Implementation of a Systematic Literature Search Strategy in a National Breast Cancer Guideline: The Relevance of Systemic Therapy in Lymph Node Recurrent Disease
Oncol Res Treat (Source: Oncology Research and Treatment)
Source: Oncology Research and Treatment - August 16, 2018 Category: Cancer & Oncology Source Type: research

Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death
Conclusion: Our study revealed that ω-3 PUFA enhanced the anti-tumor activity of Rp while minimizing its side effectsin vitro andin vivo. These results provide novel insights into the mechanisms underlying the potential beneficial effects of Rp combined with ω-3 PUFAs on the prevention of breast cancer.Cell Physiol Biochem 2018;48:2318 –2336 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - August 16, 2018 Category: Cytology Source Type: research

Comprehensive Proteomic Profiling–derived Immunohistochemistry-based Prediction Models for BRCA1 and BRCA2 Germline Mutation-related Breast Carcinomas
We present a well-applicable and accurate tool to predict which breast cancer patients may have an underlying BRCA germline mutation, largely consisting of immunohistochemical markers independent of clinical characteristics. This may improve identification of potential BRCA germline mutation carriers and optimize referral for germline mutation testing. (Source: The American Journal of Surgical Pathology)
Source: The American Journal of Surgical Pathology - August 16, 2018 Category: Pathology Tags: Original Articles Source Type: research

Comparative Pathologic Analysis of Breast Cancers Classified as HER2/neu-Amplified by FISH Using a Standard HER2/CEP17 Dual Probe and an Alternative Chromosome 17 Control Probe
This study examines whether cancers that are classified as HER2-amplified with an alternate probe are clinicopathologically similar to those that are classified as such using the HER2/CEP17 probe. Reports for 1201 breast cancers were reviewed, and clinicopathologic findings were compared between HER2/CEP17-equivocal cases that became HER2-amplified using the alternate probe (group A: n=48), HER2-amplified cases using the HER2/CEP17 probe (group B: n=169), and HER2-nonamplified cases using the HER2/CEP17 probe (group C: n=910). Of 1201 cases tested using the HER2/CEP17 probe, 169 (14%) were HER2-amplified, 122 (10%) were eq...
Source: The American Journal of Surgical Pathology - August 16, 2018 Category: Pathology Tags: Original Articles Source Type: research

Performance evaluation of breast cancer diagnosis with mammography, ultrasonography and magnetic resonance imaging.
CONCLUSION: By using a diverse dataset and comparing the diagnostic accuracy of three imaging modalities commonly used in breast cancer detection and diagnosis, this study also demonstrated that mammography, ultrasonography and MRI had different diagnostic performance in breast tumor identification. Among them, MRI yielded the highest performance even though the unexpected specificity may lead to over-diagnosis, and ultrosonography is slightly better than mammography. PMID: 30103371 [PubMed - as supplied by publisher] (Source: Journal of X-Ray Science and Technology)
Source: Journal of X-Ray Science and Technology - August 16, 2018 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Estrogen enhances tumor growth and angiogenesis indirectly via mediation of bone marrow ‑derived cells as well as directly through stimulation of tumor and endothelial cells.
Estrogen enhances tumor growth and angiogenesis indirectly via mediation of bone marrow‑derived cells as well as directly through stimulation of tumor and endothelial cells. Oncol Rep. 2018 Aug 07;: Authors: Zhuo Y, Li X, Zheng Q, Fan X, Ma W, Chen J, Zhao X, Zhao P, Liu X, Tang F, Cheng K, Feng W Abstract Estradiol (E2) is a prime culprit for enhancing the progression of female hormone‑related cancers. Bone marrow‑derived cells (BMDCs) have been found to play a pivotal role in tumor growth. Estrogen receptors (ERs) are also found on certain subtypes of BMDCs, in addition to endothelial cells (EC...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibitor of apoptosis protein ‑like protein‑2: A novel growth accelerator for breast cancer cells.
Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells. Oncol Rep. 2018 Aug 03;: Authors: Zhu L, Zhou W, Zhu X, Xiang S, Wang S, Peng Y, Lu B, Tang P, Chen Q, Wu M, Peng X, Chen Z, Sun Z, Yang K, Xiang M, Yu D Abstract Although the inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) has been shown as a serological biomarker for breast cancer, its effect on breast cancer cell growth remains elusive. The present study aimed to determine the role of ILP‑2 in breast cancer cell growth. We used immunohistochemistry to analyze ILP‑2 expression in 59 ...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Higenamine enhances the antitumor effects of cucurbitacin B in breast cancer by inhibiting the interaction of AKT and CDK2.
Authors: Jin ZQ, Hao J, Yang X, He JH, Liang J, Yuan JW, Mao Y, Liu D, Cao R, Wu XZ, Li X, Chen D Abstract Cucurbitacin B (Cu B), a tetracyclic triterpenoid derived from Trichosanthes kirilowii Maxim, exhibits anticancer effects against various types of tumor. Higenamine, isolated from Radix Aconiti Lateralis Preparata, has been used as a dietary supplement for regulating metabolic function. The present study suggested that higenamine enhances Cu B-induced cytotoxicity in breast cancer cells and in vivo. Network pharmacology analysis was used to identify the possible mechanism of action. Cu B alone i...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Taurine, glutamic acid and ethylmalonic acid as important metabolites for detecting human breast cancer based on the targeted metabolomics.
CONCLUSIONS: This study shows that amino acids and organic acids profiles will be a potential screening tool for BC patients. The dysregulated metabolism of amino acids and organic acids in breast cancer might be useful for the diagnosis, therapy, prognosis and understanding the pathogenesis of breast cancer. PMID: 30103303 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - August 16, 2018 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Assisted reproductive technology is effective for but does not affect the prognosis of young patients with breast cancer: Experience in a single institution
The Breast Journal, EarlyView. (Source: The Breast Journal)
Source: The Breast Journal - August 16, 2018 Category: Cancer & Oncology Authors: Haruko Takuwa MD , Rika Hagiwara MD , Sachiko Takahara MD, PhD , Akira Yamauchi MD, PhD Source Type: research

The Effects of the Training Program and Counseling Program Given to Women Who Underwent a Mastectomy and Spouses
This study focused on assessing the effects of the training program and counseling program given to women who underwent a mastectomy and their spouses. Sixty women and 60 spouses were recruited for this study. The women in the experimental group and their spouses were provided with a four-session training program, once a week. Following this training, a 3-month follow-up and counseling were given and an assessment made. There was significant difference between average post-test scores of spouses in the experimental and control groups, in terms of problem solving (p = .003), communication (p = .0...
Source: Journal of Cancer Education - August 16, 2018 Category: Cancer & Oncology Source Type: research

Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program
Tan et  al. discover a mechanism underlying repression of a large basally active estrogen-repressed (BAER) enhancer program. The expression of these basally active genes in human breast cancer cells is repressed by estrogen, and the indirectly bound ERα (in trans) at BAER enhancers dismisses RNA Pol II to abrogate large, eRNA-producing enhancer programs. (Source: Molecular Cell)
Source: Molecular Cell - August 16, 2018 Category: Cytology Authors: Yuliang Tan, Chunyu Jin, Wubin Ma, Yiren Hu, Bogdan Tanasa, Soohwan Oh, Amir Gamliel, Qi Ma, Lu Yao, Jie Zhang, Kenny Ohgi, Wen Liu, Aneel K. Aggarwal, Michael G. Rosenfeld Tags: Article Source Type: research

The association between IGF1 gene rs1520220 polymorphism and cancer susceptibility: a meta-analysis based on 12,884 cases and 58,304 controls
ConclusionsThe results of our meta-analysis demonstrate that the role ofIGF1 rs1520220 in cancer susceptibility varies by ethnicity and cancer type and that rs1520220 increases cancer susceptibility in Asian populations. (Source: Environmental Health and Preventive Medicine)
Source: Environmental Health and Preventive Medicine - August 16, 2018 Category: Environmental Health Source Type: research

Pathway-Based Drug Repositioning for Breast Cancer Molecular Subtypes
Ra úl A. Mejía-Pedroza, Jesús Espinal-Enríquez, Enrique Hernández-Lemus (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 15, 2018 Category: Drugs & Pharmacology Source Type: research

Increased Cellular Levels of MicroRNA-9 and MicroRNA-221 Correlate with Cancer Stemness and Predict Poor Outcome in Human Breast Cancer
Conclusion: Our findings provide strong evidence that miR-9 and miR-221 can enhance the generation of cancer stem cells to yield an invasive phenotype and that overexpression of these miRNAs predicts a poor outcome for breast cancer patients.Cell Physiol Biochem 2018;48:2205 –2218 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - August 15, 2018 Category: Cytology Source Type: research

GSE98514 Expression profiling of four replicates of MCF-7 cells treated with 100nM TCDD
Contributors : Sean Piwarski ; James Denvir ; Donald A Primerano ; Jun Fan ; Travis B SalisburySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that binds pollutants, therapeutic drugs and endogenous ligands. The AHR is expressed in all breast cancer subtypes and it can switch the aggressiveness of breast cancer cells from low to high depending on the ligand that it binds. Jagged 1 (JAG1) is a NOTCH receptor ligand that is overexpressed in basal-like breast cancer. JAG1 promotes breast cancer progression in ...
Source: GEO: Gene Expression Omnibus - August 15, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE99766 MDA-MB-231 gene expression upon IRE1 RNase inhibition with MKC-8866
Contributors : Eoghan McGrath ; Susan Logue ; Afshin SamaliSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe IRE1 Rnase domain has been implicated in the pathology of triple negative breast cancer (TNBC), a disease with limited treatment options. The IRE1 Rnase mediates it's effects on the transcriptome via activation of the trancription factor XBP1s and via direct cleavage of mRNA through a process called RIDD. The processes through which the RNase domain contributes to TNBC is not fully understood.We used a novel small molecule inhibitor of the IRE1 Rnase to find novel targets of IRE1 in TNBC, in an e...
Source: GEO: Gene Expression Omnibus - August 15, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation
New England Journal of Medicine, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - August 15, 2018 Category: Internal Medicine Authors: Jennifer K. Litton Hope S. Rugo Johannes Ettl Sara A. Hurvitz Anthony Gon çalves Kyung-Hun Lee Louis Fehrenbacher Rinat Yerushalmi Lida A. Mina Miguel Martin Henri Roch é Young-Hyuck Im Ruben G.W. Quek Denka Markova Iulia C. Tudor Alison L. Hannah Wolfg Source Type: research

Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer
Murine breast cancer models relying on intraductal tumor cell inoculations are attractive because they allow the study of breast cancer from early ductal carcinoma in situ to metastasis. Using a fully immunoco... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - August 15, 2018 Category: Cancer & Oncology Authors: Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere and Evelyne Meyer Tags: Research Source Type: research

Lymphatic Transport and Lymph Node Location of Microspheres Subcutaneously Injected in the Vicinity of Tumors in a Rabbit Model of Breast Cancer
AbstractPurposeTo assess the lymphatic transport of microparticles of 100  nm, 1 μm and 10 μm subcutaneously injected into the breast area of healthy and tumor-bearing rabbits, and to analyze their location in lymph node (LN) in relation to malignant cells.MethodsFemale rabbits (n = 9) bearing a VX2 tumor in one thoracic mammary gland were subcutaneously injected at D15 with polystyrene fluorescent particles around the nipple, on the tumor and on the healthy sides. The tumor and the LN measured by ultrasound at D9, D15 and D20 were explanted at D20. The LN metastases wer e evaluated by cy...
Source: Pharmaceutical Research - August 15, 2018 Category: Drugs & Pharmacology Source Type: research

SABCS 2017 pathology: from bench to bedside
SummaryThe 40th  International San Antonio Breast Cancer Symposium offered a multifaceted platform for the presentation of several innovative therapeutic approaches. The results of these preclinical and clinical studies provided insight into the development of novel therapy concepts from the laboratory bench to t he bedside of breast cancer patients. One main focus of last year’s symposium was the search for synergisms and opportunities for collaboration between basic research scientists and investigators in drug development. Highlights of these topics included preclinical data on selective estrogen recept ...
Source: Memo - Magazine of European Medical Oncology - August 15, 2018 Category: Cancer & Oncology Source Type: research

Can Multi-Parametric MR Based Approach Improve the Predictive Value of Pathological and Clinical Therapeutic Response in Breast Cancer Patients?
Uma Sharma, Khushbu Agarwal, Rani G. Sah, Rajinder Parshad, Vurthaluru Seenu, Sandeep Mathur, Siddhartha D. Gupta, Naranamangalam R. Jagannathan (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - August 15, 2018 Category: Cancer & Oncology Source Type: research

Radiation Therapy Field Design and Lymphedema Risk After Regional Nodal Irradiation for Breast Cancer.
Abstract PURPOSE: The occurrence of upper extremity lymphedema after regional nodal irradiation (RNI) for breast cancer treatment varies significantly based on patient and treatment factors. The relationship between the radiation therapy (RT) field design and lymphedema risk is not well-characterized. The present study sought to correlate the variations in RT field design with lymphedema outcomes. METHODS AND MATERIALS: Women with stage II-IV breast cancer receiving RNI after breast surgery that included sentinel lymph node biopsy or axillary dissection were identified. Their arm circumference was measured be...
Source: Ann Oncol - August 14, 2018 Category: Cancer & Oncology Authors: Gross JP, Sachdev S, Helenowski IB, Lipps D, Hayes JP, Donnelly ED, Strauss JB Tags: Int J Radiat Oncol Biol Phys Source Type: research

American Society of Clinical Oncology.
Authors: Alexander W Abstract We review key findings in the areas of prostate cancer, non-small-cell lung cancer, breast cancer, esophageal cancer, pancreatic cancer, leukemias, metastatic colon cancer, and one session on molecular profiling guidance of therapy. PMID: 30100691 [PubMed] (Source: P and T)
Source: P and T - August 14, 2018 Category: Drugs & Pharmacology Tags: P T Source Type: research

Effects of Exercise on Sleep in Women with Breast Cancer: A Systematic Review.
This article describes the scope and quality of evidence related to exercise interventions to improve sleep in women with breast cancer. Fifteen studies met the criteria and 12 were judged to be excellent quality. The most frequent intervention was walking, primarily during the time of chemotherapy. Eleven studies reported postintervention improvement in sleep deficiency. Most yoga, qigong, and dance intervention studies reported no differences between groups. Emerging evidence exists for the effectiveness of aerobic exercise to improve various sleep outcomes in women with breast cancer. PMID: 30098755 [PubMed - in pr...
Source: Clinical Breast Cancer - August 14, 2018 Category: Cancer & Oncology Authors: Matthews EE, Janssen DW, Djalilova DM, Berger AM Tags: Sleep Med Clin Source Type: research

The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia.
Abstract Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given ...
Source: Clinical Breast Cancer - August 14, 2018 Category: Cancer & Oncology Authors: Inzani F, Petrone G, Rindi G Tags: Endocrinol Metab Clin North Am Source Type: research

Risk factors for loco-regional recurrence in breast cancer patients: a retrospective study.
Authors: Merino T, Ip T, Domínguez F, Acevedo F, Medina L, Villaroel A, Camus M, Vinés E, Sánchez C Abstract Background: Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe & North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence. Results: Med...
Source: Oncotarget - August 14, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

CAPER as a therapeutic target for triple negative breast cancer.
Authors: Campbell MC, Pontiggia L, Russell AY, Schwarting R, Camacho J, Jasmin JF, Mercier I Abstract Breast cancers (BCas) that lack expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are referred to as triple negative breast cancers (TNBCs) and have the poorest clinical outcome. Once these aggressive tumors progress to distant organs, the median survival decreases to 12 months. With endocrine therapies being ineffective in this BCa subtype, highly toxic chemo- and radiation therapies are the only options. A better understanding of the function...
Source: Oncotarget - August 14, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Prosopis juliflora (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: in vitro and in vivo investigations.
In this study Prosopis juliflora leaves methanol extract was prepared and exposed to human breast cancer cell lines i.e. MDA-MB-231 and MCF-7 and human keratinocytes HaCaT as a representative of normal cells. Initially, a series of in vitro experiments like cell proliferation, migration, colony formation, cell cycle arrest and inhibition of angiogenesis. After confirmation of the efficient and selective activity against triple negative breast cancer cell line, we further evaluated the possible mechanism of inducing cell death and experiments like detection of reactive oxygen species, caspases and poly (ADP-ribose) polymera...
Source: Oncotarget - August 14, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells
Publication date: Available online 14 August 2018Source: International Journal of PharmaceuticsAuthor(s): Sabrina Nicolas, Marie-Alexandrine Bolzinger, Lars Petter Jordheim, Yves Chevalier, Hatem Fessi, Eyad AlmouazenAbstractClinical use of calcitriol (1,25-dihydroxyvitamin D3) as an anticancer agent is currently limited by the requirement of supraphysiological doses and associated hypercalcemia. Nanoencapsulation of calcitriol is a strategy to overcome these drawbacks, allowing reduced administrated doses and/or frequency, while retaining the therapeutic activity towards cancer cells. For this purpose, we investigated the...
Source: International Journal of Pharmaceutics - August 14, 2018 Category: Drugs & Pharmacology Source Type: research

Neoadjuvant Model as a Platform for Research in Breast Cancer and Novel Targets under Development in this Field
Breast Care (Source: Breast Care)
Source: Breast Care - August 14, 2018 Category: Cancer & Oncology Source Type: research

Induced Abortion, Birth Control Methods, and Breast Cancer Risk: A Case-Control Study in China.
Authors: Yuan X, Yi F, Hou C, Lee H, Zhong X, Tao P, Li H, Xu Z, Li J Abstract BACKGROUND: The association between induced abortion and birth control methods (including oral contraceptives and intrauterine devices) and breast cancer may vary among countries, due to the different usage and frequency of birth control methods and induced abortion among countries. A better understanding of this association may help in determining safer birth control methods for Chinese women. METHODS: A case-control study was conducted with a total of 794 cases and 805 controls. Standardized questionnaires were used to collect info...
Source: Journal of Epidemiology - August 14, 2018 Category: Epidemiology Tags: J Epidemiol Source Type: research

What causes patients with breast cancer to change employment?: evidence from the health insurance data in a medical facility.
This study aims to make clear the following aspects of breast cancer patients and their occupation. 1. What percentage of patients have changed their working status around surgery? 2. When did patients change their employment? 3. What is the cause of the employment change? We investigated 269 patients who underwent curative surgery for primary breast cancer at one university hospital in Tokyo. Patients who were under the age of 58 at the time of surgery and had the experience of being a company or government employee during a year prior to the surgery were used as sample for analysis. To determine factors related to the em...
Source: Industrial Health - August 14, 2018 Category: Occupational Health Tags: Ind Health Source Type: research

Bone in the breast? Long term toxicity 21 years after interstitial brachytherapy as a boost
Publication date: September–October 2018Source: Reports of Practical Oncology & Radiotherapy, Volume 23, Issue 5Author(s): Sara Imboden, Laura Knabben, Michael D. Mueller, Andreas R. Günthert, Kristina LösslAbstractAn 81-year-old patient developed an exulcerous tumor in her left breast 21 years after breast cancer treatment with lumpectomy and adjuvant radiotherapy. At the time of the initial treatment 21 years ago, whole breast irradiation was performed with a prescribed dose of 48 Gy and a maximal dose of 69 Gy. In addition, the patient received a 14.7 Gy boost with multicatheter brachytherapy a...
Source: Reports of Practical Oncology and Radiotherapy - August 14, 2018 Category: Cancer & Oncology Source Type: research

Synchronous bilateral breast cancer patients submitted to conservative treatment and brachytherapy – The experience of a service
ConclusionsBBC represents a complex challenge for doctors, because in some cases there is a tendency to use more aggressive treatments and, at the same time, it is not easy to achieve the timing for the correct treatment. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - August 14, 2018 Category: Cancer & Oncology Source Type: research

Assessment of biomechanical parameters of the shoulder joint at the operated side versus non-operated side in patients treated surgically for breast cancer
ConclusionNone of the treatment methods applied ensured a full release of the restriction within the shoulder and upper limb. The deficits observed may constitute a serious disorder of the musculoskeletal system; therefore, a clinical study of biomechanical parameters of the shoulder joint may be an important control of patients’ functional status after breast cancer treatment. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - August 14, 2018 Category: Cancer & Oncology Source Type: research

Apoptotic efficacy and antiproliferative potential of silver nanoparticles synthesised from aqueous extract of sumac (Rhus coriaria L.)
This study was conducted to determine the cytotoxic and apoptotic effects of AgNPs synthesised from sumac (Anacardiaceae family) fruit aqueous extract (AgSu/NPs) on human breast cancer cells (MCF-7). The anti-proliferative effect of AgSu/NPs was determined by MTT assay. The apoptotic properties of AgSu/NPs were assessed by morphological analysis and acridine orange/propidium iodide (AO/PI) and DAPI staining. The mechanism of apoptosis induction in treated cells was investigated using molecular analysis. Overall results of morphological examination and cytotoxic assay revealed that AgSu/NPs exert a concentration-dependent i...
Source: IET Nanobiotechnology - August 14, 2018 Category: Nanotechnology Source Type: research

GSE102653 Genome wide expression change by SMURF1 knocking down in MCF-7 cells
Contributor : J ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe aim to the investigate the role of SMURF1 in breast cancer progression. MCF-7 cells were used as the model and SMURF1 was silenced by siRNA. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - August 14, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies
Cancer cell dependence on activated oncogenes is therapeutically targeted, but acquired resistance is virtually unavoidable. Here we show that the treatment of addicted melanoma cells with BRAF inhibitors, and of breast cancer cells with HER2-targeted drugs, led to an adaptive rise in neuropilin-1 (NRP1) expression, which is crucial for the onset of acquired resistance to therapy. Moreover, NRP1 levels dictated the efficacy of MET oncogene inhibitors in addicted stomach and lung carcinoma cells. Mechanistically, NRP1 induced a JNK-dependent signaling cascade leading to the upregulation of alternative effector kinases EGFR ...
Source: Journal of Clinical Investigation - August 14, 2018 Category: Biomedical Science Authors: Sabrina Rizzolio, Gabriella Cagnoni, Chiara Battistini, Stefano Bonelli, Claudio Isella, Jo A. Van Ginderachter, René Bernards, Federica Di Nicolantonio, Silvia Giordano, Luca Tamagnone Source Type: research

Pattern of mortality after menopausal hormone therapy: long-term follow-up in a population based cohort.
CONCLUSIONS: In this long-term follow-up study, taking hormones during menopause was not associated with overall mortality among middle-aged women. Investigating cause-specific mortality revealed significant albeit weak associations differential according to both causes of death and over time underlining the importance of carefully considering individual risks and duration of treatment when making decisions on hormone therapy. This article is protected by copyright. All rights reserved. PMID: 30106241 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 14, 2018 Category: OBGYN Authors: Holm M, Olsen A, Au Yeung SL, Overvad K, Lidegaard Ø, Kroman N, Tjønneland A Tags: BJOG Source Type: research

Heart sparing breast cancer radiotherapy using continuous positive airway pressure (CPAP) and conventional supine tangential fields: an alternative method for patients with limited accessibility to advanced radiotherapy techniques.
PMID: 30106320 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 14, 2018 Category: Cancer & Oncology Authors: Kil WJ, Pham T, Kim K Tags: Acta Oncol Source Type: research

FDG / PET-CT based lymph node atlas in breast cancer patients
The aim of this study was to localize loco-regional lymph node metastases (LN) using FDG-PET datasets in 235 patients with 580 lymph nodes. A comprehensive LN atlas was created in this study comprising the largest number of lymph node metastases so far. Our quantitative data illustrate where lymph node metastases occur in different clinical situations and present areas at high risk (i.e “hot spots” of lymph node metastases). The ESTRO CTV and RTOG CTV do not provide coverage of the whole loco-regional lymphatic drainage. Whether target volumes that cover the whole loco-regional lymphatic drainage system are nec...
Source: International Journal of Radiation Oncology * Biology * Physics - August 14, 2018 Category: Radiology Authors: Kai Joachim Borm, Julia Voppichler, Mathias D üsberg, Markus Oechsner, Tibor Vag, Wolfgang Weber, Stephanie Elisabeth Combs, Marciana Nona Duma Tags: Physics Contribution Source Type: research

The mode of progressive disease affects the prognosis of patients with metastatic breast cancer
According to the Response Evaluation Criteria in Solid Tumors (RECIST), progressive disease (PD) is diagnosed under two conditions: an increase in size of pre-existing lesions (IS) and the appearance of new le... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - August 14, 2018 Category: Cancer & Oncology Authors: Ryutaro Mori, Manabu Futamura, Kasumi Morimitsu, Yoshimi Asano, Yoshihisa Tokumaru, Mai Kitazawa and Kazuhiro Yoshida Tags: Research Source Type: research

IJERPH, Vol. 15, Pages 1747: Breast Cancer and Its Relationship with the Microbiota
laza-Díaz Luis Fontana The microorganisms that live symbiotically in human beings are increasingly recognized as important players in health and disease. The largest collection of these microorganisms is found in the gastrointestinal tract. Microbial composition reflects both genetic and lifestyle variables of the host. This microbiota is in a dynamic balance with the host, exerting local and distant effects. Microbial perturbation (dysbiosis) could contribute to the risk of developing health problems. Various bacterial genes capable of producing estrogen-metabolizing enzymes have been identified. Accordingly,...
Source: International Journal of Environmental Research and Public Health - August 14, 2018 Category: Environmental Health Authors: Mariana F. Fern ández Iris Reina-P érez Juan Manuel Astorga Andrea Rodr íguez-Carrillo Julio Plaza-D íaz Luis Fontana Tags: Review Source Type: research

Disrupting a negative feedback loop drives endocrine therapy-resistant breast cancer [Medical Sciences]
According to the American Cancer Society, 266,120 women in the United States will be diagnosed with breast cancer and 40,920 will die in 2018 (1). Approximately 70% of all these breast cancers express estrogen receptor α (ERα) and are initially treated with endocrine therapies that target this nuclear hormone receptor... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 14, 2018 Category: Science Authors: Charles E. Foulds Tags: Commentaries Source Type: research

Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain [Medical Sciences]
The action of the collagen binding receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) in both tumor and tumor stromal cells has been established as critical for breast cancer metastasis. Small molecule inhibitors that target the extracellular domain of RTKs are rare, as they have classically been regarded as... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 14, 2018 Category: Science Authors: Whitney R. Grither, Gregory D. Longmore Tags: PNAS Plus Source Type: research

BRCA1/2 Testing in Medically Underserved Women With Breast or Ovarian Cancer
This study uses US community cohort data to assessBRCA1 andBRCA2 testing among medically underserved Medicare beneficiaries with breast cancer, ovarian cancer, or both. (Source: JAMA)
Source: JAMA - August 14, 2018 Category: General Medicine Source Type: research

Molecules, Vol. 23, Pages 2031: Synthesis and Cytotoxicity Studies of Novel NHC*-Gold(I) Complexes Derived from Lepidiline A
ng Zhu Matthias Tacke Ten novel N-heterocyclic carbene gold(I) complexes derived from lepidiline A (1,3-dibenzyl-4,5-dimethylimidazolium chloride) are reported here with full characterisation and biological testing. (1,3-Dibenzyl-4,5-diphenylimidazol-2-ylidene)gold(I) chloride (NHC*-AuCl) (1) was modified by substituting the chloride for the following: cyanide (2), dithiocarbamates (3–5), p-mercaptobenzoate derivatives (12–14) and N-acetyl-l-cysteine derivatives (15–17). All complexes were synthesised in good yields of 57–78%. Complexes 2, 12, 13, and 14 were fu...
Source: Molecules - August 14, 2018 Category: Chemistry Authors: Danielle Curran Oyinlola Dada Helge M üller-Bunz Matthias Rothemund Goar S ánchez-Sanz Rainer Schobert Xiangming Zhu Matthias Tacke Tags: Article Source Type: research

Unusual presentation of epidermoid cyst mimicking breast cancer involving the areola- case report
ConclusionIt is important to be aware of this entity of epidermoid cyst mimicking breast cancer, and the treatment options available in these cases. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - August 13, 2018 Category: Surgery Source Type: research

EBV Associated Breast Cancer Whole Methylome Analysis Reveals Viral and Developmental Enriched Pathways
Mohammad O. E. Abdallah, Ubai K. Algizouli, Maram A. Suliman, Rawya A. Abdulrahman, Mahmoud Koko, Ghimja Fessahaye, Jamal H. Shakir, Ahmed H. Fahal, Ahmed M. Elhassan, Muntaser E. Ibrahim, Hiba S. Mohamed (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - August 13, 2018 Category: Cancer & Oncology Source Type: research