Molecular Breast Imaging of HER2-Positive Breast Cancer in the Era of PHERGain Trial: The past, the Present, and the Prospects
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Source: Cancer Biotherapy and Radiopharmaceuticals - May 3, 2024 Category: Cancer & Oncology Authors: Luca Filippi Martin W. Brechbiel Source Type: research
Tailoring micellar nanocarriers for pemetrexed in breast cancer: design, fabrication and in vitro evaluation
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - May 3, 2024 Category: Nanotechnology Authors: Nalla Usha Kumari Padakanti Sandeep Chary Ekta Pardhi Neelesh Kumar Mehra Source Type: research
Tailoring micellar nanocarriers for pemetrexed in breast cancer: design, fabrication and in vitro evaluation
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - May 3, 2024 Category: Nanotechnology Authors: Nalla Usha Kumari Padakanti Sandeep Chary Ekta Pardhi Neelesh Kumar Mehra Source Type: research
Atypical memory B cells increase in the peripheral blood of patients with breast cancer regardless of lymph node involvement
Breast cancer is the most common cancer in females. The immune system has a crucial role in the fight against cancer. B and T cells, the two main components of the adaptive immunity, are critical players that ... (Source: BMC Immunology)
Source: BMC Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Atefeh Azizi, Fereshteh Mehdipour, Morteza Samadi, Reza Rasolmali, Abdol-Rasoul Talei and Abbas Ghaderi Tags: Research Source Type: research
Machine-learning and mechanistic modeling of metastatic breast cancer after neoadjuvant treatment
by Sebastien Benzekry, Michalis Mastri, Chiara Nicol ò, John M. L. Ebos
Clinical trials involving systemic neoadjuvant treatments in breast cancer aim to shrink tumors before surgery while simultaneously allowing for controlled evaluation of biomarkers, toxicity, and suppression of distant (occult) metastatic disease. Yet neoadjuvant clinical trials are rarely preceded by preclinical testing involving neoadjuvant treatment, surgery, and post-surgery monitoring of the disease. Here we used a mouse model of spontaneous metastasis occurring after surgical removal of orthotopically implanted primary tumors to develop a predi...
Source: PLoS Computational Biology - May 3, 2024 Category: Biology Authors: Sebastien Benzekry Source Type: research
Young Patients Without Genetic Risk Have Low Chance of Second Breast Cancer
Previous research has suggested that young people with breast cancer had 2 to 3 times the risk of being diagnosed with secondary breast cancer. But a new study in JAMA Oncology suggests that may not be true for those who do not have a genetic change linked with higher risk of the disease, such as BRCA1 or BRCA2. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 3, 2024 Category: General Medicine Source Type: research
Role of Gut Microbe Composition in Psychosocial Symptom Response to Exercise Training in Breast Cancer Survivors (ROME) study: protocol for a randomised controlled trial
The objective of this study is to determine if fitness-related modifications to gut microbiota occur and, if so, mediate the effects of aerobic exercise on fatigue response.
Methods and analysis
The research is a randomised controlled trial among breast cancer survivors aged 18–74 with fatigue. The primary aim is to determine the effects of aerobic exercise training compared with an attention control on gut microbiota composition. The secondary study aims are to test if exercise training (1) affects the gut microbiota composition directly and/or indirectly through inflammation (serum cytokines), autonomic nervous sy...
Source: BMJ Open - May 3, 2024 Category: General Medicine Authors: Little, R. B., Carter, S. J., Motl, R. W., Hunter, G., Cook, A., Liu, N., Krontiras, H., Lefkowitz, E. J., Turan, B., Schleicher, E., Rogers, L. Q. Tags: Open access, Oncology Source Type: research
Optimal Glycated Hemoglobin Cutoff for Diagnosis of Diabetes and Prediabetes in Chinese Breast Cancer Women
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - May 2, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):270-277. doi: 10.1080/21691401.2024.2347369. Epub 2024 May 2.ABSTRACTSpherical gold/polyacrylic acid (Au/PAA) polymer-inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer ...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Hanieh Montaseri Heidi Abrahamse Source Type: research
Real-world clinical evaluation of natural and induced vasomotor symptoms in the USA and Europe
CONCLUSION: Significant burden from the triad of natural or induced menopausal symptoms, sleep disturbances and mood changes affected women's daily activities, work and quality of life more than vasomotor symptoms alone.PMID:38695491 | DOI:10.1080/13697137.2024.2340472 (Source: Climacteric)
Source: Climacteric - May 2, 2024 Category: Geriatrics Authors: Sheryl Kingsberg Victoria Banks Cecilia Caetano Cecile Janssenswillen Carsten Moeller Nils Schoof Lauren Lee Megan Scott Rossella E Nappi Source Type: research
Prediction of breast cancer and axillary positive-node response to neoadjuvant chemotherapy based on multi-parametric magnetic resonance imaging radiomics models
CONCLUSIONS: Our study established non-invasive combining models to predict the therapeutic response of primary breast cancer and axillary positive-node prior to NAC, which may help to modify preoperative treatment and determine post-NAC surgery strategy.PMID:38696854 | PMC:PMC11070644 | DOI:10.1016/j.breast.2024.103737 (Source: Breast)
Source: Breast - May 2, 2024 Category: Cancer & Oncology Authors: Yingyu Lin Jifei Wang Meizhi Li Chunxiang Zhou Yangling Hu Mengyi Wang Xiaoling Zhang Source Type: research
Clinicopathological Significance and Prognostic Role of High Mobility Group Box 1 (HMGB1), Toll-Like Receptor (TLR) 2 and TLR4 in Breast Cancer
Acta Histochem Cytochem. 2024 Apr 25;57(2):75-83. doi: 10.1267/ahc.24-00006. Epub 2024 Apr 17.ABSTRACTHigh-mobility group box 1 (HMGB1) functions as damage-associated molecular pattern (DAMPs), released into extracellular space during cellular stress. Extracellular HMGB1 act as signal molecules through Toll-like receptor (TLR) 2 or TLR4, exerting diverse functions in both normal cells and malignant cells including breast cancer. However, their comprehensive examination in breast cancer tissues is lacking. Thus, we immunolocalized them in 112 breast cancer tissues, correlating their immunoreactivity with clinicopathological...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Reina Taguchi Mio Yamaguchi-Tanaka Kiyoshi Takagi Ai Sato Yasuhiro Miki Minoru Miyashita Takashi Suzuki Source Type: research
Clinicopathological Significance and Prognostic Role of High Mobility Group Box 1 (HMGB1), Toll-Like Receptor (TLR) 2 and TLR4 in Breast Cancer
Acta Histochem Cytochem. 2024 Apr 25;57(2):75-83. doi: 10.1267/ahc.24-00006. Epub 2024 Apr 17.ABSTRACTHigh-mobility group box 1 (HMGB1) functions as damage-associated molecular pattern (DAMPs), released into extracellular space during cellular stress. Extracellular HMGB1 act as signal molecules through Toll-like receptor (TLR) 2 or TLR4, exerting diverse functions in both normal cells and malignant cells including breast cancer. However, their comprehensive examination in breast cancer tissues is lacking. Thus, we immunolocalized them in 112 breast cancer tissues, correlating their immunoreactivity with clinicopathological...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Reina Taguchi Mio Yamaguchi-Tanaka Kiyoshi Takagi Ai Sato Yasuhiro Miki Minoru Miyashita Takashi Suzuki Source Type: research
Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):270-277. doi: 10.1080/21691401.2024.2347369. Epub 2024 May 2.ABSTRACTSpherical gold/polyacrylic acid (Au/PAA) polymer-inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer ...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Hanieh Montaseri Heidi Abrahamse Source Type: research
Real-world clinical evaluation of natural and induced vasomotor symptoms in the USA and Europe
CONCLUSION: Significant burden from the triad of natural or induced menopausal symptoms, sleep disturbances and mood changes affected women's daily activities, work and quality of life more than vasomotor symptoms alone.PMID:38695491 | DOI:10.1080/13697137.2024.2340472 (Source: Climacteric)
Source: Climacteric - May 2, 2024 Category: Geriatrics Authors: Sheryl Kingsberg Victoria Banks Cecilia Caetano Cecile Janssenswillen Carsten Moeller Nils Schoof Lauren Lee Megan Scott Rossella E Nappi Source Type: research
