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Differential expression of various clones of estrogen receptor in cell block preparation of lung adenocarcinoma
ConclusionsA small subset of pulmonary adenocarcinomas shows immunoreactivity for ER clones 6F11 and 1D5 in FNA samples (18.2% and 9.1%, respectively). The absence of immunoreactivity for ER‐SP1 clone indicates higher specificity of this clone in non‐breast tissue. The differential diagnostic value of all ER clones in malignant PEs appears to be secure. Larger studies are necessary to validate this observation. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - February 21, 2018 Category: Pathology Authors: Laleh Hakima, Kathie Schlesinger, Jaya Sunkara, Rouzan G. Karabakhtsian Tags: ORIGINAL ARTICLE Source Type: research

EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid
AbstractThe diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44 –67% at first lumbar puncture which increases to 84–91% upon second CSF sampling. Epithelial cell adhesion molecule (EpCAM) is expressed by solid tumors of epithelial origin like non-small-cell lung cancer, breast cancer or ovarium cancer. Recently, a CELLSEARCH® assay and flow cytometry laboratory techniques have been developed ...
Source: Journal of Neuro-Oncology - February 21, 2018 Category: Cancer & Oncology Source Type: research

Chemical Composition, Antibacterial and Antioxidant Activities of Essential Oils of Dryobalanops lanceolata Burck. Leaf
Conclusion: These results demonstrate that Dryobalanops lanceolata oil has high antimicrobial activity for bacterial that cause dental caries disease and are antioxidant. (Source: Research Journal of Medicinal Plant)
Source: Research Journal of Medicinal Plant - February 21, 2018 Category: Complementary Medicine Source Type: research

Screening mammography for average-risk women
This Practice Pearl describes an approach to screening mammography for average-risk women that encourages the use of shared decision-making that addresses benefits (early diagnosis and decreased mortality) and potential harms (false positives and overdiagnosis/overtreatment) in determining screening mammography initiation, frequency, and duration for women at average risk of breast cancer. (Source: Menopause)
Source: Menopause - February 21, 2018 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Polydopamine-Functionalized CA-(PCL-ran-PLA) Nanoparticles for Target Delivery of Docetaxel and Chemo-photothermal Therapy of Breast Cancer
Na Kong, Mei Deng, Xiu-Na Sun, Yi-Ding Chen, Xin-Bing Sui (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 21, 2018 Category: Drugs & Pharmacology Source Type: research

Ribociclib for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer.
Authors: Burris HA Abstract INTRODUCTION: The emergence of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors marked a significant advancement in the treatment of advanced breast cancer. Ribociclib is an orally bioavailable, highly selective inhibitor of CDK4/6. In combination with various endocrine therapies, ribociclib has demonstrated clinical activity as a first-line therapy for patients with HR+, HER2- advanced breast cancer, without compromising the favorable toxicity profile associated with endocrine therapy. Thus, ribociclib is now considered a new standard of care for HR+, HER2- advanced breast cancer. A...
Source: Expert Review of Anticancer Therapy - February 21, 2018 Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research

Unmet support needs of sexual and gender minority breast cancer survivors
ConclusionThis study provides quantitative and qualitative evidence that many SGM breast cancer patients face a dearth of appropriate social supports, both from breast cancer survivor organizations and from within the medical system. These findings confirm the need for research on the physical and emotional effects of breast cancer treatment on SGM breast cancer survivors, as well as further exploration of the social support needs and experiences of SGM breast cancer patients and their partners. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - February 21, 2018 Category: Cancer & Oncology Source Type: research

Serotonin transporter polymorphism, depressive symptoms, and emotional impulsivity among advanced breast cancer patients
This study tested a theory linking a marker of low serotonergic function to both depression and impulsivity in a sample of advanced breast cancer patients, among whom elevated depressive symptoms and difficulty regulating emotions are commonly reported.MethodsA total of 95 patients provided blood samples for serotonin transporter polymorphic region of the gene (5-HTTLPR) and completed questionnaires that measured depressive symptoms and emotional impulsivity.ResultsStructural equation modeling revealed that thes allele of 5-HTTLPR was related to greater depressive symptoms (β = .20,p 
Source: Supportive Care in Cancer - February 21, 2018 Category: Cancer & Oncology Source Type: research

Adolescent-young adults (AYA) with cancer seeking integrative oncology consultations: demographics, characteristics, and self-reported outcomes
ConclusionAYA patients make up a small number of overall referrals to an IO consultation, presenting with a low to moderate symptom burden. Physical CIM interventions such as yoga and pilates are of greater interest to the AYA population, suggesting the importance of making such interventions available in cancer programs serving this population. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - February 21, 2018 Category: Cancer & Oncology Source Type: research

miR-372 promotes breast cancer cell proliferation by directly targeting LATS2.
Authors: Cheng X, Chen J, Huang Z Abstract MicroRNAs (miRs) have previously been demonstrated to be important in the tumorigenesis and progression of breast cancer. miR-372 was previously revealed to be involved in various types of human cancer, however its function in breast cancer remains largely unknown. The present study demonstrated that miR-372 is frequently overexpressed in breast cancer cell lines and tissues. The downregulation of miR-372 markedly inhibited cell proliferation, arrested the cell cycle in the G1/S phase, and increased the apoptosis of breast cancer cells. Consistently, an in vivo xenograft s...
Source: Experimental and Therapeutic Medicine - February 21, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Silencing of TGIF sensitizes MDA-MB-231 human breast cancer cells to cisplatin-induced apoptosis.
Authors: Pan T, Mao T, Yang H, Wang H, Wang Y Abstract The present study was designed to explore the sensitivity of MDA-MB-231 cells to cisplatin after silencing the expression of TG-interacting factor (TGIF) protein. Cell viability was measured using an MTT assay. Cell apoptosis was detected by the annexin V and dead cell assay and the Hoechst staining assay. Protein expression was analyzed using western blot analysis. A colony formation assay was also performed. It was observed that cisplatin reduced the expression of TGIF protein in a dose- and time-dependent manner. Silencing TGIF significantly suppressed the c...
Source: Experimental and Therapeutic Medicine - February 21, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

GSE110824 Parallel-factor ER ChIP-seq of Breast Cancer PDX Material
Contributor : Andrew N HoldingSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo demonstrate the versatility of parallel-factor ChIP-seq, we applied our method to the analysis of ER binding in five patient-derived xenograft (PDX) samples. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 21, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Exploring Meaning in the Life of Chinese Breast Cancer Survivors
Conclusion: Chinese breast cancer survivors value physical health as well as spiritual fulfillment. The experience of adapting to life with cancer, having a good relationship with others, pursuing life goals, and fulfilling responsibility consists of a satisfying life, which makes life more meaningful. Implications for Practice: Health providers should pay more attention to survivors’ experience of meaning in life and help them enhance meaning in life and improve their quality of life through building good relationship with others, achieving purpose in life, and fulfilling responsibility for family and society. ...
Source: Cancer Nursing - February 21, 2018 Category: Nursing Tags: Articles Source Type: research

An Integrative Review of Psychosocial Concerns Among Young African American Breast Cancer Survivors
Conclusions: The review revealed key areas of psychosocial concerns among young AA survivors including ongoing anxiety/depression, cognitive changes, and relationships. Identified gaps include paucity of research with young AA survivors and their residual psychosocial concerns. Implications for Practice: Review findings indicate a need to increase survivorship research on young AA survivors. Researchers, clinicians, and young AA survivors must partner in efforts to understand psychosocial concerns and translate findings into clinical practice (ie, use of psychosocial distress tools, distress de-escalation protocols, a...
Source: Cancer Nursing - February 21, 2018 Category: Nursing Tags: Articles Source Type: research

Religiousness, Spirituality, and Salivary Cortisol in Breast Cancer Survivorship: A Pilot Study
Conclusions: Feasibility, validity, and acceptability of self-collected SDC biospecimens with an optional mail-back protocol (at moderate temperatures) were demonstrated. Positive spiritual beliefs were associated with neuroendocrine-mediated peak cortisol awakening response activity; however, additional research is recommended. Implications for Practice: Objective measures of DSC sampling that include enough collection time points to assess DSC parameters would increase the rigor of future DSC measurement. Breast cancer survivors may benefit from nursing care that includes spiritual assessment and therapeutic convers...
Source: Cancer Nursing - February 21, 2018 Category: Nursing Tags: Articles Source Type: research

Validation of the European Health Literacy Survey Questionnaire in Women With Breast Cancer
Conclusions: Our results supported the factorial validity of the 12-subdomain HLS-EU-Q with 46 items in women with breast cancer. It is recommended that the 12 subdomain scores be summed up to represent overall health literacy. Implications for Practice: The HLS-EU-Q with 46 items is recommended for use in capturing the diverse health literacy competencies of women with breast cancer in different health contexts. (Source: Cancer Nursing)
Source: Cancer Nursing - February 21, 2018 Category: Nursing Tags: Articles: Online Only Source Type: research

The Benefit of Pro Re Nata Antiemetics Provided With Guideline-Consistent Antiemetics in Delayed Nausea Control
Conclusion: Providing patients with strategies to further control nausea (p.r.n. antiemetics) in addition to guideline-consistent antiemetics is recommended for practice. Because the nausea experience contributes to symptom incidence in the next phase and cycle and because the nausea intensity demonstrated a significant relationship with function and global health/QOL, proactive supportive approaches are strongly recommended. Implications for Practice: Delayed nausea control may be improved by adhering to guideline-consistent antiemetics and using p.r.n. antiemetics. Delayed nausea control would contribute to patients...
Source: Cancer Nursing - February 21, 2018 Category: Nursing Tags: Articles: Online Only Source Type: research

Personalized Mammography Screening and Screening Adherence —A Simulation and Economic Evaluation
Personalized breast cancer screening has so far been economically evaluated under the assumption of full screening adherence. This is the first study to evaluate the effects of nonadherence on the evaluation and selection of personalized screening strategies. (Source: Value in Health)
Source: Value in Health - February 21, 2018 Category: International Medicine & Public Health Authors: Matthias Arnold, Anne S. Quante Source Type: research

Baseline factors predicting a response to neoadjuvant chemotherapy with implications for non ‐surgical management of triple‐negative breast cancer
ConclusionThe presence of microcalcifications on imaging and DCIS on initial CNB are associated with residual disease after neoadjuvant chemotherapy in TNBC. These variables can aid in identifying patients with TNBC suitable for inclusion in trials evaluating non‐surgical management after neoadjuvant chemotherapy. (Source: British Journal of Surgery)
Source: British Journal of Surgery - February 21, 2018 Category: Surgery Authors: R. F. D. van la Parra, A. B. Tadros, C. M. Checka, G. M. Rauch, A. Lucci, B. D. Smith, S. Krishnamurthy, V. Valero, W. T. Yang, H. M. Kuerer Tags: Original article Source Type: research

Pre-treatment anxiety is associated with persistent chemotherapy-induced peripheral neuropathy in women treated with neoadjuvant chemotherapy for breast cancer
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse reaction caused by chemotherapeutic agents, especially the taxanes. CIPN can persist from months to years after completion of chemotherapy, decreasing quality of life for cancer survivors. The aim of this study was to explore the incidence and risk factors of persistent CIPN among women with breast cancer receiving neoadjuvant chemotherapy. (Source: Journal of Psychosomatic Research)
Source: Journal of Psychosomatic Research - February 21, 2018 Category: Psychiatry & Psychology Authors: Kwang-Min Lee, Dooyoung Jung, Heesung Hwang, Kyung-Lak Son, Tae-Yong Kim, Seock-Ah Im, Kyung-Hun Lee, Bong-Jin Hahm Source Type: research

Cognitive Behavior Therapy for Fear of Cancer Recurrence: A Case Study
AbstractThis case study describes the course and content of cognitive behavior therapy (CBT) for clinical fear of cancer recurrence (FCR) in a breast cancer survivor. The CBT for clinical FCR consisted of seven face-to-face therapy sessions and one telephone session. The primary treatment goal was to reduce FCR severity by modifying cognitive processes and dysfunctional behavior. Assessments of FCR and quality of life were completed by the breast cancer survivor pre-therapy, post-therapy, and at 6 and 12 months of post-therapy. In each treatment session, perceived control over FCR was assessed. A clinical nurse specialist ...
Source: Journal of Clinical Psychology in Medical Settings - February 21, 2018 Category: Psychiatry & Psychology Source Type: research

The Role of Optimism, Social Constraints, Coping, and Cognitive Processing in Psychosocial Adjustment Among Breast Cancer Survivors
AbstractThe social-cognitive processing model suggests that a socially constrained environment may impede adjustment to a chronic illness. The present study primarily investigated the mediating psychological pathways through which social constraints on cancer-related disclosure, low optimism, disengagement-oriented coping, and brooding could be associated with low levels of psychosocial adjustment. One hundred twenty-five female breast cancer survivors participated in a cross-sectional study. Path analysis was used to examine the proposed model. Low optimism, increased social constraints, and higher levels of brooding appe...
Source: Journal of Clinical Psychology in Medical Settings - February 21, 2018 Category: Psychiatry & Psychology Source Type: research

Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer
ConclusionThese findings reveal for the first time that hydroxytyrosol is an active partner in combined therapies with paclitaxel against breast cancer. Combination with hydroxytyrosol would also ensure a less oxidative impact of chemotherapeutic drugs that could potentially improve patient wellness. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - February 21, 2018 Category: Nutrition Source Type: research

Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids
Publication date: Available online 21 February 2018 Source:Acta Pharmaceutica Sinica B Author(s): Jian Bai, Rong Mu, Man Dou, Daojiang Yan, Bingyu Liu, Qian Wei, Jun Wan, Yi Tang, Youcai Hu Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula ΔhdaA strain resu...
Source: Acta Pharmaceutica Sinica B - February 21, 2018 Category: Cancer & Oncology Source Type: research

Novel guidelines on surveillance for breast cancer, cardiomyopathy, male gonadotoxicity, and premature ovarian insufficiency from the PanCare and International Guideline Harmonization Group on long-term follow-up after cancer in childhood
SummarySurvival after childhood cancer has improved substantially; therefore, the number of childhood cancer survivors is increasing. This growing population of childhood cancer survivors, however, is at risk of a  spectrum of adverse health outcomes. Unfortunately, until now, there was a lack of comprehensive follow-up recommendations. The purpose of this article is to provide information on recently developed harmonized evidence-based guidelines on surveillance investigations to screen for the early detec tion of breast cancer, cardiomyopathy, male gonadotoxicity, and premature ovarian failure in childhood canc...
Source: Memo - Magazine of European Medical Oncology - February 21, 2018 Category: Cancer & Oncology Source Type: research

X ‐ray‐enhanced cancer cell migration requires the linker of nucleoskeleton and cytoskeleton complex
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 21, 2018 Category: Cancer & Oncology Authors: Hiromasa Imaizumi, Katsutoshi Sato, Asuka Nishihara, Kazumasa Minami, Masahiko Koizumi, Nariaki Matsuura, Miki Hieda Tags: Original Article Source Type: research

Randomized phase II study of anastrozole plus tegafur-uracil as neoadjuvant therapy for ER-positive breast cancer in postmenopausal Japanese women (Neo-ACET BC)
ConclusionAlthough the study was terminated owing to the altered liver function, it showed that there was a trend to greater shrinkage of tumor in the combination group for ER-positive, HER2-negative postmenopausal breast cancer. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - February 21, 2018 Category: Cancer & Oncology Source Type: research

Tumor-associated macrophages and crown-like structures in adipose tissue in breast cancer
AbstractPurposeWe aimed to evaluate macrophage infiltration and to identify the status of crown-like structures (CLSs) in mammary adipose tissue of human breast tissue in cases with and without breast cancer.MethodsBreast adipose tissue was obtained from reduction mammoplasty (N = 56, Group 1), non-neoplastic breast tissue of breast cancer patients (N = 84, Group 2), and breast cancer with adipose stroma (N = 140, Group 3). Immunohistochemical staining of CD68 and CD163 was performed, and the infiltrating macrophages and CLSs within breast adipose tissue were evaluated.ResultsGroup 3 had the l...
Source: Breast Cancer Research and Treatment - February 21, 2018 Category: Cancer & Oncology Source Type: research

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient
ConclusionThis novel human breast cancer-bone metastasis cell line will be a useful model to study aspects of breast cancer biology, particularly metastasis-related changes from breast to bone. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - February 21, 2018 Category: Cancer & Oncology Source Type: research

An electrochemical aptasensor based on gold nanoparticles and graphene oxide doped poly(3,4-ethylenedioxythiophene) nanocomposite for detection of MUC1
Publication date: 15 March 2018 Source:Journal of Electroanalytical Chemistry, Volume 813 Author(s): Pernika Gupta, Anu Bharti, Navpreet Kaur, Suman Singh, Nirmal Prabhakar In the present work, we have developed an electrochemical aptasensor for detection of breast cancer biomarker protein, mucin1 (MUC1). Gold nanoparticles (AuNPs) and graphene oxide (GO) doped Poly(3,4-ethylenedioxythiophene) (PEDOT) nanocomposite films were deposited onto the surface of fluorine tin oxide (FTO) glass sheets by electropolymerization using chronoamperometry technique at a potential of 1.0 V for 180 s. MUC1 specific biotinylated aptame...
Source: Journal of Electroanalytical Chemistry - February 21, 2018 Category: Chemistry Source Type: research

Preservation of the nipple –areola complex in skin-sparing mastectomy for early breast cancer
ConclusionsThe outcomes of SSM in this series were excellent and NSM might have been an option for about one-third of the patients. (Source: Surgery Today)
Source: Surgery Today - February 21, 2018 Category: Surgery Source Type: research

Expression of MAGE ‐A and NY‐ESO‐1 cancer‐testis antigens is enriched in triple‐negative invasive breast cancers
Abstract AimsA better understanding of the expression of cancer testis antigens (CTA) in breast cancer might identify new immunotherapy options, especially for triple‐negative (TN) tumours, which lack expression of conventional therapeutic targets ER, PR and HER2 (receptors for Oestrogen, Progesterone and Human epidermal growth factor). The aim of this study was to quantify the expression of MAGE‐A and NY‐ESO‐1 CTAs in breast cancer, and relate this to known clinicopathologic parameters. Methods and resultsWe surveyed MAGE‐A and NY‐ESO‐1 protein expression in an unselected cohort of 367 breast tumours (out o...
Source: Histopathology - February 21, 2018 Category: Pathology Authors: Ashwini Raghavendra, Priyakshi Kalita ‐de Croft, Ana Cristina Vargas, Chanel E. Smart, Peter T. Simpson, Jodi M. Saunus, Sunil R. Lakhani Tags: Original Article Source Type: research

Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy.
Authors: Cao S, Guo J, He Y, Alahdal M, Tang S, Zhao Y, Yang Z, Gao H, Hu W, Jiang H, Qin L, Jin L Abstract The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired...
Source: Artificial Cells, Nanomedicine and Biotechnology - February 20, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Support with nutrition for women receiving chemotherapy for breast cancer.
Abstract Nurses are in a unique position to provide nutritional advice and information to women with breast cancer who are undergoing chemotherapy, supporting them with making decisions regarding nutrition and diet. This narrative review evaluated the research evidence relating to the nutritional challenges experienced during chemotherapy and the most effective approaches for supporting women in dietary choice. Weight gain was identified as a specific problem for women undergoing chemotherapy. The evidence indicated that information about nutrition and food preparation support may go some way in assisting women to...
Source: British Journal of Nursing - February 20, 2018 Category: Nursing Authors: Gilmour F, Williams A Tags: Br J Nurs Source Type: research

Supporting patients with breast cancer through communication and research.
PMID: 29457947 [PubMed - in process] (Source: British Journal of Nursing)
Source: British Journal of Nursing - February 20, 2018 Category: Nursing Authors: Mitchell H Tags: Br J Nurs Source Type: research

From nurse to service user: a personal cancer narrative.
This article presents a snapshot of my experience of being a nurse who became a service user with breast cancer. It begins by outlining the Humanization of Healthcare Framework ( Todres et al, 2009 ), which is a values-based context that can be used to underpin daily care. Generic applications for each of the dimensions of the framework are suggested. This framework is then used to contextualise my experience of receiving my diagnosis and the ensuing chemotherapy. Using examples from my personal narrative, I make some recommendations for 'small actions' that can contribute to more humanised and person-centred care. I also ...
Source: British Journal of Nursing - February 20, 2018 Category: Nursing Authors: Knight A Tags: Br J Nurs Source Type: research

Men seeking counselling in a Breast Cancer Risk Evaluation Clinic.
Conclusion: We observed a high adherence to counselling, genetic testing and active surveillance by men belonging to hereditary BC families. Male carriers of pathogenic DNA variants are at risk for several cancers and should be included in prospective follow-up studies. PMID: 29456621 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Estrogen receptor- α promoter methylation is a biomarker for outcome prediction of cisplatin resistance in triple-negative breast cancer.
Estrogen receptor-α promoter methylation is a biomarker for outcome prediction of cisplatin resistance in triple-negative breast cancer. Oncol Lett. 2018 Mar;15(3):2855-2862 Authors: Xu J, Sun T, Guo X, Wang Y, Jing M Abstract A number of previous studies have indicated the presence of a link between estrogen receptor-α (ERα) methylation and triple-negative breast cancer (TNBC). However, the association between ERα methylation and drug resistance during the treatment of TNBC remains unclear. Methylation-specific polymerase chain reaction was used to investigate the methylation o...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-96 promotes breast cancer metastasis by suppressing MTSS1.
In conclusion, it was identified that miR-96 exhibited an increased level in serum samples of patients with malignant breast cancer in comparison with benign breast tumor types and health controls and may be substantially reduced by chemotherapy treatment, implying that it may be used as a prognostic marker in breast cancer. miR-96 overexpression may inhibit migration of breast cancer cells by downregulating MTSS1 expression. PMID: 29456723 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype.
Authors: Yang M, Xu J, Wang Q, Zhang AQ, Wang K Abstract A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor-bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, particularly distributed in regions surrounding the bacteria. M2 macrophages are associated with breast cancer aggressiveness, whereas M1 macrophages are prone to devouring bacteria and killing cancer cells. Therefore, this engineered tumor-targeting...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Checkpoint Inhibitors in Breast Cancer - Current Status and Future Directions
Breast Care (Source: Breast Care)
Source: Breast Care - February 20, 2018 Category: Cancer & Oncology Source Type: research

Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling
In this study, we investigated the functional a... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 20, 2018 Category: Cancer & Oncology Authors: Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun, Li-Sheng Zheng, Li-Xia Peng, Jun-Ping Yang, Dong-Fang Meng, Yan-Hong Lang, Yan Mei, Ping Xie, Liang Xu, Yun Cao, Wen-Wen Wei, Li Cao, Hao Hu, Qin Yang & hellip; Tags: Research Source Type: research

Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes
Epigenetic regulators are frequently mutated or aberrantly expressed in a variety of cancers, leading to altered transcription states that result in changes in cell identity, behavior, and response to therapy. (Source: BMC Genomics)
Source: BMC Genomics - February 20, 2018 Category: Genetics & Stem Cells Authors: Yuanxin Xi, Jiejun Shi, Wenqian Li, Kaori Tanaka, Kendra L. Allton, Dana Richardson, Jing Li, Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Luis Della Coletta, Melissa S. Simper, Khandan Keyomarsi, Jianjun Shen, Mark T. Bedford, Xiaobing Shi & helli Tags: Research article Source Type: research

MR Imaging –Guided Breast Interventions
MR imaging is now routinely performed for breast cancer screening and staging. For suspicious MR imaging –detected lesions that are mammographically and sonographically occult, MR imaging–guided breast interventions, including biopsy, clip placement, and preoperative needle localization, have been developed to permit accurate tissue diagnosis and aid in surgical planning. These procedures are safe, accurate, and effective when performed according to key principles, including proper patient selection, use of appropriate technique, adequate preprocedure preparation and postprocedure patient care, and postprocedur...
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2018 Category: Radiology Authors: Lumarie Santiago, Rosalind P. Candelaria, Monica L. Huang Source Type: research

Comparison of Contrast-Enhanced Mammography and Contrast-Enhanced Breast  MR Imaging
Contrast-enhanced mammography (CEM) is a contrast-enhanced modality for breast cancer detection that utilizes iodinated contrast and dual-energy imaging performed on a digital mammography unit with only slight modifications. It is approved by the US Food and Drug Administration, commercially available, and in routine clinical use at centers around the world. It has similar sensitivity and specificity to MR Imaging and has advantages in terms of cost, patient acceptability, and examination time. MR Imaging has some advantages compared with CEM, especially in its ability to image the complete axilla and the chest wall. (Sour...
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2018 Category: Radiology Authors: John Lewin Source Type: research

How Does MR Imaging Help Care for My Breast Cancer Patient? Perspective of a Radiation Oncologist
Radiation therapy is used in many cases of both early and late breast cancer. The authors examine the role of MR imaging as it pertains to radiotherapy planning and treatment approaches for patients with breast cancer. MR imaging can assist the radiation oncologist in determining the best radiation approach and in creating treatment planning volumes. MR imaging may be useful in the setting of accelerated partial breast irradiation. Radiation oncologists should attend to MR breast images, when obtained, to ensure that these imaging findings are taken into consideration when developing a radiation therapy plan. (Source: Magn...
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2018 Category: Radiology Authors: Kaitlin M. Christopherson, Benjamin D. Smith Source Type: research

Role of MR Imaging for the Locoregional Staging of Breast Cancer
Breast MR imaging has been shown to identify unsuspected sites of cancer in the ipsilateral breast in 16% of women with newly diagnosed breast cancer. Breast MR imaging identifies occult cancer in the contralateral breast in 3% to 5% of women. Early evidence suggests that the added value of MR imaging for staging may be attenuated in women who also undergo tomosynthesis, particularly those with nondense breasts. Breast MR imaging is complementary to ultrasound imaging in evaluating regional nodal basins. Ongoing prospective randomized clinical trials should clarify the impact of preoperative breast MR imaging on clinical o...
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2018 Category: Radiology Authors: Kimberly M. Ray, Jessica H. Hayward, Bonnie N. Joe Source Type: research

How Does MR Imaging Help Care for My Breast Cancer Patient? Perspective of a Surgical Oncologist
MR imaging is now readily available for surgeons to incorporate into their practice, thus, begging the question, is this new modality clinically useful? Current literature and expert opinion are reviewed concerning the implementation of breast MR imaging to clinical management of breast cancer. Although breast MR imaging is acknowledged to be highly sensitive in detection of breast cancer, its routine application to surgical practice remains controversial because these gains in sensitivity have not been demonstrated to translate into improved long-term patient outcomes. Current clinical trials and the future of breast MR i...
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2018 Category: Radiology Authors: Benjamin Raber, Vivian J. Bea, Isabelle Bedrosian Source Type: research

Problem-Solving MR Imaging for Equivocal Imaging Findings and Indeterminate Clinical Symptoms of the Breast
Breast MR imaging is commonly used for high-risk screening and for assessing the extent of disease in patients with newly diagnosed breast cancer, but its utility for assessing suspicious symptoms and equivocal imaging findings is less widely accepted. The authors review current literature and guidelines regarding the use of breast MR imaging for these indications. Overall, problem-solving breast MR imaging is best reserved for pathologic nipple discharge and sonographically occult architectural distortion with limited biopsy options. Further study is necessary to define the role of problem-solving MR imaging for calcifica...
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2018 Category: Radiology Authors: Ethan Cohen, Jessica W.T. Leung Source Type: research

How Does MR Imaging Help Care for the Breast Cancer Patient? Perspective of a Medical Oncologist
This article reviews the impact of MR imaging in different settings on medical oncology decision-making in patients with breast cancer. (Source: Magnetic Resonance Imaging Clinics of North America)
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2018 Category: Radiology Authors: Akshara S. Raghavendra, Debu Tripathy Source Type: research