. High-resolution CT (HRCT) showed cysts and ground glass with reticular infiltrates (figure 1A-D). In 2006, ...
Source: Thorax - March 15, 2024 Category: Respiratory Medicine Authors: Fagundes, M. d. C., Bianco, T., Nunes, D. P., Ostroski, T. K. D., Bridi, G. d. P., Kawassaki, A. M., Barbas, C. S. V., Mendonca, L. O., Barros, S. F., Kalil, J., Shum, A. K., Escuissato, D. L. Tags: Thorax Pulmonary puzzle Source Type: research
ERS/EBMT clinical practice guideline on treatment of pulmonary chronic graft- < em > versus < /em > -host disease in adults
Eur Respir J. 2024 Mar 14:2301727. doi: 10.1183/13993003.01727-2023. Online ahead of print.ABSTRACTChronic graft-versus-host disease (cGvHD) is a common complication after allogeneic haematopoietic stem cell transplantation, characterised by a broad disease spectrum that can affect virtually any organ. Although pulmonary cGvHD is a less common manifestation, it is of great concern due to its severity and poor prognosis. Optimal management of patients with pulmonary cGvHD is complicated and no standardised approach is available.The purpose of this joint European Respiratory Society and European Society for Blood and Marrow ...
Source: Respiratory Care - March 14, 2024 Category: Respiratory Medicine Authors: Saskia Bos John Murray Monia Marchetti Guang-Shing Cheng Anne Bergeron Daniel Wolff Clare Sander Akshay Sharma Sherif M Badawy Zinaida Peric Agnieszka Piekarska Joseph Pidala Kavita Raj Olaf Penack Samar Kulkarni Molly Beestrum Andrea Linke Matthew Rutter Source Type: research
Air pollution and bronchiolitis: a case –control study in Antwerp, Belgium
Conclusion: This study suggests a possible link between severe bronchiolitis and medium-term (31 days) air pollution exposure (PM10 and NO2), particularly in daycare. Larger studies are warranted to confirm these findings.What is Known:• Bronchiolitis is a leading cause of hospitalization in infants globally and causes a yearly seasonal wave of admissions in paediatric departments worldwide.• Existing studies, mainly from the USA, show heterogeneous outcomes regarding the association between air pollution and bronchiolitis.What is New:• There is a possible link between severe bronchiolitis and medium-term (31 days)...
Source: European Journal of Pediatrics - March 12, 2024 Category: Pediatrics Source Type: research
Respiratory syncytial virus-associated hospitalizations among children: an Italian retrospective observational study
ConclusionsOur study contributes to outlining the baseline profile of RSV-associated hospitalizations among Italian children by providing epidemiological/clinical/economic estimates. While awaiting new recommendations on immunization, healthcare-workers should persist in implementing public health measures and appropriate case management to control RSV seasonal epidemics. Strengthened laboratory RSV surveillance is needed to inform the implementation of the new immunization strategies. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 7, 2024 Category: Pediatrics Source Type: research
Knowledge, attitudes and behaviours of a sample of Italian paediatricians towards RSV and its preventive strategies: a cross-sectional study
ConclusionsPaediatricians ’ limited knowledge or awareness could represent a barrier to the implementation of preventive strategies against RSV infection. Strategies to improve paediatricians’ education on RSV prevention are, therefore, crucial. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 29, 2024 Category: Pediatrics Source Type: research
Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?
In this retrospective study, we aimed to evaluate the factors associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children aged under 2 years who were admitted to the Children ’s ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Shuo Yang, Sukun Lu, Yakun Wang, Yinghui Guo, Zhuang Zhang, Weijian Wang and Le Wang Tags: Research Source Type: research
IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans
CONCLUSION: The present study suggests that a decrease in IL-27 may be associated with an increase in neutrophils in BALF and may contribute to the pathogenesis of PIBO.PMID:38369903 | DOI:10.22034/iji.2024.99760.2659 (Source: Iranian Journal of Immunology)
Source: Iranian Journal of Immunology - February 19, 2024 Category: Allergy & Immunology Authors: Wenjing Liu Yiyao Zhang Xia Chen Source Type: research
A rare pulmonary manifestation of Crohn's disease: Acute fibrinous and organizing pneumonia presenting as multifocal nodules
Respir Med Case Rep. 2024 Feb 6;48:101993. doi: 10.1016/j.rmcr.2024.101993. eCollection 2024.ABSTRACTAcute Fibrinous and Organizing Pneumonia (AFOP) is a rare pulmonary disease, and it has not been recorded in literature as a pulmonary manifestation of Crohn's disease. A 22-year-old individual with an extensive history of Crohn's disease presented to the hospital initially for hematochezia and diarrhea. Computed tomography of her abdomen and pelvis showed multiple pulmonary nodules bilaterally. The patient did not report cough, sputum production, or dyspnea. Autoimmune and infectious workup were overall unremarkable. A CT-...
Source: Respiratory Care - February 15, 2024 Category: Respiratory Medicine Authors: Sohi Mistry Asangi R Kumarapeli Harsha V Mudrakola Source Type: research
