GSE250419 Gut microbiota-derived TMAO aggravated BOS by increasing TREM-1+ macrophages through NLRP3 inflammasome after orthotopic tracheal transplantation in mice

Conclusions: The results indicated that gut microbiota dysbiosis and gut microbiota derived TMAO induced TREM-1+ macrophages via NLRP3 inflammasome activation, thereby exacerbating OB progression. The clear implications of this study suggest novel therapeutic targets for allograft rejection.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research