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Preclinical impact of high dose intermittent antiangiogenic tyrosine kinase inhibitor pazopanib in intrinsically resistant tumor models
In conclusion, these results overall suggest that primary tumors showing sensitivity to continuous pazopanib treatment may predict response to this drug when given at high doses intermittently in the context of advanced metastatic disease, that are otherwise resistant to the conventional protocol. (Source: Angiogenesis)
Source: Angiogenesis - May 21, 2018 Category: Molecular Biology Source Type: research

Synthesis, characterization, crystal structure, Hirshfeld interaction and bio-evaluation studies of 4-amino quinazoline sulfonamide derivatives
Publication date: 5 September 2018 Source:Journal of Molecular Structure, Volume 1167 Author(s): A. Sunil Kumar, Jyothi Kudva, S. Madan Kumar, U. Vishwanatha, Vasantha Kumar, Damodara Naral In the present work, two new potentially active quinazolin-4-yl-aminobenzenesulfonamide derivatives, N-(5-methyl-1,2-oxazol-3-yl)-4-[(quinazolin-4-yl)amino]benzene-1-sulfonamide (4a) and N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-[(quinazolin-4-yl)amino]benzene-1-sulfonamide (4b), were synthesized and the structures were confirmed by different spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, HRMS and elemental analysis. The crystal struct...
Source: Journal of Molecular Structure - May 21, 2018 Category: Molecular Biology Source Type: research

Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance
Publication date: Available online 20 May 2018 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Cristina Amaral, Tiago Vieira Augusto, Elisiário Tavares-da-Silva, Fernanda M.F. Roleira, Georgina Correia-da-Silva, Natércia Teixeira The leading cause of cancer death in women around the world is breast cancer. The aromatase inhibitors (AIs) are considered a first-line treatment for estrogen receptor-positive (ER+) breast tumors, in postmenopausal women. Exemestane (Exe) is a powerful steroidal AI, however, despite its therapeutic success, Exe-acquired resistance may occur leading to t...
Source: The Journal of Steroid Biochemistry and Molecular Biology - May 21, 2018 Category: Biochemistry Source Type: research

3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents
Publication date: 1 August 2018 Source:Life Sciences, Volume 206 Author(s): Qian Zhou, Chaoqun You, Cong Zheng, Yawen Gu, Hongchao Gu, Rui Zhang, Hongshuai Wu, Baiwang Sun DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer therapy. A series of novel 3-nitroacridine-based derivati...
Source: Life Sciences - May 20, 2018 Category: Biology Source Type: research

Inequities in genetic testing for hereditary breast cancer: implications for public health practice
AbstractThe Ontario Breast Screening Program for women with a genetic predisposition to breast cancer is one of the first international models of a government-funded public health service that offers systematic genetic screening to women at a high risk of breast cancer. However, since the implementation of the program in 2011, enrolment rates have been lower than anticipated. Whilst there may be several reasons for this to happen, it does call into consideration the ‘inverse equity law’, whereby the more advantaged in society are the first to participate and benefit from universal health services. An outcome of...
Source: Journal of Community Genetics - May 20, 2018 Category: Genetics & Stem Cells Source Type: research

Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors.
Authors: Meirson T, Genna A, Lukic N, Makhnii T, Alter J, Sharma VP, Wang Y, Samson AO, Condeelis JS, Gil-Henn H Abstract Metastatic dissemination of cancer cells from the primary tumor and their spread to distant sites in the body is the leading cause of mortality in breast cancer patients. While researchers have identified treatments that shrink or slow metastatic tumors, no treatment that permanently eradicates metastasis exists at present. Here, we show that the ABL kinase inhibitors imatinib, nilotinib, and GNF-5 impede invadopodium precursor formation and cortactin-phosphorylation dependent invadopodium matur...
Source: Oncotarget - May 19, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy.
Authors: Aqbi HF, Tyutyunyk-Massey L, Keim RC, Butler SE, Thekkudan T, Joshi S, Smith TM, Bandyopadhyay D, Idowu MO, Bear HD, Payne KK, Gewirtz DA, Manjili MH Abstract Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse earlier than others. In addition, some tumor clones respond to immunotherapy while others do not. We investigated how autophagy plays a role in accelerating or delaying recurrence of neu-overexpressing...
Source: Oncotarget - May 19, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Long-term exposure to carcinoma-associated fibroblasts makes breast cancer cells addictive to integrin β1.
Long-term exposure to carcinoma-associated fibroblasts makes breast cancer cells addictive to integrin β1. Oncotarget. 2018 Apr 24;9(31):22079-22094 Authors: Dittmer A, Dittmer J Abstract We studied the long-term effect of stromal factors on the development of fulvestrant-resistance (FR) and fulvestrant-induced dormancy (D). Sublines established from stroma-treated FR-cells (C-FR cells) and D-cells (C-D cells) show permanently high expression of integrin β1 as well as Bcl-3 and P-STAT3 (C-FR) or IGF1R (C-D). Yet, cells fail to withstand fulvestrant better and do not migrate or grow faster tha...
Source: Oncotarget - May 19, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Breast cancer and cervical cancer prevention programmes carried out by local government units in Poland in 2009-2014.
Conclusion: It was found that the number of programmes implemented by particular local government units and the financial resources employed in the implementation of the programmes were different. It is probable that some of the initiatives of local government units related to secondary prevention coincide with the actions undertaken under the National Programme for Fighting Cancer. The entities that carry out breast cancer and cervical cancer prevention programmes need to coordinate their actions. PMID: 29774114 [PubMed] (Source: Oncotarget)
Source: Oncotarget - May 19, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance.
Authors: Piktel E, Prokop I, Wnorowska U, Król G, Cieśluk M, Niemirowicz K, Savage PB, Bucki R Abstract Natural antimicrobial peptides and ceragenins, as non-peptide amphipathic mimics, have been proposed as anti-cancer agents. To date, it has been confirmed that cathelicidin LL-37 and ceragenin CSA-13, both in free form and immobilized on the surface of magnetic nanoparticles (MNP@LL-37, MNP@CSA-13) induce apoptosis in colon cancer cells. Nevertheless, the question remains whether ceragenins, as synthetic analogs of LL-37 peptide and mimicking a number of its properties, act as antineoplastic agents in bre...
Source: Oncotarget - May 19, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

SIK2 attenuates proliferation and survival of breast cancer cells with simultaneous perturbation of MAPK and PI3K/Akt pathways.
Authors: Zohrap N, Saatci Ö, Ozes B, Coban I, Atay HM, Battaloglu E, Şahin Ö, Bugra K Abstract Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as a potential tumor suppressor in breast cancer whose expression was reduced in tumor tissues and breast cancer cell lines compared to normal counterparts. In vitro loss- and gain-of-function experiments combined with xenograft studies demonstrated that SIK2-mediated attenuation of proliferation ...
Source: Oncotarget - May 19, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Sternocleidomastoid muscle metastasis of breast cancer: case report.
Authors: Khettab M, Barrascout E, Lamuraglia M Abstract The authors report a case of 84-year-old women, with dysphagia to liquids and solid foods, and with infiltration of right stemocleidomastoid muscle that compressed the upper third of the esophagus to the thoracic hull. The biopsy of sternocleidomastoid muscle permitted the diagnosis of metastatic breast cancer relapse after 22 years. PMID: 29767876 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Treosulfan for advanced breast cancer in a heavily pre-treated patient - a case report.
CONCLUSION: Treosulfan might be an effective and well-tolerated treatment even in heavily pre-treated patients with metastatic breast cancer. PMID: 29767877 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Influence of VEGF, COX-2, and MMP-9 expression on the molybdenum-targeted X-ray in breast cancer.
CONCLUSION: Expression of VEGF, COX-2, and MMP-9 is highly correlated to the mammaographic appearance of spiculation, vascular abnormalities, and lymph node metastasis. However, the present results suggest that expression of VEGF, COX-2, and MMP-9 is either not or weakly correlated to mammographic appereance of calcification. PMID: 29767863 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Patterns of recurrence and outcomes in patients with luminal breast cancer: a retrospective study.
CONCLUSIONS: Luminal breast cancer patients with recurrence or/and metastasis had better prognosis after reasonable treatment. These results are of potential clinical relevance, especially for clinical prognosis monitoring and targeted therapy interventions in patients with luminal breast cancer. PMID: 29767858 [PubMed - in process] (Source: European Journal of Gynaecological Oncology)
Source: European Journal of Gynaecological Oncology - May 19, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

The impact of different tumour subtypes on management and survival of New Zealand women with Stage I-III breast cancer.
CONCLUSIONS: The pattern of phenotype in women with Stage I-III breast cancer is similar to the overseas cohorts. Most New Zealand women with Luminal A breast cancer have a very good prognosis, but the less common subtypes have relatively poor outcomes. PMID: 29771902 [PubMed - in process] (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - May 19, 2018 Category: General Medicine Tags: N Z Med J Source Type: research

IMP3 promotes TNBC stem cell property through miRNA-34a regulation.
CONCLUSIONS: IMP3 plays a vital role in maintaining stem cell properties of breast cancer cells, which could be regulated by mir-34a. PMID: 29771420 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 19, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MiR-1271 as a tumor suppressor in breast cancer proliferation and progression via targeting SPIN1.
CONCLUSIONS: miR-1271 can suppress breast cancer cell proliferation and progression via SPIN1, which may provide a potential therapeutic target in treatment for breast cancer. PMID: 29771421 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 19, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Impact of Second-Opinion Interpretation of  Breast Imaging Studies in Patients Not Currently Diagnosed With Breast Cancer
To study the impact of second-opinion interpretation of breast imaging studies submitted from outside facilities to a tertiary cancer center. (Source: Journal of the American College of Radiology : JACR)
Source: Journal of the American College of Radiology : JACR - May 19, 2018 Category: Radiology Authors: Lauren Q. Chang Sen, Ray C. Mayo, Michele D. Lesslie, Wei T. Yang, Jessica W.T. Leung Tags: Original article Source Type: research

Current Frontline Endocrine Treatment Options for Women with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Advanced-Stage Breast Cancer
Publication date: Available online 19 May 2018 Source:Hematology/Oncology and Stem Cell Therapy Author(s): Hikmat N. Abdel-Razeq Despite the recent advances in breast cancer early detection and awareness, a significant portion of patients present with an advanced-stage disease and more patients will progress to stage IV despite adequate treatment of their initial early-stage disease. Hormone receptor (HR)-positive, Human Epidermal Growth Factor Receptor-2 (HER2)-negative subtype is the commonest among all breast cancer subtypes. The management of the advanced-stage disease of this subtype has evolved significantly over th...
Source: Hematology Oncology and Stem Cell Therapy - May 19, 2018 Category: Cancer & Oncology Source Type: research

Corrigendum to “CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells” [Cancer Lett 412 (2018 Jan 1) 88–98]
The authors regret that upper (#1) and bottom (#4) pictures were mistakenly identical in normal and ovarian cancer patient's tissues in Fig. 1C. The authors would like to apologise for any inconvenience caused. (Source: Cancer Letters)
Source: Cancer Letters - May 19, 2018 Category: Cancer & Oncology Authors: E.J. Sohn, D.B. Jung, H. Lee, I. Han, J. Lee, H. Lee, S.H. Kim Tags: Corrigendum Source Type: research

Modeling triple-negative breast cancer heterogeneity: Effects of stromal macrophages, fibroblasts and tumor vasculature
In this study we focus on the contributions of stromal cells, specifically macrophages, fibroblasts, and endothelial cells on tumor progression. We develop a computational model of triple-negative breast cancer based on our previous work and expand it to include macrophage infiltration, fibroblasts, and angiogenesis. In vitro studies have shown that the secretomes of tumor-educated macrophages and fibroblasts increase both the migration and proliferation rates of triple-negative breast cancer cells. In vivo studies also demonstrated that blocking signaling of selected secreted factors inhibits tumor growth and metastasis i...
Source: Journal of Theoretical Biology - May 19, 2018 Category: Biology Source Type: research

Functionalized graphene oxides for drug loading, release and delivery of poorly water soluble anticancer drug: A comparative study
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Neha Karki, Himani Tiwari, Mintu Pal, Alok Chaurasia, Rajaram Bal, Penny Joshi, Nanda Gopal Sahoo In this work, the modification of graphene oxides (GOs) have been done with hydrophilic and biodegradable polymer, polyvinylpyrrolidone (PVP) and other excipient β −cyclodextrin (β-CD) through covalent functionalization for efficient loading and compatible release of sparingly water soluble aromatic anticancer drug SN-38 (7-ethyl-10-hydroxy camptothecin). The drug was loaded onto both GO-PVP and GO-β-CD...
Source: Colloids and Surfaces B: Biointerfaces - May 19, 2018 Category: Biochemistry Source Type: research

In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark.
Abstract The present study was designed to evaluate the in vitro and in vivo antitumor effects of A. seyal hydroethanolic extract on breast cancer. The cytotoxicity of A. seyal extract was evaluated using resazurin reduction assay in 9 cell lines. Further, the protective effect of the hydroethanolic extract of A. seyal stem barks was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast cancer rat model. Incidence, burden, volume, and histological analysis of mammary tumors were measured. The Acacia seyal extract exhibited CC50 of 100 in MCF-7 cells after 24 h. In vivo, no tumors were detected...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Zingue S, Njuh AN, Tueche AB, Tamsa J, Tchoupang EN, Kakene SD, Sipping MTK, Njamen D Tags: Biomed Res Int Source Type: research

A novel non-invasive strategy for low-level laser-induced cancer therapy by using new Ag/ZnO and Nd/ZnO functionalized reduced graphene oxide nanocomposites.
Authors: Jafarirad S, Hammami Torghabe E, Rasta SH, Salehi R Abstract In the present research, an effective drug-free approach was developed to kill MCF7 breast cancer cells using low-level laser therapy (LLLT) combined with reduced graphene oxide (rGO)-based hybrid nanocomposites (NCs). Here, fruit extract of Rosa canina was used for the first time to obtain the rGO/ZnO, Ag-ZnO/rGO and Nd-ZnO/rGO NCs by green synthesis. Physico/photochemical properties of these NCs were evaluated using FTIR, XRD, Raman, XPS, SEM/EDX, UV-Vis, DLS and AFM. The potential of the as-synthesized NCs on ROS generating and antioxidant act...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 18, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Differential microRNA profiles between fulvestrant-resistant and tamoxifen-resistant human breast cancer cells
Increasing evidence has shown that the dysregulation of microRNAs (miRNAs) is associated with drug resistance. Fulvestrant and tamoxifen represent the major endocrine drugs for the treatment of breast cancer patients, and yet little is known about the biological mechanisms of acquiring resistance to fulvestrant and tamoxifen, let alone the differences between cell lines resistant to these two drugs. Exploration of the differential miRNA profiles between these two cell lines is a useful way to further clarify these resistance mechanisms. The fulvestrant-resistant cell line (MCF7-F) and the tamoxifen-resistant cell line (MCF...
Source: Anti-Cancer Drugs - May 18, 2018 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

Methotrexate-conjugated to polymer quantum dot for cytotoxicity effect improved against MCF-7 and Hela cells
AbstractMethotrexate (MTX) is a folic acid derivative that is used for the treatment of different malignancies, whose applications have become limited by its toxic dose-related side effect and the possible initiation of drug resistance. The aim of the present research is to study the enhancement of the cellular cytotoxicity of MTX as an anticancer drug by conjugation to the synthesized polymer dots ’ (Pdots) surface. This conjugation was developed covalently by carbodiimide chemistry and characterized with Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), and UV–Vis spectroscopy. ...
Source: Medicinal Chemistry Research - May 18, 2018 Category: Chemistry Source Type: research

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab
In conclusion, we identified no SNPs significantly associated with NAC. The observation, in a hypothesis-generating GWAS, of an SNP in CDKAL1 associated with pCR in the bevacizumab arm of both B-40 and GeparQuinto requires further validation and study. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - May 18, 2018 Category: Genetics & Stem Cells Tags: Short Communication Source Type: research

ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer
Heather M. Bond, Stefania Scicchitano, Emanuela Chiarella, Nicola Amodio, Valeria Lucchino, Annamaria Aloisio, Ylenia Montalcini, Maria Mesuraca, Giovanni Morrone (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - May 18, 2018 Category: Endocrinology Source Type: research

Acquired resistance to everolimus in aromatase inhibitor-resistant breast cancer.
Authors: Kimura M, Hanamura T, Tsuboi K, Kaneko Y, Yamaguchi Y, Niwa T, Narui K, Endo I, Hayashi SI Abstract We previously reported the establishment of several types of long-term estrogen-depleted-resistant (EDR) cell lines from MCF-7 breast cancer cells. Type 1 EDR cells exhibited the best-studied mechanism of aromatase inhibitor (AI) resistance, in which estrogen receptor (ER) expression remained positive and PI3K signaling was upregulated. Type 2 EDR cells showed reduced ER activity and upregulated JNK-related signaling. The mTOR inhibitor everolimus reduced growth in cells similar to Type 1 EDR cells. The pres...
Source: Oncotarget - May 18, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer.
Authors: Avivar-Valderas A, McEwen R, Taheri-Ghahfarokhi A, Carnevalli LS, Hardaker EL, Maresca M, Hudson K, Harrington EA, Cruzalegui F Abstract The PI3Kα signaling pathway is frequently hyper-activated in breast cancer (BrCa), as a result of mutations/amplifications in oncogenes (e.g. HER2), decreased function in tumor suppressors (e.g. PTEN) or activating mutations in key components of the pathway. In particular, activating mutations of PIK3CA (~45%) are frequently found in luminal A BrCa samples. Genomic studies have uncovered inactivating mutations in MAP3K1 (13-20%) and MAP2K4 (~8%), two upstream kinase...
Source: Oncotarget - May 18, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Proteomic screening identifies the zonula occludens protein ZO-1 as a new partner for ADAM12 in invadopodia-like structures.
Authors: Dekky B, Ruff M, Bonnier D, Legagneux V, Théret N Abstract The epithelial mesenchymal transition (EMT) is a key process for cancer cell invasion and migration. This complex program whereby epithelial tumor cells loose polarity and acquire mesenchymal phenotype is driven by the regulation of cell-cell adhesion and cell-substrate interactions. We recently described the association of ADAM12 with EMT and we now use immunoprecipitation and proteomic approaches to identify interacting partners for ADAM12 during EMT. We identify twenty proteins that are involved in molecular mechanisms associated with adh...
Source: Oncotarget - May 18, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Wnt5a-induced cell migration is associated with the aggressiveness of estrogen receptor-positive breast cancer.
Authors: Kobayashi Y, Kadoya T, Amioka A, Hanaki H, Sasada S, Masumoto N, Yamamoto H, Arihiro K, Kikuchi A, Okada M Abstract Elevated expression of Wnt5a is associated with malignancy, cell invasion, and metastasis. The role of Wnt5a expression in breast cancer remains elusive. We investigated the significance of Wnt5a expression in breast cancer. The relationship between Wnt5a expression and clinicopathologic factors was assessed in invasive breast cancer (n = 178) resected at Hiroshima University Hospital between January 2011 and February 2014. Wnt5a was expressed in 69 of 178 cases (39%) of invasive breast cance...
Source: Oncotarget - May 18, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Combining Photodynamic Therapy and Chemotherapy: Improving Breast Cancer Treatment with Nanotechnology
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - May 18, 2018 Category: Nanotechnology Authors: Candido, Natalia Maria de Melo, Maryanne Trafani Franchi, Leonardo Pereira Primo, Fernando Lucas Tedesco, Ant ônio Cláudio Rahal, Paula Calmon, Mar ília Freitas Tags: Research Articles Source Type: research

Risks and protective factors for triple negative breast cancer with a focus on micronutrients and infections.
Authors: Horakova D, Bouchalova K, Cwiertka K, Stepanek L, Vlckova J, Kollarova H Abstract Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - May 18, 2018 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Expression of truncated HER2 and its prognostic value in HER2-positive breast cancer patients
Conclusion Expression of p95-HER2 in HER2-positive BC patients is significantly associated with negative hormonal receptors expression, high Ki-67 expression, presence of visceral metastases and worse overall survival. A larger study is required to confirm its association with different prognostic factors and its effect on survival. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - May 18, 2018 Category: Cancer & Oncology Source Type: research

Estrogen receptor positive breast tumors resist chemotherapy by the overexpression of P53 in Cancer Stem Cells
Conclusion Our results suggest that CSCs in the ER+ cells escape the effect of DOX treatment by the elevation of p53 expression. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - May 18, 2018 Category: Cancer & Oncology Source Type: research

Can Bovine Leukemia Virus Be Related to Human Breast Cancer? A Review of the Evidence
We present a compilation of the current knowledge on the subject and some prospective analysis that is required to fully end this controversy. (Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - May 18, 2018 Category: Cancer & Oncology Source Type: research

Molecules, Vol. 23, Pages 1215: In Vitro Estrogenic and Breast Cancer Inhibitory Activities of Chemical Constituents Isolated from Rheum undulatum L.
Ki Kang We investigated the estrogenic and breast cancer inhibitory activities of chemical constituents isolated from Rhei undulati Rhizoma (roots of Rheum undulatum L.), which is used as a laxative, an anti-inflammatory, and an anti-blood stagnation agent. Estrogen-like activity was studied using the well characterized E-screen assay in estrogen receptor (ER)-positive MCF-7 cells. The mechanism underlying the breast cancer inhibitory activity of the compounds was studied using human ER-negative MDA-MB-231 and ER-positive MCF-7 cells. The activation of apoptosis pathway-related proteins was investigated by western bl...
Source: Molecules - May 18, 2018 Category: Chemistry Authors: Dahae Lee SeonJu Park Sungyoul Choi Seung Kim Ki Kang Tags: Article Source Type: research

Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort
Conclusion We were unable to confirm previously reported findings, suggesting that individual SNPs are unlikely to be of clinical utility. Further investigations in well powered studies are warranted, which consider genetic heterogeneity according to subdomains of CRF. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - May 18, 2018 Category: Neurology Source Type: research

The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells
Conclusion4-Vinylphenol was shown to inhibit metastasis and cancer stemness in CSC-enriched breast cancer cells. Since conventional therapies not targeting CSCs possibly lead to failure to eliminate cancer, 4-vinylphenol is a highly potential therapeutic agent for breast cancer patients. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - May 18, 2018 Category: Cancer & Oncology Source Type: research

Overexpression of ABCB4 contributes to acquired doxorubicin resistance in breast cancer cells in vitro
ConclusionsOur results indicate that ABCB4 is overexpressed in breast cancer cells with acquired doxorubicin resistance, which could be attributed, at least partially, to the epigenetic modifications of ABCB4 gene. ABCB4 mediates the efflux transport of doxorubicin, and contributes to the acquired resistance of doxorubicin in breast cancer cells. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - May 18, 2018 Category: Cancer & Oncology Source Type: research

Apoptosis induction in human breast cancer cell lines by synergic effect of raloxifene and resveratrol through increasing proapoptotic genes
Publication date: 15 July 2018 Source:Life Sciences, Volume 205 Author(s): Pegah Mirzapur, Mohammad Rasool Khazaei, Mohammad Taher Moradi, Mozafar Khazaei Aims Breast cancer is the most common cancer of women. The aim of this study was to investigate the synergic effect of raloxifene (Ral) and resveratrol (Res) on apoptosis of breast cancer cell lines (MCF7 and MDA-MB-231). Main methods Cells were treated with Ral and Res alone and in combination. Cell viability (MTT assay), apoptosis (TUNEL assay) and nitric oxide (NO) production (Griess method) were investigated. Expression of proapoptotic gene (Bax and p53), anti-apopt...
Source: Life Sciences - May 18, 2018 Category: Biology Source Type: research

Screen for MicroRNA and Drug Interactions in Breast Cancer Cell Lines Points to miR-126 as a Modulator of CDK4/6 and PIK3CA Inhibitors
Federica Baldassari, Carlotta Zerbinati, Marco Galasso, Fabio Corr à, Linda Minotti, Chiara Agnoletto, Maurizio Previati, Carlo M. Croce, Stefano Volinia (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - May 18, 2018 Category: Genetics & Stem Cells Source Type: research

Impact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 patients” project
Impact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 patients” projectImpact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 patients” project, Published online: 18 May 2018; doi:10.1038/s41416-018-0114-xImpact of timing of trastuzumab initiation on long-term outcome of patients with early-stage HER2-positive breast cancer: the “one thousand HER2 patients” project (Source: British Journal of Cancer)
Source: British Journal of Cancer - May 18, 2018 Category: Cancer & Oncology Authors: Giuseppe Gullo Naomi Walsh David Fennelly Reetesh Bose Janice Walshe Dimitrios Tryfonopoulos Kate O ’Mahony Lisa Hammond Nuno Silva Deirdre McDonnell Josephine Ballot Cecily Quinn Enda W. McDermott Denis Evoy Ruth Prichard James Geraghty John Amstrong J Source Type: research

Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo
We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status of the hemochromatosis gene. High-dose chloroquine was used to successfully achieve clinical remission and normalize her uroporphyrins. While on chloroquine she developed extensive classic vitiligo. It is not clear if this is another feature of her complex and unusual PCT, or a consequence of her antimalarial therapy.Case Rep Dermatol 2018;10:115 –121 (Source...
Source: Case Reports in Dermatology - May 17, 2018 Category: Dermatology Source Type: research

Inhibition effects of acridone on the growth of breast cancer cells in vivo.
CONCLUSIONS: We showed that acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein and adjusted hormone level. The results suggested that acridone could serve as a chemotherapeutic agent for treatment of breast cancer in vivo. PMID: 29762857 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 17, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Study on the Mechanism of Cell Cycle Checkpoint Kinase 2 (CHEK2) Gene Dysfunction in Chemotherapeutic Drug Resistance of Triple Negative Breast Cancer Cells.
CONCLUSIONS Our findings indicated that CHEK2 Y390C mutation induced the drug resistance of TNBC cells to chemotherapeutic drugs through administrating cell apoptosis and cell cycle arrest via regulating p53 activation and CHEK2-p53 apoptosis pathway. PMID: 29761796 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

GSE100403 A kinome-wide high-content siRNA screen identifies MEK5-ERK5 signaling as critical for breast cancer cell EMT and metastasis
Contributors : Simona Pavan ; Nathalie Meyer-Schaller ; Ravi K Kalathur ; Meera Saxena ; Gerhard ChristoforiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have employed a high-content microscopy screen in combination with a kinome and phosphatome-wide siRNA library to identify signaling pathways underlying an EMT of murine mammary epithelial cells and breast cancer cells. This screen identified the MEK5-ERK5 axis as a critical player in TGFb-mediated EMT. Suppression of MEK5-ERK5 signaling completely prevented the morphological and molecular changes occurring during a TGFb-induced...
Source: GEO: Gene Expression Omnibus - May 17, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

[ASAP] Design and Synthesis of a Biocompatible 1D Coordination Polymer as Anti-Breast Cancer Drug Carrier, 5-Fu: In Vitro and in Vivo Studies
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b03111 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - May 17, 2018 Category: Materials Science Authors: Mahsa Rezaei, Alireza Abbasi, Rassoul Dinarvand, Mahmood Jeddi-Tehrani, Jan Janczak Source Type: research