Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neurochirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neuro-Chirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neurochirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neuro-Chirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: a Case Report and Literature Review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neurochirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: A case report and literature review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neuro-Chirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Primary intradural Extraosseous Ewing's sarcoma of the cauda equina: A case report and literature review
We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma. The patient was then treated with targeted radiation therapy and chemotherapy. The rarity of IEES in this specific location underscores the significance of evaluating and managing patient...
Source: Neurochirurgie - April 15, 2024 Category: Neurosurgery Authors: Manel Krouma Kaissar Farah Anis Choucha Romain Appay Florence Duffaud Stephane Fuentes Henry Dufour Source Type: research
Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression
Cancer Gene Therapy, Published online: 15 April 2024; doi:10.1038/s41417-024-00773-9Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - April 15, 2024 Category: Cancer & Oncology Authors: Kentaro Watanabe Keiji Tasaka Hideto Ogata Shota Kato Hiroo Ueno Katsutsugu Umeda Tomoya Isobe Yasuo Kubota Masahiro Sekiguchi Shunsuke Kimura Aiko Sato-Otsubo Mitsuteru Hiwatari Tetsuo Ushiku Motohiro Kato Akira Oka Satoru Miyano Seishi Ogawa Junko Takit Source Type: research
Regulation of cellular responses to X-ray irradiation through the activation of lysophosphatidic acid (LPA) receptor-3 (LPA < sub > 3 < /sub > ) and LPA < sub > 2 < /sub > in osteosarcoma cells
Pathol Res Pract. 2024 Apr 5;257:155293. doi: 10.1016/j.prp.2024.155293. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) binds to its specific G protein-coupled LPA receptors (LPA1 to LPA6), resulting in the activation of various cellular functions. LPA receptor-mediated signaling facilitates tumor progression in human malignancies. In the present study, we investigated whether LPA receptor-mediated signaling contributes to cellular responses to X-ray irradiation in osteosarcoma MG-63 cells. After X-ray irradiation (2, 4 and 8 Gy), LPAR2 and LPAR3 expression levels in MG-63 cells were significantly elevated in a ...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Hiroko Ikeda Miwa Takai Narumi Yashiro Yuka Amano Koki Hara Mao Yamamoto Toshifumi Tsujiuchi Source Type: research
Regulation of cellular responses to X-ray irradiation through the activation of lysophosphatidic acid (LPA) receptor-3 (LPA < sub > 3 < /sub > ) and LPA < sub > 2 < /sub > in osteosarcoma cells
Pathol Res Pract. 2024 Apr 5;257:155293. doi: 10.1016/j.prp.2024.155293. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) binds to its specific G protein-coupled LPA receptors (LPA1 to LPA6), resulting in the activation of various cellular functions. LPA receptor-mediated signaling facilitates tumor progression in human malignancies. In the present study, we investigated whether LPA receptor-mediated signaling contributes to cellular responses to X-ray irradiation in osteosarcoma MG-63 cells. After X-ray irradiation (2, 4 and 8 Gy), LPAR2 and LPAR3 expression levels in MG-63 cells were significantly elevated in a ...
Source: Pathology, Research and Practice - April 14, 2024 Category: Pathology Authors: Hiroko Ikeda Miwa Takai Narumi Yashiro Yuka Amano Koki Hara Mao Yamamoto Toshifumi Tsujiuchi Source Type: research
Regulation of cellular responses to X-ray irradiation through the activation of lysophosphatidic acid (LPA) receptor-3 (LPA < sub > 3 < /sub > ) and LPA < sub > 2 < /sub > in osteosarcoma cells
Pathol Res Pract. 2024 Apr 5;257:155293. doi: 10.1016/j.prp.2024.155293. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) binds to its specific G protein-coupled LPA receptors (LPA1 to LPA6), resulting in the activation of various cellular functions. LPA receptor-mediated signaling facilitates tumor progression in human malignancies. In the present study, we investigated whether LPA receptor-mediated signaling contributes to cellular responses to X-ray irradiation in osteosarcoma MG-63 cells. After X-ray irradiation (2, 4 and 8 Gy), LPAR2 and LPAR3 expression levels in MG-63 cells were significantly elevated in a ...
Source: Pathology, Research and Practice - April 14, 2024 Category: Pathology Authors: Hiroko Ikeda Miwa Takai Narumi Yashiro Yuka Amano Koki Hara Mao Yamamoto Toshifumi Tsujiuchi Source Type: research
GSE243561 High Expression of SRSF1 Facilitates Osteosarcoma Progression and Unveilsits Potential Mechanisms
In this study, we aimed to investigate the functions of SRSF1 and its underlying mechanism in OS.SRSF1 expression level in OS was obtained from the TCGA dataset, TAGET-OS database. qRT-PCR and Western blotting were employed to assess SRSF1 expression in human OS cell lines and human bone marrow mesenchymal stem cells (BMSC), as well as the interfered ectopic expression states. The effect of SRSF1 on cell migration, invasion, proliferation, and apoptosis of OS cells were measured by transwell assay and flow cytometry. RNA sequence and bioinformatic analyses were conducted to elucidate the relevant biological pathways regula...
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Transient Receptor Potential Ankyrin 1 Ion Channel Is Expressed in Osteosarcoma and Its Activation Reduces Viability
Int J Mol Sci. 2024 Mar 28;25(7):3760. doi: 10.3390/ijms25073760.ABSTRACTOsteosarcoma is a highly malignant, painful cancer with poor treatment opportunities and a bad prognosis. Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are non-selective cation channels that have been of great interest in cancer, as their expression is increased in some malignancies. In our study we aim to characterize the expression and functionality of the TRPA1 and TRPV1 channels in human and mouse osteosarcoma tissues and in a mouse cell line. TRPA1/Trpa1 and TRPV1/Trpv1 mRNA expressions were demonstrated by PCR ...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Lina Hudhud Katalin Rozmer Ang éla Kecskés Krisztina Poh óczky No émi Bencze Krisztina Buz ás Éva Szőke Zsuzsanna Helyes Source Type: research
Resveratrol-Loaded Polydimethylsiloxane-Silica Hybrid Materials: Synthesis, Characterization, and Antitumoral Activity
Polymers (Basel). 2024 Mar 22;16(7):879. doi: 10.3390/polym16070879.ABSTRACTIn this work, hybrid materials within the polydimethylsiloxane-silica (PDMS-SiO2) system, synthesized via the sol-gel method, were developed and characterized for their potential to incorporate and release the bioactive compound resveratrol (RES). RES was incorporated into the materials with a high loading efficiency (>75%) using the rotary evaporator technique. This incorporation induced the amorphization of RES, resulting in enhanced solubility and in vitro release when compared to the free polyphenolic compound. The release profiles displayed...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Sofia Viegas Diogo Marinheiro Ver ónica Bastos Ana L Daniel-da-Silva Ricardo Vieira Helena Oliveira Jos é Carlos Almeida B árbara J M L Ferreira Source Type: research
Transient Receptor Potential Ankyrin 1 Ion Channel Is Expressed in Osteosarcoma and Its Activation Reduces Viability
Int J Mol Sci. 2024 Mar 28;25(7):3760. doi: 10.3390/ijms25073760.ABSTRACTOsteosarcoma is a highly malignant, painful cancer with poor treatment opportunities and a bad prognosis. Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are non-selective cation channels that have been of great interest in cancer, as their expression is increased in some malignancies. In our study we aim to characterize the expression and functionality of the TRPA1 and TRPV1 channels in human and mouse osteosarcoma tissues and in a mouse cell line. TRPA1/Trpa1 and TRPV1/Trpv1 mRNA expressions were demonstrated by PCR ...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Lina Hudhud Katalin Rozmer Ang éla Kecskés Krisztina Poh óczky No émi Bencze Krisztina Buz ás Éva Szőke Zsuzsanna Helyes Source Type: research
