Social characteristics and social benefit use among premenopausal breast cancer survivors in Denmark: a population-based cohort study
CONCLUSIONS: Use of social benefits reflecting lost ability to work was highest in less educated women and in women living alone.IMPLICATIONS FOR CANCER SURVIVORS: Awareness of these groups is crucial when tailoring efforts to support work participation in cancer survivors.PMID:38647591 | DOI:10.1007/s11764-024-01598-z (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Cathrine F Hjorth Julie A Schmidt D óra K Farkas Deirdre Cronin-Fenton Source Type: research
Antibody-drug conjugates in lung and breast cancer: Current evidence and future directions - a position statement from the ETOP IBCSG Partners Foundation
Ann Oncol. 2024 Apr 20:S0923-7534(24)00108-X. doi: 10.1016/j.annonc.2024.04.002. Online ahead of print.ABSTRACTFollowing the approval of the first antibody-drug conjugates (ADCs) in the early 2000s, development has increased dramatically, with 14 ADCs now approved and >100 in clinical development. In lung cancer, trastuzumab deruxtecan (T-DXd) is approved in human epidermal growth factor receptor 2 (HER2)-mutated, unresectable or metastatic non-small cell lung cancer, with ADCs targeting HER3 (patritumab deruxtecan), trophoblast cell-surface antigen 2 (datopotamab deruxtecan and sacituzumab govitecan [SG]) and mesenchym...
Source: Ann Oncol - April 22, 2024 Category: Cancer & Oncology Authors: S Peters S Loi F Andr é S Chandarlapaty E Felip S P Finn P A J änne K M Kerr E Munzone A Passaro M P érol E F Smit C Swanton G Viale R A Stahel Source Type: research
The Role of Axillary Lymph Node Dissection versus Sentinel Lymph Node Dissection in Breast Cancer Patients with Clinical N2b-N3c Disease Who Receive Adjuvant Radiotherapy
CONCLUSIONS: ALND in patients with advanced nodal disease was not associated with improved survival compared with SLNB for women who receive adjuvant radiotherapy.PMID:38647915 | DOI:10.1245/s10434-024-15280-2 (Source: Ann Oncol)
Source: Ann Oncol - April 22, 2024 Category: Cancer & Oncology Authors: Eric A Roach Christopher R Weil George Cannon Jon Grant Margaret Van Meter Dustin Boothe Source Type: research
Cost of disease progression among US patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
Conclusion: Disease progression was associated with significant increases in HCRU and costs. Delays in progression were associated with lower cumulative healthcare costs. Earlier use of more clinically effective treatments to delay progression may reduce the economic burden among these patients.PMID:38647165 | DOI:10.57264/cer-2023-0166 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - April 22, 2024 Category: General Medicine Authors: Clara Lam Brandon Diessner Katherine Andrade Sydnie Stackland Leah Park Sandhya Mehta Feng Lin Winghan Jackie Kwong Source Type: research
Comparison between a single dose of PEG G-CSF and multiple doses of non-PEG G-CSF: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
CONCLUSIONS: A single dose of PEG G-CSF is strongly recommended over multiple-dose non-PEG G-CSF therapy for the primary prophylaxis of FN.PMID:38649648 | DOI:10.1007/s10147-024-02504-4 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Tetsuhiro Yoshinami Kazuki Nozawa Takamichi Yokoe Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Yuji Miura Makoto Endo Shingo Yano Dai Maruyama Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito Eishi Baba Nobuaki Ochi Toshio K Source Type: research
Breast density quantification in dual-energy mammography using virtual anthropomorphic phantoms
CONCLUSIONS: Our results in virtual phantoms indicate that the material decomposition method can produce accurate VBD measurements if the presence of a third material (skin) is considered. The results from our proof of concept showed agreement between MRI and dual-energy mammography VBD. Assessment of VBD using dual-energy images could provide complementary information in dual-energy mammography and tomosynthesis examinations.PMID:38648734 | DOI:10.1002/acm2.14360 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Gustavo Pacheco Jorge Patricio Castillo-Lopez Yolanda Villase ñor-Navarro Mar ía-Ester Brandan Source Type: research
Stepwise analysis of thyroid diagnostic modalities with genomic imprinting detection
CONCLUSIONS: Our study demonstrated the significant stepwise diagnostic contributions of standard clinical assessments in the malignancy risk stratification of thyroid nodules. However, the addition of molecular imprinting detection further enabled a more accurate and definitive preoperative evaluation especially for morphologically indeterminate thyroid nodules and cases with potentially discordant results among standard modalities.PMID:38644545 | DOI:10.21037/cco-23-89 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Wanting Yang Ming Yin Jiehong Zhou Yun Zhu Beibei Ye Hui Shi Bingjie Zhang Can Yue Yifeng Zhang Hongxun Wu Haohao Li Xuliang Xia Shufang Yang Buyun Ma Source Type: research
Social characteristics and social benefit use among premenopausal breast cancer survivors in Denmark: a population-based cohort study
CONCLUSIONS: Use of social benefits reflecting lost ability to work was highest in less educated women and in women living alone.IMPLICATIONS FOR CANCER SURVIVORS: Awareness of these groups is crucial when tailoring efforts to support work participation in cancer survivors.PMID:38647591 | DOI:10.1007/s11764-024-01598-z (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Cathrine F Hjorth Julie A Schmidt D óra K Farkas Deirdre Cronin-Fenton Source Type: research
Comprehensive profiling of L1 retrotransposons in mouse
Nucleic Acids Res. 2024 Apr 22:gkae273. doi: 10.1093/nar/gkae273. Online ahead of print.ABSTRACTL1 elements are retrotransposons currently active in mammals. Although L1s are typically silenced in most normal tissues, elevated L1 expression is associated with a variety of conditions, including cancer, aging, infertility and neurological disease. These associations have raised interest in the mapping of human endogenous de novo L1 insertions, and a variety of methods have been developed for this purpose. Adapting these methods to mouse genomes would allow us to monitor endogenous in vivo L1 activity in controlled, experimen...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Xuanming Zhang Ivana Celic Hannah Mitchell Sam Stuckert Lalitha Vedula Jeffrey S Han Source Type: research
Inhibition of CDK7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy
CONCLUSIONS: Activation of CDK7 is necessary for DOX-induced cardiomyocyte apoptosis and cardiomyopathy. Our findings uncover a novel proapoptotic role for CDK7 in cardiomyocytes. Moreover, this study suggests that inhibition of CDK7 attenuates DOX-induced cardiotoxicity, but augments the anticancer efficacy of DOX. Therefore, combined administration of CDK7 inhibitor and DOX may exhibit diminished cardiotoxicity but superior anticancer activity.PMID:38646672 | DOI:10.1093/cvr/cvae084 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Jingrui Chen Jing Wei Peng Xia Yuening Liu Mahder Dawit Belew Ryan Toohill Boyang Jason Wu Zhaokang Cheng Source Type: research
Expression of c-erb-B2 oncoprotein as a neoantigen strategy to repurpose anti-neu antibody therapy in a model of melanoma
In this study, we tested a novel approach of "repurposing" a biomarker typically associated with breast cancer for use in melanoma. HER2/neu is a well characterized biomarker in breast cancer for which effective anti-HER2/neu therapies are readily available. We constructed a lentivirus encoding c-erb-B2 (the animal homolog to HER2/neu). This was used to transfect B16 melanoma in vitro for use in an orthotopic preclinical mouse model, which resulted in expression of c-erb-B2 as a neoantigen target for anti-c-erb-B2 monoclonal antibody (7.16.4). The c-erb-B2-expressing melanoma was designated B16/neu. 7.16.4 produced statist...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Emmanuel M Gabriel Brian Necela Deborah Bahr Sneha Vivekanandhan Barath Shreeder Sanjay Bagaria Keith L Knutson Source Type: research
Demonstration Study of Reflector-Based Volumetric Speed-of-Sound Imaging With Linear Ultrasound Arrays
In this study, we introduce a 3D SoS reconstruction system that utilizes hand-held linear arrays instead. This system employs a passive reflector positioned opposite the linear arrays, serving as an echogenic reference for time-of-flight (ToF) measurements, and a high-definition camera to track the location corresponding to each group of transmit-receive data. To merge these two streams of ToF measurements and location tracking, a voxel-based reconstruction algorithm is implemented. Experimental results with gelatin phantom and ex vivo tissue have demonstrated the stability of our proposed method. Moreover, the results und...
Source: Ultrasonic Imaging - April 22, 2024 Category: Radiology Authors: Xiaoyi Jiang Kexin Gan Yuxin Wang Chao Tao Xiaojun Liu Jie Yuan Zhibin Jin Source Type: research
Perspectives for the clinical application of ctDNA analysis to breast cancer drug therapy
Breast Cancer. 2024 Apr 23. doi: 10.1007/s12282-024-01571-9. Online ahead of print.ABSTRACTCirculating tumor DNA (ctDNA) consists of DNA fragments released from cancer cells into the blood circulation with quick clearance. Analysis of ctDNA can enable real-time assessment of the presence of cancer cells and their genomic characteristics. Therefore, ctDNA is expected to be one of the most useful biomarkers for cancer. In recent years, several ultra-sensitive assays for ctDNA analysis have been developed, and many clinical trials are using these assays to investigate the efficacy of ctDNA-based therapeutic strategies. In the...
Source: Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Tetsuhiro Yoshinami Source Type: research
Number of lines of previous chemotherapy regimen might affect the oucome of sacituzumab govitecan in metastatic triple-negative breast cancer patients
Breast Cancer. 2024 Apr 22. doi: 10.1007/s12282-024-01587-1. Online ahead of print.NO ABSTRACTPMID:38647866 | DOI:10.1007/s12282-024-01587-1 (Source: Breast Cancer)
Source: Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Kadri Altundag Source Type: research
GSE261713 Linking single cell genomes and transcriptomes at scale to decode breast cancer progression [scRNA-seq]
Contributors : Kaile Wang ; Rui Ye ; Nicholas NavinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding epithelial lineages in breast cancer and genotype-phenotype interactions requires direct measurements of the genome and transcriptome of the same single cells at scale. To achieve this, we developed wellDR-seq, the first high-genomic resolution, high-throughput method to simultaneously profile the whole genome and transcriptome of thousands of single cells. We profiled 17,427 single cells in 6 ER-positive breast cancer patients, which identified ancestral subclones in t...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
