ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions
Expansion of type 2 innate lymphoid cells (ILC2s) in hypercholesterolaemic mice protects against atherosclerosis while different ILC2 subsets have been described (natural, inflammatory) based on their suppress... (Source: BMC Immunology)
Source: BMC Immunology - December 10, 2019 Category: Allergy & Immunology Authors: Polyxeni T. Mantani, Pontus Dun ér, Irena Ljungcrantz, Jan Nilsson, Harry Björkbacka and Gunilla Nordin Fredrikson Tags: Research article Source Type: research

NK cell predicts the severity of acute graft-versus-host disease in patients after allogeneic stem cell transplantation using antithymocyte globulin (ATG) in pretreatment scheme
Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard of grading system is based on clinical symptoms in skin, liver and intesti... (Source: BMC Immunology)
Source: BMC Immunology - December 9, 2019 Category: Allergy & Immunology Authors: Ping Zhang, Shujun Yang, Yujing Zou, Xiao Yan, Hao Wu, Miao Zhou, Yong Cheng Sun, Yi Zhang, Huiling Zhu, Kaihong Xu, Yi Wang, Li Xia Sheng, Qitian Mu, Liguang Sun and Guifang Ouyang Tags: Research article Source Type: research

The effect of tuberculosis on immune reconstitution among HIV patients on highly active antiretroviral therapy in Adigrat general hospital, eastern Tigrai, Ethiopia; 2019: a retrospective follow up study
Ethiopia initiated antiretroviral therapy early in 2005. Managing and detecting antiretroviral treatment response is important to monitor the effectiveness of medication and possible drug switching for low imm... (Source: BMC Immunology)
Source: BMC Immunology - December 5, 2019 Category: Allergy & Immunology Authors: Hadush Negash, Haftom Legese, Mebrahtu Tefera, Fitsum Mardu, Kebede Tesfay, Senait Gebresilasie, Berhane Fseha, Tsega Kahsay, Aderajew Gebrewahd and Brhane Berhe Tags: Research article Source Type: research

Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc- μTP-L309C, a recombinant IgG1 Fc hexamer
High-dose intravenous immunoglobulin (IVIg), and more recently, subcutaneously-delivered Ig (SCIg), are used to treat a variety of autoimmune diseases; however, there are challenges associated with product pro... (Source: BMC Immunology)
Source: BMC Immunology - December 4, 2019 Category: Allergy & Immunology Authors: Bonnie J. B. Lewis, Jade Ville, Megan Blacquiere, Selena Cen, Rolf Spirig, Adrian W. Zuercher, Fabian K äsermann and Donald R. Branch Tags: Research article Source Type: research

Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma
Mutant peptides presented by cancer cells are superior vaccine candidates than self peptides. The efficacy of mutant K-Ras, P53 and EGFR (Epidermal Growth Factor Receptor) peptides have been tested as cancer v... (Source: BMC Immunology)
Source: BMC Immunology - November 13, 2019 Category: Allergy & Immunology Authors: Deng Pan, Dapeng Zhou, Weijing Cai, Weibo Wu, Wen Ling Tan, Caicun Zhou and Yanyan Lou Tags: Research article Source Type: research

Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD
Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity.... (Source: BMC Immunology)
Source: BMC Immunology - November 12, 2019 Category: Allergy & Immunology Authors: Hong Liu, Suryasarathi Dasgupta, Yu Fu, Brandi Bailey, Christian Roy, Eric Lightcap and Benjamin Faustin Tags: Research article Source Type: research

The effect of pneumococcal immunization on total and antigen-specific B cells in patients with severe chronic kidney disease
While the 23-valent pneumococcal polysaccharide vaccine (PPV23) is routinely used in Canada and some other countries to prevent pneumococcal infection in adults with chronic kidney disease (CKD), patients deve... (Source: BMC Immunology)
Source: BMC Immunology - November 12, 2019 Category: Allergy & Immunology Authors: Gabrielle Nicole Gaultier, William McCready and Marina Ulanova Tags: Research article Source Type: research

Low pre-transplant levels of mannose-binding lectin are associated with viral infections and mortality after haematopoietic allogeneic stem cell transplantation
Mannose-binding lectin (MBL) is a key component of innate immunity. Low serum MBL levels, related to promoter polymorphism and structural variants, have been associated with an increased risk of infection. The... (Source: BMC Immunology)
Source: BMC Immunology - November 9, 2019 Category: Allergy & Immunology Authors: M. Puente, C. Fari ñas-Alvarez, A. Moreto, P. Sánchez-Velasco, J. G. Ocejo-Vinyals and M. C. Fariñas Tags: Research article Source Type: research

Circulating monocyte subsets in multiple myeloma patients receiving autologous stem cell transplantation – a study of the preconditioning status and the course until posttransplant reconstitution for a consecutive group of patients
Induction therapy of multiple myeloma patients prior to autologous stem cell transplantation has changed from conventional chemotherapy to treatment based on proteasome inhibitors or immunomodulatory drugs. We... (Source: BMC Immunology)
Source: BMC Immunology - November 8, 2019 Category: Allergy & Immunology Authors: Ida Marie Rundgren, Elisabeth Ersv ær, Aymen Bushra Ahmed, Anita Ryningen and Øystein Bruserud Tags: Research article Source Type: research

Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection
Helios has been reported to stabilize regulatory T (Treg) suppressive function. Programmed cell death protein 1 (PD-1) expression in three human monocyte subsets modulates immune responses. Recently, our team ... (Source: BMC Immunology)
Source: BMC Immunology - October 24, 2019 Category: Allergy & Immunology Authors: Lifeng Liu, Qiuyue Zhang, Peng Chen, Na Guo, Aixin Song, Xiaojie Huang, Wei Xia, Li Li, Christiane Moog, Hao Wu, Bin Su and Tong Zhang Tags: Research article Source Type: research

Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysis
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus that presents a high risk of end-stage renal disease. In the present study, we used CIBERSORT and gene set enrichment analysis (GSE... (Source: BMC Immunology)
Source: BMC Immunology - October 21, 2019 Category: Allergy & Immunology Authors: Yiling Cao, Weihao Tang and Wanxin Tang Tags: Research article Source Type: research

IgA and IgG antibody detection of mycobacterial antigens in pleural fluid and serum from pleural tuberculous patients
A previous study demonstrated pleural fluid (PF) IgA immunodominance for the fused MT10.3:MPT64 protein in pleural tuberculosis (PLTB) cases. However, no clue on the role of IgA and IgG against this and other ... (Source: BMC Immunology)
Source: BMC Immunology - October 17, 2019 Category: Allergy & Immunology Authors: Renan Jeremias da Silva, Raquel da Silva Corr êa, Isabela Gama Sardella, Ana Carla de Paulo Mulinari, Thiago Thomaz Mafort, Ana Paula Santos, Rogério Rufino, Luciana Silva Rodrigues and Maria Helena Féres Saad Tags: Research article Source Type: research

Enhanced IFN- γ, but not IL-2, response to Mycobacterium tuberculosis antigens in HIV/latent TB co-infected patients on long-term HAART
HIV-infected individuals with latent TB infection are at increased risk of developing active TB. HAART greatly reduces the incidence rate of TB in HIV-infected patients and reconstitutes Mycobacterium tuberculosi... (Source: BMC Immunology)
Source: BMC Immunology - October 11, 2019 Category: Allergy & Immunology Authors: Girmay Desalegn, Aster Tsegaye, Dawit Gebreegziabiher, Abraham Aseffa and Rawleigh Howe Tags: Research article Source Type: research

Simple propagation method for resident macrophages by co-culture and subculture, and their isolation from various organs
Resident macrophages (M ø) originating from yolk sac Mø and/or foetal monocytes colonise tissues/organs during embryonic development. They persist into adulthood by self-renewal at a steady state, independent o... (Source: BMC Immunology)
Source: BMC Immunology - September 18, 2019 Category: Allergy & Immunology Authors: Kazushige Ogawa, Mayu Tsurutani, Aya Hashimoto and Miharu Soeda Tags: Methodology article Source Type: research

Biological variation of immunological blood biomarkers in healthy individuals and quality goals for biomarker tests
Cytokines, chemokines, adipocytokines, soluble cell receptors, and immune activation markers play an important role in immune responsiveness and can provide prognostic value since they reflect underlying condi... (Source: BMC Immunology)
Source: BMC Immunology - September 14, 2019 Category: Allergy & Immunology Authors: Najib Aziz, Roger Detels, Joshua J. Quint, David Gjertson, Timothy Ryner and Anthony W. Butch Tags: Research article Source Type: research

Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients
The development of Systemic lupus erythematosus (SLE) has been associated with the balance of Th17 and Treg cells. IL-2 and rapamycin can influence the populations of both Th17 and Treg cells. However, it is u... (Source: BMC Immunology)
Source: BMC Immunology - September 4, 2019 Category: Allergy & Immunology Authors: Chunmiao Zhao, Yanfang Chu, Zhaoyun Liang, Bingying Zhang, Xuxia Wang, Xiaona Jing, Meihua Hao, Yiqi Wang, Jia An, Xingzhe Zhang, Liguang Sun and Junwei Chen Tags: Research article Source Type: research

The predictive role of CD4+ cell count and CD4/CD8 ratio in immune reconstitution outcome among HIV/AIDS patients receiving antiretroviral therapy: an eight-year observation in China
The immune reconstitution after initiation of highly active antiretroviral therapy (HAART) among HIV-infected individuals substantially affects patients ’ prognosis. However, the dynamic characteristics and pre... (Source: BMC Immunology)
Source: BMC Immunology - August 28, 2019 Category: Allergy & Immunology Authors: Chong-Xi Li, Yu-Ye Li, Li-Ping He, Jing Kou, Jin-Song Bai, Jun Liu, Bo Tian, Li-Juan Cao, Kun-Hua Wang and Yi-Qun Kuang Tags: Research article Source Type: research

Genetic polymorphisms and epigenetic regulation of survivin encoding gene, BIRC5, in multiple sclerosis patients
The persistent the inflammatory condition in multiple sclerosis (MS) may due to the aberrant regulation of the elimination of the pathogenic autoreactive lymphocytes through apoptosis. Survivin, encoded by the... (Source: BMC Immunology)
Source: BMC Immunology - August 22, 2019 Category: Allergy & Immunology Authors: Dariush Rahban, Forogh Mohammadi, Mehdi Alidadi, Taha Ghantabpour, Pedram Abbasi Ghasem Kheyli and Majid Ahmadi Tags: Research article Source Type: research

Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations
We sought to compare Pneumovax ®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or Ig... (Source: BMC Immunology)
Source: BMC Immunology - August 20, 2019 Category: Allergy & Immunology Authors: Antony R. Parker, Markus Skold, Stephen Harding, J. Clayborn Barton, Luigi F. Bertoli and James C. Barton Tags: Research article Source Type: research

CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B
Immune inhibitory receptors play an important role in chronic infections. However, little is known about their role in hepatitis B virus (HBV) infection. Here, we analyzed the relationship between programmed d... (Source: BMC Immunology)
Source: BMC Immunology - August 7, 2019 Category: Allergy & Immunology Authors: Yuejiao Dong, Xuefen Li, Lu Zhang, Qiaoyun Zhu, Chunlei Chen, Jiaqi Bao and Yu Chen Tags: Research article Source Type: research

Comprehensive analyses of long non-coding RNA expression profiles by RNA sequencing and exploration of their potency as biomarkers in psoriatic arthritis patients
The aim of the current study was to investigate the long non-coding RNA (lncRNA) expression profiles in psoriatic arthritis (PSA) patients by RNA sequencing, and to further explore potential biomarkers that we... (Source: BMC Immunology)
Source: BMC Immunology - August 7, 2019 Category: Allergy & Immunology Authors: Tao Yue, Mei Ji, Huanru Qu, Mengru Guo, Fengmin Bai, Zhanming Zhang, Weifeng Wang, Xuming Gong and Zhenghua Zhang Tags: Research article Source Type: research

Increased circulating Tfh to Tfr ratio in chronic renal allograft dysfunction: a pilot study
T follicular helper (Tfh) cells play a control role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit Tfh-B cell interaction. (Source: BMC Immunology)
Source: BMC Immunology - August 5, 2019 Category: Allergy & Immunology Authors: Lin Yan, Yamei Li, Yi Li, Xiaojuan Wu, Xianding Wang, Lanlan Wang, Yunying Shi and Jiangtao Tang Tags: Research article Source Type: research

Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits
In this study, seven adjuvants were compared for use with Plasmodium falciparum DiCo-Apical Membrane Antigen 1 (Pf-DiCo-AMA1), with the aim to identify an ideal adjuvant which yields high antibody titres and pote... (Source: BMC Immunology)
Source: BMC Immunology - July 30, 2019 Category: Allergy & Immunology Authors: Sumera Younis, Bart W. Faber, Clemens H.M. Kocken and Edmond J. Remarque Tags: Research article Source Type: research

Changes of B cell subsets in central pathological process of autoimmune encephalomyelitis in mice
This study was conducted to examine the pathological changes and B cell subsets in experimental aut... (Source: BMC Immunology)
Source: BMC Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Yingqiong Xiong, Shaomin Cheng, Xiaomu Wu, Yue Ren and Xufang Xie Tags: Research article Source Type: research

Association of proinflammatory genes expression with serum interleukin 1 β and free fatty acids in metabolically healthy and unhealthy abdominally obese individuals: a case-control study
Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the ... (Source: BMC Immunology)
Source: BMC Immunology - July 4, 2019 Category: Allergy & Immunology Authors: Parichehr Amiri, Behzad Baradaran, Maryam Saghafi-Asl, Mahsa Naghizadeh, Dariush Shanehbandi, Nahid Karamzad and Sepideh Zununi Vahed Tags: Research article Source Type: research

Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils
C5a is important for antineutrophil cytoplasmic antibody (ANCA)-mediated activation of neutrophils. The present study aimed to assess the role of macrophage migration inhibitory factor (MIF) in ANCA-mediated a... (Source: BMC Immunology)
Source: BMC Immunology - June 27, 2019 Category: Allergy & Immunology Authors: Jian Hao, Tiegang Lv, Liping Xu, Mao Ran and Kaili Wu Tags: Research article Source Type: research

A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins
Autoimmune diseases result from aberrant immune attacks by the body itself. It is mysterious how autoantigens, a large cohort of seemingly unconnected molecules expressed in different parts of the body, can in... (Source: BMC Immunology)
Source: BMC Immunology - June 26, 2019 Category: Allergy & Immunology Authors: Wei Zhang, Jung-hyun Rho, Michael H. Roehrl and Julia Y. Wang Tags: Research article Source Type: research

Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors
The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell ’s specificity for antigens is determined by its T cell receptors (TCRs), which together... (Source: BMC Immunology)
Source: BMC Immunology - June 21, 2019 Category: Allergy & Immunology Authors: Nathaniel D. Chu, Haixin Sarah Bi, Ryan O. Emerson, Anna M. Sherwood, Michael E. Birnbaum, Harlan S. Robins and Eric J. Alm Tags: Research article Source Type: research

Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear
CD44 is a multifunctional molecule that plays major roles in both leukocyte recruitment and tissue proliferation. Since mucosal hyperplasia and leukocyte infiltration of the middle ear cavity are major feature... (Source: BMC Immunology)
Source: BMC Immunology - June 21, 2019 Category: Allergy & Immunology Authors: Hyun Woo Lim, Kwang Pak, Arwa Kurabi and Allen F. Ryan Tags: Research article Source Type: research

Similar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols
Mouse models have been extremely valuable in identifying the fundamental mechanisms of airway inflammation that underlie human allergic asthma. Several models are commonly used, employing different methods and... (Source: BMC Immunology)
Source: BMC Immunology - June 4, 2019 Category: Allergy & Immunology Authors: Evelyn J. Hyde, Kirsty A. Wakelin, Naomi J. Daniels, Sayani Ghosh and Franca Ronchese Tags: Research article Source Type: research

Distinct variations of antibody secreting cells and memory B cells during the course of Kawasaki disease
Both antibody secreting cells (ASCs) and memory B cells are essential for the maintenance of humoral immunity. To date, limit studies have focused on the two populations in Kawasaki disease (KD). To address th... (Source: BMC Immunology)
Source: BMC Immunology - June 3, 2019 Category: Allergy & Immunology Authors: Meng Xu, Yanfang Jiang, Jinghua Wang, Jinxiang Liu, Congcong Liu, Deying Liu and Sirui Yang Tags: Research article Source Type: research

Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis
Early diagnosis of bacterial sepsis in neonates is hampered by non-specific symptoms and the lack of rapid responding laboratory measures. The biomarker soluble CD14 subtype (sCD14-ST) seems promising in the d... (Source: BMC Immunology)
Source: BMC Immunology - June 3, 2019 Category: Allergy & Immunology Authors: Iris van Maldeghem, Charlotte M. Nusman and Douwe H. Visser Tags: Research article Source Type: research

Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency
Mannose-binding lectin (MBL) deficiency may increase risk of respiratory tract infection in adults unselected for IgG or IgG subclass levels. In a retrospective study, we sought to determine associations of se... (Source: BMC Immunology)
Source: BMC Immunology - May 22, 2019 Category: Allergy & Immunology Authors: James C. Barton, Jackson C. Barton and Luigi F. Bertoli Tags: Research article Source Type: research

Identification and characterisation of transient receptor potential melastatin 2 and CD38 channels on natural killer cells using the novel application of flow cytometry
Natural Killer (NK) cells are effector lymphocytes of the innate immune system and are subclassed into CD56BrightCD16Dim/ − and CD56DimCD16+ NK cells. Intracellular calcium (Ca2+) is fundamental to regulate a numb... (Source: BMC Immunology)
Source: BMC Immunology - May 10, 2019 Category: Allergy & Immunology Authors: Cassandra Balinas, Helene Cabanas, Donald Staines and Sonya Marshall-Gradisnik Tags: Research article Source Type: research

Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in HeLa cells
Tristetraprolin (TTP) is an RNA binding protein that plays a critical role in regulating proinflammatory immune responses by destabilizing target mRNAs via binding to their AU-rich elements (AREs) in the 3 ′-UT... (Source: BMC Immunology)
Source: BMC Immunology - May 2, 2019 Category: Allergy & Immunology Authors: Yafang Tu, Xiongfei Wu, Fengyun Yu, Jianzhong Dang, Juan Wang, Yaxun Wei, Zhitao Cai, Zhipeng Zhou, Wenliang Liao, Lian Li and Yi Zhang Tags: Research article Source Type: research

A novel approach reveals that HLA class 1 single antigen bead-signatures provide a means of high-accuracy pre-transplant risk assessment of acute cellular rejection in renal transplantation
Acute cellular rejection (ACR) is associated with complications after kidney transplantation, such as graft dysfunction and graft loss. Early risk assessment is therefore critical for the improvement of transp... (Source: BMC Immunology)
Source: BMC Immunology - April 27, 2019 Category: Allergy & Immunology Authors: Nicole Wittenbrink, Sabrina Herrmann, Arturo Blazquez-Navarro, Chris Bauer, Eric Lindberg, Kerstin Wolk, Robert Sabat, Petra Reinke, Birgit Sawitzki, Oliver Thomusch, Christian Hugo, Nina Babel, Harald Seitz and Michal Or-Guil Tags: Research article Source Type: research

Immunoglobulin G responses against falciparum malaria specific antigens are higher in children with homozygous sickle cell trait than those with normal hemoglobin
High Immunoglobulin G (IgG) response to Plasmodium falciparum antigens is associated with partial malaria protection in sickle hemoglobin (HbS) children. However, this response has been more studied in children w... (Source: BMC Immunology)
Source: BMC Immunology - April 27, 2019 Category: Allergy & Immunology Authors: George Msema Bwire, Mtebe Majigo, Robert Makalla, Lillian Nkinda, Akili Mawazo, Mucho Mizinduko and Julie Makani Tags: Research article Source Type: research

Patients with idiopathic recurrent miscarriage have abnormally high TGF ß+ blood NK, NKT and T cells in the presence of abnormally low TGFß plasma levels
Previously, we demonstrated up-regulated activated CD4+ and CD8+ T lymphocytes as well as up-regulated cytotoxic NK cells in the blood of patients with idiopathic recurrent miscarriage. In the present study, w... (Source: BMC Immunology)
Source: BMC Immunology - March 4, 2019 Category: Allergy & Immunology Authors: Li Zhu, Mostafa Aly, Ruben Jeremias Kuon, Bettina Toth, Haihao Wang, Hristos Karakizlis, Rolf Weimer, Christian Morath, Eman Ibrahim, Naruemol Ekpoom, Gerhard Opelz and Volker Daniel Tags: Research article Source Type: research

Active immunization with norovirus P particle-based amyloid- β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice
Active immunotherapy targeting amyloid- β (Aβ) is a promising treatment for Alzheimer’s disease (AD). Numerous preclinical studies and clinical trials demonstrated that a safe and effective AD vaccine should in... (Source: BMC Immunology)
Source: BMC Immunology - February 12, 2019 Category: Allergy & Immunology Authors: Ping Yang, Yongqing Guo, Yao Sun, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu and Wei Kong Tags: Research article Source Type: research

Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function
Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors. Human Leukocyte Antigen nul... (Source: BMC Immunology)
Source: BMC Immunology - January 29, 2019 Category: Allergy & Immunology Authors: Alexandra Tremblay-McLean, Sita Coenraads, Zahra Kiani, Franck P. Dupuy and Nicole F. Bernard Tags: Research article Source Type: research

CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes
Systemic inflammation and the fever response to pathogens are coordinately regulated by IL-6 and IL-1 β. We previously showed that CEACAM1 regulates the LPS driven expression of IL-1β in murine neutrophils thro... (Source: BMC Immunology)
Source: BMC Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Zhifang Zhang, Deirdre La Placa, Tung Nguyen, Maciej Kujawski, Keith Le, Lin Li and John E. Shively Tags: Research article Source Type: research

Monoclonal antibody against EV71 3Dpol inhibits the polymerase activity of RdRp and virus replication
Enterovirus A 71 (EV71) is a neurotropic virus that may lead to acute flaccid paralysis, encephalitis, cardiopulmonary failure or even death. No vaccine and defensive drug controlling EV71 is currently availab... (Source: BMC Immunology)
Source: BMC Immunology - January 22, 2019 Category: Allergy & Immunology Authors: Yaoming Li, Jie Yu, Xiuwen Qi and Huimin Yan Tags: Research article Source Type: research

Phenotypic and functional stability of leukocytes from human peripheral blood samples: considerations for the design of immunological studies
Human peripheral blood mononuclear cells (PBMCs) are extensively used for research of immune cell functions, identification of biomarkers and development of diagnostics and therapeutics for human diseases, amo... (Source: BMC Immunology)
Source: BMC Immunology - January 18, 2019 Category: Allergy & Immunology Authors: Adriana Navas, Lina Giraldo-Parra, Miguel Dar ío Prieto, Juliana Cabrera and María Adelaida Gómez Tags: Research article Source Type: research

Correlate tumor mutation burden with immune signatures in human cancers
Tumor mutation burden (TMB) has been associated with cancer immunotherapeutic response and cancer prognosis. Although many explorations have revealed that high TMB may yield many neoantigens to incite antitumo... (Source: BMC Immunology)
Source: BMC Immunology - January 11, 2019 Category: Allergy & Immunology Authors: Xiaosheng Wang and Mengyuan Li Tags: Research article Source Type: research

Treatment of established TH2 cells with 4 μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion
T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1 α), an activator of the unfolded protein response (UPR) pathway. Inhibition of IRE1α RNase activity in activated CD4+ spl... (Source: BMC Immunology)
Source: BMC Immunology - January 10, 2019 Category: Allergy & Immunology Authors: Cody Poe, Cheyanne Youngblood, Karissa Hodge and Kyeorda Kemp Tags: Research article Source Type: research

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection
The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as HIV-1 and to investigate multiple aspects of human i... (Source: BMC Immunology)
Source: BMC Immunology - January 7, 2019 Category: Allergy & Immunology Authors: Raghubendra Singh Dagur, Amanda Branch-Woods, Saumi Mathews, Poonam S. Joshi, Rolen M. Quadros, Donald W. Harms, Yan Cheng, Shana M. Miles, Samuel J. Pirruccello, Channabasavaiah B. Gurumurthy, Santhi Gorantla and Larisa Y. Poluektova Tags: Research article Source Type: research

Mannose-binding lectin concentrations in people living with HIV/AIDS infected by HHV-8
Mannose-binding lectin (MBL) plays an important role in the innate immune response by activating the complement system via the lectin pathway, and it has been studied in several viral infections; however, the ... (Source: BMC Immunology)
Source: BMC Immunology - January 3, 2019 Category: Allergy & Immunology Authors: Viviane Martha Santos de Morais, Juliana Prado Gon çales, Georgea Gertrudes de Oliveira Mendes Cahú, Tania Regina Tozetto-Mendoza and Maria Rosângela Cunha Duarte Coêlho Tags: Research article Source Type: research

Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease
Circulating follicular helper T (cTfh) cells are a specialized subset of CD4+ T cells that express the CXC-chemokine receptor 5 (CXCR5). These cells exhibit immune activities by inducing B cell differentiation an... (Source: BMC Immunology)
Source: BMC Immunology - December 27, 2018 Category: Allergy & Immunology Authors: Meng Xu, Yanfang Jiang, Jian Zhang, Yan Zheng, Deying Liu, Lishuang Guo and Sirui Yang Tags: Research article Source Type: research

Correction to: blood handling and leukocyte isolation methods impact the global transcriptome of immune cells
It has been highlighted that the original article [1] contained a typesetting mistake in the middle name of Arthur F. Steinschneider. (Source: BMC Immunology)
Source: BMC Immunology - December 21, 2018 Category: Allergy & Immunology Authors: Brittany A. Goods, Jacqueline M. Vahey, Arthur F. Steinschneider, Michael H. Askenase, Lauren Sansing and J. Christopher Love Tags: Correction Source Type: research

5-Aminolevulinic acid regulates the immune response in LPS-stimulated RAW 264.7 macrophages
Macrophages are crucial players in a variety of inflammatory responses to environmental cues. However, it has been widely reported that macrophages cause chronic inflammation and are involved in a variety of d... (Source: BMC Immunology)
Source: BMC Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Yuta Sugiyama, Yukari Hiraiwa, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura Tags: Research article Source Type: research