Determination of < em > In Vitro < /em > and < em > In Vivo < /em > Effects of Taxifolin and Epirubicin on Epithelial-Mesenchymal Transition in Mouse Breast Cancer Cells
Conclusion: The in vitro and in vivo results of our study indicate that the concurrent use of Epirubicin with Taxifolin has supportive effects on breast cancer treatment.PMID:38515396 | PMC:PMC10958820 | DOI:10.1177/15330338241241245 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 22, 2024 Category: Cancer & Oncology Authors: Muhammet Ocak Duygu Deniz Usta Gokce Nur Arik Erol Gulnur Take Kaplanoglu Ece Konac Atiye Seda Yar Saglam Source Type: research

PROM2 overexpression induces metastatic potential through epithelial-to-mesenchymal transition and ferroptosis resistance in human cancers
CONCLUSION: Our results open the way for further studies using PROM2 as a bio-target in resort situations in human metastatic melanoma and also in other cancer types.PMID:38515278 | PMC:PMC10958126 | DOI:10.1002/ctm2.1632 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Justine Paris Claire Wilhelm Celeste Lebb é Mohammed Elmallah Fr édéric Pamoukdjian Audrey H éraud Guillaume Gapihan Aurore Van De Walle Van Nhan Tran Diaddin Hamdan Clara Allayous Maxime Battistella Emmanuel Van Glabeke Kah Wai Lim Christophe Leboeuf Source Type: research

Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results
CONCLUSIONS: One-week UHF adjuvant locoregional radiation is well-tolerated, displaying low-toxicity profiles comparable to other studies using similar irradiation schedules.PMID:38516338 | PMC:PMC10955656 | DOI:10.1016/j.ctro.2024.100764 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Ivica Ratosa Angel Montero Raquel Ciervide Beatriz Alvarez Mariola Garc ía-Aranda Jeannette Valero Xin Chen-Zhao Mercedes Lopez Daniel Zucca Ovidio Hernando Emilio S ánchez Miguel Angel de la Casa Rosa Alonso Pedro Fernandez-Leton Carmen Rubio Source Type: research

Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Clinical Breast Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research

How Long Does Contouring Really Take? Results of the Royal College of Radiologists Contouring Surveys
CONCLUSION: Contouring for radical radiotherapy is complex and time-consuming, and despite increasing involvement of non-medical professionals, clinical oncology consultants remain the primary practitioners. Peer review practice is variable and time is often a limiting factor. Many factors influence the time required for contouring, and departments should take these factors and the need for peer-review into account when developing job plans.PMID:38519383 | DOI:10.1016/j.clon.2024.03.005 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 22, 2024 Category: Cancer & Oncology Authors: E Montague T Roques K Spencer A Burnett J Lourenco N Thorp Source Type: research

Alpelisib for PIK3CA-mutated advanced gynecological cancers: First clues of clinical activity
CONCLUSION: Alpelisib represents an active treatment option in patients with recurrent gynecological cancers harboring a PIK3CA mutation. These findings support the need of biomarker-driven randomized trials of PI3K inhibitors in gynecological cancers.PMID:38518529 | DOI:10.1016/j.ygyno.2024.02.029 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 22, 2024 Category: Cancer & Oncology Authors: Anna Passarelli Vittoria Carbone Sandro Pignata Roberta Mazzeo Domenica Lorusso Giovanni Scambia Stefania Canova Teresa Di Palma Giulia Tasca Mara Mantiero Emanuele Naglieri Claudia Andreetta Martina Rauso Anna Elisabetta Brunetti Letizia Laera Chiara Abe Source Type: research

Deep learning approaches for breast cancer detection in histopathology images: A review
CONCLUSION: This review has presented a thorough account of the current state-of-the-art techniques for detecting breast cancer using histopathology images. The integration of machine learning and deep learning algorithms has demonstrated promising results in accurately identifying breast cancer from histopathology images. The insights gathered from this review can act as a valuable reference for researchers in this field who are developing diagnostic strategies using histopathology images. Overall, the objective of this review is to spark interest among scholars in this complex field and acquaint them with cutting-edge te...
Source: Cancer Biomarkers : Section A of Disease Markers - March 22, 2024 Category: Cancer & Oncology Authors: Lakshmi Priya C V Biju V G Vinod B R Sivakumar Ramachandran Source Type: research

Deep learning approaches for breast cancer detection in histopathology images: A review
CONCLUSION: This review has presented a thorough account of the current state-of-the-art techniques for detecting breast cancer using histopathology images. The integration of machine learning and deep learning algorithms has demonstrated promising results in accurately identifying breast cancer from histopathology images. The insights gathered from this review can act as a valuable reference for researchers in this field who are developing diagnostic strategies using histopathology images. Overall, the objective of this review is to spark interest among scholars in this complex field and acquaint them with cutting-edge te...
Source: Cancer Biomarkers - March 22, 2024 Category: Cancer & Oncology Authors: Lakshmi Priya C V Biju V G Vinod B R Sivakumar Ramachandran Source Type: research

Thiazolyl-isatin derivatives: Synthesis, in silico studies, in vitro biological profile against breast cancer cells, mRNA expression, P-gp modulation, and interactions of Akt2 and VIM proteins
Chem Biol Interact. 2024 Mar 20:110954. doi: 10.1016/j.cbi.2024.110954. Online ahead of print.ABSTRACTThe literature reports that thiazole and isatin nuclei present a range of biological activities, with an emphasis on anticancer activity. Therefore, our proposal was to make a series of compounds using the molecular hybridization strategy, which has been used by our research group, producing hybrid molecules containing the thiazole and isatin nuclei. After structural planning and synthesis, the compounds were characterized and evaluated in vitro against breast cancer cell lines (T-47D, MCF-7 and MDA-MB-231) and against nor...
Source: Chemico-Biological Interactions - March 22, 2024 Category: Molecular Biology Authors: Luiz Alberto Barros Freitas Carolina Souza Beatriz Silva Lima Denise Duarte Paulo Andr é Teixeira de Moraes Gomes Camila Gabriela Costa Ramos Val écia de Cássia Mendonça Costa Maira Galdino da Rocha Pitta Moacyr Jesus Barreto de Melo R êgo Carlos Alb Source Type: research

SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation
J Cell Mol Med. 2024 Apr;28(7):e18212. doi: 10.1111/jcmm.18212.ABSTRACTSBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast cancer cell lines were treated with SBFI26 and CCK-8 assessed cytotoxicity. Transcriptome was performed on the Illumina platform and verified by qPCR. Western blot evaluated protein levels. Malondialdehyde (MDA), total superoxide dismutase (T-SOD), Fe, glutathione (GSH) and oxidized glutathione (GSSG) were measured. SB...
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Gang He Yiyuan Zhang Yanjiao Feng Tangcong Chen Mei Liu Yue Zeng Xiaojing Yin Shaokui Qu Lifen Huang Youqiang Ke Li Liang Jun Yan Wei Liu Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation
J Cell Mol Med. 2024 Apr;28(7):e18212. doi: 10.1111/jcmm.18212.ABSTRACTSBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast cancer cell lines were treated with SBFI26 and CCK-8 assessed cytotoxicity. Transcriptome was performed on the Illumina platform and verified by qPCR. Western blot evaluated protein levels. Malondialdehyde (MDA), total superoxide dismutase (T-SOD), Fe, glutathione (GSH) and oxidized glutathione (GSSG) were measured. SB...
Source: J Cell Mol Med - March 22, 2024 Category: Molecular Biology Authors: Gang He Yiyuan Zhang Yanjiao Feng Tangcong Chen Mei Liu Yue Zeng Xiaojing Yin Shaokui Qu Lifen Huang Youqiang Ke Li Liang Jun Yan Wei Liu Source Type: research

Epigenetic mechanisms of cancer progression and therapy resistance in estrogen-receptor (ER+) breast cancer
Biochim Biophys Acta Rev Cancer. 2024 Mar 20:189097. doi: 10.1016/j.bbcan.2024.189097. Online ahead of print.ABSTRACTEstrogen receptor-positive (ER+) breast cancer is the most frequent breast cancer subtype. Agents targeting the ER signaling pathway have been successful in reducing mortality from breast cancer for decades. However, mechanisms of resistance to these treatments arise, especially in the metastatic setting. Recently, it has been recognized that epigenetic dysregulation is a common feature that facilitates the acquisition of cancer hallmarks across cancer types, including ER+ breast cancer. Alterations in epige...
Source: Biochimica et Biophysica Acta - March 22, 2024 Category: Biochemistry Authors: Eneda Toska Source Type: research

Development of benzimidazole-substituted spirocyclopropyl oxindole derivatives as cytotoxic agents: tubulin polymerization inhibition and apoptosis inducing studies
ChemMedChem. 2024 Mar 22:e202400052. doi: 10.1002/cmdc.202400052. Online ahead of print.ABSTRACTA series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most of the molecules exhibited significant antiproliferative activity with compound 12p being the most potent. It exhibited significant cytotoxicity against MCF-7 breast cancer cells (IC50 value 3.14 ± 0.50 µM), evidenced by the decrease in viable cells and increased apoptotic features during phase contrast microscopy, AO/EB, DAPI and DCFDA staining studies. Compound 12...
Source: ChemMedChem - March 22, 2024 Category: Chemistry Authors: Akash P Sakla Mohd Rabi Bazaz Ashutosh Mahale Pravesh Sharma Durgesh Gurukkala Valapil Onkar Prakash Kulkarni Manoj P Dandekar Nagula Shankaraiah Source Type: research

Personalised graded psychological intervention on negative emotion and quality of life in patients with breast cancer
CONCLUSIONS: The use of personalised graded psychological intervention for the nursing of patients with breast cancer in clinical practice can significantly reduce patients' negative emotions as well as improve positive emotions and quality of life; thus, this method can be popularised in the nursing process.PMID:38517824 | DOI:10.3233/THC-232021 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Xianjie Hao Yanli Yi Xian Lin Jie Li Cheng Chen Yanfeng Shen Yuhang Sun Jinglan He Source Type: research