Predictors for early recurrence beyond up-to-7 or distant metastasis after hepatocellular carcinoma resection: proposal for borderline resectable HCC
ConclusionsIn this retrospective analysis, MVI, TBS, and ALBI could predict severe early recurrence after hepatic resection for HCC, and patients with these risk factors had a poor prognosis. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - January 16, 2024 Category: Cancer & Oncology Source Type: research
Radiomics nomogram for preoperative differentiation of early-stage serous borderline ovarian tumors and serous malignant ovarian tumors
ConclusionsThe nomogram model can be employed as an individualized preoperative non-invasive tool for differentiating early-stage SBOTs from SMOTs. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 15, 2024 Category: Cancer & Oncology Source Type: research
Intratumoral heterogeneity of Ki67 proliferation index outperforms conventional immunohistochemistry prognostic factors in estrogen receptor-positive HER2-negative breast cancer
This study utilized digital image analysis (DIA) and computational pathology methods to investigate the prognostic value of ITH indicators in ER-positive (ER+) HER2-negative (HER2 −) BC patients. Whole slide images (WSIs) of surgically excised specimens stained for ER, PR, Ki67, and HER2 from 254 patients were used. DIA with tumor tissue segmentation and detection of biomarker-positive cells was performed. The DIA-generated data were subsampled by a hexagonal grid to comput e Haralick’s texture indicators for ER, PR, and Ki67. Cox regression analyses were performed to assess the prognostic significance of the immunohis...
Source: Virchows Archiv - January 13, 2024 Category: Pathology Source Type: research
Surgical margins and prognosis of borderline and malignant phyllodes tumors
ConclusionsA negative surgical margin of at least 1 cm (with secondary resection if necessary) should be achieved for borderline and malignant PTs. Tumor size ≥ 5 cm and age < 45 years were predictive of recurrence, suggesting multiple therapy modalities may be considered for these high-risk patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 13, 2024 Category: Cancer & Oncology Source Type: research
CT-Based Radiomics and Machine Learning for Differentiating Benign, Borderline, and Early-Stage Malignant Ovarian Tumors
AbstractTo explore the value of CT-based radiomics model in the differential diagnosis of benign ovarian tumors (BeOTs), borderline ovarian tumors (BOTs), and early malignant ovarian tumors (eMOTs). The retrospective research was conducted with pathologically confirmed 258 ovarian tumor patients from January 2014 to February 2021. The patients were randomly allocated to a training cohort (n = 198) and a test cohort (n = 60). By providing a three-dimensional (3D) characterization of the volume of interest (VOI) at the maximum level of images, 4238 radiomic features were extracted from the VOI per patient. The Wilcox...
Source: Journal of Digital Imaging - January 11, 2024 Category: Radiology Source Type: research
A Successful Live Birth From a Vitrified Oocyte for Fertility Preservation of a Patient With Borderline Ovarian Tumor Undergoing Bilateral Ovarian Surgery: A Case Report
This article reports the live birth of a healthy newborn using vitrified-warmed oocytes from fertility preservation before ovarian surgery. The patient in our case underwent two cycles of controlled ovarian stimulation before laparoscopic bilateral ovarian cystectomy for endometriosis, and a total of 23 mature oocytes were vitrified. After surgery, her pathologic reports revealed a serous borderline tumor and endometrioma. Fifteen months after her second surgery of laparoscopic right salpingo-oophorectomy and left ovarian cystectomy owing to recurrence, she had been married by then, and three of the frozen oocytes were tha...
Source: J Korean Med Sci - January 9, 2024 Category: General Medicine Authors: Yae Ji Choi Yeon Hee Hong Haerin Paik Seul Ki Kim Jung Ryeol Lee Chang Suk Suh Source Type: research
A Successful Live Birth From a Vitrified Oocyte for Fertility Preservation of a Patient With Borderline Ovarian Tumor Undergoing Bilateral Ovarian Surgery: A Case Report
This article reports the live birth of a healthy newborn using vitrified-warmed oocytes from fertility preservation before ovarian surgery. The patient in our case underwent two cycles of controlled ovarian stimulation before laparoscopic bilateral ovarian cystectomy for endometriosis, and a total of 23 mature oocytes were vitrified. After surgery, her pathologic reports revealed a serous borderline tumor and endometrioma. Fifteen months after her second surgery of laparoscopic right salpingo-oophorectomy and left ovarian cystectomy owing to recurrence, she had been married by then, and three of the frozen oocytes were tha...
Source: Journal of Korean Medical Science - January 9, 2024 Category: Biomedical Science Authors: Yae Ji Choi Yeon Hee Hong Haerin Paik Seul Ki Kim Jung Ryeol Lee Chang Suk Suh Source Type: research
A Successful Live Birth From a Vitrified Oocyte for Fertility Preservation of a Patient With Borderline Ovarian Tumor Undergoing Bilateral Ovarian Surgery: A Case Report
This article reports the live birth of a healthy newborn using vitrified-warmed oocytes from fertility preservation before ovarian surgery. The patient in our case underwent two cycles of controlled ovarian stimulation before laparoscopic bilateral ovarian cystectomy for endometriosis, and a total of 23 mature oocytes were vitrified. After surgery, her pathologic reports revealed a serous borderline tumor and endometrioma. Fifteen months after her second surgery of laparoscopic right salpingo-oophorectomy and left ovarian cystectomy owing to recurrence, she had been married by then, and three of the frozen oocytes were tha...
Source: J Korean Med Sci - January 9, 2024 Category: General Medicine Authors: Yae Ji Choi Yeon Hee Hong Haerin Paik Seul Ki Kim Jung Ryeol Lee Chang Suk Suh Source Type: research
A Successful Live Birth From a Vitrified Oocyte for Fertility Preservation of a Patient With Borderline Ovarian Tumor Undergoing Bilateral Ovarian Surgery: A Case Report
This article reports the live birth of a healthy newborn using vitrified-warmed oocytes from fertility preservation before ovarian surgery. The patient in our case underwent two cycles of controlled ovarian stimulation before laparoscopic bilateral ovarian cystectomy for endometriosis, and a total of 23 mature oocytes were vitrified. After surgery, her pathologic reports revealed a serous borderline tumor and endometrioma. Fifteen months after her second surgery of laparoscopic right salpingo-oophorectomy and left ovarian cystectomy owing to recurrence, she had been married by then, and three of the frozen oocytes were tha...
Source: Journal of Korean Medical Science - January 9, 2024 Category: Biomedical Science Authors: Yae Ji Choi Yeon Hee Hong Haerin Paik Seul Ki Kim Jung Ryeol Lee Chang Suk Suh Source Type: research
Gynecological cancer during pregnancy —From a gyne‐oncological perspective
AbstractGynecological cancer diagnosed during pregnancy requires accurate diagnosis and staging to determine optimal treatment based on gestational age. Cervical and ovarian cancers are the most common and multidisciplinary team collaboration is pivotal. Magnetic resonance imaging and ultrasound can be used without causing fetal harm. In cervical cancer, early-stage treatments can often be delayed until fetal lung maturation and cesarean section is recommended if disease prevails, in combination with a simple/radical hysterectomy and lymphadenectomy. Chemoradiotherapy, the recommended treatment for advanced stages, is not ...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 6, 2024 Category: OBGYN Authors: Katja Stenstr öm Bohlin,
Mats Brännström,
Pernilla Dahm‐Kähler Tags: COMMENTARY Source Type: research
Female advantage in neoadjuvant pancreatic cancer therapy: is it down to macrophages?
Pancreatic cancer still carries the worst survival rate among all solid tumours, mostly due to the absence of early symptoms and a lack of satisfying treatment options, leading to an appalling 5-year survival rate of less than 12%. The only potentially curative treatment option is surgical resection followed by adjuvant chemotherapy. Since pancreatic cancer is usually diagnosed at advanced stage, treatment with curative intent can be provided to only 15–20% of patients. However, even after surgical resection, most patients develop local or systemic recurrence. During recent years, neoadjuvant chemotherapeutic regimen...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Michl, P., Roth, L. Tags: Gut Commentary Source Type: research
Long ‐term outcomes of neoadjuvant gemcitabine, nab‐paclitaxel, and S1 (GAS) in borderline resectable pancreatic cancer with arterial contact: Results from a phase II trial
ConclusionsThis long-term evaluation of the neoadjuvant GAS trial demonstrated the high efficacy of the regimen, suggesting that it is a promising treatment option for patients with BRPC-A. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - December 30, 2023 Category: Gastroenterology Authors: Kenichiro Uemura,
Naru Kondo,
Takeshi Sudo,
Tatsuaki Sumiyoshi,
Ryuta Shintakuya,
Kenjiro Okada,
Kenta Baba,
Takumi Harada,
Yoshiaki Murakami,
Shinya Takahashi Tags: ORIGINAL ARTICLE Source Type: research
D-dimer, Fibrinogen and Tumor Marker Levels in Patients with benign and Malignant Ovarian Tumors
Asian Pac J Cancer Prev. 2023 Dec 1;24(12):4263-4268. doi: 10.31557/APJCP.2023.24.12.4263.ABSTRACTLimited studies have investigated the differences between the levels of plasma coagulants and tumor markers in ovarian cancer. Therefore, we conducted this study to determine and compare the level of coagulation, fibrinolysis and tumor markers in patients with benign and malignant ovarian tumors. This cross-sectional study was conducted between January 2022 and February 2023 in Imam Hossein Hospital on patients with ovarian mass. Laboratory tests included platelet count, PT, INR, PTT, fibrinogen and D-dimer were sent to the pa...
Source: Asian Pacific Journal of Cancer Prevention - December 29, 2023 Category: Cancer & Oncology Authors: Farah Farzaneh Maryam Salimnezhad Maryam Sadat Hosseini Tahereh Ashraf Ganjouee Maliheh Arab Maryam Talayeh Source Type: research
