Cancers, Vol. 16, Pages 1628: Peripheral Soluble Immune Checkpoint-Related Proteins Were Associated with Survival and Treatment Efficacy of Osteosarcoma Patients, a Cohort Study
Conclusion: Four soluble ICK-related proteins were associated with the survival of OS patients. Soluble ICK-related proteins could be promising biomarkers for the outcomes and immunotherapy of OS patients, though more research is warranted. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Binghao Li Qinchuan Wang Yihong Luo Sicong Wang Sai Pan Wenting Zhao Zhaoming Ye Xifeng Wu Tags: Article Source Type: research
ALP-Responsive, Anionic Iridium complex for Specific Recognition of Osteosarcoma Cells
Dalton Trans., 2024, Accepted Manuscript DOI: 10.1039/D4DT00568F, PaperShuang Shen, Shu Nong, Xianpeng Zhang, Jiaqi Song, Caiting Meng, Xinling Liu, Liang Shao, Guanying Li, Li Xu Poor cellular permeability greatly hampers the utilization of anionic Ir(III) complexes, though efficiently emissive and remarkably stable, in cell-based diagnosis. To overcome this barrier, we present the development of an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - April 23, 2024 Category: Chemistry Authors: Shuang Shen Source Type: research
Development of a novel six DNA damage response-related prognostic signature in osteosarcoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):110-115. doi: 10.14715/cmb/2024.70.3.16.ABSTRACTDNA damage response (DDR) plays a vital role in the development of cancer. Nevertheless, in osteosarcoma, the potential of DDR-related genes (DDRGs) remains unclear. Thus, the current research is intended to investigate the mechanisms of DDRGs in the development of osteosarcoma and to explore potential DDR-related biomarkers in forecasting the prognosis of osteosarcoma patients. The osteosarcoma genomic data from TCGA, GEO and cBioPortal databases were utilized for screening and identification of differentially expressed DDRGs...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Tianyang Li Zhenzhou Tang Sucheng Li Minhua Lu Source Type: research
Development of a novel six DNA damage response-related prognostic signature in osteosarcoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):110-115. doi: 10.14715/cmb/2024.70.3.16.ABSTRACTDNA damage response (DDR) plays a vital role in the development of cancer. Nevertheless, in osteosarcoma, the potential of DDR-related genes (DDRGs) remains unclear. Thus, the current research is intended to investigate the mechanisms of DDRGs in the development of osteosarcoma and to explore potential DDR-related biomarkers in forecasting the prognosis of osteosarcoma patients. The osteosarcoma genomic data from TCGA, GEO and cBioPortal databases were utilized for screening and identification of differentially expressed DDRGs...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Tianyang Li Zhenzhou Tang Sucheng Li Minhua Lu Source Type: research
Development of a novel six DNA damage response-related prognostic signature in osteosarcoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):110-115. doi: 10.14715/cmb/2024.70.3.16.ABSTRACTDNA damage response (DDR) plays a vital role in the development of cancer. Nevertheless, in osteosarcoma, the potential of DDR-related genes (DDRGs) remains unclear. Thus, the current research is intended to investigate the mechanisms of DDRGs in the development of osteosarcoma and to explore potential DDR-related biomarkers in forecasting the prognosis of osteosarcoma patients. The osteosarcoma genomic data from TCGA, GEO and cBioPortal databases were utilized for screening and identification of differentially expressed DDRGs...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Tianyang Li Zhenzhou Tang Sucheng Li Minhua Lu Source Type: research
Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain
(Source: Journal of Pain Research)
Source: Journal of Pain Research - April 23, 2024 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Disparities in incidence and survival for patients with Ewing sarcoma in Florida
ConclusionsFlorida Hispanic males have a higher-than-expected incidence of osseous ES compared to the US. Hispanics of both sexes show remarkably worse survival for nonmetastatic disease compared to NHW. This disparity is likely multifactorial and requires further in-depth studies. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Aditi Dhir,
Rachna Rahul,
Qinran Liu,
Dan Pham,
Rachel Kronenfeld,
Tulay Koru ‐Sengul,
Paulo S. Pinheiro Tags: RESEARCH ARTICLE Source Type: research
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
ConclusionsscRNA-seq illuminated the activation of the PDGF signaling pathway in primary lesion of non-metastatic osteosarcoma. PDGFD displayed an inhibitory effect on osteosarcoma metastasis, likely through the suppression of the EMT signaling pathway. (Source: Cellular Oncology)
Source: Cellular Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway
Osteosarcoma is a diverse and aggressive bone tumor. Driver genes regulating osteosarcoma initiation and progression remains incompletely defined. Zinc finger protein 692 (ZNF692), a kind of Kr üppel C2H2 zinc ... (Source: Biology Direct)
Source: Biology Direct - April 22, 2024 Category: Biology Authors: Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu and Weichun Guo Tags: Research Source Type: research
Locally released dexamethasone and its effects on osteogenic activity at implant-tissue interface
This study emphasizes the promising implications for functionalizing surfaces of implant materials with DEX-loaded chitosan microspheres to improve their biocompatibility and bioactivity.PMID:38642019 | DOI:10.1002/jbm.a.37722 (Source: Biomed Res)
Source: Biomed Res - April 20, 2024 Category: Research Authors: Gizem Kerem Sakip Önder Abdulhalim K ılıç Source Type: research
[Corrigendum] Long non ‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p
Oncol Rep. 2024 Jun;51(6):78. doi: 10.3892/or.2024.8737. Epub 2024 Apr 19.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the cell invasion assay experiments shown in Fig. 2D on p. 5, there appeared to be an overlapping section of data comparing between the Sao‑2/Control and MG‑63/siH19 panels, such that these data had been derived from the same original source where the panels were intended to portray the results from differently performed epxeriments. Upon examining their original data, the authors have realized that, in Fig. 2D, an inadvertent err...
Source: Oncology Reports - April 19, 2024 Category: Cancer & Oncology Authors: Hao Jin Huan Wang Xin Jin Wenbo Wang Source Type: research
Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule
Bioorg Med Chem Lett. 2024 Apr 16;105:129759. doi: 10.1016/j.bmcl.2024.129759. Online ahead of print.ABSTRACTHistone H2A mono-ubiquitination plays important roles in epigenetic gene expression and is also involved in tumorigenesis. Small molecules controlling H2A ubiquitination are of interest as potential chemical tools and anticancer drugs. To identify novel small molecule inhibitors of H2A ubiquitination, we synthesized and evaluated several compounds designed based on PRT4165 (1), which is a reported histone ubiquitin ligase RING1A inhibitor. We found that compound 11b strongly inhibited the viability and reduced histo...
Source: Bioorganic and Medicinal Chemistry Letters - April 18, 2024 Category: Chemistry Authors: Siyao Ni Yuri Takada Takaaki Ando Shengwang Yu Yasunobu Yamashita Yukari Takahashi Miho Sawada Makoto Oba Yukihiro Itoh Takayoshi Suzuki Source Type: research
A New Perspective for Early Detection of Bone Tumour: Metamaterial-Based Antenna Solution
In this study, we designed a non-invasive mathematically supported antenna and tested this antenna on a clinically suitable tibia bone and tumour phantom. The results proved that bone tumour can be detected non-invasively with microwave antennas. (Source: Plasmonics)
Source: Plasmonics - April 18, 2024 Category: Biomedical Science Source Type: research
Incidence rates of the most common canine tumors based on data from the Swiss Canine Cancer Registry (2008 to 2020)
In conclusion, the calculated IRs and IRRs revealed previously unknown predisposing factors, including novel breed-specific suscepti bilities. The results may have implications for cancer screening, diagnostic work-up, breeding management and oncologic and translational research. (Source: PLoS One)
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Elena Sophie Dhein Source Type: research
