Somatic genomic and transcriptomic characterization of primary ovarian serous borderline tumors and low-grade serous carcinomas.

Low-grade serous carcinomas (LGSC) probably develop from serous borderline tumors (SBT), where the micropapillary type (mSBT) has the highest risk of progression. The sensitivity of LGSC to standard chemotherapy is limited, so alternative therapeutic approaches are needed, including targeted treatment. However, current knowledge about molecular landscape of LGSC and mSBT is limited.A sample set of 137 pathologically well-defined cases of 40 mSBT and 97 LGSC was analysed using capture DNA NGS (727 genes) and RNA-Seq (147 genes) to show the landscape of somatic mutations, gene fusions, and the expression pattern, as well as their prognostic and predictive relevance.

Source: Journal of Molecular Diagnostics - January 24, 2024 Category: Pathology Authors: Ivana Stru žinská, Nikola Hájková, Jan Hojný, Eva Krkavcová, Romana Michálková, Quang Hiep Bui, Radoslav Matěj, Jan Laco, Jana Drozenová, Pavel Fabian, Petr Škapa, Zuzana Špůrková, David Cibula, Filip Frühauf, Tomáš Jirásek, Tomáš Zima Tags: Regular Article Source Type: research