Osteosarcoma cells exhibit functional interactions with stromal cells, fostering a lung microenvironment conducive to the establishment of metastatic tumor cells
CONCLUSIONS: Our assessment focused on two complementary tumor capabilities crucial to metastatic spread, emphasizing the significance of inherent cell features. The findings underscore the pivotal role of signaling integration within the niche, with a complex interplay of migratory responses among established OS cells in the lungs, prometastatic OS cells in the primary tumor, and circulating MSCs. Pulmonary metastases continue to be a significant factor contributing to OS mortality. Understanding these mechanisms and identifying differentially expressed genes is essential for pinpointing markers and targets to manage meta...
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: Mat ías J P Valenzuela Alvarez Luciana M Gutierrez Juan M Bayo Mar ía J Cantero Mariana G Garcia Marcela F Bolontrade Source Type: research
Osteosarcoma cells exhibit functional interactions with stromal cells, fostering a lung microenvironment conducive to the establishment of metastatic tumor cells
CONCLUSIONS: Our assessment focused on two complementary tumor capabilities crucial to metastatic spread, emphasizing the significance of inherent cell features. The findings underscore the pivotal role of signaling integration within the niche, with a complex interplay of migratory responses among established OS cells in the lungs, prometastatic OS cells in the primary tumor, and circulating MSCs. Pulmonary metastases continue to be a significant factor contributing to OS mortality. Understanding these mechanisms and identifying differentially expressed genes is essential for pinpointing markers and targets to manage meta...
Source: Mol Biol Cell - March 29, 2024 Category: Molecular Biology Authors: Mat ías J P Valenzuela Alvarez Luciana M Gutierrez Juan M Bayo Mar ía J Cantero Mariana G Garcia Marcela F Bolontrade Source Type: research
Living with a tumor: A case of osteosarcoma involving the medullary region in Phrynops cf. P. geoffroanus (Testudines: Chelidae)
Anat Rec (Hoboken). 2024 Mar 28. doi: 10.1002/ar.25437. Online ahead of print.ABSTRACTThe individual Geoffroy's side-necked turtle, Phrynops cf. P. geoffroanus, was diagnosed postmortem with osteosarcoma associated with the forelimb through morphological and histological analysis. Osteosarcoma stands as the most prevalent primary malignant bone tumor in tetrapods. The tumor presents itself as a large mass in the distal epiphysis, characterized by spicular outgrowths and a rugose external texture. Histologically, the afflicted humerus displayed a high degree of vascularity and exhibited an extensive bone resorption process ...
Source: Anatomical Record - March 29, 2024 Category: Anatomy Authors: Hugo Bert Hayat Lamrous Mariana Val éria de Araújo Sena Source Type: research
Living with a tumor: A case of osteosarcoma involving the medullary region in Phrynops cf. P. geoffroanus (Testudines: Chelidae)
Anat Rec (Hoboken). 2024 Mar 28. doi: 10.1002/ar.25437. Online ahead of print.ABSTRACTThe individual Geoffroy's side-necked turtle, Phrynops cf. P. geoffroanus, was diagnosed postmortem with osteosarcoma associated with the forelimb through morphological and histological analysis. Osteosarcoma stands as the most prevalent primary malignant bone tumor in tetrapods. The tumor presents itself as a large mass in the distal epiphysis, characterized by spicular outgrowths and a rugose external texture. Histologically, the afflicted humerus displayed a high degree of vascularity and exhibited an extensive bone resorption process ...
Source: Anatomical Record - March 29, 2024 Category: Anatomy Authors: Hugo Bert Hayat Lamrous Mariana Val éria de Araújo Sena Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: J Cell Mol Med - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: J Cell Mol Med - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
Dysregulated MicroRNAs and long non-coding RNAs associated with extracellular matrix stiffness
Exp Cell Res. 2024 Mar 26:114014. doi: 10.1016/j.yexcr.2024.114014. Online ahead of print.ABSTRACTExtracellular matrix (ECM) stiffness regulates development and homeostasis in vivo and affects both physiological and pathological processes. A variety of studies have demonstrated that mRNAs, such as Piezo1, integrin β1, and Yes-associated protein (YAP)/tafazzin (TAZ), can sense the mechanical signals induced by ECM stiffness and transmit them from the extracellular space into the cytoplasm. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been reported to play important roles in ...
Source: Experimental Cell Research - March 28, 2024 Category: Cytology Authors: Huimin Qiu Yi Fu Zhinan Guo Xinjia Zhang Xinyue Wang Hailong Wu Source Type: research
Dysregulated MicroRNAs and long non-coding RNAs associated with extracellular matrix stiffness
Exp Cell Res. 2024 Mar 26:114014. doi: 10.1016/j.yexcr.2024.114014. Online ahead of print.ABSTRACTExtracellular matrix (ECM) stiffness regulates development and homeostasis in vivo and affects both physiological and pathological processes. A variety of studies have demonstrated that mRNAs, such as Piezo1, integrin β1, and Yes-associated protein (YAP)/tafazzin (TAZ), can sense the mechanical signals induced by ECM stiffness and transmit them from the extracellular space into the cytoplasm. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been reported to play important roles in ...
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Huimin Qiu Yi Fu Zhinan Guo Xinjia Zhang Xinyue Wang Hailong Wu Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: J Cell Mol Med - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
Dysregulated MicroRNAs and long non-coding RNAs associated with extracellular matrix stiffness
Exp Cell Res. 2024 Mar 26:114014. doi: 10.1016/j.yexcr.2024.114014. Online ahead of print.ABSTRACTExtracellular matrix (ECM) stiffness regulates development and homeostasis in vivo and affects both physiological and pathological processes. A variety of studies have demonstrated that mRNAs, such as Piezo1, integrin β1, and Yes-associated protein (YAP)/tafazzin (TAZ), can sense the mechanical signals induced by ECM stiffness and transmit them from the extracellular space into the cytoplasm. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been reported to play important roles in ...
Source: Experimental Cell Research - March 28, 2024 Category: Cytology Authors: Huimin Qiu Yi Fu Zhinan Guo Xinjia Zhang Xinyue Wang Hailong Wu Source Type: research
GSE252470 Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-na ïve primary osteosarcoma in dogs
Contributors : Dylan T Ammons ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisWe used single-cell RNA sequencing to characterize the heterogeneity of canine osteosarcoma (OS) tumors. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
Ewing Sarcoma-Chest Wall Reconstruction Following Resection of Rare Primary Chest Wall Tumor
We report the case of a 26-year-old man who was found to have a right lung mass extending into his anterolateral chest wall after presenting to the hospital for evaluation of unremitting chest pain. Biopsy was performed and the patient diagnosed with ES. After completion of neoadjuvant chemotherapy, the patient underwent resection of the right chest wall mass. The chest wall was reconstructed in a novel fashion with titanium plates and a reinforced tissue matrix patch. Due to a paucity of cases, no treatment or reconstruction algorithm currently exists for management of these malignancies.PMID:38532255 | DOI:10.1177/000313...
Source: The American Surgeon - March 27, 2024 Category: Surgery Authors: Ilya Sakharuk Thomas McKinley Gabrielle Moore Daniel Miller Source Type: research
Nanofibrous polyelectrolyte complex incorporated BSA-alginate composite bioink for 3D bioprinting of bone mimicking constructs
This study successfully fabricated a high-shape fidelity bioink with potential in bone tissue engineering.PMID:38537853 | DOI:10.1016/j.ijbiomac.2024.131123 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 27, 2024 Category: Biochemistry Authors: Shreya Chrungoo Tanmay Bharadwaj Devendra Verma Source Type: research
