GSE247355 Targeting Osteosarcoma with Canine B7-H3 CAR T Cells and Impact of CXCR2 Co-Expression on Functional Activity
Contributors : Jennifer W Cao ; Jessica Lake ; Renata Impastato ; Lyndah Chow ; Luisanny Perez ; Laura Chubb ; Jade Kurihara ; Michael R Verneris ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisAbstract. The use of large animal spontaneous models of solid cancers, such as dogs with osteosarcoma (OS), can help develop new cancer immunotherapy approaches, including chimeric antigen receptor (CAR) T cells. Therefore, the goal of the present study was to generate canine CAR T cells targeting the B7-H3 (CD276) co-stimulatory molecule overexpressed by several so...
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
