A Single-Center Retrospective Study of Patients with Double Primary Cancers: Breast Cancer and < b > < i > EGFR < /i > < /b > -Mutant Non-Small Cell Lung Cancer
Background: Second primary malignancies (SPM) in the lung are not common in breast cancer (BC) patients.EGFR-mutant lung cancer (LC) is a separate molecular subset, and the co-existence ofEGFR-mutant LC and BC has not been explored. We hypothesized thatEGFR-mutant LC patients could have higher rates of primary BC than those withEGFR-wild type (WT).Methods: We collected data on clinical and molecular characteristics and outcomes of female patients with LC and a previous or simultaneous history of primary BC treated in our hospital from 2008 to 2014.Results: Data on treatment, follow-up, andEGFR mutation status were availabl...
Source: Oncology Research and Treatment - February 22, 2019 Category: Cancer & Oncology Source Type: research

A theranostic approach to breast cancer by a quantum dots- and magnetic nanoparticles-conjugated peptide
Publication date: Available online 21 February 2019Source: Journal of the Taiwan Institute of Chemical EngineersAuthor(s): Chih-Hsiang Chang, I-Chi Tsai, Chung-Jen Chiang, Yun-Peng ChaoAbstractThe heterogeneous nature of cancers renders the efficacy of the therapeutic treatment diversified. To address this issue, a theranostic approach was proposed by development of a hybrid peptide for simultaneous diagnosis and therapy of cancer cells. Peptide A was composed of the biotinylation site (BS), the HER2/neu-binding motif, and the dockerin domain (Doc). Peptide B was designed with BS and the cohesin domain (Coh). Individually ...
Source: Journal of the Taiwan Institute of Chemical Engineers - February 22, 2019 Category: Chemistry Source Type: research

Microfluidic three-dimensional biomimetic tumor model for studying breast cancer cell migration and invasion in the presence of interstitial flow
Publication date: Available online 22 February 2019Source: Chinese Chemical LettersAuthor(s): Chao Song, Dan Gao, Tianying Yuan, Yongli Chen, Liping Liu, Xiaowu Chen, Yuyang JiangAbstractCell migration and invasion are critical steps in cancer metastasis, which are the major cause of death in cancer patients. Tumor-associated macrophages (TAMs) and interstitial flow (IF) are two important biochemical and biomechanical cues in tumor microenvironment, play essential roles in tumor progression. However, their combined effects on tumor cell migration and invasion as well as molecular mechanism remains largely unknown. In this ...
Source: Chinese Chemical Letters - February 22, 2019 Category: Chemistry Source Type: research

A platinum(IV) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis
Dalton Trans., 2019, Advance Article DOI: 10.1039/C9DT00335E, CommunicationYan Guo, Shuren Zhang, Hao Yuan, Dongfan Song, Suxing Jin, Zijian Guo, Xiaoyong Wang A PtIV prodrug bearing a vascular disrupting agent demonstrates antiangiogenic and antimetastatic potentialities against metastatic triple-negative breast cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - February 22, 2019 Category: Chemistry Authors: Yan Guo Source Type: research

Effect of Novartis Access on availability and price of non-communicable disease medicines in Kenya: a cluster-randomised controlled trial
Publication date: Available online 21 February 2019Source: The Lancet Global HealthAuthor(s): Peter C Rockers, Richard O Laing, Paul G Ashigbie, Monica A Onyango, Carol K Mukiira, Veronika J WirtzSummaryBackgroundNovartis Access is a Novartis programme that offers a portfolio of non-communicable disease medicines at a wholesale price of US$1 per treatment per month in low-income and middle-income countries. We evaluated the effect of Novartis Access in Kenya, the first country to receive the programme.MethodsWe did a cluster-randomised controlled trial in eight counties in Kenya. Counties (clusters) were randomly assigned ...
Source: The Lancet Global Health - February 22, 2019 Category: International Medicine & Public Health Source Type: research

HOXA1 upregulation is associated with poor prognosis and tumor progression in breast cancer.
Authors: Liu J, Liu J, Lu X Abstract Breast cancer (BC) is the most commonly diagnosed cancer and the second leading cause of cancer-associated mortality among females worldwide. As a member of the homeobox (HOX) gene family, HOXA1 is involved in tumor progression and prognosis in several types of human cancer. However, the clinical significance and biological functions of HOXA1 in BC remains unknown. The current study assessed the expression of HOXA1 in BC tissues and cells via western blotting and reverse transcription-quantitative polymerase chain reaction. The association between HOXA1 expression and the clinic...
Source: Experimental and Therapeutic Medicine - February 22, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Fuzzy controller design for breast cancer treatment based on fractal dimension using breast thermograms
In this study, three non-linear indices consist of compression, one-dimensional (1D) and two-dimensional (2D) fractal dimensions are used for the determination of the malignancy or benignity of cancer tumours in breast thermograms. On the other hand, by developing the high-precision infrared cameras as well as new methods of image processing, biomedical thermography images have found a prominent position among the others. Furthermore, cancerous tissue can be affected by the laser. In this study, in order to treat the cancerous lesion identified by breast thermograms, the laser parameters are designed. The basis of controll...
Source: IET Systems Biology - February 22, 2019 Category: Biology Source Type: research

Older Biologic Age Linked to Elevated Breast Cancer Risk
Biologic age, a DNA-based estimate of a person’s age, is associated with future development of breast cancer, according to scientists at the National Institutes of Health. Biologic age was determined by measuring DNA methylation, a chemical modification to DNA that is part of the normal aging process. The study showed for every five years a woman’s biologic age was older than her chron... (Source: NIEHS - National Institute of Environmental Health Sciences - News)
Source: NIEHS - National Institute of Environmental Health Sciences - News - February 22, 2019 Category: Environmental Health Source Type: research

Diagnostic and interventional imaging techniques in breast cancer
Imaging plays a critical role in the diagnosis and management of breast cancer. Two-view mammography and ultrasound form the mainstay of breast imaging and are essential components of the triple assessment. Digital mammography is rapidly replacing analogue mammography, and recent advances such as digital tomosynthesis add a third dimension to conventional 2D mammographic images. The versatility of ultrasound allows assessment of the breast and axilla as well as accurately targeted interventions, from the simple diagnostic core biopsy to preoperative tumour localization. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - February 22, 2019 Category: Surgery Authors: Simon Lowes, Alice Leaver, Alan Redman Tags: Breast Source Type: research

Aberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer
Evidence suggests that fatty acid receptor FFAR4 plays a tumor-promoting role in adipose tissue-adjacent malignancies, but its clinical relevance remains unexplored. Here, we investigated the clinical signific... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 22, 2019 Category: Cancer & Oncology Authors: Xiao Chu, Qi Zhou, Yingchun Xu, Jingting Jiang, Qing Li, Qianjun Zhou, Qiong Wu, Min Jin, Hui Wang, Yuting Gu, Xue Wang, Bei Wang, Songbing He, Xiaozhou He, Changping Wu, Fengchun Zhang & hellip; Tags: Research Source Type: research

Single-center long-term results from the randomized phase-3 TARGIT-A trial comparing intraoperative and whole-breast radiation therapy for early breast cancer
We report the results of a cohort of patients from a single center treated as part of the randomized phase-3 TARGIT-A trial.MethodsPatients ( ≥50 years) with cT1 cN0 cM0 and invasive ductal histology on biopsy were randomized between IORT with 20 Gy (arm-A) or postoperative whole-breast RT (WBRT) up to 56 Gy in 2 Gy fractions (arm-B). Postoperatively, patients in arm-A with multifocality, lymphovascular invasion, nodal invasion, extensive intraductal component, invasive lobular carcinoma, or resection margins
Source: Strahlentherapie und Onkologie - February 22, 2019 Category: Cancer & Oncology Source Type: research

Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases
Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases, Published online: 22 February 2019; doi:10.1038/s41388-019-0756-zEstradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases (Source: Oncogene)
Source: Oncogene - February 22, 2019 Category: Cancer & Oncology Authors: Maria J. Contreras-Z árate Nicole L. Day D. Ryan Ormond Virginia F. Borges Stuart Tobet Brunilde Gril Patricia S. Steeg Diana M. Cittelly Source Type: research

Comparison of protein expression between formalin-fixed core-cut biopsies and surgical excision specimens using a novel multiplex approach
AbstractPurposeWe evaluated whether multiplex protein quantification using antibody bar-coding with photocleavable oligonucleotides (NanoString) can be applied to evaluate protein expression in breast cancer FFPE specimens. We also assessed whether diagnostic core-cuts fixed immediately at time of procedures and surgical excision sections from routinely fixed breast cancers are affected by the same fixation related differences noted using immunohistochemistry (IHC).MethodsThe expression of 26 proteins was analysed using NanoString technology in 16 pairs of FFPE breast cancer core-cuts and surgical excisions. The measuremen...
Source: Breast Cancer Research and Treatment - February 22, 2019 Category: Cancer & Oncology Source Type: research

Germline TP53 mutation spectrum in Sudanese premenopausal breast cancer patients: correlations with reproductive factors
ConclusionsOur study suggests that the codon 72 Arg>Pro polymorphism is not implicated in premenopausal BC susceptibility, whereas multiparity and breastfeeding might be BC risk factors for carriers of deleteriousTP53 mutations. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - February 22, 2019 Category: Cancer & Oncology Source Type: research

Strong impact of MammaPrint and BluePrint on treatment decisions in luminal early breast cancer: results of the WSG-PRIMe study
ConclusionsMammaPrint and BluePrint test results strongly impacted physicians ’ therapy decisions in luminal EBC with up to three involved lymph nodes. The high adherence to genetically determined risk assessment represents a key prerequisite for achieving a personalized cost-effective approach to disease management of early breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - February 22, 2019 Category: Cancer & Oncology Source Type: research

Trends in utilization of hypofractionated whole breast irradiation (HF-WBI) in triple negative breast cancer (TNBC): a national cancer database (NCDB) analysis
AbstractPurposeWe sought to identify trends over time with respect to the use of hypofractionated whole breast irradiation (HF-WBI) in women with triple negative breast cancer (TNBC) in the national cancer database (NCDB).MethodsTrends in utilization of HF-WBI in women diagnosed with T1-2N0 TNBC in the NCDB between 2008 and 2013 were analyzed. Case-matched luminal A women were used for comparison. Variables included age, race, year of diagnosis, insurance status, income quartile, receipt of neoadjuvant chemotherapy, and institution (academic vs. community). Chi square, logistic regression, and multivariate analysis was per...
Source: Breast Cancer Research and Treatment - February 22, 2019 Category: Cancer & Oncology Source Type: research

Validation of the breast cancer surveillance consortium model of breast cancer risk
ConclusionsThe BCSC model is a well-validated risk assessment tool for breast cancer that may be particularly useful when assessing the utility of supplemental screening in women with dense breasts. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - February 22, 2019 Category: Cancer & Oncology Source Type: research

The estrogen receptor coactivator AIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative invasive lobular carcinoma of the breast
ConclusionsAIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative ILC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - February 22, 2019 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 11, Pages 259: A Retrospective Dosimetric Study of Radiotherapy Patients with Left-Sided Breast Cancer; Patient Selection Criteria for Deep Inspiration Breath Hold Technique
Conclusion: The TLV measured on a FB plan could potentially be utilised to predict cardiac exposure and assist with patient selection for DIBH. This is important in resource allocation, as DIBH may be unnecessarily recommended for some patients with little dosimetric benefit. (Source: Cancers)
Source: Cancers - February 22, 2019 Category: Cancer & Oncology Authors: Mikaela Dell ’Oro Eileen Giles Amy Sharkey Martin Borg Caroline Connell Eva Bezak Tags: Article Source Type: research

Correction: The prognostic significance of combined androgen receptor, E-Cadherin, Ki67 and CK5/6 expression in patients with triple negative breast cancer.
Authors: Adamo B, Ricciardi GRR, Ieni A, Franchina T, Fazzari C, Sanò MV, Angelico G, Caruso M, Tuccari G, Adamo V Abstract [This corrects the article DOI: 10.18632/oncotarget.20293.]. PMID: 30783520 [PubMed - in process] (Source: Oncotarget)
Source: Oncotarget - February 21, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pregnancies in young women with diagnosis and treatment of HER2-positive breast cancer.
Authors: Lambertini M, Viglietti G PMID: 30783509 [PubMed] (Source: Oncotarget)
Source: Oncotarget - February 21, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Sinomenine inhibits osteolysis in breast cancer by reducing IL-8/CXCR1 and c-Fos/NFATc1 signaling
Publication date: Available online 20 February 2019Source: Pharmacological ResearchAuthor(s): Yueyang Zhang, Binhua Zou, Yanhui Tan, Jianbing Su, Yiyuan Wang, Jialan Xu, Lei Tao, Hua Zhou, Liang Liu, Xiaojuan LiAbstractSinomenine (SIN) is an anti-inflammatory and antiarthritic alkaloid derived from Sinomenium acutum, and the product Zhengqing Fengtongning produced from SIN has been marketed in China for treating rheumatoid arthritis (RA). Interestingly, we recently found that SIN could significantly ameliorate bone destruction induced by breast cancer cells in mice. Micro-CT examination showed that bone loss of the trabecu...
Source: Pharmacological Research - February 21, 2019 Category: Drugs & Pharmacology Source Type: research

Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis
ConclusionsOverall, our findings proved that EEOD could inhibit breast cancer metastasis by attenuating the expression of Cav-1, highlighting the use of EEOD as an adjunctive therapy for metastatic breast cancer patients. This study also provides novel insights into network pharmacology and bioinformatics analysis as effective tools to illuminate the scientific basis of TCM. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 21, 2019 Category: Drugs & Pharmacology Source Type: research

A novel Trans-Pt(II) complex bearing 2-acetoxymethylbenzimidazole as a non-leaving ligand (trans-[Pt(AMBi)2Cl2]): Synthesis, antiproliferative activity, DNA interaction and molecular docking studies compared with its cis isomer (cis-[Pt(AMBi)2Cl2])
Publication date: Available online 20 February 2019Source: Journal of Molecular StructureAuthor(s): Gokcen Eren, Esra Emerce, Leyla Acik, Betul Aydin, Fatma GumusAbstractTrans-[Pt(AMBi)2Cl2 (1) in which AMBi is 2-acetoxymethylbenzimidazole, was synthesized and characterized by spectroscopic methods. Novel complex 1 was evaluated for its potential antiproliferative effect against three human cancer cell lines, including HeLa (human cervix cancer), MCF-7 (human breast cancer) and A549 (human non-small-cell lung cancer) in comparison with those of cis-[Pt(AMBi)2Cl2 (2) and cisplatin by means of the MTT assay. Interaction of c...
Source: Journal of Molecular Structure - February 21, 2019 Category: Molecular Biology Source Type: research

Colorectal and Breast Cancer Screening Status for People in Ontario Provincial Correctional Facilities
Publication date: Available online 21 February 2019Source: American Journal of Preventive MedicineAuthor(s): Andres McConnon, Kinwah Fung, Aisha Lofters, Stephen W. Hwang, Fiona G. KouyoumdjianIntroductionPrimary care represents an opportunity to improve health for people who experience imprisonment, and screening for colorectal and breast cancer indicate primary care quality. The study objectives were to examine the proportion of people released from provincial correctional facilities who were overdue for colorectal or breast cancer screening on admission to the correctional facility and who were still overdue after 3 yea...
Source: American Journal of Preventive Medicine - February 21, 2019 Category: International Medicine & Public Health Source Type: research

[ASAP] Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy
Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.9b00028 (Source: Bioconjugate Chemistry)
Source: Bioconjugate Chemistry - February 21, 2019 Category: Biochemistry Authors: Amita M Vaidya, Zhanhu Sun, Nadia Ayat, Andrew Schilb, Xujie Liu, Hongfa Jiang, Da Sun, Josef Scheidt, Victoria Qian, Siyuan He, Hannah Gilmore, William P. Schiemann, Zheng-Rong Lu Source Type: research

GSE118148 RNA-seq analysis of AKTi MK2206 resistant BT474 and T47D cells
Contributors : Binhua P Zhou ; Jian ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated gene transcription is required for tumor cells to develop drug resistance. Our data show that prolonged treatment of luminal breast cancer cells with AKT inhibitors induces FOXO3a de-phosphorylation, nuclear translocation, and disrupts its association with SIRT6, eventually leading to FOXO3a acetylation...
Source: GEO: Gene Expression Omnibus - February 21, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Effect of miR-34a on resistance to sunitinib in breast cancer by regulating the Wnt/ β-catenin signaling pathway.
CONCLUSIONS: MiR-34a affects the sensitivity to sunitinib in breast cancer by regulating the Wnt/β-catenin signaling pathway. PMID: 30779084 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Breast cancer in women living with HIV.
Authors: D'Andrea F, Ceccarelli M, Facciolà A, Nunnari G, Pellicanò GF, Venanzi Rullo E Abstract With the introduction of HAART, the life expectancy of the patients infected with HIV almost approached that of the general population. The incidence of certain HIV-Associated cancers as Kaposi Sarcoma (KS) and Non-Hodgkin Lymphoma (NHL) decreased, while an increase in Non-AIDS-Defining cancers (NADCs) has been documented. HIV infection is a risk factor for numerous cancers in PLWH. Breast cancer is the most common cancer worldwide among all women. The association between HIV infection and breast cancer ha...
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation
Triple negative breast cancer (TNBC) is a malignancy with very poor prognosis, due to its aggressive clinical characteristics and lack of response to receptor-targeted drug therapy. In TNBC, immune-related pat... (Source: BMC Genomics)
Source: BMC Genomics - February 21, 2019 Category: Genetics & Stem Cells Authors: Fernando J. Velloso, Alexandre R. Campos, Mari C. Sogayar and Ricardo G. Correa Tags: Research article Source Type: research

Non ‐invasive analysis of tumor mutation profiles and druggable mutations by sequencing of cell free DNA of Chinese metastatic breast cancer patients
ConclusionTargeted deep sequencing of cell free DNA is a highly sensitive, noninvasive method to depict tumor mutation profiles, identify druggable mutations in MBC, and predict patient outcome. Our study shed light on the utility of ctDNA as noninvasive “liquid biopsy” in the management of MBC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - February 21, 2019 Category: Cancer & Oncology Authors: Shunying Li, Xiaobao Wang, Yuquan Li, Hongna Lai, Yujie Liu, Liang Jin Tags: ORIGINAL ARTICLE Source Type: research

Value of Axillary Ultrasound after Negative Axillary MRI for Evaluating Nodal Status in High-Risk Breast Cancer
The routine use of axillary ultrasound after negative MRI is low-yield and therefore may be unnecessary in breast cancer patients undergoing neoadjuvant therapy. Eliminating the redundancy of performing this ultrasound can reduce unneeded patient workups and anxiety, limit strain on resources in radiology, and reduce delays to surgery and treatment. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - February 21, 2019 Category: Surgery Authors: Tariq Almerey, Diego Villacreses, Zhuo Li, Bhavika Patel, Mary Ann McDonough, Tammeza Gibson, Santo Maimone, Richard Gray, Sarah A. McLaughlin Tags: Original Scientific Article Source Type: research

An analysis of 11.3 million screening tests examining the association between needle biopsy rates and cancer detection rates in the English NHS Breast Cancer Screening Programme
To examine the association between recall, needle biopsy, and cancer detection rates to inform the setting of target ranges to optimise the benefit to harm ratio of breast screening programmes. (Source: Clinical Radiology)
Source: Clinical Radiology - February 21, 2019 Category: Radiology Authors: R.G. Blanks, R. Given-Wilson, R. Alison, J. Jenkins, M.G. Wallis Source Type: research

Cytotoxic Alkaloids from Leaves of Pilea aff. martinii
Planta Med DOI: 10.1055/a-0826-0483Two new phenanthroquinolizidine alkaloids (1 and 2) and a new piperidine derivative (3) were isolated from the leaves of Pilea aff. martinii together with 3 known alkaloids: julandine (4), cryptopleurine (5), and 1,3,6,6-tetramethyl-5,6,7,8-tetrahydro-isoquinolin-8-one (6). Their structures were determined by spectral data analyses including mass spectrometry and 2-dimensional nuclear magnetic resonance data. The absolute configurations of 1–3 were established by comparison of their experimental circular dichroism data with the calculated electronic circular dichroism spectra. The i...
Source: Planta Medica - February 21, 2019 Category: Drugs & Pharmacology Authors: Doan Thi Thuy, Ai Trinh Thi Thanh, Van Doan Thi Mai, Huong Le, Huyen Tram Litaudon, Marc Nguyen, Van Hung Chau, Van Minh Pham, Van Cuong Tags: Original Papers Source Type: research

Cancers, Vol. 11, Pages 251: Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer
This study provides significant and novel information regarding the frequency, causes, and consequences of elevated FOXM1 expression in human cancer. (Source: Cancers)
Source: Cancers - February 21, 2019 Category: Cancer & Oncology Authors: Carter J Barger Connor Branick Linda Chee Adam R. Karpf Tags: Article Source Type: research

Cancers, Vol. 11, Pages 253: Trending Towards Safer Breast Cancer Surgeries? Examining Acute Complication Rates from A 13-Year NSQIP Analysis
This study provides data comparing nationwide acute complication rates following different breast cancer surgeries. These can be used to inform patients during surgical decision making. (Source: Cancers)
Source: Cancers - February 21, 2019 Category: Cancer & Oncology Authors: Michael M. Jonczyk Jolie Jean Roger Graham Abhishek Chatterjee Tags: Article Source Type: research

Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/ β-catenin signaling pathway by regulating WNT2
Breast cancer is one the most common cancers, making it the second leading cause of cancer-related death among women. Long non-coding RNAs (lncRNAs), with tightly regulated expression patterns, also serve as t... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 21, 2019 Category: Cancer & Oncology Authors: Dian-Hui Xiu, Gui-Feng Liu, Shao-Nan Yu, Long-Yun Li, Guo-Qing Zhao, Lin Liu and Xue-Feng Li Tags: Research Source Type: research

Economic modeling of risk-adapted screen-and-treat strategies in women at high risk for breast or ovarian cancer
ConclusionThe provision of genetic testing to high-risk women with a BRCA1 and two mutation probability of ≥ 10% based on the individual family cancer history appears to be a cost-effective option for the SHI. (Source: The European Journal of Health Economics)
Source: The European Journal of Health Economics - February 21, 2019 Category: Health Management Source Type: research

miR-29a contributes to breast cancer cells epithelial–mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targeting SUV420H2
miR-29a contributes to breast cancer cells epithelial–mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targeting SUV420H2miR-29a contributes to breast cancer cells epithelial–mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targeting SUV420H2, Published online: 21 February 2019; doi:10.1038/s41419-019-1437-0miR-29a contributes to breast cancer cells epithelial–mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targe...
Source: Cell death and disease - February 21, 2019 Category: Internal Medicine Authors: You Wu Wanyue Shi Tingting Tang Yidong Wang Xin Yin Yanlin Chen Yanfeng Zhang Yun Xing Yumeng Shen Tiansong Xia Changying Guo Yi Pan Liang Jin Source Type: research

Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancerAngiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer, Published online: 21 February 2019; doi:10.1038/s41419-019-1427-2Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer (Source: Cell death and disease)
Source: Cell death and disease - February 21, 2019 Category: Internal Medicine Authors: Jiao Yang Xiaoman Zhang Zheling Chen Yanwei Shen Fan Wang Yaochun Wang Yu Liu Peijun Liu Jin Yang Source Type: research

Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signalingPotassium channel activity controls breast cancer metastasis by affecting β-catenin signaling, Published online: 21 February 2019; doi:10.1038/s41419-019-1429-0Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling (Source: Cell death and disease)
Source: Cell death and disease - February 21, 2019 Category: Internal Medicine Authors: Eun-Kyoung Breuer Daniela Fukushiro-Lopes Annika Dalheim Miranda Burnette Jeremiah Zartman Simon Kaja Claire Wells Loredana Campo Kimberly J. Curtis Ricardo Romero-Moreno Laurie E. Littlepage Glen L. Niebur Kent Hoskins Michael I. Nishimura Saverio Gentil Source Type: research

Genome-wide association study of germline variants and breast cancer-specific mortality
Genome-wide association study of germline variants and breast cancer-specific mortality, Published online: 21 February 2019; doi:10.1038/s41416-019-0393-xGenome-wide association study of germline variants and breast cancer-specific mortality (Source: British Journal of Cancer)
Source: British Journal of Cancer - February 21, 2019 Category: Cancer & Oncology Authors: Maria Escala-Garcia Qi Guo Thilo D örk Sander Canisius Renske Keeman Joe Dennis Jonathan Beesley Julie Lecarpentier Manjeet K. Bolla Qin Wang Jean Abraham Irene L. Andrulis Hoda Anton-Culver Volker Arndt Paul L. Auer Matthias W. Beckmann Sabine Behrens J Source Type: research

Correction: BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors
Correction: BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors, Published online: 21 February 2019; doi:10.1038/s41436-019-0459-4Correction: BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors (Source: Genetics in Medicine)
Source: Genetics in Medicine - February 21, 2019 Category: Genetics & Stem Cells Authors: Andrew Lee Nasim Mavaddat Amber N. Wilcox Alex P. Cunningham Tim Carver Simon Hartley Chantal Babb de Villiers Angel Izquierdo Jacques Simard Marjanka K. Schmidt Fiona M. Walter Nilanjan Chatterjee Montserrat Garcia-Closas Marc Tischkowitz Paul Pharoah Do Source Type: research

Potentially inappropriate medications defined by STOPP criteria in older patients with breast and colorectal cancer
ConclusionsWe found no consistent association between pre-chemotherapy PIM defined by STOPP and outcomes. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - February 20, 2019 Category: Cancer & Oncology Source Type: research

CACNG2 polymorphisms associate with chronic pain after mastectomy
In this study, we revisited this claim by independently evaluating the proposed marker haplotype using 2 different patient cohorts recruited in different research settings. Meta-analysis of these new postmastectomy cohorts and the original cohort confirmed significant association of the CACNG2 haplotype with PMP. In addition, we tested whether the same markers would predict chronic postsurgical pain in men who underwent surgery for inguinal hernia repair, and whether there is significant genetic association with cutaneous thermal sensitivity in postmastectomy and postherniotomy patients. We found that the biomarker is sele...
Source: Pain - February 20, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Poor compliance despite equal access: Military experience with screening breast MRI in high risk women
Publication date: Available online 20 February 2019Source: The American Journal of SurgeryAuthor(s): Woo S. Do, Jessica B. Weiss, Helen F. McGregor, Dominic M. Forte, Rowan R. Sheldon, Vance Y. SohnAbstractBackgroundUsing the military as a model for an equal-access, no-cost healthcare system, we sought to (1) describe screening breast MRI compliance rates and (2) identify patient-perceived barriers to screening.MethodsIn this retrospective cohort study of a prospectively maintained database at a tertiary level center, we compared compliance among women at ≥20% risk of developing breast cancer (Tyrer-Cuzick) and conducte...
Source: The American Journal of Surgery - February 20, 2019 Category: Surgery Source Type: research

Patient Reported Outcomes and Cosmesis in a Feasibility Study of 4D Simulated Image Guided Accelerated Partial Breast Irradiation (APBI)
Publication date: Available online 20 February 2019Source: Practical Radiation OncologyAuthor(s): Elham Rahimy, Joanne Weidhaas, Wei Wei, Donald Lannin, Nina Horowitz, Susan Higgins, Lynn D. Wilson, Christin Knowlton, Meena S. Moran, Melissa Rasar Young, Brigid Killelea, Anees Chagpar, Debra Nana Yeboa, Dan Zelterman, Suzanne EvansAbstractPurposeThree-dimensional Conformal Accelerated Partial Breast Irradiation (APBI) is a treatment option for well selected women with breast cancer, despite reports of adverse cosmetic outcome with this technique. It is postulated that dose-volume relationships may be responsible for this p...
Source: Practical Radiation Oncology - February 20, 2019 Category: Cancer & Oncology Source Type: research

Prediction of Oncotype Dx Recurrence Score Using Clinical Parameters: A Comparison of Available Tools and a Simple Predictor Based on Grade and Progesterone Receptor
ConclusionThe simple GR-PR predictor proposed in this study seems to be at least as accurate as more complex tools and should be the preferred tool for the prediction of Oncotype Dx RS from clinicopathologic parameters when the Oncotype Dx test is not available. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - February 20, 2019 Category: Cancer & Oncology Source Type: research

Network-pharmacology-based identi fication of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis.
CONCLUSIONS: Overall, our findings proved that EEOD could inhibit breast cancer metastasis by attenuating the expression of Cav-1, highlighting the use of EEOD as an adjunctive therapy for metastatic breast cancer patients. This study also provides novel insights into network pharmacology and bioinformatics analysis as effective tools to illuminate the scientific basis of TCM. PMID: 30784915 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 20, 2019 Category: Drugs & Pharmacology Authors: Yang B, Wang N, Wang S, Li X, Zheng Y, Li M, Song J, Zhang F, Mei W, Lin Y, Wang Z Tags: Biomed Pharmacother Source Type: research

Factors affecting tamoxifen metabolism in breast cancer patients; preliminary results of the French PHACS study (NCT01127295).
mas F Abstract In addition to the effect of CYP2D6 genetic polymorphisms, the metabolism of tamoxifen may be impacted by other factors with possible consequences on therapeutic outcome (efficacy, toxicity). This analysis focused on the pharmacokinetic-pharmacogenetic evaluation of tamoxifen in 730 adjuvant breast cancer patients included in a prospective multicenter study. Plasma concentrations of tamoxifen and six major metabolites, the genotype for 63 single nucleotide polymorphisms and co-medications were obtained 6 months after treatment initiation. Plasma concentrations of endoxifen were significantly associa...
Source: Clinical Breast Cancer - February 20, 2019 Category: Cancer & Oncology Authors: Puszkiel A, Arellano C, Vachoux C, Evrard A, Le Morvan V, Boyer JC, Robert J, Delmas C, Dalenc F, Debled M, Venat-Bouvet L, Jacot W, Suc E, Sillet Bach I, Filleron T, Roché H, Chatelut E, White-Koning M, Thomas F Tags: Clin Pharmacol Ther Source Type: research