Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not. Additionally...
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Satomi Shiba Michiko Harao Akira Saito Masako Sakuragi Joji Kitayama Naohiro Sata Source Type: research

Hypofractionated Partial Breast Irradiation With Intensity-Modulated Radiotherapy in Early Breast Cancer or Carcinoma < em > In Situ < /em > : An Investigational Short-Term Analysis
CONCLUSION: Hypofractionated PBI demonstrated favorable IBTR rates in patients with early breast cancer, with low incidence of acute and late toxicities in the short-term analysis.PMID:38529590 | DOI:10.4048/jbc.2023.0296 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Nam Kyu Kang Soo-Yoon Sung Sung Hwan Kim Ye Won Jeon Young Jin Suh Jong Hoon Lee Source Type: research

Correlation of Neutrophil-Lymphocyte and Albumin-Globulin Ratios With Outcomes in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy or Upfront Surgery
CONCLUSION: NLR and AGR are useful in predicting the response to NACT as well as prognosis of patients with breast cancer. Further studies are needed to explore their value in clinical decision making.PMID:38529588 | DOI:10.4048/jbc.2023.0242 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Shi Hui Yang Min Li Tey Siqin Zhou Phyu Nitar Hanis Mariyah Yirong Sim Grace Kusumawidjaja Wen Yee Chay Wong Fuh Yong Ru Xin Wong Source Type: research

A real-world study of treatment sequences and second-line clinical outcomes in patients with HER2-positive metastatic breast cancer in US community practice
CONCLUSION: This real-world US study showed that approximately two-thirds of 2L patients received subsequent therapy and disease progression was the most common reason for 2L discontinuation highlighting the need for timely 2L treatment with the most efficacious drug to allow patients to achieve longer treatment duration and delayed progression.PMID:38528295 | DOI:10.1007/s10147-024-02492-5 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Della Varghese Giovanna I Cruz Colden Johanson Liz Toland Miguel Miranda Eleanor C Faherty David Harland Henry G Kaplan Source Type: research

Treatment withdrawal experiences of women with breast cancer: A phenomenological study
CONCLUSION: Women's behaviours became transformed by suffering. Actions were influenced by physical and psychological distress, misconceptions about treatments, and appearance changes by self-determination through self-protection.RELEVANCE TO CLINICAL PRACTICE: Healthcare professionals should respect women's autonomy and work collaboratively to ensure their decision-making with accurate information and awareness of the potential risks and benefits of treatment withdrawal need to concern.PMID:38528376 | DOI:10.1111/jocn.17142 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Shu-Ching Chi Yu-Chen Liu Sriyani Padmalatha Konara Mudiyanselage Susan Fetzer Mei-Feng Lin Source Type: research

Pharmacological suppression of the OTUD4-CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers
J Clin Invest. 2024 Mar 26:e176390. doi: 10.1172/JCI176390. Online ahead of print.ABSTRACTDespite widespread utilization of immunotherapy, challenge to treat immune-cold tumors needs to be resolved. Multiomic analyses and experimental validation identified the OTUD4-CD73 proteolytic axis as a promising target in treating immune-suppressive triple negative breast cancer (TNBC). Mechanistically, deubiquitylation of CD73 by OTUD4 counteracted its ubiquitylation by TRIM21, resulting in CD73 stabilization that inhibits tumor immune responses. We further demonstrated the importance of TGF-β signaling for orchestrating the OTUD4...
Source: Clinical Genitourinary Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Yueming Zhu Anupam Banerjee Ping Xie Andrey A Ivanov Amad Uddin Qiao Jiao Junlong J Chi Lidan Zeng Ji Young Lee Yifan Xue Xinghua Lu Massimo Cristofanilli William J Gradishar Curtis J Henry Theresa W Gillespie Manali Ajay Bhave Kevin Kalinsky Haian Fu Ive Source Type: research

Pharmacological suppression of the OTUD4-CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers
J Clin Invest. 2024 Mar 26:e176390. doi: 10.1172/JCI176390. Online ahead of print.ABSTRACTDespite widespread utilization of immunotherapy, challenge to treat immune-cold tumors needs to be resolved. Multiomic analyses and experimental validation identified the OTUD4-CD73 proteolytic axis as a promising target in treating immune-suppressive triple negative breast cancer (TNBC). Mechanistically, deubiquitylation of CD73 by OTUD4 counteracted its ubiquitylation by TRIM21, resulting in CD73 stabilization that inhibits tumor immune responses. We further demonstrated the importance of TGF-β signaling for orchestrating the OTUD4...
Source: Clinical Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Yueming Zhu Anupam Banerjee Ping Xie Andrey A Ivanov Amad Uddin Qiao Jiao Junlong J Chi Lidan Zeng Ji Young Lee Yifan Xue Xinghua Lu Massimo Cristofanilli William J Gradishar Curtis J Henry Theresa W Gillespie Manali Ajay Bhave Kevin Kalinsky Haian Fu Ive Source Type: research

Treatment withdrawal experiences of women with breast cancer: A phenomenological study
CONCLUSION: Women's behaviours became transformed by suffering. Actions were influenced by physical and psychological distress, misconceptions about treatments, and appearance changes by self-determination through self-protection.RELEVANCE TO CLINICAL PRACTICE: Healthcare professionals should respect women's autonomy and work collaboratively to ensure their decision-making with accurate information and awareness of the potential risks and benefits of treatment withdrawal need to concern.PMID:38528376 | DOI:10.1111/jocn.17142 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Shu-Ching Chi Yu-Chen Liu Sriyani Padmalatha Konara Mudiyanselage Susan Fetzer Mei-Feng Lin Source Type: research

A real-world study of treatment sequences and second-line clinical outcomes in patients with HER2-positive metastatic breast cancer in US community practice
CONCLUSION: This real-world US study showed that approximately two-thirds of 2L patients received subsequent therapy and disease progression was the most common reason for 2L discontinuation highlighting the need for timely 2L treatment with the most efficacious drug to allow patients to achieve longer treatment duration and delayed progression.PMID:38528295 | DOI:10.1007/s10147-024-02492-5 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Della Varghese Giovanna I Cruz Colden Johanson Liz Toland Miguel Miranda Eleanor C Faherty David Harland Henry G Kaplan Source Type: research

The critical role and functional mechanism of microRNA-146a in doxorubicin-induced apoptosis in breast cancer cells
CONCLUSION: Considering the role of doxorubicin in inducing apoptosis and increasing the expression of miR-146a, it can be suggested that this miR is involved in inducing apoptosis in BC cells. In addition, miR-146a can be considered a therapeutic candidate.PMID:38531028 | DOI:10.1080/15257770.2024.2330592 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - March 26, 2024 Category: Biochemistry Authors: Sara Tutunchi Parisa Nourmohammadi Roghayeh Tofigh Saeedeh Akhavan Mina Zare Sadra Samavarchi Tehrani Ghodratollah Panahi Source Type: research

Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment
In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs) and developed ECM hydrogels from decellularized tissues (dECM) to assess the effects of RT-induced ECM changes on breast cancer cell behavior. Irradiated MFPs were characterized by increased ECM deposition and fiber density compared to unirradiated controls, which may provide a platform for cell invasion and proliferation. ECM component changes in collagens I, IV, and VI, and fibronectin were observed following irradiation in both MFPs and dECM hydrogels. Encapsulated TNBC cell proliferat...
Source: Biomaterials - March 26, 2024 Category: Materials Science Authors: Tian Zhu Steven M Alves Arianna Adamo Xiaona Wen Kevin C Corn Anastasia Shostak Shereena Johnson Nicholas D Shaub Shannon E Martello Benjamin C Hacker Antonio D'Amore Rizia Bardhan Marjan Rafat Source Type: research

Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells
Cancer Res Commun. 2024 Mar 26. doi: 10.1158/2767-9764.CRC-23-0488. Online ahead of print.ABSTRACTDetection of viral double-stranded RNA (dsRNA) is an important component of innate immunity. However, many endogenous RNAs containing double-stranded regions can be misrecognized and activate innate immunity. The interferon inducible ADAR1-p150 suppresses dsRNA sensing, an essential function for ADAR1 in many cancers, including breast. Although ADAR1-p150 has been well established in this role, the functions of the constitutively expressed ADAR1-p110 isoform are less understood. We used proximity labeling to identify putative ...
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Kyle A Cottrell Sua Ryu Jackson R Pierce Luisangely Soto Torres Holly E Bohlin Angela M Schab Jason D Weber Source Type: research

DNA Methylation-Regulated HOXC8's Role in HER2-Positive Breast Cancer Function and its Contribution to Herceptin Resistance
CONCLUSIONS: In HER2-positive breast cancer, the expression of HOXC8 is elevated in a manner dependent on DNA methylation, and this elevated expression is closely linked to the pathology of the patient. Interfering with HOXC8 expression demonstrates the potential to partially inhibit the development and spread of breast cancer, as well as to alleviate resistance to Herceptin.PMID:38531796 | DOI:10.24976/Discov.Med.202436182.52 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Xiaofeng Xie Sijia Tang Zhengyang Yu Source Type: research

Formononetin Restrains Tumorigenesis of Breast Tumor by Restraining STING-NF- κB and Interfering with the Activation of PD-L1
CONCLUSION: Formononetin can restrain the proliferation of BC cells, which may be mediated through the interference of PD-L1 and suppression of the activation of the STING-NF-κB pathway.PMID:38531802 | DOI:10.24976/Discov.Med.202436182.58 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Hongmei Liu Zhipeng Wang Zhigang Liu Source Type: research

Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Cell Mol Biol Lett. 2024 Mar 26;29(1):40. doi: 10.1186/s11658-024-00560-2.ABSTRACTFerroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and react...
Source: Cellular and Molecular Biology Letters - March 26, 2024 Category: Biochemistry Authors: Shasha Xiang Wen Yan Xing Ren Jianbo Feng Xuyu Zu Source Type: research