Chronic Lung Allograft Dysfunction Is Associated with Significant Disability after Lung Transplantation-A Burden of Disease Analysis in 1025 Cases
CONCLUSIONS: CLAD after lung transplantation is a major public health problem and is associated with substantial disability and costs. Further work is needed to develop therapeutic interventions that reduce its development.PMID:37887076 | DOI:10.3390/arm91050033 (Source: Adv Data)
Source: Adv Data - October 27, 2023 Category: Epidemiology Authors: Roland Diel Susanne Simon Jens Gottlieb Source Type: research
Chronic Lung Allograft Dysfunction Is Associated with Significant Disability after Lung Transplantation-A Burden of Disease Analysis in 1025 Cases
CONCLUSIONS: CLAD after lung transplantation is a major public health problem and is associated with substantial disability and costs. Further work is needed to develop therapeutic interventions that reduce its development.PMID:37887076 | PMC:PMC10603923 | DOI:10.3390/arm91050033 (Source: Adv Data)
Source: Adv Data - October 27, 2023 Category: Epidemiology Authors: Roland Diel Susanne Simon Jens Gottlieb Source Type: research
Modified six-minutes walk test in children with medical complexity and chronic lung disease
Conclusions: CMC-CLD have a decreased functional exercise capacity and Modified 6MWT was safe and reliable for this population. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Villarroel Silva, G., Faundez Silva, M., Vera Tapia, P., Moscoso Altamira, G., Moya Torres, B., Miranda Mino, M. J., Oyarzun Aguirre, I. Tags: Rehabilitation and chronic care Source Type: research
Estimating costs associated with paediatric Respiratory Syncytial Virus infection managed in the hospital setting in England.
Conclusion: The proposed cost of hospitalisation in medically attended RSV can be used to inform future pharmacoeconomic evaluation of RSV immunisation programmes to determine cost-effective prices. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Butfield, R., Said, J. Tags: Ethics and economics Source Type: research
Multiple-breath washout is more sensitive than spirometry to detect lung function impairment in children and adults with bronchiectasis
Conclusion: Our data show that MBW is feasible and more sensitive than spirometry to detect lung function impairment in children and adults with bronchiectasis. This supports further development of LCI2.5 for diagnostic monitoring and as outcome measure in clinical trials. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Ziegahn, N., Stahl, M., Thee, S., Yoosefi Moridani, M., Zagkla, S., Tröltzsch, L., Pioch, C. O., Allomba, C., Busack, L. M., Tosolini, A., Fuhlrott, B. R., Mall, M. A., Röhmel, J. F. Tags: Respiratory infections and bronchiectasis Source Type: research
Lower tidal breathing lung function at 6 weeks of age, higher maternal BMI in pregnancy and larger sibship size are associated with viral bronchiolitis hospitalisations
Conclusion: Lower lung function at six weeks of age is associated with increased risk to bronchiolitis hospital admission in the first year of life.Future research is required to explore whether the prioritisation of infants for RSV immunisation due to lower lung function is cost-effective. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Da Silva Sena, C. R., De Queiroz Andrade, E., De Gouveia Belinelo, P., E Murphy, V., D Robinson, P., G Gibson, P., D Sly, P., Karmaus, W., Collison, A., Mattes, J. Tags: Paediatric respiratory physiology and sleep Source Type: research
Effect of AAT augmentation therapy on bronchiolitis obliterans development in mice model
Obliterative bronchiolitis (BO) is one of the major limitations to long-term survival after lung transplantation (LuTx), which is recognized as a major factor of chronic lung allograft dysfunction (CLAD). Acute rejection is a significant risk factor that leads to BO development. Therefore, therapeutic strategies limiting the severity of acute inflammation can be of critical importance in preventing acute rejection episodes and BO. Both preclinical and clinical experiences show that the therapy with plasma-purified alpha1-antitrypsin (AAT) is beneficial for a broad spectrum of inflammatory conditions. We previously de...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Janciauskiene Wallmark, S., Nakagiri, T. Tags: Mechanisms of lung injury and repair Source Type: research
Pattern and risk factor of lower respiratory illness in children who survived meconium aspiration syndrome
Conclusion: Laboratory findings and treatment at birth in infants with MAS appear to have impact on determining LRTI in those who survived MAS. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Kim, K. H., Kim, D., Youn, Y., Lee, J., Kim, H. S. Tags: Paediatric asthma and allergy Source Type: research
Evaluation of the efficacy of inhaled bronchodilators in infants with bronchiolitis through respiratory function testing: a pilot study
Conclusion: Our study demonstrated that some infants with bronchiolitis can benefit from a treatment with inhaled salbutamol. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Petrarca, L., Nenna, R., Conti, M. G., La Regina, D. P., Mancino, E., Iovine, E., Frassanito, A., Midulla, F. Tags: Paediatric bronchology Source Type: research
Association between airway dimension, the clinical severity of bronchiolitis and the development of pre-school wheezing
Conclusions: Airway obstruction, indirectly evaluated through TBFVL, is associated with a more severe presentation of bronchiolitis and with wheezing in the first months after the acute episode. Later on, other factors (e.g. atopic predisposition, environment, etc) could be predominant. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Di Mattia, G., Petrarca, L., Mancino, E., Matera, L., Conti, M. G., Bloise, S., Frassanito, A., La Regina, D. P., Iovine, E., Di Jorgi, M., Bonci, E., Nenna, R., Midulla, F. Tags: Paediatric asthma and allergy Source Type: research
The soluble form of the receptor for advanced glycation end products (sRAGE) in infants with first and recurrent episodes of wheezing in correlation with lung ultrasound findings
Conclusions: Children with lower sRAGE are prone to more severe clinical presentation and the risk for recurrent wheezing due to a deficiency in its anti-inflammatory effect. This project was financially supported by GRANT 173/2022-Medical University of Sofia. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Mileva, S., Petrova, G., Kostova, P., Mihailova, S., Alexiev, V. Tags: Paediatric asthma and allergy Source Type: research
Environmental risk factors for respiratory infection and wheeze in early childhood: a multi-centre cohort study
Conclusion: Potentially modifiable environmental factors contribute to the risk of respiratory infections and symptoms in early childhood. The study informs on the benefits of breastfeeding and avoiding exposure to damp, vehicle emissions and secondhand smoke to mitigate these conditions. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Ruffles, T., Inglis, S., Memon, A., Seddon, P., Basu, K., Bremner, S., Rabe, H., Tavendale, R., Palmer, C., Mukhopadhyay, S., Fidler, K. Tags: Paediatric respiratory infection and immun. Source Type: research
Passive maternal anti-RSV immunization is influenced by the season of birth
Conclusions. Birth season influences the level of neonatal RSV-specific antibodies received by the mother. Our results could guide future RSV vaccination strategies. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Conti, M. G., Sorrentino, L., Lelli, L., Fravolini, G., Cresta, E., Petrarca, L., Mancino, E., Iovine, E., La Regina, D., Virgili, F., Pierangeli, A., Bonci, E., Nenna, R., Midulla, F. Tags: Paediatric respiratory infection and immun. Source Type: research
Monocyte-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as biomarkers for severity in hospitalized children with RSV bronchiolitis
Conclusion: MLR and NLR are associated with severe clinical outcomes in hospitalized children with RSV bronchiolitis. MLR excelled in predicting PICU admission. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Burrack, N., Adar, A., Goldbart, A., Weissmann, S., Cohen, B., Hazan, I., Horev, A., Golan- Tripto, I. Tags: Paediatric respiratory infection and immun. Source Type: research
