Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway
Exp Cell Res. 2024 Apr 23:114053. doi: 10.1016/j.yexcr.2024.114053. Online ahead of print.ABSTRACTBladder cancer is a common tumor that impacts the urinary system and marked by a significant fatality rate and an unfavorable prognosis. Promising antineoplastic properties are exhibited by brusatol, which is obtained from the dried ripe fruit of Brucea javanica. The present study aimed to evaluate the influence of brusatol on the progression of bladder cancer and uncover the molecular mechanism involved. We used Cell Counting Kit-8, colony formation and EdU assays to detect cell numbers, viability and proliferation. We used t...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: X I Yu Z I Q I He Q I N G H U A Wang S H U A I Ke H U A X I N Wang Z H O N G Wang S H E N G L A N Li Source Type: research
The quantity, function and anti-tumor effect of Mucosal associated invariant T cells in patients with bladder cancer
CONCLUSIONS: This study sheds light on the role of MAIT cells in BC. While the quantity of MAIT cells showed no significant change in BC patients, their functional attributes and association with tumor characteristics suggest their potential as an immunotherapy target in BC treatment.PMID:38663315 | DOI:10.1016/j.intimp.2024.111892 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Baodan Zhang Pengcheng Chen Jie Zhu Yongyong Lu Source Type: research
20-hydroxyecdysone suppresses bladder cancer progression via inhibiting USP21: A mechanism associated with deubiquitination and degradation of p65
Transl Oncol. 2024 Apr 24;45:101958. doi: 10.1016/j.tranon.2024.101958. Online ahead of print.ABSTRACTBladder cancer is one of the most common malignancies of the urinary tract and a prevalent cancer worldwide, still requiring efficient therapeutic agents and approaches. 20-Hydroxyecdysone (20-HE), a steroid hormone, can be found in insects and few plants and mediate numerous biological events to control the progression of varying diseases; however, its impacts on bladder cancer remain unclear. In the study, we found that 20-HE treatments effectively inhibited the viability and proliferation of bladder cancer cells and ind...
Source: Translational Oncology - April 25, 2024 Category: Cancer & Oncology Authors: Qiang Ma Fei Wu Xiaohui Liu Cuifang Zhao Yang Sun Yuanyuan Li Wei Zhang Hongge Ju Yukun Wang Source Type: research
Perfusion drugs for non ‑muscle invasive bladder cancer (Review)
Oncol Lett. 2024 Apr 15;27(6):267. doi: 10.3892/ol.2024.14400. eCollection 2024 Jun.ABSTRACTThe high recurrence rate and poor prognosis of non-muscle invasive bladder cancer (BC) are challenges that need to be urgently addressed. Transurethral cystectomy for bladder tumors is often combined with bladder perfusion therapy, which can effectively reduce the recurrence and progression rates of BC. The present review integrated and analyzed currently available bladder perfusion drugs, mainly including chemotherapeutic agents, immunotherapeutic agents and other adjuvant perfusion drugs. Bacillus Calmette-Guerin (BCG) perfusion w...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Jingyuan Qian Qiuchen Zhang Yang Cao Xi Chu Yiyang Gao Haifei Xu Hongzhou Cai Jiajia Wu Source Type: research
PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
CONCLUSIONS: Expression of PD-L1 was detected in a cohort of NCC patients, although the PD-L1 positivity rate was lower than that in BC. Our results demonstrate that the degree of PD-L1 expression in bladder tissue is associated with the presence of viral infections and with the degree of inflammatory infiltration of the bladder wall in both NCC and BC.PMID:38662109 | DOI:10.1007/s00192-024-05782-8 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Inga Kosova Vagan Barsegian Lyudmila Gundorova Dmitriy Kolbasov Source Type: research
An exploratory study investigating the impact of the bladder tumor microbiome on Bacillus Calmette Guerin (BCG) response in non-muscle invasive bladder cancer
CONCLUSION: A compositional difference exists in the tumor microbiome of BCG responders and non-responders with Lactobacillus having increased abundance in BCG responders.PMID:38664180 | DOI:10.1016/j.urolonc.2024.04.011 (Source: Urologic Oncology)
Source: Urologic Oncology - April 25, 2024 Category: Urology & Nephrology Authors: Jacob Knorr Zaeem Lone Glenn Werneburg Ava Adler Jose Agudelo Mangesh Suryavanshi Rebecca A Campbell Kyle Ericson Hong Qiu Petar Bajic Georges-Pascal Haber Christopher J Weight Philip P Ahern Nima Almassi Aaron W Miller Byron H Lee Source Type: research
Voided urine cytology is a useful tool predicting non-muscle-invasive bladder cancer risk before surgery
CONCLUSIONS: VUC appears to be a good, inexpensive and easily available method to determine risk stratification before surgery. This can be useful in daily practice to determine which patients should receive a single instillation of MMC and to prioritize patients more likely to have a high- risk tumor.PMID:38664179 | DOI:10.1016/j.urolonc.2024.03.014 (Source: Urologic Oncology)
Source: Urologic Oncology - April 25, 2024 Category: Urology & Nephrology Authors: Carmen G ómez Del Cañizo Ignacio Gonz ález Ginel Cristina Mart ín-Arriscado Arroba Ana de la Calle Moreno Mario Hern ández Arroyo Alfredo Rodr íguez Antolín F élix Guerrero Ramos Source Type: research
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility
In this study, we derived TCMGs from metabolic pathways of polycyclic aromatic hydrocarbons and tobacco-specific nitrosamines, and then explored genetic associations between TCMGs and bladder cancer risk in two populations: a Chinese population of 580 cases and 1101 controls, and a European population of 5930 cases and 5468 controls, along with interaction and joint analyses. Expression patterns of TCMGs were sourced from Nanjing Bladder Cancer (NJBC) study and publicly available datasets. Among 43 TCMGs, we observed that rs7087341 T > A in AKR1C2 was associated with a reduced risk of bladder cancer in the Chinese popul...
Source: Archives of Toxicology - April 25, 2024 Category: Toxicology Authors: Yanping Xiao Yang Shen Hui Song Fang Gao Zhenguang Mao Qiang Lv Chao Qin Lin Yuan Dongmei Wu Haiyan Chu Meilin Wang Mulong Du Rui Zheng Zhengdong Zhang Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway
Exp Cell Res. 2024 Apr 23:114053. doi: 10.1016/j.yexcr.2024.114053. Online ahead of print.ABSTRACTBladder cancer is a common tumor that impacts the urinary system and marked by a significant fatality rate and an unfavorable prognosis. Promising antineoplastic properties are exhibited by brusatol, which is obtained from the dried ripe fruit of Brucea javanica. The present study aimed to evaluate the influence of brusatol on the progression of bladder cancer and uncover the molecular mechanism involved. We used Cell Counting Kit-8, colony formation and EdU assays to detect cell numbers, viability and proliferation. We used t...
Source: Experimental Cell Research - April 25, 2024 Category: Cytology Authors: X I Yu Z I Q I He Q I N G H U A Wang S H U A I Ke H U A X I N Wang Z H O N G Wang S H E N G L A N Li Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
The quantity, function and anti-tumor effect of Mucosal associated invariant T cells in patients with bladder cancer
CONCLUSIONS: This study sheds light on the role of MAIT cells in BC. While the quantity of MAIT cells showed no significant change in BC patients, their functional attributes and association with tumor characteristics suggest their potential as an immunotherapy target in BC treatment.PMID:38663315 | DOI:10.1016/j.intimp.2024.111892 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Baodan Zhang Pengcheng Chen Jie Zhu Yongyong Lu Source Type: research
20-hydroxyecdysone suppresses bladder cancer progression via inhibiting USP21: A mechanism associated with deubiquitination and degradation of p65
Transl Oncol. 2024 Apr 24;45:101958. doi: 10.1016/j.tranon.2024.101958. Online ahead of print.ABSTRACTBladder cancer is one of the most common malignancies of the urinary tract and a prevalent cancer worldwide, still requiring efficient therapeutic agents and approaches. 20-Hydroxyecdysone (20-HE), a steroid hormone, can be found in insects and few plants and mediate numerous biological events to control the progression of varying diseases; however, its impacts on bladder cancer remain unclear. In the study, we found that 20-HE treatments effectively inhibited the viability and proliferation of bladder cancer cells and ind...
Source: Translational Oncology - April 25, 2024 Category: Cancer & Oncology Authors: Qiang Ma Fei Wu Xiaohui Liu Cuifang Zhao Yang Sun Yuanyuan Li Wei Zhang Hongge Ju Yukun Wang Source Type: research
Perfusion drugs for non ‑muscle invasive bladder cancer (Review)
Oncol Lett. 2024 Apr 15;27(6):267. doi: 10.3892/ol.2024.14400. eCollection 2024 Jun.ABSTRACTThe high recurrence rate and poor prognosis of non-muscle invasive bladder cancer (BC) are challenges that need to be urgently addressed. Transurethral cystectomy for bladder tumors is often combined with bladder perfusion therapy, which can effectively reduce the recurrence and progression rates of BC. The present review integrated and analyzed currently available bladder perfusion drugs, mainly including chemotherapeutic agents, immunotherapeutic agents and other adjuvant perfusion drugs. Bacillus Calmette-Guerin (BCG) perfusion w...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Jingyuan Qian Qiuchen Zhang Yang Cao Xi Chu Yiyang Gao Haifei Xu Hongzhou Cai Jiajia Wu Source Type: research
An exploratory study investigating the impact of the bladder tumor microbiome on Bacillus Calmette Guerin (BCG) response in non-muscle invasive bladder cancer
CONCLUSION: A compositional difference exists in the tumor microbiome of BCG responders and non-responders with Lactobacillus having increased abundance in BCG responders.PMID:38664180 | DOI:10.1016/j.urolonc.2024.04.011 (Source: Urologic Oncology)
Source: Urologic Oncology - April 25, 2024 Category: Urology & Nephrology Authors: Jacob Knorr Zaeem Lone Glenn Werneburg Ava Adler Jose Agudelo Mangesh Suryavanshi Rebecca A Campbell Kyle Ericson Hong Qiu Petar Bajic Georges-Pascal Haber Christopher J Weight Philip P Ahern Nima Almassi Aaron W Miller Byron H Lee Source Type: research
