A rare pulmonary manifestation of Crohn's disease: Acute fibrinous and organizing pneumonia presenting as multifocal nodules
Respir Med Case Rep. 2024 Feb 6;48:101993. doi: 10.1016/j.rmcr.2024.101993. eCollection 2024.ABSTRACTAcute Fibrinous and Organizing Pneumonia (AFOP) is a rare pulmonary disease, and it has not been recorded in literature as a pulmonary manifestation of Crohn's disease. A 22-year-old individual with an extensive history of Crohn's disease presented to the hospital initially for hematochezia and diarrhea. Computed tomography of her abdomen and pelvis showed multiple pulmonary nodules bilaterally. The patient did not report cough, sputum production, or dyspnea. Autoimmune and infectious workup were overall unremarkable. A CT-...
Source: Respiratory Care - February 15, 2024 Category: Respiratory Medicine Authors: Sohi Mistry Asangi R Kumarapeli Harsha V Mudrakola Source Type: research
Phlebotomy ‐free days in children hospitalized with common infections and their association with clinical outcomes
AbstractBackgroundPhlebotomy for hospitalized children has consequences (e.g., pain, iatrogenic anemia), and unnecessary testing is a modifiable source of waste in healthcare. Days without blood draws or phlebotomy-free days (PFDs) has the potential to serve as a hospital quality measure.ObjectiveTo describe: (1) the frequency of PFDs in children hospitalized with common infections and (2) the association of PFDs with clinical outcomes.Design, Settings and ParticipantsWe performed a cross-sectional study of children hospitalized 2018 –2019 with common infections at 38 hospitals using the Pediatric Health Information Syst...
Source: Journal of Hospital Medicine - February 13, 2024 Category: Hospital Management Authors: Megan E. Collins,
Matt Hall,
Samir S. Shah,
Matthew J. Molloy,
Paul L. Aronson,
Jillian M. Cotter,
Michael J. Steiner,
Elisha McCoy,
Michael J. Tchou,
John R. Stephens,
Jessica L. Markham Tags: ORIGINAL RESEARCH Source Type: research
Detection of bronchiolitis obliterans syndrome using nitrogen multiple breath washout in children post-haemopoietic stem cell transplant
Bronchiolitis obliterans syndrome (BOS) is a severe pulmonary complication following haemopoietic stem cell transplantation (HSCT) and is often undetected until there is significant deterioration in expiratory airflow and volume. The condition usually develops between day 100 and 2 years post-HSCT, although later onset has been described.1 BOS is characterised by a progressive obstructive ventilatory defect with reductions observed in the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory flow between 25% and 75% of the FVC (FEF25-75). (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 13, 2024 Category: Hematology Authors: Nicole Westrupp, Cassidy Du Berry, Theresa Cole, Shivanthan Shanthikumar, Liam Welsh Source Type: research
Increased bronchiolitis burden and severity after the pandemic: a national multicentric study
ConclusionsThis study shows a growth of nearly 70% in hospitalisations for bronchiolitis, and an increase in invasive respiratory support and coinfections, suggesting a more severe disease course this winter compared to the last five years. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 13, 2024 Category: Pediatrics Source Type: research
Increased bronchiolitis burden and severity after the pandemic: a national multicentric study
The coronavirus 2019 (COVID-19) related containment measures led to the disruption of all virus distribution. Bronchiolitis-related hospitalizations shrank during 2020 –2021, rebounding to pre-pandemic numbers ... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 13, 2024 Category: Pediatrics Authors: Sergio Ghirardo, Nicola Ullmann, Alessandro Zago, Michele Ghezzi, Marta Minute, Barbara Madini, Enza D ’Auria, Cecilia Basile, Francesca Castelletti, Federica Chironi, Agata Capodiferro, Beatrice Andrenacci, Francesco Maria Risso, Salvatore Aversa, Laur Tags: Research Source Type: research
Bacterial small RNAs may mediate immune response differences seen in respiratory syncytial virus versus rhinovirus bronchiolitis
Bronchiolitis, a viral lower respiratory infection, is the leading cause of infant hospitalization, which is associated with an increased risk for developing asthma later in life. Bronchiolitis can be caused by several respiratory viruses, such as respiratory syncytial virus (RSV), rhinovirus (RV), and others. It can also be caused by a solo infection (e.g., RSV- or RV-only bronchiolitis) or co-infection with two or more viruses. Studies have shown viral etiology-related differences between RSV- and RV-only bronchiolitis in the immune response, human microRNA (miRNA) profiles, and dominance of certain airway microbiome con...
Source: Frontiers in Immunology - February 12, 2024 Category: Allergy & Immunology Source Type: research
Cancers, Vol. 16, Pages 731: Machine-Learning-Based Classification Model to Address Diagnostic Challenges in Transbronchial Lung Biopsy
Conclusion: The machine-learning model developed has the potential to distinguish between benign and malignant conditions in TBLB samples excluding the presence or absence of tumor cells, thereby improving diagnostic accuracy and reducing the burden of repeated sampling procedures for patients. (Source: Cancers)
Source: Cancers - February 9, 2024 Category: Cancer & Oncology Authors: Hisao Sano Ethan N. Okoshi Yuri Tachibana Tomonori Tanaka Kris Lami Wataru Uegami Yoshio Ohta Luka Brcic Andrey Bychkov Junya Fukuoka Tags: Article Source Type: research
Emergency management and asthma risk in young Medicaid-enrolled children with recurrent wheeze
CONCLUSIONS: Young children with persistent wheeze are at risk for childhood asthma. Thus, identification of risk factors associated with persistent wheeze in young children with recurrent wheeze might aid in early detection of asthma and initiation of preventative therapies.PMID:38324665 | DOI:10.1080/02770903.2024.2314623 (Source: Journal of Asthma)
Source: Journal of Asthma - February 7, 2024 Category: Respiratory Medicine Authors: Isabel J Hardee Isabella Zaniletti Melisa S Tanverdi Andrew H Liu Rakesh D Mistry Nidhya Navanandan Source Type: research
Understanding the use and outcomes of high-flow nasal cannula among infants admitted to Canadian hospitals with bronchiolitis (CanFLO): a protocol for a multicentre, retrospective cohort study
This study aims to understand the factors associated with failure of HFNC support among patients with bronchiolitis and to describe the current practice variations of HFNC use in patients with bronchiolitis in Canadian hospitals including fluid management and parameters to initiate, escalate and discontinue HFNC support.
Methods and analysis
This is a multicentre retrospective cohort study including hospitalised patients aged 0–24 months with bronchiolitis requiring support with HFNC between January 2017 and December 2021. Clinical data will be collected from patient medical records from Canadian hospitals (n=12), i...
Source: BMJ Open - February 7, 2024 Category: General Medicine Authors: DAlessandro, M., Fricano, C., Abdulsatar, F., Bechard, N., Brar, J. S., Drouin, O., Foulds, J. L., Giglia, L., Gill, P. J., Gupta, R., Li, P., McConnery, J., Metcalf, J., Sakran, M., Seaton, C., Sehgal, A., Sirizzotti, N., Mbuagbaw, L., Wahi, G., On behal Tags: Open access, Paediatrics Source Type: research
Inpatient Rsv-Management 2016 –2022: Epidemiology and
Adherence to A Bronchiolitis Treatment Standard at a German University
Children’s Hospital
Conclusions This audit confirms the strong impact of public preventive
measures directed against SARS-CoV-2 transmission on RSV epidemiology. Few weeks
after easing public COVID-19 restrictions (summer 2021), RSV inpatient cases
rapidly increased, lasting until Dec. 2021. The audit of bronchiolitis
management revealed surprisingly low adherence to the internal guidance, despite
a face-to-face educational session with the attending pediatricians in Oct.
2021. Low adherence resulted in an unnecessary exposure of RSV patients to
systemic medications of ques...
Source: Klinische Padiatrie - February 6, 2024 Category: Pediatrics Authors: Heidtmann, Solvej Baltaci, Yeliz Meyer, Sascha Zemlin, Michael Furtw ängler, Rhoikos Rissland, Juergen Simon, Arne Tags: Original Article Source Type: research
Short stay unit led by pediatric hospital medicine advanced practice providers
AbstractBackgroundIn response to a critical pediatric bed shortage in 2022, an urgent process change was required to provide safe and timely medical care. We proposed a pilot for an advanced practice provider (APP)-run short stay unit (SSU) for select pediatric hospital medicine (PHM) patients.ObjectiveTo compare length of stay (LOS) and cost before and after implementation of a PHM APP-led SSU pilot at a tertiary pediatric hospital.Designs, Settings, and ParticipantsSingle-center prospective pilot observational cohort study with historical control. Observation encounters for patients with asthma, bronchiolitis, croup, and...
Source: Journal of Hospital Medicine - February 2, 2024 Category: Hospital Management Authors: Brittany K. Potts,
Jonathan H. Pelletier,
Leah Rawdon,
Michael L. Forbes Tags: ORIGINAL RESEARCH Source Type: research
Viruses, Vol. 16, Pages 230: Impact of SARS-CoV-2 Pandemic and Lockdown on the HRSV Circulation: Experience of Three Spoke Hospitals in Northern Italy
In conclusion, an increase in HRSV cases after the Pandemic has been demonstrated with an anticipated peak, while no differences were recorded in severity. (Source: Viruses)
Source: Viruses - February 1, 2024 Category: Virology Authors: Francesca Parola Adalberto Brach del Prever Virginia Deut Giulia Costagliola Carla Guidi Neftj Ragusa Antonella Tuscano Fabio Timeus Massimo Berger Tags: Article Source Type: research
Characterization of microbial components present in bioconcept metalworking fluid that may contribute to the development of severe lung pathology
Workers at a manufacturing facility using bioconcept metalworking fluid (MWF) engineered to selectively grow the biocontrol organism Pseudomonas pseudoalcaligenes developed a severe lung disease described as bronchiolitis, alveolar ductitis, and emphysema (BADE). Analysis of lung biopsies from affected workers indicated the lung microbiome was similar to that observed in used MWF. We hypothesized that this shift in the lung microbiome may contribute to the development of BADE. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Angela Lemons, Michael Sulyok, Marcia Stanton, Tara Croston Source Type: research
Success and Feasibility of Multiple Breath Washout: Prospective, Multi-Center Results from the Transpire Study
Pulmonary complications, pulmonary chronic graft vs host disease (cGVHD) and bronchiolitis obliterans, are a major cause of morbidity and mortality following hematopoietic stem cell transplant (HSCT). Pulmonary function testing is insensitive for detecting changes in small airways (SA). Multiple breath nitrogen washout (MBW) is a technique to detect ventilation heterogeneity; a measure of peripheral SA disease often seen in early manifestations of pulmonary cGVHD. Primary outcome of MBW testing is lung clearance index (LCI), the number of lung turnovers required to clear an inert gas (N2). (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Matthew F. Abts, Manuel Silva-Carmona, Julian L. Allen, Erin E Doherty, Scott Baker, Margaret L. MacMillan, Alan Genatassio, Philip Lacher, Tamara Griffin, Merve Tekman, Sheri Ballard, Mashid Sababi Azamian, Bri Schimelpfenig, Jane Koo, Stephanie L. Edwar Tags: 183 Source Type: research
