Alteration in the Expression of Circular Rnas and its association with the Development and Progression of Osteosarcoma, an Integrative Review with High Sensitivity Research
Asian Pac J Cancer Prev. 2024 Apr 1;25(4):1195-1203. doi: 10.31557/APJCP.2024.25.4.1195.ABSTRACTBACKGROUND: Osteosarcoma is the most common primary malignant bone tumor, mainly affecting children, young adults, and the elderly. It is an aggressive cancer with a poor prognosis, exhibiting low survival rates even with standard treatment. Recently, circular RNA molecules capable of influencing gene expression through various functions, with their main role being acting as microRNA sponges and reducing their intracellular expression, have been identified. Recent studies have linked circular RNAs to osteosarcoma development and...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Felipe Alves De Lima Fernando Liberalino Fernandes Daria Raquel Queiroz De Almeida Amanda Estevam Carvalho Val éria Duarte Almeida Gilson Aquino Cavalcante Nickson Melo De Morais Tayline Dantas Rodrigues Ellany Gurgel Cosme Do Nascimento Ivana Teixeira D Source Type: research
Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors
Int J Mol Sci. 2024 Apr 9;25(8):4139. doi: 10.3390/ijms25084139.ABSTRACTBone tumors, particularly osteosarcoma, are prevalent among children and adolescents. This ailment has emerged as the second most frequent cause of cancer-related mortality in adolescents. Conventional treatment methods comprise extensive surgical resection, radiotherapy, and chemotherapy. Consequently, the management of bone tumors and bone regeneration poses significant clinical challenges. Photothermal tumor therapy has attracted considerable attention owing to its minimal invasiveness and high selectivity. However, key challenges have limited its w...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Mengzhang Xie Taojun Gong Yitian Wang Zhuangzhuang Li Minxun Lu Yi Luo Li Min Chongqi Tu Xingdong Zhang Qin Zeng Yong Zhou Source Type: research
From biology to personalized medicine: recent knowledge in Osteosarcoma
Eur J Med Genet. 2024 Apr 25:104941. doi: 10.1016/j.ejmg.2024.104941. Online ahead of print.ABSTRACTHigh-grade osteosarcoma is the most common paediatric bone cancer. More than one third of patients relapse and die of osteosarcoma using current chemotherapeutic and surgical strategies. To improve outcomes in osteosarcoma, two crucial challenges need to be tackled: 1-the identification of hard-to-treat disease, ideally from diagnosis; 2- choosing the best combined or novel therapies to eradicate tumor cells which are resistant to current therapies leading to disease dissemination and metastasize as well as their favorable m...
Source: European Journal of Medical Genetics - April 27, 2024 Category: Genetics & Stem Cells Authors: Audrey Mohr Maria Eugenia Marques Da Costa Olivia Fromigue Baptiste Audinot Thierno Balde Robin Droit Samuel Abbou Pierre Khneisser Pablo Berlanga Esperanza Perez Antonin Marchais Nathalie Gaspar Source Type: research
A Semiautomated Proteomics and Phosphoproteomics Protocol for the Identification of Novel Therapeutic Targets and Predictive Biomarkers in In Vivo Xenograft Models of Pediatric Cancers
Methods Mol Biol. 2024;2806:229-242. doi: 10.1007/978-1-0716-3858-3_17.ABSTRACTGenomic profiling has identified therapeutic targets for precision treatment of certain cancers, but many patients lack actionable mutations. Additional omics approaches, like proteomics and phosphoproteomics, are essential for comprehensive mapping of cancer-associated molecular phenotypes. In vivo models, such as cell line and patient-derived xenografts (PDX), offer valuable insights into cancer biology and treatment strategies.This chapter presents a semiautomated high-throughput workflow for integrated proteomics and phosphoproteomics analys...
Source: Mol Biol Cell - April 27, 2024 Category: Molecular Biology Authors: Terry C C Lim Kam Sian Christie Sun Jason E Cain Joel R Steele Iresha Hanchapola Stoyan Stoychev Ralf B Schittenhelm Pouya Faridi Source Type: research
From biology to personalized medicine: recent knowledge in Osteosarcoma
Eur J Med Genet. 2024 Apr 25:104941. doi: 10.1016/j.ejmg.2024.104941. Online ahead of print.ABSTRACTHigh-grade osteosarcoma is the most common paediatric bone cancer. More than one third of patients relapse and die of osteosarcoma using current chemotherapeutic and surgical strategies. To improve outcomes in osteosarcoma, two crucial challenges need to be tackled: 1-the identification of hard-to-treat disease, ideally from diagnosis; 2- choosing the best combined or novel therapies to eradicate tumor cells which are resistant to current therapies leading to disease dissemination and metastasize as well as their favorable m...
Source: European Journal of Medical Genetics - April 27, 2024 Category: Genetics & Stem Cells Authors: Audrey Mohr Maria Eugenia Marques Da Costa Olivia Fromigue Baptiste Audinot Thierno Balde Robin Droit Samuel Abbou Pierre Khneisser Pablo Berlanga Esperanza Perez Antonin Marchais Nathalie Gaspar Source Type: research
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications
CONCLUSION: Composite reconstruction with extracorporeal irradiated autografts plus total hip replacement is a feasible reconstruction technique after Type II pelvic resections, although complications and reoperations were common. Although no reconstruction technique has been proven superior to other alternatives, the high risk of complications and reoperations associated with this technique should be considered when selecting from among possible alternative reconstruction methods.LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:38666740 | DOI:10.1097/CORR.0000000000003097 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 26, 2024 Category: Orthopaedics Authors: Arman Vahabi H üseyin Kaya Hakan Koray Tosyal ı Bur çin Keçeci D ündar Sabah Source Type: research
High-Grade Osteosarcoma of the Maxillary Sinus
Dtsch Arztebl Int. 2024 Mar 22;121(6):204. doi: 10.3238/arztebl.m2023.0088.NO ABSTRACTPMID:38666680 | DOI:10.3238/arztebl.m2023.0088 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 26, 2024 Category: General Medicine Authors: Maximilian Linxweiler Mathias Wagner Source Type: research
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications
CONCLUSION: Composite reconstruction with extracorporeal irradiated autografts plus total hip replacement is a feasible reconstruction technique after Type II pelvic resections, although complications and reoperations were common. Although no reconstruction technique has been proven superior to other alternatives, the high risk of complications and reoperations associated with this technique should be considered when selecting from among possible alternative reconstruction methods.LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:38666740 | DOI:10.1097/CORR.0000000000003097 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 26, 2024 Category: Orthopaedics Authors: Arman Vahabi H üseyin Kaya Hakan Koray Tosyal ı Bur çin Keçeci D ündar Sabah Source Type: research
High-Grade Osteosarcoma of the Maxillary Sinus
Dtsch Arztebl Int. 2024 Mar 22;121(6):204. doi: 10.3238/arztebl.m2023.0088.NO ABSTRACTPMID:38666680 | DOI:10.3238/arztebl.m2023.0088 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 26, 2024 Category: General Medicine Authors: Maximilian Linxweiler Mathias Wagner Source Type: research
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications
CONCLUSION: Composite reconstruction with extracorporeal irradiated autografts plus total hip replacement is a feasible reconstruction technique after Type II pelvic resections, although complications and reoperations were common. Although no reconstruction technique has been proven superior to other alternatives, the high risk of complications and reoperations associated with this technique should be considered when selecting from among possible alternative reconstruction methods.LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:38666740 | DOI:10.1097/CORR.0000000000003097 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 26, 2024 Category: Orthopaedics Authors: Arman Vahabi H üseyin Kaya Hakan Koray Tosyal ı Bur çin Keçeci D ündar Sabah Source Type: research
High-Grade Osteosarcoma of the Maxillary Sinus
Dtsch Arztebl Int. 2024 Mar 22;121(6):204. doi: 10.3238/arztebl.m2023.0088.NO ABSTRACTPMID:38666680 | DOI:10.3238/arztebl.m2023.0088 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 26, 2024 Category: General Medicine Authors: Maximilian Linxweiler Mathias Wagner Source Type: research
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications
CONCLUSION: Composite reconstruction with extracorporeal irradiated autografts plus total hip replacement is a feasible reconstruction technique after Type II pelvic resections, although complications and reoperations were common. Although no reconstruction technique has been proven superior to other alternatives, the high risk of complications and reoperations associated with this technique should be considered when selecting from among possible alternative reconstruction methods.LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:38666740 | DOI:10.1097/CORR.0000000000003097 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 26, 2024 Category: Orthopaedics Authors: Arman Vahabi H üseyin Kaya Hakan Koray Tosyal ı Bur çin Keçeci D ündar Sabah Source Type: research
