Epigenetic deregulation in breast cancer microenvironment: Implications for tumor progression and therapeutic strategies
This article delves into the complex connections between breast cancer treatment response, underlying epigenetic changes, and vital interactions within the TME. To restore sensitivity to treatment, it emphasizes the need for combination therapies considering epigenetic changes specific to individual members of the TME. Recognizing the pivotal role of epigenetics in drug resistance and comprehending the specificities of breast TME is essential for devising more effective therapeutic strategies. The development of reliable biomarkers for patient stratification will facilitate tailored and precise treatment approaches.PMID:38...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2024 Category: Drugs & Pharmacology Authors: Lenka Trnkova Verona Buocikova Michal Mego Andrea Cumova Monika Burikova Martin Bohac Svetlana Miklikova Marina Cihova Bozena Smolkova Source Type: research
Phase II Study of Erdafitinib in Patients With Tumors With < em > FGFR < /em > Amplifications: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K1
CONCLUSION: Erdafitinib did not meet its primary end point of efficacy as determined by ORR in treatment-refractory solid tumors harboring FGFR1-4 amplifications. Our findings support that rearrangements and gene mutations, but not amplifications, of FGFR remain the established FGFR alterations with approved indications for FGFR inhibition.PMID:38603651 | DOI:10.1200/PO.23.00406 (Source: Ann Oncol)
Source: Ann Oncol - April 11, 2024 Category: Cancer & Oncology Authors: Jun Gong Alain C Mita Zihan Wei Heather H Cheng Edith P Mitchell John J Wright S Percy Ivy Victoria Wang Robert C Gray Lisa M McShane Larry V Rubinstein David R Patton P Mickey Williams Stanley R Hamilton Ajjai S Alva James V Tricoli Barbara A Conley Carl Source Type: research
A systematic review and meta-analysis of English language online patient education materials in breast cancer: Is readability the only story?
CONCLUSION: Average readability of breast cancer OPEMs is nearly double the AMA's recommended 6th grade level. Readability and other health literacy-associated metrics are inconsistently reported in the current literature. Standardization of future readability studies, with a focus on holistic evaluation of patient materials, may aid shared decision-making and be critical to increased screening rates and breast cancer awareness.PMID:38603836 | DOI:10.1016/j.breast.2024.103722 (Source: Breast)
Source: Breast - April 11, 2024 Category: Cancer & Oncology Authors: Joey Z Gu Grayson L Baird Antonio Escamilla Guevara Young-Jin Sohn Melis Lydston Christopher Doyle Sarah E A Tevis Randy C Miles Source Type: research
Global representativeness and impact of funding sources in cost-effectiveness research on systemic therapies for advanced breast cancer: A systematic review
CONCLUSIONS: Breast cancer CE literature scarcely represents low-and-middle-income countries' perspectives and is influenced by pharmaceutical industry funding which targets European countries', frequently utilizes comparisons within same-drug class, and is more likely to have favorable conclusions.PMID:38603837 | DOI:10.1016/j.breast.2024.103727 (Source: Breast)
Source: Breast - April 11, 2024 Category: Cancer & Oncology Authors: Felippe Lazar Neto Marina Acevedo Zarzar de Melo Cassio Murilo Trovo Hidalgo Filho Maria Cec ília Mathias-Machado Laura Testa Alessandro Gon çalves Campolina Source Type: research
Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study
CONCLUSIONS: Screening activities should be revised and the guidelines on diabetes should be complemented with recommendations on cancer prevention also considering that the cancer incidence is highest around the time of the diagnosis of diabetes. For prostate cancer, our results contradict many previous studies, and further research is recommended to clarify this.PMID:38604444 | DOI:10.1016/j.diabres.2024.111665 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Hel éna Safadi Ágnes Balogh Judit L ám Attila Nagy Éva Belicza Source Type: research
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer
Transl Oncol. 2024 Apr 10;44:101960. doi: 10.1016/j.tranon.2024.101960. Online ahead of print.ABSTRACTThe interaction between tumor fatty acid metabolism and immune microenvironment is a novel topic in oncology research, and the relationship of lipid-derived factors with immune editing in tumor is unclear. The breast cancer samples from the TCGA database were used as the training set, and samples from GSE42568 were employed as the validation set for constructing a model to identify a signature associated with fatty acid metabolism through Lasso Cox regression. And the changes in immune related signatures and risk score bef...
Source: Translational Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Andi Zhao Jin Yang Ran Ran Shidi Zhao Yuxin Cui Fang Hu Yan Zhou Source Type: research
Significance of Estrogen/Progesterone Receptor Expression in Metaplastic Breast Carcinoma
CONCLUSION: MBC is a rare breast neoplasm. MBC was found to be triple negative in most cases, but a significant percentage were HR (ER/PR) positive. Moreover, we found an association between HR status and various clinicopathological features, indicating that HR status is a significant predictor of MBC prognosis.PMID:38601434 | PMC:PMC11006451 | DOI:10.1155/2024/2540356 (Source: Disease Markers)
Source: Disease Markers - April 11, 2024 Category: Laboratory Medicine Authors: Atif Ali Hashmi Bakhtawar Allauddin Mallick Khushbakht Rashid Umair Arshad Malik Shamail Zia Fazail Zia Muhammad Irfan Source Type: research
Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models
CONCLUSIONS: Chitin, as a general CLP blocker, reduces CLP production, enhances anti-tumor immunity as well as ICB responses, supporting its potential clinical relevance in immunosuppressed TNBC patients.PMID:38605414 | DOI:10.1186/s13058-024-01815-8 (Source: Cell Research)
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Robbe Salembier Caro De Haes Julie Bellemans Kristel Demeyere Wim Van Den Broeck Niek N Sanders Steven Van Laere Traci R Lyons Evelyne Meyer Jonas Steenbrugge Source Type: research
The HLA-I landscape confers prognosis and antitumor immunity in breast cancer
In conclusion, we presented an overview of HLA-I indicators in breast cancer and provided hints for precision treatment for low-Pr TNBCs.PMID:38602320 | PMC:PMC11007120 | DOI:10.1093/bib/bbae151 (Source: Briefings in Bioinformatics)
Source: Briefings in Bioinformatics - April 11, 2024 Category: Bioinformatics Authors: Xiao-Hong Ding Yi Xiao Fenfang Chen Cheng-Lin Liu Tong Fu Zhi-Ming Shao Yi-Zhou Jiang Source Type: research
Transcriptomics studies reveal functions of Transglutaminase 2 in breast cancer cells using membrane permeable and impermeable inhibitors
J Mol Biol. 2024 Apr 9:168569. doi: 10.1016/j.jmb.2024.168569. Online ahead of print.ABSTRACTTransglutaminase 2 (TG2) performs many functions both under physiological and pathological conditions. In cancer, its expression is associated with aggressiveness, propensity to epithelial-mesenchymal transition, and metastasis. Since TG2 performs key functions both outside and inside the cell, using inhibitors with different membrane permeability we analyzed the changes in the transcriptome induced in two triple-negative cell lines (MDA-MB-436 and MDA-MB-231) with aggressive features. By characterizing pathways and gene networks, ...
Source: Mol Biol Cell - April 11, 2024 Category: Molecular Biology Authors: Pietro Ancona Alessandro Trentini Anna Terrazzan Silvia Grassilli Pauline Navals Eric W J Gates Valentina Rosta Carlo Cervellati Carlo M Bergamini Angela Pignatelli Jeffrey W Keillor Cristian Taccioli Nicoletta Bianchi Source Type: research
Deep learning for high-resolution dose prediction in high dose rate brachytherapy for breast cancer treatment
This study aimed to enable dose predictions as accurate as MC simulations in 1mm × 1mm × 1mm voxels within a clinically acceptable timeframe.
Approach: Computed tomography scans of 98 breast cancer patients treated with Iridium-192-based HDR BT were used: 70 for training, 14 for validation, and 14 for testing. A new cropping strategy based on the distance to the seed was devised to reduce the volume size, enabling efficient training of 3D DL models using 1 mm × 1 mm × 1 mm dose grids. Additionally, novel DL architecture with layer-level fusion were proposed to predict MC simulated dose to medium-in-medium (Dm,m...
Source: Physics in Medicine and Biology - April 11, 2024 Category: Physics Authors: S ébastien Quetin Boris Bahoric Farhad Maleki Shirin A Enger Source Type: research
Social capital in the management of breast cancer in Lagos, Nigeria
CONCLUSION: The study emphasizes the significance of involving family members in the breast cancer management process and highlights the need for support systems within families and communities to facilitate better outcomes for breast cancer patients.PMID:38602144 | DOI:10.1017/S147895152400049X (Source: Palliative and Supportive Care)
Source: Palliative and Supportive Care - April 11, 2024 Category: Palliative Care Authors: Samuel Ojima Adejoh Peter Osazuwa Oluwakemi Tinuolaoluwa Oyelowo Maria Oyalowo Odey Titi Tade Source Type: research
Dual amplification for PEC ultrasensitive aptasensing of biomarker HER-2 based on Z-scheme UiO-66/CdIn < sub > 2 < /sub > S < sub > 4 < /sub > heterojunction and flower-like PtPdCu nanozyme
Talanta. 2024 Apr 3;274:126034. doi: 10.1016/j.talanta.2024.126034. Online ahead of print.ABSTRACTAs an important prognostic indicator in breast cancer, human epithelial growth factor receptor-2 (HER-2) is of importance for assessing prognosis of breast cancer patients, whose accurate and facile analysis are imperative in clinical diagnosis and treatment. Herein, photoactive Z-scheme UiO-66/CdIn2S4 heterojunction was constructed by a hydrothermal method, whose optical property and photoactivity were critically investigated by a range of techniques, combined by elucidating the interfacial charge transfer mechanism. Meanwhil...
Source: Talanta - April 11, 2024 Category: Chemistry Authors: Qing-Ying Ai Ben-Fang Xu Fan Xu Ai-Jun Wang Li-Ping Mei Liang Wu Pei Song Jiu-Ju Feng Source Type: research
Arsenic and Benzo[a]pyrene Co-exposure Effects on MDA-MB-231 Cell Viability and Migration
This study aimed to assess the combined impact of BaP and As on the viability and migration of MDA-MB-231 cells. The results indicated that even at low levels, both inorganic As (0.01 μM, 0.1 μM, and 1 μM) and BaP (1 μM, 2.5 μM), individually or in combination, enhanced the viability and migration of the cells. However, the cell cycle analysis revealed no significant differences between the control group and the cells exposed to BaP and As. Specifically, exposure to BaP alone or in combination with As (As 0.01 μM + BaP 1 μM) for 24 h led to a significant increase in vimentin gene expression. Interestingly, short-ter...
Source: Biological Trace Element Research - April 11, 2024 Category: Biology Authors: Ahmad Safari Maleki Mohammad Hossein Ghahremani Amir Shadboorestan Source Type: research
Trends in low-value cancer care during the COVID-19 pandemic
CONCLUSIONS: Low-value cancer care remained prevalent throughout the pandemic. Policy makers should consider changes to payment and incentive design to turn the tide against low-value cancer care.PMID:38603533 | DOI:10.37765/ajmc.2024.89530 (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - April 11, 2024 Category: Health Management Authors: Ravi B Parikh Yasin Civelek Pelin Ozluk David Debono Michael J Fisch Gosia Sylwestrzak Justin E Bekelman Aaron L Schwartz Source Type: research
