Between-Race Differences in Supplemental Breast Cancer Screening Before and After Breast Density Notification Law
We examined supplemental screening (ie, MRI, ultrasound, or tomosynthesis within 6 months of screening mammogram) among a sample of 2,764 African American (AA) and 691 European American (EA) women with negative or benign screening mammograms for whom we had data from both before and after implementation of breast density notification laws in the state of Michigan. Results indicated a 5-fold increase (from 0.14% to 0.7% of women) in supplemental screening among screen-negative women after passage of the law, driven in large part by an increase in supplemental screening among AA women. Breast density was more predictive of s...
Source: Journal of the American College of Radiology - October 19, 2018 Category: Radiology Source Type: research

Alectinib (Alecensa)-induced reversible grade IV nephrotoxicity: a case report and review of the literature
ConclusionsThis case emphasizes the uncommon adverse effect of the anaplastic lymphoma kinase-targeted therapy alectinib causing acute renal failure manifesting as acute tubular necrosis. Recognition of alectinib nephropathy requires a thorough drug history and knowledge of risk factors that lessen its margin of safety at therapeutic ingestions. Frequent monitoring of renal functions and early nephrology referral significantly reduce the mortality and morbidity of these patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - October 19, 2018 Category: General Medicine Source Type: research

Synthesis, characterization and unravelling the molecular interaction of new bioactive 4-hydroxycoumarin derivative with biopolymer: Insights from spectroscopic and theoretical aspect
Publication date: December 2018Source: Journal of Photochemistry and Photobiology B: Biology, Volume 189Author(s): Abhijit Mukherjee, Suvranil Ghosh, Rudraditya Sarkar, Satyajit Samanta, Sudipta Ghosh, Mahadeb Pal, Adinath Majee, Sukanta Kumar Sen, Bula SinghAbstractIn the progress of small molecule as drug candidates, 4-hydroxycoumarin based compounds bearing a crucial place as potent antibiotic agents with appreciable safety in drug invention. Being synthetically and easily obtainable, 4-hydroxycoumarin related compounds with planar structure have been promoted predominantly as DNA targeting agent. Nevertheless, here we ...
Source: Journal of Photochemistry and Photobiology B: Biology - October 18, 2018 Category: Speech-Language Pathology Source Type: research

Pharmacogenetic variants and response to neoadjuvant single-agent doxorubicin or docetaxel: a study in locally advanced breast cancer patients participating in the NCT00123929 phase 2 randomized trial
Conclusion We identified two polymorphisms in CYP1B1 and ABCC2 associated with tumor pathological response following docetaxel or doxorubicin neoadjuvant monotherapy, respectively. Although further validation is required, these variants could be potential predictive genetic markers for treatment outcome in breast cancer patients. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - October 18, 2018 Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLE Source Type: research

The use of virtual communities in the support to patients with breast cancer
Resumo Pensando nas comunidades virtuais como espa ço de interação e compartilhamento de experiências, principalmente entre indivíduos acometidos por doenças crônicas, objetivamos com este estudo, analisar o papel e natureza de suporte oferecido pelas comunidades virtuais às portadoras de câncer de mama. Estudo descritivo com abordagem qual itativa. Para coleta de dados foi utilizado o aplicativo Netvizz, extraindo dados dos cinco primeiros grupos abertos de câncer de mama do Facebook, no ano de 2016. Foram encontradas 2921 postagens, totalizando 1722 coment...
Source: Ciencia e Saude Coletiva - October 18, 2018 Category: Occupational Health Source Type: research

Translation and cultural adaptation of the Breast Cancer Treatment Outcome Scale (BCTOS) into Brazilian Portuguese
CONCLUSION: The translation of BCTOS into Portuguese will help us to evaluate the quality of life in BCT patients evaluating treatment-related sequelae and may be useful for oncoplastic surgery evaluation.RESUMO INTRODU ÇÃO: O tratamento conservador da mama (TCM), desde que associado à radioterapia, é seguro. As indicações inicialmente utilizadas para o TCM se elevaram, sendo importante modalidade de tratamento. Novas modalidades, como a oncoplastia associada ao TCM, tornam-se cada vez mais presentes no cotid iano. Pacientes submetidas ao TCM apresentam alguns parâmetros asso...
Source: Revista da Associacao Medica Brasileira - October 18, 2018 Category: General Medicine Source Type: research

Breast cancer: Is grief a risk factor?
SUMMARY Cancer is characterized by the disordered growth of cells that have high capacity of invasion to the tissues and organs. One of the types of tumour that has national incidence and high mortality is breast cancer. Studies show that in addition to hereditary factors, lifestyle and environmental factors, there are factors related to emotional distress (mourning), which interfere with the development of breast cancer. Thus, it is necessary to investigate if the experience of mourning can trigger the appearance of the tumour. For this, an integrative review was performed to verify the existence of the relationship betwe...
Source: Revista da Associacao Medica Brasileira - October 18, 2018 Category: General Medicine Source Type: research

A solitary presentation of panniculitis in a patient with a history of breast cancer
ConclusionPanniculitis of the breast is a rare condition that needs to be included in the differential diagnosis of subcutaneous breast masses. In all cases, but specifically in females with history of breast cancer, panniculitis still should be thought of as a possibility, and imaging as well as other diagnostic techniques can aid in making the correct diagnosis. (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - October 18, 2018 Category: General Medicine Source Type: research

Socioeconomic Inequalities in Cervical and Breast Cancer Screening among Women in Korea, 2005-2015.
CONCLUSION: Our study identified significant inequalities among socioeconomically deprived women in cervical and breast cancer screening in Korea. Especially, income-related inequalities were greater than education-related inequalities, and these were constant from 2005 to 2015 for both cervical and breast cancer screening. PMID: 30328316 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Choi E, Lee YY, Suh M, Lee EY, Mai TTX, Ki M, Oh JK, Cho H, Park B, Jun JK, Kim Y, Choi KS Tags: Yonsei Med J Source Type: research

A predictive model for high/low risk group according to Oncotype DX recurrence score using machine learning
ConclusionWe developed a predictive model using machine learning that could represent a useful and easy-to-access tool for the selection of high ODX RS patients. After additional evaluation with large data and external validation, worldwide use of our model could be expected. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

Comparison of clinicopathologic, cosmetic and quality of life outcomes in 700 oncoplastic and conventional breast-conserving surgery cases: A single-centre retrospective study
ConclusionThe investigated OBCS procedures allowed the removal of large volumes of breast tissue with improved cosmetic outcomes without delay in adjuvant therapies, maintaining the oncological safety. However, OBCS required longer operation time. Furthermore, the extended radicality of the OBCS could reduce the rate of re-excision and completion mastectomy, although it may result in the overtreatment of some breast cancer patients. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

1661. Plasma Levels of Mammaglobin-A, VEGF and PlGF in Human Breast Cancer Pathology and 8-Year Survival
Publication date: November 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 11Author(s): Liz Baker, Louise Hall, Deborah Wilson, Pud Bhaskar (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

1601. Neoadjuvant Endocrine Therapy in Breast Cancer Up-Regulates the Cytotoxic Drug Pump ABCG2/BCRP, and May Lead to Resistance to Subsequent Chemotherapy
Publication date: November 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 11Author(s): Baek Kim (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

32. Evaluation of the Efficacy of MRI Follow-up of Breast Cancer Patients
Publication date: November 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 11Author(s): Danny Kazzazi, Clare Rogers, Kathryn Rigby, Olumuyiwa Olubowale, Nazar Kazzazi, Kadappa Kolar, Emma Craig, David Ward, David Monaghan, Lynda Wyld (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

31. Neoadjuvant Endocrine Therapy in Breast Cancer Up-Regulates the Cytotoxic Drug Pump ABCG2/BCRP, and May Lead to Resistance to Subsequent Chemotherapy
Publication date: November 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 11Author(s): Baek Kim, Diana Baxter, Andrew Hanby, Eldo Verghese, Andrew Sims, Thomas Hughes (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

30. Presentation of Breast Cancer in Women Under 40 Years: Pain is not a Symptom
Publication date: November 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 11Author(s): Yvette Jaffe, Juan McDonnell, Fawzia Imtiaz-Crosbie, Victor Jaffe (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

28. Local experience at DGH shows Combination Pertuzumab and Herceptin Nearly Doubles PCR Rate of Neo-adjuvant Chemotherapy (NAC) in HER2 Positive Breast Cancer
Publication date: November 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 11Author(s): Blossom Lake, Donna Appleton, Abel Zachariah, Habib Khan, Kerry Flemming, Jennifer Neill, Laura Pettit (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

Breast conserving therapy after neoadjuvant chemotherapy; data from the Dutch Breast Cancer Audit
This study aims to analyse trends in the use of neoadjuvant chemotherapy (NAC) and the impact on surgical outcomes.MethodsWe reviewed all records of cT1-4N1-3M0 breast cancer patients diagnosed between July 2011 and June 2016 who have been registered in the Dutch National Breast Cancer Audit (NBCA) (N = 57.177). The surgical outcomes of 'BCS after NAC′ were compared with 'primary BCS′, using a multivariable logistic regression model.ResultsBetween 2011 and 2016, the use of NAC increased from 9% to 18% and 'BCS after NAC' (N = 4170) increased from 43% to 57%. We observed an involved invasive margin rate ...
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

The Learning Curve of Robotic Nipple Sparing Mastectomy for Breast Cancer: An analysis of consecutive 39 procedures with cumulative sum plot
ConclusionFrom our preliminary experience, R-NSM and IPBR (or R-NSM alone) is a safe procedure, and the operation time needed significantly decrease after cases experience accumulated. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - October 18, 2018 Category: Surgery Source Type: research

The added benefit of digital breast tomosynthesis in second breast cancer detection among treated breast cancer patients
ConclusionCombined FFDM + DBT in the post breast cancer surveillance regimen has shown to reduce the patients' RR and to increase the CDR. FFDM + DBT had higher diagnostic accuracy than FFDM alone. FFDM + DBT ought to be a standard combination in the breast cancer surveillance in treated patients. (Source: The Egyptian Journal of Radiology and Nuclear Medicine)
Source: The Egyptian Journal of Radiology and Nuclear Medicine - October 18, 2018 Category: Nuclear Medicine Source Type: research

Efflux excretion of bisdemethoxycurcumin ‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters
BioFactors, EarlyView. (Source: BioFactors)
Source: BioFactors - October 18, 2018 Category: Biochemistry Authors: Jing Yang, Beibei Zhang, Zifei Qin, Shishi Li, Jinjin Xu, Zhihong Yao, Xiaojian Zhang, Frank J Gonzalez, Xinsheng Yao Source Type: research

The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast
AbstractDuctal carcinoma in situ (DCIS) is a non-obligate precursor to most types of invasive breast cancer (IBC). Although it is estimated only one third of untreated patients with DCIS will progress to IBC, standard of care for treatment is surgery and radiation. This therapeutic approach combined with a lack of reliable biomarker panels to predict DCIS progression is a major clinical problem. DCIS shares the same molecular subtypes as IBC including estrogen receptor (ER) and progesterone receptor (PR) positive luminal subtypes, which encompass the majority (60 –70%) of DCIS. Compared to the established roles of ER...
Source: Journal of Mammary Gland Biology and Neoplasia - October 18, 2018 Category: Cancer & Oncology Source Type: research

Pregnancies during and after trastuzumab and/or lapatinib in patients with human epidermal growth factor receptor 2 –positive early breast cancer: analysis from the NeoALTTO (BIG 1‐06) and ALTTO (BIG 2‐06) trials
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - October 18, 2018 Category: Cancer & Oncology Authors: Matteo Lambertini, Samuel Martel, Christine Campbell, S ébastien Guillaume, Florentine S. Hilbers, Uwe Schuehly, Larissa Korde, Hatem A. Azim, Serena Di Cosimo, Richard C. Tenglin, Jens Huober, José Baselga, Alvaro Moreno‐Aspitia, Martine Source Type: research

A Novel Strategy to Investigate Tissue ‐Secreted Tumor Microenvironmental Proteins in Serum toward Development of Breast Cancer Early Diagnosis Biomarker Signature
PROTEOMICS – Clinical Applications, EarlyView. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - October 18, 2018 Category: Biochemistry Authors: Namita Pendharkar, Snigdha Dhali, Subodhini Abhang Source Type: research

YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect
YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect, Published online: 18 October 2018; doi:10.1038/s41419-018-1071-2YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect (Source: Cell death and disease)
Source: Cell death and disease - October 18, 2018 Category: Internal Medicine Authors: Qian Lei Lu Xiong Yong Xia Zhanzhan Feng Tiantao Gao Wei Wei Xuejiao Song Tinghong Ye Ningyu Wang Cuiting Peng Zhongping Li Zhihao Liu Luoting Yu Source Type: research

MiR ‐34b/c‐5p and the neurokinin‐1 receptor regulate breast cancer cell proliferation and apoptosis
Cell Proliferation, EarlyView. (Source: Cell Proliferation)
Source: Cell Proliferation - October 18, 2018 Category: Cytology Authors: Lufang Zhang, Lushan Wang, Dong Dong, Zhiyong Wang, Wei Ji, Man Yu, Fei Zhang, Ruifang Niu, Yunli Zhou Source Type: research

STAT1 facilitates oestrogen receptor α transcription and stimulates breast cancer cell proliferation
Journal of Cellular and Molecular Medicine, EarlyView. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - October 18, 2018 Category: Molecular Biology Authors: Yingxiang Hou, Xin Li, Qianhua Li, Juntao Xu, Huijie Yang, Min Xue, Gang Niu, Shu Zhuo, Kun Mu, Gaosong Wu, Xiumin Li, Hui Wang, Jian Zhu, Ting Zhuang Source Type: research

Efflux excretion of bisdemethoxycurcumin ‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters
BioFactors, EarlyView. (Source: BioFactors)
Source: BioFactors - October 18, 2018 Category: Biochemistry Authors: Jing Yang, Beibei Zhang, Zifei Qin, Shishi Li, Jinjin Xu, Zhihong Yao, Xiaojian Zhang, Frank J Gonzalez, Xinsheng Yao Source Type: research

Adaptation to chronic exposure to sepantronium bromide (YM155), a prototypical survivin suppressant is due to persistent DNA damage-response in breast cancer cells.
Authors: Wani TH, Surendran S, Mishra VS, Chaturvedi J, Chowdhury G, Chakrabarty A Abstract Sepantronium bromide (YM155), originally developed against the anti-apoptotic protein survivin, performed exceptionally well in pre-clinical and phase I clinical trials. However, in phase II trials of several cancer types including breast cancer it performed poorly. Additionally, no definitive correlation between survivin level and response to therapy was found. In an attempt to understand the true reason of the late-stage failure of this promising drug, we developed YM155-resistant MCF-7 breast cancer cell line and characte...
Source: Oncotarget - October 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer.
Authors: Milevskiy MJG, Sandhu GK, Wronski A, Korbie D, Brewster BL, Shewan A, Edwards SL, French JD, Brown MA Abstract Depletion of BRCA1 protein in mouse mammary glands results in defects in lactational development and increased susceptibility to mammary cancer. Extensive work has focussed on the role of BRCA1 in the normal breast and in the development of breast cancer, the cell of origin for BRCA1 tumours and the protein-coding genes altered in BRCA1 deficient cells. However, the role of non-coding RNAs in BRCA1-deficient cells is poorly understood. To evaluate miRNA expression in BRCA1 deficient mammary cells,...
Source: Oncotarget - October 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Elucidating the novel BRCA1 function as a non-genomic metabolic restraint in ER-positive breast cancer cell lines.
Authors: Koobotse M, Holly J, Perks C Abstract Within populations carrying the same genetic predisposition, the penetrance of BRCA1 mutations has increased over time. Although linked to changes in lifestyle factors associated with energy metabolism, these observations cannot be explained by the established role of BRCA1 in DNA repair alone. We manipulated BRCA1 expression using tetracycline in the UBR60-bcl2 cell line (which has an inducible, tetracycline-regulated BRCA1 expression) and siRNA in oestrogen receptor(ER)-positive MCF7 and T47D breast cancer cells. Cellular responses to BRCA1 silencing and IGF-I action...
Source: Oncotarget - October 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

CXCR4 antagonists for treatment of breast cancer.
Authors: Cortés J, Holgado E, Perez-Garcia J PMID: 30323888 [PubMed] (Source: Oncotarget)
Source: Oncotarget - October 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Immune Checkpoint Inhibitor Therapy in Breast Cancer.
Authors: Santa-Maria CA, Nanda R Abstract Initial studies investigating single-agent activity of immune checkpoint inhibitors (ICIs) serve as proof of principle that harnessing the immune system can have anticancer activity in a variety of human malignancies. Although breast cancer was historically believed to be immunogenically silent, early studies indicate overall response rates with ICIs are similar to those observed with many other solid malignancies. Overall response rates in advanced breast cancer are low, but the responses are remarkably durable. A deeper understanding of the biology of the interaction betw...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - October 17, 2018 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Progression Potential of Ductal Carcinoma in situ Assessed by Genomic Copy Number Profiling
Conclusion: Classification of breast tumors into rapidly progressive cluster A and the other (cluster B) may contribute to select the treatment appropriate for their progression risk.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 17, 2018 Category: Pathology Source Type: research

Optimization of sample preparation for transporter protein quantification in tissues by LC–MS/MS
ConclusionWe have established an improved transporter protein quantification methodology by optimizing PM isolation and protein digestion procedures. The optimized procedure resulted in a higher transporter protein yield and improved precision. (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - October 17, 2018 Category: Drugs & Pharmacology Source Type: research

Novel of nano delivery system for Linalool loaded on gold nanoparticles conjugated with CALNN peptide for application in drug uptake and induction of cell death on breast cancer cell line
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Majid S. Jabir, Ali A. Taha, Usama I. Sahib, Zainab J. Taqi, Ahmed M. Al-Shammari, Alya S. SalmanAbstractLinalool is a monoterpene alcohol which occurs naturally in several aromatic plants. The aims of this study are to load Linalool on gold nanoparticles, conjugate the complex with CALNN peptide, and investigate them for in-vitro anticancer activities against breast cancer (MCF-7) cell line. Linalool was obtained with 98% purity while gold nanoparticles and CALNN peptide were chemically synthesized. The formation of LIN-GNPs ...
Source: Materials Science and Engineering: C - October 17, 2018 Category: Materials Science Source Type: research

[Resilience, Fear of Progression and Psychosocial Distress in Patients with Breast Cancer and Gynecological Tumors Seeking a Second Opinion].
CONCLUSIONS: Further study of the connection between psychological variables and the decision for a second oncological opinion seems crucial concerning implications for doctor-patient-communication. PMID: 30326537 [PubMed - as supplied by publisher] (Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie)
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - October 17, 2018 Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research

Photosensitiser functionalised luminescent upconverting nanoparticles for efficient photodynamic therapy of breast cancer cells
Photochem. Photobiol. Sci., 2018, Advance Article DOI: 10.1039/C8PP00354H, PaperMarkus Buchner, Paula Garc ía Calavia, Verena Muhr, Anna Kröninger, Antje J. Baeumner, Thomas Hirsch, David A. Russell, María J. Marín Rose Bengal functionalised upconverting nanoparticles produce singlet oxygenvia efficient FRET following NIR excitation and have been used for the photodynamic therapy treatment of breast cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photob...
Source: RSC - Photochem. Photobiol. Sci. latest articles - October 17, 2018 Category: Chemistry Authors: Markus Buchner Source Type: research

Adverse Cutaneous Effects of Neratinib.
We present a case of a woman on neratinib for HER-2 positive infiltrating ductal carcinoma of the right breast who presented to the dermatology clinic with changes to the fingernails, acne, and a rash on the face. Physical examination revealed erythema, induration, and some serum crust along the lateral nail folds of the right 4th and left 3rd digits as well as monomorphic acneiform papules and pustules on the face. The timeline of the patient's paronychia and acneiform rash were consistent with a diagnosis of neratinib-associated skin changes. The patient was prescribed doxycycline to control the acneiform eruption. For t...
Source: Journal of Dermatological Treatment - October 17, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

[ASAP] Chitosan Immobilization on Bio-MOF Nanostructures: A Biocompatible pH-Responsive Nanocarrier for Doxorubicin Release on MCF-7 Cell Lines of Human Breast Cancer
Inorganic ChemistryDOI: 10.1021/acs.inorgchem.8b01955 (Source: Inorganic Chemistry)
Source: Inorganic Chemistry - October 17, 2018 Category: Chemistry Authors: Reza Abazari, Ali Reza Mahjoub, Farangis Ataei, Ali Morsali, Cameron L. Carpenter-Warren, Kayhan Mehdizadeh, Alexandra M. Z. Slawin Source Type: research

Return to work after breast cancer diagnosis: An observational prospective study in brazil
Cancer, EarlyView. (Source: Cancer)
Source: Cancer - October 17, 2018 Category: Cancer & Oncology Authors: Luciana C. G. Landeiro, Debora M. Gagliato, Angelo B. F êde, Natalia M. Fraile, Rossana M. Lopez, Leonardo G. Fonseca, Vanessa Petry, Laura Testa, Paulo M. Hoff, Max S. Mano Source Type: research

Validation of repeated self-reported n-3 PUFA intake using serum phospholipid fatty acids as a biomarker in breast cancer patients during treatment
The role of n-3 polyunsaturated fatty acids (PUFAs) in breast cancer is not clear and under debate. To explore this relationship it is important to have proper validated dietary assessment methods for measurin... (Source: Nutrition Journal)
Source: Nutrition Journal - October 17, 2018 Category: Nutrition Authors: Sonja H. Brunvoll, Inger Thune, Hanne Frydenberg, Vidar G. Flote, Gro F. Bertheussen, Ellen Schlichting, Kristian S. Bjerve and Anette Hjart åker Tags: Research Source Type: research

Absolute benefit from adjuvant chemotherapy in contemporary clinical trials: a systemic review and meta-analysis
The vast majority of breast cancer patients present with non-metastatic, potentially curable disease [1]. Adjuvant treatment in early-stage breast cancer has improved over time and chemotherapy has a key role in the adjuvant setting especially in patients with high risk disease as defined by classical pathology or genomic markers [2]. Adjuvant chemotherapy has evolved and currently there are 3 chemotherapy generations, with later generations showing higher efficacy than those developed earlier [3]. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - October 17, 2018 Category: Cancer & Oncology Authors: Hadar Goldvaser, Domen Ribnikar, Habeeb Majeed, Alberto Oca ña, Eitan Amir Tags: Systematic or Meta-analysis Studies Source Type: research

Decelerated DNA methylation age predicts poor prognosis of breast cancer
DNA methylation (DNAm) age was found to be an indicator for all-cause mortality, cancer incidence, and longevity, but no study has involved in the associations of DNAm age with the prognosis of breast cancer. (Source: BMC Cancer)
Source: BMC Cancer - October 17, 2018 Category: Cancer & Oncology Authors: Jun-Ting Ren, Mei-Xia Wang, Yi Su, Lu-Ying Tang and Ze-Fang Ren Tags: Research article Source Type: research

miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer
miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer, Published online: 17 October 2018; doi:10.1038/s41419-018-1091-ymiR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer (Source: Cell death and disease)
Source: Cell death and disease - October 17, 2018 Category: Internal Medicine Authors: Peng Kong Lie Chen Muxin Yu Jing Tao Jiawei Liu Yue Wang Hong Pan Wenbin Zhou Shui Wang Source Type: research

Between-Race Differences in Supplemental Breast Cancer Screening Before and After Breast Density Notification Law
We examined supplemental screening (ie, MRI, ultrasound, or tomosynthesis within 6 months of screening mammogram) among a sample of 2,764 African American (AA) and 691 European American (EA) women with negative or benign screening mammograms for whom we had data from both before and after implementation of breast density notification laws in the state of Michigan. (Source: Journal of the American College of Radiology : JACR)
Source: Journal of the American College of Radiology : JACR - October 17, 2018 Category: Radiology Authors: Mark Manning, Terrance L. Albrecht, Suzanne O ’Neill, Kristen Purrington Tags: Original article Source Type: research

Fulvestrant for Untreated Hormone-Receptor Positive Locally Advanced or Metastatic Breast Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
This article summarises the Evidence Review Group’s review of the company’s s ubmission and summarises the guidance the National Institute for Health and Care Excellence Appraisal Committee issued in January 2018. The Evidence Review Group had several concerns, the most important of which related to the degree to which fulvestrant might confer a benefit in overall survival. This was because mature data were not available from the key phase III trial FALCON. The economic model was sensitive to changes in overall survival and the Evidence Review Group considered the incremental cost-effectiveness ratio was u...
Source: PharmacoEconomics - October 17, 2018 Category: Health Management Source Type: research

Analyzing factors associated with decisional stage of adopting breast cancer screening among Korean American women using precaution adoption process model
. (Source: Ethnicity and Health)
Source: Ethnicity and Health - October 17, 2018 Category: International Medicine & Public Health Authors: Seok Won Jin Jongwook Lee Hee Yun Lee Source Type: research

Feasibility and Diagnostic Performance of Voxelwise Computed Diffusion ‐Weighted Imaging in Breast Cancer
Journal of Magnetic Resonance Imaging, EarlyView. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - October 17, 2018 Category: Radiology Authors: Jiejie Zhou, Endong Chen, Huazhi Xu, Qiong Ye, Jiance Li, Shuxin Ye, Qinyuan Cheng, Liang Zhao, Min ‐ying Su, Meihao Wang Source Type: research

Abbreviated MRI Protocols in Breast Cancer Diagnostics
Journal of Magnetic Resonance Imaging, EarlyView. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - October 17, 2018 Category: Radiology Authors: Katerina Deike ‐Hofmann, Franziska Koenig, Daniel Paech, Constantin Dreher, Stefan Delorme, Heinz‐Peter Schlemmer, Sebastian Bickelhaupt Source Type: research