Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease
Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually rel... (Source: BMC Immunology)
Source: BMC Immunology - October 1, 2020 Category: Allergy & Immunology Authors: Elise Guiedem, Eric Walter Pefura-Yone, George Mondinde Ikomey, C éline Nguefeu Nkenfou, Martha Mesembe, Mbanyamsig Mispa Yivala, Bih Hycenta Chendi, Graeme Brendon Jacobs, Novel Njweipi Chegou and Marie Claire Assoumou Okomo Tags: Research article Source Type: research

Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies
Chronic immune activation and hyperglycaemia are a hallmark of type 2 diabetes mellitus (T2D) while natural killer (NK) cells are involved in the pathogenesis of T2D. Dysregulated NK cell responses are associa... (Source: BMC Immunology)
Source: BMC Immunology - September 9, 2020 Category: Allergy & Immunology Authors: Vuyolwethu Mxinwa, Phiwayinkosi V. Dludla, Tawanda M. Nyambuya, Kabelo Mokgalaboni, Sithandiwe E. Mazibuko-Mbeje and Bongani B. Nkambule Tags: Research article Source Type: research

Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery
The use of inbred mice housed under standardized environmental conditions has been critical in identifying immuno-pathological mechanisms in different infectious and inflammatory diseases as well as revealing ... (Source: BMC Immunology)
Source: BMC Immunology - September 2, 2020 Category: Allergy & Immunology Authors: Josue Enriquez, Brianyell Mc Daniel Mims, Scott Trasti, Kathryn L. Furr and Matthew B. Grisham Tags: Review Source Type: research

Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection
Measles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) ... (Source: BMC Immunology)
Source: BMC Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Weiyun Shen, Hongzhou Ye, Xilin Zhang, Lixia Huo, Jingli Shen, Li Zhu, Xiang Wang and Dawei Cui Tags: Research article Source Type: research

Association of TIM-3 expression with glucose metabolism in Jurkat T cells
T cell activation is associated with increase in glycolysis and glutaminolysis. T cell immunoglobulin and mucin domain containing protein-3 (TIM-3), a T cell surface molecule, downregulates T cell activation a... (Source: BMC Immunology)
Source: BMC Immunology - August 20, 2020 Category: Allergy & Immunology Authors: Mi Jin Lee, Su Jin Yun, Bokyoung Lee, Eun Jeong, Gyesoon Yoon, Kyongmin Kim and Sun Park Tags: Research article Source Type: research

Subcutaneous immunoglobulin in primary immunodeficiency – impact of training and infusion characteristics on patient-reported outcomes
Subcutaneous immunoglobulin (SCIG) is increasingly utilized in primary immunodeficiency (PI). Understanding factors associated with treatment experience and satisfaction can optimize patient outcomes. We analy... (Source: BMC Immunology)
Source: BMC Immunology - August 10, 2020 Category: Allergy & Immunology Authors: R. Mallick, T. Henderson, B. J. Lahue, A. Kafal, P. Bassett and C. Scalchunes Tags: Research article Source Type: research

CD16 expression on neutrophils predicts treatment efficacy of capecitabine in colorectal cancer patients
Early detection of capecitabine-resistance could largely increase overall survival of colorectal cancer (CRC) patients. Previous studies suggested examination of immune cells in peripheral blood would help to ... (Source: BMC Immunology)
Source: BMC Immunology - August 8, 2020 Category: Allergy & Immunology Authors: Yu Lu, Yizhou Huang, Lei Huang, Yanjie Xu, Zien Wang, Han Li, Ting Zhang, Ming Zhong, Wei-qiang Gao and Yan Zhang Tags: Research article Source Type: research

Tertiary lymphoid structure related B-cell IgE isotype switching and secondary lymphoid organ linked IgE production in mouse allergy model
Numerous data obtained by different research laboratories indicate that specific IgE production is triggered independently of specific IgG or IgA ones and so it is not linked to fully matured germinal centers ... (Source: BMC Immunology)
Source: BMC Immunology - August 7, 2020 Category: Allergy & Immunology Authors: Dmitrii Borisovich Chudakov, Dmitrii Yuryevich Ryasantsev, Daria Sergeevna Tsaregorotseva, Olga Dmitrievna Kotsareva, Gulnar Vaisovna Fattakhova and Elena Viktorovna Svirshchevskaya Tags: Research article Source Type: research

Characteristics and reference ranges of CD4+T cell subpopulations among healthy adult Han Chinese in Shanxi Province, North China
Immunophenotyping of blood lymphocytes is an essential tool to evaluate the immune function of patients with immunodeficiency or autoimmunity. Predominately identified CD4+T cell subsets, Th1, Th2, Th17, as well ... (Source: BMC Immunology)
Source: BMC Immunology - August 3, 2020 Category: Allergy & Immunology Authors: Hong-Qing Niu, Xiang-Cong Zhao, Wei Li, Jian-Fang Xie, Xiao-Qing Liu, Jing Luo, Wen-Peng Zhao and Xiao-Feng Li Tags: Research article Source Type: research

Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food
The underlying cellular mechanisms causing adverse reactions to food are complex and still not fully understood. Therefore, in this study we aimed to identify functional and/or phenotypical immune cell signatu... (Source: BMC Immunology)
Source: BMC Immunology - July 22, 2020 Category: Allergy & Immunology Authors: Friederike Sonnet, Ellen Namork, Eva Stylianou, Ingvild Gaare-Olstad, Kanutte Huse, Sandra Andorf, Siri Mjaaland, Hubert Dirven and Unni Nygaard Tags: Research article Source Type: research

Assessment of weight and height of patients with primary immunodeficiency disorders and group of children with recurrent respiratory tract infections
Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there... (Source: BMC Immunology)
Source: BMC Immunology - July 16, 2020 Category: Allergy & Immunology Authors: Karolina Pieniawska- Śmiech, Kamil Bar, Mateusz Babicki, Karol Śmiech and Aleksandra Lewandowicz-Uszyńska Tags: Research article Source Type: research

EGR2 is elevated and positively regulates inflammatory IFN γ production in lupus CD4+ T cells
Recent studies have shown that early growth response 2 (EGR2) is highly induced in activated T cells and regulates T cell functions. In normal C57BL/6 (B6) mice, deletion of EGR2 in lymphocytes results in the ... (Source: BMC Immunology)
Source: BMC Immunology - July 9, 2020 Category: Allergy & Immunology Authors: Rujuan Dai, Bettina Heid, Xiguang Xu, Hehuang Xie, Christopher M. Reilly and S. Ansar Ahmed Tags: Research article Source Type: research

Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis
Outcome prediction for patients with sepsis may be conductive to early aggressive interventions. Numerous biomarkers and multiple scoring systems have been utilized in predicting outcomes, however, these tools... (Source: BMC Immunology)
Source: BMC Immunology - July 6, 2020 Category: Allergy & Immunology Authors: Lin Zhang, Cui-hua Yu, Kuan-peng Guo, Cai-zhi Huang and Li-ya Mo Tags: Research article Source Type: research

Health status and infections in patients with symptomatic primary and secondary immunoglobulin G (IgG) deficiencies receiving intravenous IgG replacement
The effects of intravenous immunoglobulin G replacement on perceived health and infection susceptibility of patients suffering from immunoglobulin G (IgG) deficiencies should be evaluated in a prospective anal... (Source: BMC Immunology)
Source: BMC Immunology - June 29, 2020 Category: Allergy & Immunology Authors: Rudolf Weide, Roland Schnell, Christof Schardt, Michael Koenigsmann, Burkhard Otremba, Mark-Oliver Zahn, Jan Wierecky, Ute Braun, Manfred Hensel, Martine Klausmann, Doris Fleckenstein, Peter Ehscheidt and Stefan Feiten Tags: Research article Source Type: research

What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?
Oral fibroblast immunological responses to bacterial stimuli are well known. However, there are few studies about pulp fibroblasts from deciduous teeth (HDPF) responses, which are important for the treatment o... (Source: BMC Immunology)
Source: BMC Immunology - June 22, 2020 Category: Allergy & Immunology Authors: Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew Seth Greene and Carlos Ferreira Santos Tags: Research article Source Type: research

RelB regulates the homeostatic proliferation but not the function of Tregs
RelB, a member of the NF- κB family, plays a critical role in the development of T cells. However, the role of RelB in Foxp3+ regulatory T cells (Tregs) remains controversial. (Source: BMC Immunology)
Source: BMC Immunology - June 18, 2020 Category: Allergy & Immunology Authors: Shuping Zhou, Weiwei Wu, Zhaoxia Wang, Zhaopeng Wang, Qinghong Su, Xiaofan Li, Yong Yu, Weidong Zhang, Mingzhao Zhu and Wei Lin Tags: Research article Source Type: research

JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells
Innate immune cells play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via release of cytokines. Small-molecule inhibitors of Janus kinases (JAKi) are clinically efficacious in patients wi... (Source: BMC Immunology)
Source: BMC Immunology - June 15, 2020 Category: Allergy & Immunology Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Furuya-Yashiro, Tomoyuki Asano, Shuzo Sato, Haruki Matsumoto, Hiroshi Watanabe, Hideko Kozuru, Hiroshi Yatsuhashi, Atsushi Kawakami and Kiyoshi Migita Tags: Research article Source Type: research

Correction to: Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells
An amendment to this paper has been published and can be accessed via the original article. (Source: BMC Immunology)
Source: BMC Immunology - June 15, 2020 Category: Allergy & Immunology Authors: Samantha S. Beauford, Anita Kumari and Charlie Garnett-Benson Tags: Correction Source Type: research

Phosphate starvation enhances phagocytosis of Mycobacterium bovis/BCG by macrophages
Tuberculosis is an important health problem worldwide. The only available vaccine is M. bovis/BCG, an attenuated mycobacterium that activates the innate and the acquired immune system after being phagocytosed by ... (Source: BMC Immunology)
Source: BMC Immunology - June 9, 2020 Category: Allergy & Immunology Authors: Patricia Espinosa-Cueto, Alejandro Magallanes-Puebla and Raul Mancilla Tags: Research article Source Type: research

Progranulin inhibits LPS-induced macrophage M1 polarization via NF- кB and MAPK pathways
Macrophage M1 polarization plays a pivotal role in inflammatory diseases. Progranulin (PGRN) has potential anti-inflammation action, however, the effect of PGRN on macrophage M1 polarization has been poorly st... (Source: BMC Immunology)
Source: BMC Immunology - June 5, 2020 Category: Allergy & Immunology Authors: Lianlian Liu, Hongmei Guo, Aimei Song, Jiahui Huang, Yu Zhang, Shanshan Jin, Shutong Li, Liguo Zhang, Chengzhe Yang and Pishan Yang Tags: Research article Source Type: research

Can presepsin uniformly respond to various pathogens? - an in vitro assay of new sepsis marker -
Presepsin (soluble CD14 subtype) is a novel biomarker of sepsis used for early diagnosis. Originally, CD14 is known as the pattern recognition receptor for the lipopolysaccharide (LPS)/LBP complexes, and the d... (Source: BMC Immunology)
Source: BMC Immunology - June 5, 2020 Category: Allergy & Immunology Authors: Yusuke Koizumi, Daisuke Sakanashi, Tetsuo Mohri, Hiroki Watanabe, Arufumi Shiota, Nobuhiro Asai, Hideo Kato, Mao Hagihara, Kenta Murotani, Yuka Yamagishi, Hiroyuki Suematsu and Hiroshige Mikamo Tags: Research article Source Type: research

Formation of ultralong DH regions through genomic rearrangement
Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–... (Source: BMC Immunology)
Source: BMC Immunology - June 2, 2020 Category: Allergy & Immunology Authors: Brevin A. Smider and Vaughn V. Smider Tags: Research article Source Type: research

Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease
Follicular helper CD4+ T (Tfh) cells have a critical role in IgG4 production by B cells in IgG4-related disease (IgG4-RD). Recent studies including ours showed that SLAMF7+CD4+ T cells are an important pathologic... (Source: BMC Immunology)
Source: BMC Immunology - June 1, 2020 Category: Allergy & Immunology Authors: Kazuhiko Higashioka, Yuri Ota, Takashi Maehara, Masafumi Moriyama, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Seiji Nakamura, Koichi Akashi and Hiroaki Niiro Tags: Research article Source Type: research

Immunogenicity and protective efficacy of a live, oral cholera vaccine formulation stored outside-the-cold-chain for 140  days
Cholera, an acute watery diarrhoeal disease caused by Vibrio cholerae serogroup O1 and O139 across the continents. Replacing the existing WHO licensed killed multiple-dose oral cholera vaccines that demand ‘cold ... (Source: BMC Immunology)
Source: BMC Immunology - May 25, 2020 Category: Allergy & Immunology Authors: Tew Hui Xian, Kurunathan Sinniah, Chan Yean Yean, Venkateskumar Krishnamoorthy, Mohd Baidi Bahari, Manickam Ravichandran and Guruswamy Prabhakaran Tags: Research article Source Type: research

Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. Recent studies have shown that the Angptl2 pathway mediated hepatic inflammatory response plays an important role in... (Source: BMC Immunology)
Source: BMC Immunology - May 19, 2020 Category: Allergy & Immunology Authors: Zengsheng Lu, Beihui He, Zhiyun Chen, Maoxiang Yan and Liyan Wu Tags: Research article Source Type: research

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
HLA class II tetramers can be used for ex vivo enumeration and phenotypic characterisation of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune d... (Source: BMC Immunology)
Source: BMC Immunology - May 18, 2020 Category: Allergy & Immunology Authors: Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars R önnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen and Vivianne Mal Tags: Research article Source Type: research

Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection
Understanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide. Recent studies demonstrated that host cholesterol levels have ... (Source: BMC Immunology)
Source: BMC Immunology - May 12, 2020 Category: Allergy & Immunology Authors: Jinrui Xu, Yanbing Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu and Yujiong Wang Tags: Research article Source Type: research

Comparison of personal and shared frameshift neoantigen vaccines in a mouse mammary cancer model
It is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging. It req... (Source: BMC Immunology)
Source: BMC Immunology - May 5, 2020 Category: Allergy & Immunology Authors: Milene Peterson, Sierra Nicole Murphy, John Lainson, Jian Zhang, Luhui Shen, Chris W. Diehnelt and Stephen Albert Johnston Tags: Research article Source Type: research

Patient experience with subcutaneous immunoglobulin 20%, Ig20Gly, for primary immunodeficiency diseases: a prespecified post hoc analysis of combined data from 2 pivotal trials
Often, patients with primary immunodeficiency diseases (PID), which are marked by the absence or loss of functional antibodies, require lifelong treatment with immunoglobulin (IG) replacement therapy administe... (Source: BMC Immunology)
Source: BMC Immunology - May 4, 2020 Category: Allergy & Immunology Authors: Lisa M. Meckley, Yanyu Wu, Diane Ito, Todd Berner, Barbara McCoy and Leman Yel Tags: Research article Source Type: research

Human CD8+CD28 − T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo
CD8+CD28 − T suppressor (Ts) cells play critical role in transplant tolerance. Our previous study has generated CD8+CD28− Ts cells in vitro which exert robust allospecific suppressive capacity in vitro. (Source: BMC Immunology)
Source: BMC Immunology - April 29, 2020 Category: Allergy & Immunology Authors: Guihuan Liu, Yuming Yu, Fu Feng, Ping Zhu, Hua Zhang, Danni Zhang, Xiaoqiang Feng, Zedan Zhang and Yanjun Liu Tags: Research article Source Type: research

Epitherapy and immune checkpoint blockade: using epigenetic reinvigoration of exhausted and dysfunctional T cells to reimburse immunotherapy response
Cancer cells subvert natural immunosuppression by upregulating the expression of checkpoint proteins and their ligands. For example, tumor cells expressing programmed death-ligand 1 (PD-L1) induce immune cell ... (Source: BMC Immunology)
Source: BMC Immunology - April 21, 2020 Category: Allergy & Immunology Authors: Isabella McGoverne, Jenny Dunn, Jacob Batham, Wen Juan Tu, Jeremy Chrisp and Sudha Rao Tags: Review Source Type: research

A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren ’s syndrome
CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the patho... (Source: BMC Immunology)
Source: BMC Immunology - April 19, 2020 Category: Allergy & Immunology Authors: Yuqi Shen, Yuhua Ma, Jingyuan Xie, Li Lin, Yifan Shi, Xiao Li, Pingyan Shen, Xiaoxia Pan and Hong Ren Tags: Research article Source Type: research

Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells
Prostaglandin E2 (PGE2) is an endogenous lipid mediator of inflammation. Its production is regulated by the rate-limiting upstream enzyme cyclooxygenase-2 (COX-2). We have recently demonstrated that the major cel... (Source: BMC Immunology)
Source: BMC Immunology - April 17, 2020 Category: Allergy & Immunology Authors: Whajung Cho and Jongseon Choe Tags: Research article Source Type: research

Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells
The use of immunotherapy strategies for the treatment of advanced cancer is rapidly increasing. Most immunotherapies rely on induction of CD8+ tumor-specific cytotoxic T cells that are capable of directly kill... (Source: BMC Immunology)
Source: BMC Immunology - April 16, 2020 Category: Allergy & Immunology Authors: Samantha S. Beauford, Anita Kumari and Charlie Garnett-Benson Tags: Research article Source Type: research

Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts
Miscellaneous memory cell populations that exist before organ transplantation are crucial barriers to transplantation. In the present study, we used a skin-primed heart transplantation model in mouse to evalua... (Source: BMC Immunology)
Source: BMC Immunology - April 16, 2020 Category: Allergy & Immunology Authors: Maoshu Zhu, Yunhan Ma, Kai Tan, Liyi Zhang, Zhaowei Wang, Yongsheng Li, Yingyu Chen, Junjun Guo, Guoliang Yan and Zhongquan Qi Tags: Research article Source Type: research

Increased Interleukin-35 suppresses peripheral CD14+ monocytes function in patients with Kawasaki disease
Interleukin-35 (IL-35) is a newly identified IL-12 cytokine family member, which regulates the activity of immune cells in infectious diseases and autoimmune disorders. However, the regulatory function of IL-3... (Source: BMC Immunology)
Source: BMC Immunology - April 10, 2020 Category: Allergy & Immunology Authors: Haijian Xing and Gang Tian Tags: Research article Source Type: research

Identification of differentially expressed circulating exosomal lncRNAs in IgA nephropathy patients
Although immunoglobulin A nephropathy (IgAN) is one of the foremost primary glomerular disease, treatment of IgAN is still in infancy. Non-invasive biomarkers are urgently needed for IgAN diagnosis. We investi... (Source: BMC Immunology)
Source: BMC Immunology - March 31, 2020 Category: Allergy & Immunology Authors: Na Guo, Qin Zhou, Xiang Huang, Jianwen Yu, Qianqian Han, Baoting Nong, Yuanyan Xiong, Peifen Liang, Jiajia Li, Min Feng, Jun Lv and Qiongqiong Yang Tags: Research article Source Type: research

Functional comparison of PBMCs isolated by Cell Preparation Tubes (CPT) vs. Lymphoprep Tubes
Cryopreserved human peripheral blood mononuclear cells (PBMCs) are a commonly used sample type for a variety of immunological assays. Many factors can affect the quality of PBMCs, and careful consideration and... (Source: BMC Immunology)
Source: BMC Immunology - March 30, 2020 Category: Allergy & Immunology Authors: Han Chen, Christian M. Sch ürch, Kevin Noble, Kenneth Kim, Peter O. Krutzik, Erika O’Donnell, Jason Vander Tuig, Garry P. Nolan and David R. McIlwain Tags: Methodology article Source Type: research

A combination of the activation marker CD86 and the immune checkpoint marker B and T lymphocyte attenuator (BTLA) indicates a putative permissive activation state of B cell subtypes in healthy blood donors independent of age and sex
The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations. (Source: BMC Immunology)
Source: BMC Immunology - March 20, 2020 Category: Allergy & Immunology Authors: Susanne Axelsson, Anders Magnuson, Anna Lange, Aseel Alshamari, Elisabeth Hultgren H örnquist and Olof Hultgren Tags: Research article Source Type: research

Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch
Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-tra... (Source: BMC Immunology)
Source: BMC Immunology - March 18, 2020 Category: Allergy & Immunology Authors: Shannon P Hilchey, Mukta G Palshikar, Jason A Emo, Dongmei Li, Jessica Garigen, Jiong Wang, Eric S Mendelson, Valentina Cipolla, Juilee Thakar and Martin S Zand Tags: Research Article Source Type: research

Specific humoral response in cancer patients treated with a VEGF-specific active immunotherapy procedure within a compassionate use program
CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterially-derived adjuvant VSSP. CIGB-247 has been already evaluated ... (Source: BMC Immunology)
Source: BMC Immunology - March 14, 2020 Category: Allergy & Immunology Authors: Javier S ánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Yenima Martín Bauta, Katty-Hind Selman-Housein Bernal, Ana Victoria de la Torre Santos, Mariela Pérez de la Iglesia, Lian Trimiño Lorenzo and Marta Aya Tags: Research article Source Type: research

The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion
Inflammation appears to be an important component of concussion pathophysiology. However, its relationship to symptom burden is unclear. Therefore, the purpose of this study was to evaluate the relationship be... (Source: BMC Immunology)
Source: BMC Immunology - March 12, 2020 Category: Allergy & Immunology Authors: Alex P. Di Battista, Nathan Churchill, Shawn G. Rhind, Doug Richards and Michael G. Hutchison Tags: Research article Source Type: research

Positive staining of the immunoligand B7-H6 in abnormal/transformed keratinocytes consistently accompanies the progression of cervical cancer
B7-H6 has been revealed as an endogenous immunoligand expressed in a variety of tumors, but not expressed in healthy tissues. Heretofore, no studies have been reported describing B7-H6 in women with cervical c... (Source: BMC Immunology)
Source: BMC Immunology - March 6, 2020 Category: Allergy & Immunology Authors: Gloria Yareli Gutierrez-Silerio, Ramon Antonio Franco-Topete, Jesse Haramati, Eduardo Miguel Navarrete-Medina, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Blanca Estela Bastidas-Ramirez, Martha Eloisa Ramos-Marquez and Susana del Toro-Arreola Tags: Research article Source Type: research

Allo-HSCT compared with immunosuppressive therapy for acquired aplastic anemia: a system review and meta-analysis
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and immunosuppressive therapy (IST) are two major competing treatment strategies for acquired aplastic anemia (AA). Whether allo-HSCT is superior ... (Source: BMC Immunology)
Source: BMC Immunology - March 6, 2020 Category: Allergy & Immunology Authors: Yangmin Zhu, Qingyan Gao, Jing Hu, Xu Liu, Dongrui Guan and Fengkui Zhang Tags: Research article Source Type: research

The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer
Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on t... (Source: BMC Immunology)
Source: BMC Immunology - February 27, 2020 Category: Allergy & Immunology Authors: Andrea J. Luker, Laura J. Graham, Timothy M. Smith Jr, Carmen Camarena, Matt P. Zellner, Jamie-Jean S. Gilmer, Sheela R. Damle, Daniel H. Conrad, Harry D. Bear and Rebecca K. Martin Tags: Research article Source Type: research

Inducible nitric oxide synthase and systemic lupus erythematosus: a systematic review and meta-analysis
There is a growing body of evidences indicating iNOS has involved in the pathogenesis of SLE. However, the role of iNOS in SLE is inconsistency. This systematic review was designed to evaluate the association ... (Source: BMC Immunology)
Source: BMC Immunology - February 17, 2020 Category: Allergy & Immunology Authors: Lu Pan, Sirui Yang, Jinghua Wang, Meng Xu, Shaofeng Wang and Huanfa Yi Tags: Research article Source Type: research

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis
Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinens... (Source: BMC Immunology)
Source: BMC Immunology - February 17, 2020 Category: Allergy & Immunology Authors: Xiangyang Li, Ying Yang, Suping Qin, Fanyun Kong, Chao Yan, Wanpeng Cheng, Wei Pan, Qian Yu, Hui Hua, Kuiyang Zheng and Renxian Tang Tags: Research article Source Type: research

Dysregulation of TNF- α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei
Melioidosis is endemic in Southeast Asia and Northern Australia and is caused by the Gram-negative, facultative intracellular pathogen Burkholderia pseudomallei. Diagnosis of melioidosis is often difficult becaus... (Source: BMC Immunology)
Source: BMC Immunology - February 3, 2020 Category: Allergy & Immunology Authors: Kei Amemiya, Jennifer L. Dankmeyer, Jeremy J. Bearss, Xiankun Zeng, Spencer W. Stonier, Carl Soffler, Christopher K. Cote, Susan L. Welkos, David P. Fetterer, Taylor B. Chance, Sylvia R. Trevino, Patricia L. Worsham and David M. Waag Tags: Research article Source Type: research

Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus
Quantitative PCR (qPCR) is a powerful tool that is particularly well-suited to measure mRNA levels in clinical samples, especially those with relatively low cell counts. However, a caveat of this approach is t... (Source: BMC Immunology)
Source: BMC Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Justin G. Roy, Janet E. McElhaney and Chris P. Verschoor Tags: Research article Source Type: research

miR32-5p promoted vascular smooth muscle cell calcification by upregulating TNF α in the microenvironment
Vascular calcification is often associated with chronic inflammation and is a risk factor for brain arterial stiffness. Our previous results showed that miR32-5p was positively correlated with vascular smooth ... (Source: BMC Immunology)
Source: BMC Immunology - January 17, 2020 Category: Allergy & Immunology Authors: Jingsong Cao, Ling Chen, Xiaoling Zhong, Yingying Shen, Yan Gao, Qian Chen, Xuyu Zu and Jianghua Liu Tags: Research article Source Type: research