Cancers, Vol. 15, Pages 5356: New Achievements from Molecular Biology and Treatment Options for Refractory/Relapsed Ovarian Cancer & mdash;A Systematic Review
The objective is to highlight the molecular mechanisms of the most promising targeted agents under clinical investigation to demonstrate their potential relevance in recurrent/refractory OC. (Source: Cancers)
Source: Cancers - November 10, 2023 Category: Cancer & Oncology Authors: Cornelia Bachmann Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 5355: Endoscopic Ultrasound-Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Patients with Pancreatic Cancer
man
Manoop S. Bhutani
Accurate delivery of stereotactic body radiotherapy (SBRT) to pancreatic tumors relies on successful EUS-guided placement of fiducial markers. The aim of this study is to report the technical feasibility and safety of EUS-guided fiducial placement and to evaluate the characteristics and technical benefit of SBRT in a cohort of patients with pancreatic cancer (PC). A retrospective chart review was performed for all (n = 82) PC patients referred for EUS-guided fiducial placement by a single endosonographer at a tertiary cancer center. Data regarding EUS-related technical details, SBRT characterist...
Source: Cancers - November 10, 2023 Category: Cancer & Oncology Authors: Irina M. Cazacu Ben S. Singh Rachael M. Martin-Paulpeter Sam Beddar Stephen Chun Emma B. Holliday Albert C. Koong Prajnan Das Eugene J. Koay Cullen Taniguchi Joseph M. Herman Manoop S. Bhutani Tags: Article Source Type: research
Developments in pancreatic cancer surgery
AbstractPancreatic cancer surgery, with one of the worst prognoses in oncology, is a challenge to the surgical community. Centralization of pancreatic surgery has led to the foundation of high-volume centers, thereby greatly facilitating the successful performance of more radical approaches. This review spotlights on recent advances in surgical approaches to pancreatic cancer and the risks and benefits of vascular reconstruction to improve resectability. Surgery being the only modality to achieve cure, multivisceral and vascular resections are being incorporated to improve dismal operability rates of < 10%. Great ...
Source: Updates in Surgery - November 9, 2023 Category: Surgery Source Type: research
Cancers, Vol. 15, Pages 5327: Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study
This study examined treatment outcomes, including preserved fertility, menstrual regularity, and pregnancy outcomes, in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs) who underwent fertility-sparing surgery (FSS). Patients with stage I EOC and BOTs who were aged 18&ndash;45 years and underwent FSS between 2007 and 2022 were retrospectively reviewed. Significant differences between various subgroups in terms of disease recurrence, menstrual irregularity due to the disease, and pregnancy outcomes were analyzed. A total of 71 patients with BOTs and 33 patients with EOC were i...
Source: Cancers - November 8, 2023 Category: Cancer & Oncology Authors: Mu-En Ko Yi-Heng Lin Kuan-Ju Huang Wen-Chun Chang Bor-Ching Sheu Tags: Article Source Type: research
A 3-Year Survival Update from a Phase 2 Study of Paclitaxel Plus Cisplatin and 5-Fuorouracil Induction Chemotherapy for Locally Advanced Borderline-Resectable Esophageal Squamous Cell Carcinoma: The NEOCRTEC-1601 Clinical Trial
CONCLUSION: Long-term follow-up evaluation confirmed that TPF followed by surgery is feasible and promising in terms of survival for BR-ESCC patients. Trial Registration ClinicalTrials.gov identifer: NCT02976909.PMID:37919448 | DOI:10.1245/s10434-023-14513-0 (Source: Ann Oncol)
Source: Ann Oncol - November 3, 2023 Category: Cancer & Oncology Authors: Jia-Di Wu Zhi-Qiang Wang Qiao-Qiao Li Zhi-Chao Li Chao Ren De-Shen Wang Ji-Yang Chen Qiong Tan Yu-Hong Li Hong Yang Source Type: research
A 3-Year Survival Update from a Phase 2 Study of Paclitaxel Plus Cisplatin and 5-Fuorouracil Induction Chemotherapy for Locally Advanced Borderline-Resectable Esophageal Squamous Cell Carcinoma: The NEOCRTEC-1601 Clinical Trial
CONCLUSION: Long-term follow-up evaluation confirmed that TPF followed by surgery is feasible and promising in terms of survival for BR-ESCC patients. Trial Registration ClinicalTrials.gov identifer: NCT02976909.PMID:37919448 | DOI:10.1245/s10434-023-14513-0 (Source: Ann Oncol)
Source: Ann Oncol - November 3, 2023 Category: Cancer & Oncology Authors: Jia-Di Wu Zhi-Qiang Wang Qiao-Qiao Li Zhi-Chao Li Chao Ren De-Shen Wang Ji-Yang Chen Qiong Tan Yu-Hong Li Hong Yang Source Type: research
A 3-Year Survival Update from a Phase 2 Study of Paclitaxel Plus Cisplatin and 5-Fuorouracil Induction Chemotherapy for Locally Advanced Borderline-Resectable Esophageal Squamous Cell Carcinoma: The NEOCRTEC-1601 Clinical Trial
CONCLUSION: Long-term follow-up evaluation confirmed that TPF followed by surgery is feasible and promising in terms of survival for BR-ESCC patients. Trial Registration ClinicalTrials.gov identifer: NCT02976909.PMID:37919448 | DOI:10.1245/s10434-023-14513-0 (Source: Ann Oncol)
Source: Ann Oncol - November 3, 2023 Category: Cancer & Oncology Authors: Jia-Di Wu Zhi-Qiang Wang Qiao-Qiao Li Zhi-Chao Li Chao Ren De-Shen Wang Ji-Yang Chen Qiong Tan Yu-Hong Li Hong Yang Source Type: research
A 3-Year Survival Update from a Phase 2 Study of Paclitaxel Plus Cisplatin and 5-Fuorouracil Induction Chemotherapy for Locally Advanced Borderline-Resectable Esophageal Squamous Cell Carcinoma: The NEOCRTEC-1601 Clinical Trial
ConclusionLong-term follow-up evaluation confirmed that TPF followed by surgery is feasible and promising in terms of survival for BR-ESCC patients.Trial Registration ClinicalTrials.gov identifer: NCT02976909. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 2, 2023 Category: Cancer & Oncology Source Type: research
10292 Paratubal Borderline Tumor in Adolescence - A Case Report and Review of Literature.
Review the incidence, clinical presentation, diagnosis and treatment of Para-tubal borderline tumors in adolescent patients. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 27, 2023 Category: OBGYN Authors: A Saad, S Alameri, S Ricci Source Type: research
Tumor necrosis factor-alpha mediates the negative association between telomere length and kidney dysfunction
Conclusion: Baseline LTL could independently predict kidney dysfunction at follow-up, especially in participants with hypertension. TNF-a partially mediated the negative association between LTL and kidney dysfunction.PMID:37859695 | PMC:PMC10583187 | DOI:10.7150/ijms.87254 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - October 20, 2023 Category: Biomedical Science Authors: Mengya Qi Jie Yu Fan Ping Lingling Xu Wei Li Huabing Zhang Yuxiu Li Source Type: research
