Perspectives for the clinical application of ctDNA analysis to breast cancer drug therapy
Breast Cancer. 2024 Apr 23. doi: 10.1007/s12282-024-01571-9. Online ahead of print.ABSTRACTCirculating tumor DNA (ctDNA) consists of DNA fragments released from cancer cells into the blood circulation with quick clearance. Analysis of ctDNA can enable real-time assessment of the presence of cancer cells and their genomic characteristics. Therefore, ctDNA is expected to be one of the most useful biomarkers for cancer. In recent years, several ultra-sensitive assays for ctDNA analysis have been developed, and many clinical trials are using these assays to investigate the efficacy of ctDNA-based therapeutic strategies. In the...
Source: Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Tetsuhiro Yoshinami Source Type: research
Number of lines of previous chemotherapy regimen might affect the oucome of sacituzumab govitecan in metastatic triple-negative breast cancer patients
Breast Cancer. 2024 Apr 22. doi: 10.1007/s12282-024-01587-1. Online ahead of print.NO ABSTRACTPMID:38647866 | DOI:10.1007/s12282-024-01587-1 (Source: Breast Cancer)
Source: Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Kadri Altundag Source Type: research
GSE261713 Linking single cell genomes and transcriptomes at scale to decode breast cancer progression [scRNA-seq]
Contributors : Kaile Wang ; Rui Ye ; Nicholas NavinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding epithelial lineages in breast cancer and genotype-phenotype interactions requires direct measurements of the genome and transcriptome of the same single cells at scale. To achieve this, we developed wellDR-seq, the first high-genomic resolution, high-throughput method to simultaneously profile the whole genome and transcriptome of thousands of single cells. We profiled 17,427 single cells in 6 ER-positive breast cancer patients, which identified ancestral subclones in t...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE263963 The temporal progression of lung immune remodeling during breast cancer metastasis
Contributors : Christopher McGinnis ; Juliane Winkler ; Ansuman SatpathySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe dynamics of immune reprogramming in the breast cancer lung metastastic niche remains incomplete. We used MULTI-seq (McGinnis, Patterson, et al., Nature Methods, 2019) to perform multiplexed single-cell RNA-sequencing analysis of cryopreserved lung immune cells isolated from PyMT mice, freshly-isolated lung immune cells isolated from PyMT mice, and cryopreserved lung immune cells isolated from 4T1 tumor-bearing mice from the onset of primary tumorigenesis throu...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Economic assessment of abemaciclib for the adjuvant treatment of luminal HER2- breast cancer from the perspective of the Spanish health system
ConclusionDespite the significant gains of abemaciclib as adjuvant treatment in terms of progression-free survival, this treatment is not cost-effective for the Spanish National Health System at published prices. It may be cost-effective with an appropriate discount on the official price. (Source: The European Journal of Health Economics)
Source: The European Journal of Health Economics - April 22, 2024 Category: Health Management Source Type: research
Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer
This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (T... (Source: BMC Cell Biology)
Source: BMC Cell Biology - April 22, 2024 Category: Cytology Authors: Jeeyeon Lee, Eun-Ae Kim, Jieun Kang, Yee Soo Chae, Ho Yong Park, Byeongju Kang, Soo Jung Lee, In Hee Lee, Ji-Young Park, Nora Jee-young Park and Jin Hyang Jung Tags: Research Source Type: research
Remnant cholesterol is an effective biomarker for predicting survival in patients with breast cancer
This study inve... (Source: Nutrition Journal)
Source: Nutrition Journal - April 22, 2024 Category: Nutrition Authors: Jinyu Shi, Tong Liu, Chenan Liu, Heyang Zhang, Guotian Ruan, Hailun Xie, Shiqi Lin, Xin Zheng, Yue Chen, Qi Zhang, Xiaowei Zhang, Xiangrui Li, Xiaoyue Liu, Li Deng and Han-Ping Shi Tags: Research Source Type: research
Experiences of women with breast cancer disclosing cancer-related cognitive impairment symptoms to health professionals: a Systematic review and meta-synthesis
. (Source: Journal of Psychosocial Oncology)
Source: Journal of Psychosocial Oncology - April 22, 2024 Category: Cancer & Oncology Authors: Susan HamiltonMelissa OxladYianni SianisSchool of Psychology, The University of Adelaide, Adelaide, Australia Source Type: research
Social characteristics and social benefit use among premenopausal breast cancer survivors in Denmark: a population-based cohort study
ConclusionsUse of social benefits reflecting lost ability to work was highest in less educated women and in women living alone.Implications for Cancer Survivors.Awareness of these groups is crucial when tailoring efforts to support work participation in cancer survivors. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - April 22, 2024 Category: Cancer & Oncology Source Type: research
Comparison of clinicopathological and prognostic features of breast cancer patients younger than 40 years and older than 65 years
ConclusionTo our knowledge, no study directly compares these two groups. In our study, similar to many studies, more aggressive tumor features were found in young patients, but unlike many studies, mortality was found to be significantly higher in older patients. The presence of metastasis and poor ECOG PS were found to be the most influential factors in breast cancer-specific death risk. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 22, 2024 Category: Cancer & Oncology Source Type: research
The Impact of Sleep on the Lives of Women Who Have Breast Cancer-Related Lymphedema: A Qualitative Exploration
Lymphatic Research and Biology, Ahead of Print. (Source: Lymphatic Research and Biology)
Source: Lymphatic Research and Biology - April 22, 2024 Category: Biology Authors: Karen J. Bock Kristen Kelly Delainey R. Pospichal Catherine F. Siengsukon Jill Peltzer Source Type: research
Economic assessment of abemaciclib for the adjuvant treatment of luminal HER2- breast cancer from the perspective of the Spanish health system
ConclusionDespite the significant gains of abemaciclib as adjuvant treatment in terms of progression-free survival, this treatment is not cost-effective for the Spanish National Health System at published prices. It may be cost-effective with an appropriate discount on the official price. (Source: The European Journal of Health Economics)
Source: The European Journal of Health Economics - April 22, 2024 Category: Health Management Source Type: research
Effects of yoga intervention on the fatigue-pain-sleep disturbance symptom cluster in breast cancer patients: A systematic review
This systematic review aimed to evaluate the effectiveness of yoga intervention on the fatigue-pain-sleep disturbance symptom cluster in breast cancer patients. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - April 22, 2024 Category: Cancer & Oncology Authors: Yishu QI, Huiyuan LI, Dorothy NS. CHAN, Xing MA, Cho Lee WONG Source Type: research
Impact of concurrent antibody –drug conjugates and radiotherapy on symptomatic radiation necrosis in breast cancer patients with brain metastases: a multicenter retrospective study
ConclusionsThis study suggests that concurrent ADC and radiotherapy are associated with a higher risk of SRN in HER2-positive breast cancer patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Differential role of glucocorticoid receptor based on its cell type specific expression on tumor cells and infiltrating lymphocytes
CONCLUSION: This study underscores the cell type-specific role of GR, where its expression on tumor cells is associated with aggressive features like EMT, while in infiltrating lymphocytes, it predicts a better prognosis, particularly within TNBC tumors. The GRsig emerges as a promising independent prognostic indicator across diverse BC subtypes.PMID:38643748 | DOI:10.1016/j.tranon.2024.101957 (Source: Translational Oncology)
Source: Translational Oncology - April 21, 2024 Category: Cancer & Oncology Authors: V P Snijesh Vidya P Nimbalkar Sharada Patil Savitha Rajarajan C E Anupama S Mahalakshmi Annie Alexander Ramu Soundharya Rakesh Ramesh B S Srinath Mohit Kumar Jolly Jyothi S Prabhu Source Type: research
