GSE247355 Targeting Osteosarcoma with Canine B7-H3 CAR T Cells and Impact of CXCR2 Co-Expression on Functional Activity
Contributors : Jennifer W Cao ; Jessica Lake ; Renata Impastato ; Lyndah Chow ; Luisanny Perez ; Laura Chubb ; Jade Kurihara ; Michael R Verneris ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisAbstract. The use of large animal spontaneous models of solid cancers, such as dogs with osteosarcoma (OS), can help develop new cancer immunotherapy approaches, including chimeric antigen receptor (CAR) T cells. Therefore, the goal of the present study was to generate canine CAR T cells targeting the B7-H3 (CD276) co-stimulatory molecule overexpressed by several so...
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
Osteosarcoma of Mandible — A Case Report
AbstractAfter plasma cell neoplasia, osteosarcoma is the most common primary bone tumor which accounts for 20% of all sarcomas. A malignant tumor is characterized by the formation of bone or osteoid by tumor cells. Long bones are the most common site of involvement. In the jaw bones, approximately 5% of involvement with an incidence of 1 in 1.5 million persons per year. It develops in a broad range of ages but is more common in the third and fourth decades, slightly more often in the mandible than in the maxilla. In this case report, a 24-year-old male patient reported a mass in the left mandible for the past 1 week whic...
Source: Indian Journal of Surgical Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p
Circular RNAs (circRNAs) are a class of highly multifunctional single-stranded RNAs that play crucial roles in cancer progression, including osteosarcoma (OS). Circ_0002669, generated from the dedicator of cyt... (Source: Biology Direct)
Source: Biology Direct - April 3, 2024 Category: Biology Authors: Ying Zhang, Yizhou Zhan, Zhaoyong Liu, Huancheng Guo, Dongchen Liu and Chuangzhen Chen Tags: Research Source Type: research
An Enantioselective Aminocatalytic Cascade Reaction Affording Bioactive Hexahydroazulene Scaffolds
Chemistry. 2024 Apr 2:e202401156. doi: 10.1002/chem.202401156. Online ahead of print.ABSTRACTA novel cascade reaction initiated by an enantioselective aminocatalysed 1,3-dipolar [6+4] cycloaddition between catalytically generated trienamines and 3-oxidopyridinium betaines is presented. The [6+4] cycloadduct spontaneously undergoes an intramolecular enamine-mediated aldol, hydrolysis, and E1cb sequence, which ultimately affords a chiral hexahydroazulene framework. In this process, three new C-C bonds and three new stereocenters are formed, enabled by a formal unfolding of the pyridine moiety from the dipolar reagent. The he...
Source: Chemistry - April 2, 2024 Category: Chemistry Authors: Jonas Faghtmann Macarena Eugui Eugui Johannes Nygaard Lamhauge Signe Sofie Pladsbjerg Andresen Anne Rask Østergaard Esben Bjerregaard Svenningsen Thomas Poulsen Karl Anker J ørgensen Source Type: research
ACSL4 accelerates osteosarcoma progression via modulating TGF- β/Smad2 signaling pathway
In this study, we investigated the expression of ACSL4 in OS tissues using immunohistochemistry staining (IHC) staining of a human tissue microarray and in OS cells by qPCR assay. Our findings revealed a significant up-regulation of ACSL4 in both OS tissues and cells. To further understand its biological effects, we conducted a series of loss-of-function experiments using ACSL4-depleted MNNG/HOS and U-2OS cell lines, focusing on OS cell proliferation, migration, and apoptosis in vitro. Our results demonstrated that ACSL4 knockdown remarkably suppressed OS cell proliferation, arrested cells in the G2 phase, induced cell apo...
Source: Molecular and Cellular Biochemistry - April 2, 2024 Category: Biochemistry Authors: Xiaofeng Li Qianfen Chen Duo Zhao Jianshi Tan Rongbo Liao Yurong Gu Jinwei Zhu Huying Zhang Jian Xie Lu Chen Source Type: research
A case of retroperitoneal Ewing sarcoma
Asian J Surg. 2024 Apr 1:S1015-9584(24)00554-2. doi: 10.1016/j.asjsur.2024.03.126. Online ahead of print.NO ABSTRACTPMID:38565443 | DOI:10.1016/j.asjsur.2024.03.126 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 2, 2024 Category: Surgery Authors: Yizhi Chen Tianfeng Liu Jingping Chen Source Type: research
An Enantioselective Aminocatalytic Cascade Reaction Affording Bioactive Hexahydroazulene Scaffolds
Chemistry. 2024 Apr 2:e202401156. doi: 10.1002/chem.202401156. Online ahead of print.ABSTRACTA novel cascade reaction initiated by an enantioselective aminocatalysed 1,3-dipolar [6+4] cycloaddition between catalytically generated trienamines and 3-oxidopyridinium betaines is presented. The [6+4] cycloadduct spontaneously undergoes an intramolecular enamine-mediated aldol, hydrolysis, and E1cb sequence, which ultimately affords a chiral hexahydroazulene framework. In this process, three new C-C bonds and three new stereocenters are formed, enabled by a formal unfolding of the pyridine moiety from the dipolar reagent. The he...
Source: Chemistry - April 2, 2024 Category: Chemistry Authors: Jonas Faghtmann Macarena Eugui Eugui Johannes Nygaard Lamhauge Signe Sofie Pladsbjerg Andresen Anne Rask Østergaard Esben Bjerregaard Svenningsen Thomas Poulsen Karl Anker J ørgensen Source Type: research
ACSL4 accelerates osteosarcoma progression via modulating TGF- β/Smad2 signaling pathway
In this study, we investigated the expression of ACSL4 in OS tissues using immunohistochemistry staining (IHC) staining of a human tissue microarray and in OS cells by qPCR assay. Our findings revealed a significant up-regulation of ACSL4 in both OS tissues and cells. To further understand its biological effects, we conducted a series of loss-of-function experiments using ACSL4-depleted MNNG/HOS and U-2OS cell lines, focusing on OS cell proliferation, migration, and apoptosis in vitro. Our results demonstrated that ACSL4 knockdown remarkably suppressed OS cell proliferation, arrested cells in the G2 phase, induced cell apo...
Source: Molecular and Cellular Biochemistry - April 2, 2024 Category: Biochemistry Authors: Xiaofeng Li Qianfen Chen Duo Zhao Jianshi Tan Rongbo Liao Yurong Gu Jinwei Zhu Huying Zhang Jian Xie Lu Chen Source Type: research
Single-cell RNA-seq reveals T cell exhaustion and immune response landscape in osteosarcoma
ConclusionIn summary, our research elucidates the role of T cell exhaustion in the immunotherapy and progression of OS, the prognostic model constructed based on T cell exhaustion-related genes holds promise as a potential method for prognostication in the management and treatment of OS patients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 2, 2024 Category: Allergy & Immunology Source Type: research
Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma
Oncol Res. 2024 Mar 20;32(4):691-702. doi: 10.32604/or.2023.030767. eCollection 2024.ABSTRACTOsteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the pho...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Jijie Xiao Hong Xiao Yujun Cai Jianwei Liao Jue Liu Lin Yao Shaolin Li Source Type: research
Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma
Oncol Res. 2024 Mar 20;32(4):691-702. doi: 10.32604/or.2023.030767. eCollection 2024.ABSTRACTOsteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the pho...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Jijie Xiao Hong Xiao Yujun Cai Jianwei Liao Jue Liu Lin Yao Shaolin Li Source Type: research
CPPs-modified chitosan as permeability-enhancing chemotherapeutic combined with gene therapy nanosystem by thermosensitive hydrogel for the treatment of osteosarcoma
CONCLUSION: Hydrogel encapsulation of permeable nanoparticles provides an effective strategy for doxorubicin-resistant OS, showing that gene therapy blocking DNA damage tolerance can enhance treatment response to chemotherapy and appears to enhance the effect of ICD inducers to activate the immune system.PMID:38561118 | DOI:10.1016/j.ijbiomac.2024.130915 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 1, 2024 Category: Biochemistry Authors: Jie Cao Chenghong Zhu Ziqi Cao Xue Ke Source Type: research
Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma
Oncol Res. 2024 Mar 20;32(4):691-702. doi: 10.32604/or.2023.030767. eCollection 2024.ABSTRACTOsteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the pho...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Jijie Xiao Hong Xiao Yujun Cai Jianwei Liao Jue Liu Lin Yao Shaolin Li Source Type: research
