Characterization of microbial components present in bioconcept metalworking fluid that may contribute to the development of severe lung pathology

Workers at a manufacturing facility using bioconcept metalworking fluid (MWF) engineered to selectively grow the biocontrol organism Pseudomonas pseudoalcaligenes developed a severe lung disease described as bronchiolitis, alveolar ductitis, and emphysema (BADE). Analysis of lung biopsies from affected workers indicated the lung microbiome was similar to that observed in used MWF. We hypothesized that this shift in the lung microbiome may contribute to the development of BADE.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research