7 Signs That Say “Do Not Resuscitate”
It is a moment in time that you will certainly face at some point in your EMS career. Most of us will face this decision many times over throughout our tenure. Should I attempt resuscitation?
The question may be complicated by family, friends or bystanders who have, in good faith, started CPR prior to your arrival and fully anticipate that you will continue. Or perhaps other members of emergency services arrived before you and declared the patient not workable. They may advise you of their findings, without much further detail. “This guys dead.”
Often, responders who aren’t responsible for documentin...
Source: The EMT Spot - November 14, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Antimicrobial Coating Prevents Infections Around Ortho Implants
A group at Duke University engineered an antibiotic delivery system to make the surfaces of orthopedic implants resistant to bacterial infiltration. The technique involves spraying or painting a combination of hydrophilic and hydrophobic polymers, mixed with an antibiotic of choice, onto the surface of the implant. A UV light is then used to cure the coating in place. The coating then releases the antibiotic over a period of 2-3 weeks, helping to reduce the chance of infection.
Existing orthopedic implants are at risk of infection, resulting in patient morbidity and revision surgeries. The metal surface of most implants...
Source: Medgadget - September 29, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Orthopedic Surgery Duke Source Type: blogs
Fight Aging! Newsletter, September 20th 2021
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
NANOG Expression versus Cellular Senescence
https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living a...
Source: Fight Aging! - September 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is it Possible to Safely Tip the Balance in Cancer Treatment Towards Cell Death Rather than Cell Senescence?
Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function when consistently present. Growing numbers of senescent cells in old tissues are an important contribution to degenerative aging.
The straightforward approach to this issue would be to treat cancer patients with senolytic therapies to clear senescent cells after the anti-cancer treatment is complete...
Source: Fight Aging! - September 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Science Snippet: Apoptosis Explained
Apoptosis is the process by which cells in the body die in a controlled and predictable way because they have DNA damage or are no longer needed. The term comes from a Greek word meaning “falling off,” as in leaves falling from a tree.
When a cell undergoes apoptosis, it shrinks and pulls away from its neighbors. As the cytoskeleton that gives it shape and structure collapses, the envelope around the cell’s nucleus breaks down, and its DNA breaks into pieces. Its surface changes, signaling its death to other cells and leading a healthy cell to engulf the dying one and recycle its components.
Two cells in a heal...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 28, 2021 Category: Research Authors: Chrissa Chverchko Tags: Cells Cellular Processes Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of th...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using CRISPR to Remove Mutated Sequences of Nuclear DNA Required by Cancerous Cells
Fusion genes feature in many cancers, a form of mutation in which two genes are joined together, such as through deletion of the DNA sequences that normally separate the two genes. The resulting mutant fusion gene sequence encodes a fusion protein that can have novel effects, or in which both portions remain functional, but are now produced in at inappropriate times and in inappropriate amounts. This change in cell biochemistry can be important in driving cancerous behavior, and this appears to be the case in a meaningful fraction of cancer types.
Today's research materials discuss a clever use of CRISPR DNA editing...
Source: Fight Aging! - October 16, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Pain from an Unknown Cause
"My left hip has been hurting for a couple years, but it just got really bad in the past few weeks."My patient, who was in her 70s, didn't add much more to the history. No trauma. No fevers. No bowel or bladder problems. No significant past medical history. Her hip just hurt. She thought she needed an x-ray, and one was obtained.The left femoral head didn't look terrible. There was some irregularity, but there were no fractures or significant joint narrowing. This wasn't a case of neglected severe degenerative joint disease or avascular necrosis that needed a hip replacement.Some red flags started to show up t...
Source: Lions and Tigers and Bears - May 1, 2020 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Artificial Intelligence vs. Tuberculosis, Part 1
By SAURABH JHA, MD
Slumdog TB
No one knows who gave Rahul Roy
tuberculosis. Roy’s charmed life as a successful trader involved traveling in his
Mercedes C class between his apartment on the plush Nepean Sea Road in South
Mumbai and offices in Bombay Stock Exchange. He cared little for Mumbai’s weather.
He seldom rolled down his car windows – his ambient atmosphere, optimized for
his comfort, rarely changed.
Historically TB, or
“consumption” as it was known, was a Bohemian malady; the chronic suffering produced
a rhapsody which produced fine art. TB was fashionable in Victorian Britain, in
part, because c...
Source: The Health Care Blog - December 5, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Health Tech Saurabh Jha TB tuberculosis Source Type: blogs
Fight Aging! Newsletter, November 4th 2019
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice.
Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - November 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Consume their Neighbors
The accumulation of lingering senescent cells is an important contributing cause of degenerative aging. In this intriguing report, researchers note that senescent cells resulting from chemotherapy treatment can consume neighboring cells in order to prolong their survival. This is most likely the case for senescent cells in general, whatever their origin. This cellular cannibalism is probably detrimental to tissue function to some small degree, but, since senescent cells are always a tiny minority of all cells, even in old tissues, it is nowhere near as detrimental as the inflammatory signaling profile that accompanies cell...
Source: Fight Aging! - October 31, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Podcast: Haunted Asylums – Stigmatizing or Just Entertainment?
Each Halloween we encounter the same debate: are haunted asylums stigmatizing or are they simply entertainment? While some may think haunted asylums are tasteless at worst, they don’t feel like they’re an actual detriment to the mental illness community. In this episode, we look at this argument from both sides and really dig into what happens when we use mental illness as a theme for entertainment. While Jackie and Gabe both make great arguments, we toss this question back to you.
Are you offended by haunted asylums or do you see them as harmless entertainment — or something in between? Listen now and decide...
Source: World of Psychology - October 28, 2019 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: General Not Crazy Podcast Stigma Trauma Source Type: blogs
Timed release of curcumin inhibits bone cancer cells …
Since I’ve been pretty much housebound because of my fractured humerus, I finally decided to go through our closets and get rid of all the clothes we don’t/can’t wear anymore. Of course, I have to be careful not to hurt my shoulder, and believe me, careful I am! But I can’t just lie around with the cats (our Pixie, in the photo) and watch TV series nonstop…
Speaking of my shoulder, well it’s healing…and healing well, I think. I can now raise my arm above my head. Compare that to a month ago when I could barely lift my arm! Thank you, physiotherapy!
I have my third checkup, with ...
Source: Margaret's Corner - July 15, 2019 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll bone cancer curcumin Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD
Keynote speech on the JAVELIN not going far enough to improve survival
The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs
