Predictive Role of HE4 in Diagnosis of Ovarian Tumors
ConclusionMeasuring serum HE4 along with CA-125 in preoperative diagnosis helps in excluding benign ovarian tumors in which CA-125 was falsely raised, especially in center where frozen section is not available, thus potentially decreasing morbid debulking surgeries done for benign ovarian tumors. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - February 15, 2024 Category: OBGYN Source Type: research
Potential interplay between tumor size and vitamin D receptor (VDR) polymorphisms in breast cancer prognosis: a prospective cohort study
ConclusionVDR genotypes were associated with breast cancer prognosis and the association might be modified by tumor size. Further research is needed to confirm the findings and elucidate their potential clinical implications. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - February 14, 2024 Category: Cancer & Oncology Source Type: research
Oncologic and reproductive outcomes after fertility-sparing surgery for bilateral borderline ovarian tumors: A retrospective study
Borderline ovarian tumors (BOTs) comprise 10 –20 % of all ovarian malignancies. BOTs show histological properties and biological functions between noncancerous and cancerous epithelial ovarian tumors [1]. Most women with BOTs show significantly higher survival rates [2]. Because BOTs generally occur in teenage girls or young women, fertili ty-sparing surgical treatment that preserves the uterus and at least a part of one ovary has become the gold standard for women with BOTs desiring to preserve their childbearing potential. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 14, 2024 Category: OBGYN Authors: Lili Guo, Xiaoyan Kang, Yue Su, Xiaoyu Liu, Wan Xie, Silu Meng, Yuhuan Liu, Weijiao Wang, Changyu Wang Tags: Full length article Source Type: research
Patterns of Failure Following Preoperative Chemotherapy and Stereotactic Body Radiation Therapy and Resection for Patients with Borderline Resectable or Locally Advanced Pancreatic Cancer
ConclusionsFollowing preoperative chemotherapy and SBRT, locoregional failure outside of the target volume occurred in 3 of 5 recurrences; ENI was associated with improved LRC and LRRFS. Further studies are necessary to define the optimal techniques for preoperative radiation therapy. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 13, 2024 Category: Cancer & Oncology Source Type: research
Postmenopausal onset of androgen excess: a diagnostic and therapeutic algorithm based on extensive clinical experience
ConclusionsClinical or biochemical features of an aggressive androgen-secreting tumor should lead to urgently obtaining a targeted imaging. At first, an abdominal-pelvic CT scan represents the best choice to perceive adrenal malignancy, and may identify aggressive ovarian tumors. When warning signs are lacking, a calm and orderly work-up allows properly addressing the diagnostic challenge of postmenopausal hyperandrogenism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 13, 2024 Category: Endocrinology Source Type: research
Cancers, Vol. 16, Pages 739: Management of Intrahepatic Cholangiocarcinoma: A Narrative Review
The objective of this review is to summarize the current recommendations regarding the diagnosis, surgical resection, and systemic therapy for anatomically resectable intrahepatic cholangiocarcinoma. Our review demonstrates that surgical resection with microscopic negative margins and lymphadenectomy remains the cornerstone of treatment. High-level evidence regarding specific systemic therapies for use in resectable intrahepatic cholangiocarcinoma remains sparse, as most of the evidence is extrapolated from trials involving heterogeneous tumor populations. Targeted therapies are an evolving practice for intrahepatic cholan...
Source: Cancers - February 10, 2024 Category: Cancer & Oncology Authors: Carolyn Tsung Patrick L. Quinn Aslam Ejaz Tags: Review Source Type: research
Real-world data on malignant and borderline phyllodes tumors of the breast: a population-based study of all 921 cases in the Netherlands (1989 -2020).
The aim of our study is to analyze patterns in treatment and outcome in a population-based series of patients with borderline and malignant phyllodes tumors (PT). (Source: European Journal of Cancer)
Source: European Journal of Cancer - February 9, 2024 Category: Cancer & Oncology Authors: Sanne A.L. Bartels, Josefien P. van Olmen, Astrid N. Scholten, Elise M. Bekers, Caroline A. Drukker, Marie-Jeanne T.F.D. Vrancken Peeters, Frederieke H. van Duijnhoven Tags: Original Research Source Type: research
Treatment Response to Neoadjuvant Therapy in Squamous Esophageal Cancer —Correlation Between Metabolic Response and Histopathology
ConclusionOur study confirms the correlation of post neoadjuvant chemotherapy PET SUV with histopathological response, the cut-off of SUV being 5.05 in our cohort. This confirms the predictive value of FDG PET as demonstrated in other studies. Furthermore, its prognostic value with respect to survival has been verified in multiple other studies. With larger scale randomized studies, we may be able to identify the group of patients who have borderline operability anatomically as well as physiologically, where alternative treatment regimens may be indicated to improve outcomes. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 3, 2024 Category: Cancer & Oncology Source Type: research
A giant mucinous borderline ovarian tumour. A caese report
Introduction: Nowadays huge ovarian tumours are rare findings due to the widespread use of ultrasound or other radiological imaging in medical practice. In some cases undiagnosed ovarian masses can grow to gigantic sizes and even cause life-threatening complications. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Anastassia Koppel, Irina Ploom Source Type: research
Expression of selected epithelial –mesenchymal transition (EMT) transcription factors in serous borderline ovarian tumors and type I ovarian cancers
Introduction: Epithelial ovarian neoplasms are a heterogeneous group including tumor subsets with distinct clinicopathologic and molecularfeatures. The transformation of borderline ovarian tumors into an invasive neoplasm is associated with an array of molecular changes (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: P. Sad łecki Source Type: research
Somatic genomic and transcriptomic characterization of primary ovarian serous borderline tumors and low-grade serous carcinomas.
Low-grade serous carcinomas (LGSC) probably develop from serous borderline tumors (SBT), where the micropapillary type (mSBT) has the highest risk of progression. The sensitivity of LGSC to standard chemotherapy is limited, so alternative therapeutic approaches are needed, including targeted treatment. However, current knowledge about molecular landscape of LGSC and mSBT is limited.A sample set of 137 pathologically well-defined cases of 40 mSBT and 97 LGSC was analysed using capture DNA NGS (727 genes) and RNA-Seq (147 genes) to show the landscape of somatic mutations, gene fusions, and the expression pattern, as well as ...
Source: Journal of Molecular Diagnostics - January 24, 2024 Category: Pathology Authors: Ivana Stru žinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Romana Michálková, Quang Hiep Bui, Radoslav Matěj, Jan Laco, Jana Drozenová, Pavel Fabian, Petr Škapa, Zuzana Špůrková, David Cibula, Filip Frühauf, Tomáš Jirásek, Tomáš Zima Tags: Regular Article Source Type: research
Assessment of resectability of pancreatic cancer using novel immersive high-performance virtual reality rendering of abdominal computed tomography and magnetic resonance imaging
ConclusionVR enhanced visualisation of abdominal CT and MRI scan data provides intuitive handling and understanding of anatomy and might allow for more accurate staging of PDAC and could thus become a valuable adjunct in PDAC resectability assessment in the future. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - January 22, 2024 Category: Intensive Care Source Type: research
Active Tuberculosis in a Patient Receiving Adalimumab for Psoriatic Arthritis and Chemoprophylaxis for Latent Tuberculosis Infection
We report a rare case of active tuberculosis despite chemoprophylaxis for LTBI in a patient receiving adalimumab for PsA. A 60-year-old Japanese woman who had received a diagnosis of psoriasis at age 35 years presented with arthralgia of the right hand, which she first noticed 2 months previously. Physical examination showed scattered erythematous papules and plaques with scales on her trunk, extremities, and scalp. Her right metacarpophalangeal and proximal interphalangeal joints were swollen and painful, and her right wrist and elbow were painful. PsA was diagnosed and adalimumab was initiated. Because an interferon-γ r...
Source: Journal of Nippon Medical School - January 21, 2024 Category: Universities & Medical Training Authors: Shun Miyazaki Kazue Fujita Saeko Ozaki Susumu Ichiyama Michiko Ito Toshihiko Hoashi Naoko Kanda Hidehisa Saeki Source Type: research
Active Tuberculosis in a Patient Receiving Adalimumab for Psoriatic Arthritis and Chemoprophylaxis for Latent Tuberculosis Infection
We report a rare case of active tuberculosis despite chemoprophylaxis for LTBI in a patient receiving adalimumab for PsA. A 60-year-old Japanese woman who had received a diagnosis of psoriasis at age 35 years presented with arthralgia of the right hand, which she first noticed 2 months previously. Physical examination showed scattered erythematous papules and plaques with scales on her trunk, extremities, and scalp. Her right metacarpophalangeal and proximal interphalangeal joints were swollen and painful, and her right wrist and elbow were painful. PsA was diagnosed and adalimumab was initiated. Because an interferon-γ r...
Source: Journal of Nippon Medical School - January 21, 2024 Category: Universities & Medical Training Authors: Shun Miyazaki Kazue Fujita Saeko Ozaki Susumu Ichiyama Michiko Ito Toshihiko Hoashi Naoko Kanda Hidehisa Saeki Source Type: research
