Trichosanthin-derived peptide Tk-PQ attenuates immune rejection in mouse tracheal allotransplant model by suppressing PI3K-Akt and inducing type II immune polarization
In this study, we evaluated the efficacy of Tk-PQ (a peptide derived from trichosanthin) in alleviating OB in a mouse ectopic tracheal transplant model. We found that post-transplantation treatment of Tk-PQ significant ameliorated OB symptoms including luminal occlusion, epithelial cells loss and fibrosis in the allograft. In addition, Tk-PQ promoted immune suppressive environment by inducing Th2 polarization and increasing Treg population which in turn led to elevated levels of anti-inflammatory cytokines IL-4, IL-10, IL-33 and decreased levels of pro-inflammatory IL-1β. Mechanistically, we used transcriptome analysis of...
Source: International Immunopharmacology - October 20, 2023 Category: Allergy & Immunology Authors: Lin Zhou Yafei Hou Xufeng Pan Xue Wang Haizhen Jin Xiaohua Yang Kefan Wang Xuping Ding Kai Wang Minfang Zhu Yan Pan Weimin Wang Liming Lu Source Type: research
Trichosanthin-derived peptide Tk-PQ attenuates immune rejection in mouse tracheal allotransplant model by suppressing PI3K-Akt and inducing type II immune polarization
In this study, we evaluated the efficacy of Tk-PQ (a peptide derived from trichosanthin) in alleviating OB in a mouse ectopic tracheal transplant model. We found that post-transplantation treatment of Tk-PQ significant ameliorated OB symptoms including luminal occlusion, epithelial cells loss and fibrosis in the allograft. In addition, Tk-PQ promoted immune suppressive environment by inducing Th2 polarization and increasing Treg population which in turn led to elevated levels of anti-inflammatory cytokines IL-4, IL-10, IL-33 and decreased levels of pro-inflammatory IL-1β. Mechanistically, we used transcriptome analysis of...
Source: International Immunopharmacology - October 20, 2023 Category: Allergy & Immunology Authors: Lin Zhou Yafei Hou Xufeng Pan Xue Wang Haizhen Jin Xiaohua Yang Kefan Wang Xuping Ding Kai Wang Minfang Zhu Yan Pan Weimin Wang Liming Lu Source Type: research
Outcomes of viral coinfections in infants hospitalized for acute bronchiolitis
The clinical relevance of the detection of multiple respiratory viruses in acute bronchiolitis (AB) has not been established. Our goal was to evaluate the effect of viral coinfections on the progression and se... (Source: Virology Journal)
Source: Virology Journal - October 16, 2023 Category: Virology Authors: Lorena Berm údez-Barrezueta, Pablo López-Casillas, Silvia Rojo-Rello, Laura Sáez-García, José Manuel Marugán-Miguelsanz and María de la Asunción Pino-Vázquez Tags: Research Source Type: research
A neonatal in-vitro study on the effect of the inflation pressure on end-tidal carbon dioxide levels
CONCLUSIONS: The change in ETCO2 in response to increasing PIP was larger for higher ETCO2 values and in a model simulating neonatal RDS, compared to BPD and bronchiolitis.PMID:37838403 | DOI:10.1016/j.medengphy.2023.104052 (Source: Health Physics)
Source: Health Physics - October 14, 2023 Category: Physics Authors: Theodore Dassios Ourania Kaltsogianni Jonathan Saka Anne Greenough Source Type: research
Identifying and prioritising future interventions with stakeholders to improve paediatric urgent care pathways in Scotland, UK: a mixed-methods study
Conclusions
Health professionals and families want future interventions that are patient-centred, community-based and aligned to outcomes that matter to them. (Source: BMJ Open)
Source: BMJ Open - October 12, 2023 Category: General Medicine Authors: King, E., France, E., Malcolm, C., Kumar, S., Dick, S., Kyle, R. G., Wilson, P., Aucott, L., Turner, S., Hoddinott, P. Tags: Open access, Paediatrics Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | DOI:10.3346/jkms.2023.38.e308 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - October 11, 2023 Category: Biomedical Science Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: J Korean Med Sci)
Source: J Korean Med Sci - October 11, 2023 Category: General Medicine Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - October 11, 2023 Category: Biomedical Science Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: J Korean Med Sci)
Source: J Korean Med Sci - October 11, 2023 Category: General Medicine Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - October 11, 2023 Category: Biomedical Science Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: J Korean Med Sci)
Source: J Korean Med Sci - October 11, 2023 Category: General Medicine Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - October 11, 2023 Category: Biomedical Science Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: J Korean Med Sci)
Source: J Korean Med Sci - October 11, 2023 Category: General Medicine Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Clinical Factors for Successful Removal of Airway Silicone Stents in Patients With Post-Tuberculosis Tracheobronchial Stenosis
CONCLUSION: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.PMID:37821085 | PMC:PMC10562181 | DOI:10.3346/jkms.2023.38.e308 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - October 11, 2023 Category: Biomedical Science Authors: Bo-Guen Kim Byeong-Ho Jeong Hojoong Kim Source Type: research
Association between household cleaning product exposure in infancy and development of recurrent wheeze and asthma
ConclusionWe found no association between household cleaning product exposure in infancy and later development of recurrent wheeze or asthma, even among children who are at high risk for asthma due to history of severe bronchiolitis. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - October 11, 2023 Category: Occupational Health Source Type: research
