DNA damage, obesity and obesity-related health complications: what are new data telling us?
This article surveys new data that support these contentions.RECENT FINDINGS: Whole exome sequencing analyses have identified rare variants linked to high BMI and adiposity. Two of the identified genes are linked to DNA damage and DNA repair, suggesting that DNA damage itself may play a role in the cause of obesity. It has also been recognized that obesity increases DNA damage in breast tissue of carriers of BRCA mutations and rates of tumour formation in BRCA1+ mice, indicating effect of obesity on cancer development in high-risk populations. In addition, obesity promotes cancer cell chemoresistance by decreasing fatty ac...
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Marta W łodarczyk Gra żyna Nowicka Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Fulfilling the Role of a Parent While Undergoing Treatment for Cancer: A Review of the Literature and the Potential Impact of Childcare Support on Cancer Outcomes
Am J Clin Oncol. 2024 Apr 23. doi: 10.1097/COC.0000000000001102. Online ahead of print.ABSTRACTBreast cancer is the most prevalent malignancy among adolescents and young adults (AYAs). Despite the efficacy of chemotherapy, AYA patients contend with psychosocial challenges, including psychological distress and financial toxicity, exacerbated further by those with dependent children. Parenting responsibilities intersect with cancer care, impacting both family dynamics and treatment adherence. Despite recognized needs, however, the impact of parenting concerns or even parenting status and the presence of dependents has not be...
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Kang Woo Kim Mary Lopresti Stephanie L Graff Sabrina Witherby Don S Dizon Mary Anne Fenton Source Type: research
Potential utility of pretreatment serum miRNAs for optimal treatment selection in advanced high-grade serous ovarian cancer
CONCLUSIONS: Pretreatment microRNA profiles could be used to select subgroups of patients who benefited more from primary debulking surgery or neoadjuvant chemotherapy and might contribute to selecting the optimal primary treatment modality in advanced high-grade serous ovarian cancer patients.PMID:38651188 | DOI:10.1093/jjco/hyae051 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Takashi Uehara Juntaro Matsuzaki Hiroshi Yoshida Yuto Ogawa Junichiro Miura Hitoshi Fujimiya Yusuke Yamamoto Junpei Kawauchi Satoko Takizawa Kan Yonemori Hiromi Sakamoto Ken Kato Mitsuya Ishikawa Takahiro Ochiya Source Type: research
Increased prevalence of germline pathogenic CHEK2 variants in individuals with pituitary adenomas
CONCLUSIONS: This is the first study to suggest a role for the breast cancer predisposition gene, CHEK2, in pituitary tumorigenesis, with pathogenic/likely pathogenic variants found in 3% of patients with pituitary adenomas. As pituitary adenomas are relatively common and typically lack classical autosomal dominant family histories, risk alleles - such as these variants found in CHEK2 - might be a significant contributor to pituitary adenoma risk in the general population.PMID:38651569 | DOI:10.1210/clinem/dgae268 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Sunita M C De Sousa Ann McCormack Andreas Orsmond Angeline Shen Christopher J Yates Roderick Clifton-Bligh Stephen Santoreneos James King Jinghua Feng John Toubia David J Torpy Hamish S Scott Source Type: research
Clinical value of KiSS-1 and MMP-2 expression levels in breast cancer tissue in evaluating prognosis of elderly breast cancer patients after modified radical mastectomy
In conclusion, KiSS-1 and MMP-2 levels in BC tissue possess relation to adverse prognosis of MCM. KiSS-1 and MMP-2 levels in elderly BC patients before surgery may be detected in the future to assist in prognosis evaluation of elderly BC patients after MCM.PMID:38650158 | DOI:10.14715/cmb/2024.70.3.38 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Jiyang Lv Junya Zhang Fangfang Wu Source Type: research
circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis
This study aimed to investigate the roles of circ_0006743 (circ_JMJD1C) in breast cancer. The downstream of circ_JMJD1C and their interaction network was determined by bioinformatic analyses. Gene expression were analyzed through western blot and qRT-PCR assays. Functional assays were conducted in vitro and in vivo to verify circ_JMJD1C role in BC. FISH and confocal analysis indicated the cellular distribution of circ_JMJD1C. Luciferase reporter, RNA immune-precipitation (RIP) assays, as well as Pearson's correlation analysis, were implemented to test the relation of miR-182-5p, JMJD1C and circ_JMJD1C. Circ_JMJD1C and JMJD...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Renyuan Xu Haomiao Lan Li Zhang Sisi Yang Yu Mao Hongying Che Source Type: research
Revisiting the Association of ECOG Performance Status With Clinical Outcomes in Diverse Patients With Cancer
CONCLUSIONS: ECOG PS and upper gastrointestinal and stage IV cancers were independently associated with increased risk of emergency department visits, hospitalizations, and mortality, whereas African American and Asian race and female sex were associated with decreased risk of mortality. An ECOG PS of 3 or 4 was more predictive of an increased risk of mortality in younger patients and patients with breast cancer. These findings can enhance the use of ECOG PS for clinical decision-making and defining eligibility for clinical trials.PMID:38653321 | DOI:10.6004/jnccn.2023.7111 (Source: Journal of the National Comprehensive Ca...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 23, 2024 Category: Cancer & Oncology Authors: Deepika Kumar Elad Neeman Shiyun Zhu Hongxin Sun Dinesh Kotak Raymond Liu Source Type: research
Vital Signs: Mammography Use and Association with Social Determinants of Health and Health-Related Social Needs Among Women - United States, 2022
CONCLUSIONS AND IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: Identifying specific adverse SDOH and HRSNs that women experience and coordinating activities among health care providers, social services, community organizations, and public health programs to provide services that help address these needs might increase mammography use and ultimately decrease breast cancer deaths.PMID:38652735 | PMC:PMC11037433 | DOI:10.15585/mmwr.mm7315e1 (Source: MMWR Morb Mortal Wkl...)
Source: MMWR Morb Mortal Wkl... - April 23, 2024 Category: Epidemiology Authors: Jacqueline W Miller Jessica A King Katrina F Trivers Machell Town Susan A Sabatino Mary Puckett Lisa C Richardson Source Type: research
A ratiometric electrochemical biosensor based on ARGET ATRP for detection of HER2 gene
Talanta. 2024 Apr 22;275:126130. doi: 10.1016/j.talanta.2024.126130. Online ahead of print.ABSTRACTHuman epidermal growth factor receptor 2 (HER2), a common proto-oncogene, is overexpressed in a subset of breast cancer patients. It is essential to track HER2 expression for early breast cancer diagnosis. Herein, a ratiometric electrochemical biosensor for detection of HER2 based on activators generated by electron transfer for atom transfer radical polymerisation (AGET ATRP) and hairpin DNA was developed. Specifically, hairpin DNA was first self-assembled on the gold electrode by Au-S bond. Upon capturing HER2, the stem-loo...
Source: Talanta - April 23, 2024 Category: Chemistry Authors: Aozi Feng Li Li Ningxia He Daoxiang Li Danna Zheng Yanju Liu Huaixia Yang Source Type: research
Clinical value of KiSS-1 and MMP-2 expression levels in breast cancer tissue in evaluating prognosis of elderly breast cancer patients after modified radical mastectomy
In conclusion, KiSS-1 and MMP-2 levels in BC tissue possess relation to adverse prognosis of MCM. KiSS-1 and MMP-2 levels in elderly BC patients before surgery may be detected in the future to assist in prognosis evaluation of elderly BC patients after MCM.PMID:38650158 | DOI:10.14715/cmb/2024.70.3.38 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jiyang Lv Junya Zhang Fangfang Wu Source Type: research
circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis
This study aimed to investigate the roles of circ_0006743 (circ_JMJD1C) in breast cancer. The downstream of circ_JMJD1C and their interaction network was determined by bioinformatic analyses. Gene expression were analyzed through western blot and qRT-PCR assays. Functional assays were conducted in vitro and in vivo to verify circ_JMJD1C role in BC. FISH and confocal analysis indicated the cellular distribution of circ_JMJD1C. Luciferase reporter, RNA immune-precipitation (RIP) assays, as well as Pearson's correlation analysis, were implemented to test the relation of miR-182-5p, JMJD1C and circ_JMJD1C. Circ_JMJD1C and JMJD...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Renyuan Xu Haomiao Lan Li Zhang Sisi Yang Yu Mao Hongying Che Source Type: research
Brystkreft hos menn – histopatologi og biomarkører
Tidsskr Nor Laegeforen. 2024 Mar 27;144(5). doi: 10.4045/tidsskr.23.0438. Print 2024 Apr 23.ABSTRACTBACKGROUND: Breast cancer in men accounts for around 1 % of all cases of the disease. The study aimed to identify histopathological parameters and selected biomarkers in men with breast cancer.MATERIAL AND METHOD: Retrospective study of archival material from 53 men diagnosed with breast cancer at the department of pathology, Haukeland University Hospital, in the period 1996-2020. The prevalence of the oestrogen receptor (ER), progesterone receptor (PGR) and Human Epidermal Growth Factor (HER2) biomarkers was examined.RESULT...
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Ingvild Kathrin Lok øy Inga Sofie Bakken Elisabeth Wik Ingunn Marie Stefansson Source Type: research
A woman in her fifties with a post-operative infection, generalised rash and organ failure
This article presents a case of a middle-aged woman who developed symptoms of toxic shock syndrome five days after elective breast cancer surgery, with high fever, multiorgan failure and a characteristic desquamation of the palms.INTERPRETATION: Toxic shock syndrome is a potentially lethal, toxin-mediated disease. Symptoms develop quickly, within hours. Early recognition and appropriate surgical management, intensive care and antibiotics are therefore important to reduce mortality and sequelae.PMID:38651709 | DOI:10.4045/tidsskr.23.0623 (Source: Tidsskrift for den Norske Laegeforening)
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Naima Borg Tahri Berit Gravdehaug Nazli Bahrami Laurens Reitsma Source Type: research
Increased prevalence of germline pathogenic CHEK2 variants in individuals with pituitary adenomas
CONCLUSIONS: This is the first study to suggest a role for the breast cancer predisposition gene, CHEK2, in pituitary tumorigenesis, with pathogenic/likely pathogenic variants found in 3% of patients with pituitary adenomas. As pituitary adenomas are relatively common and typically lack classical autosomal dominant family histories, risk alleles - such as these variants found in CHEK2 - might be a significant contributor to pituitary adenoma risk in the general population.PMID:38651569 | DOI:10.1210/clinem/dgae268 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sunita M C De Sousa Ann McCormack Andreas Orsmond Angeline Shen Christopher J Yates Roderick Clifton-Bligh Stephen Santoreneos James King Jinghua Feng John Toubia David J Torpy Hamish S Scott Source Type: research
